Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.


RATIONALE:Adrenal hepatoid adenocarcinoma typically secretes alpha-fetoprotein (AFP). Here, we report a case of non-AFP-producing adrenal hepatoid adenocarcinoma. Next-generation sequencing (NGS) was conducted to identify gene mutations. PATIENT CONCERNS:A 64-year-old man presented with mild back pain and unexplained weight loss for 3 months. DIAGNOSES:Contrast-enhanced magnetic resonance imaging (MRI) showed a mass (9.9 × 9.7 × 9.1 mm) above the upper pole of the left kidney. The left renal artery and vein were compressed. The tumor was positive for CK8/18, CK19, CK7, hepatocyte marker (Hepatocyte), and Hep Par 1, but negative for AFP. Plasma AFP was 2.75 ng/mL (normal range: 0-7 ng/mL). NGS revealed mutations of the following genes: ATM, CDKN2A, EGFR, STK11, TP53, BIM, and MLH1. A diagnosis of adrenal hepatoid adenocarcinoma was established. INTERVENTIONS:The treatment included 4 cycles of the mFOLFOX6 regimen (oxaliplatin, leucovorin, and fluorouracil), transcatheter arterial chemoembolization, and apatinib. OUTCOMES:The patient died 9 months after the diagnosis. LESSONS:This case highlights the importance of thorough clinical, radiological, and immunohistochemical investigation for suspected adrenal hepatoid adenocarcinoma. Metastasis from other primary tumors should be ruled out. Furthermore, AFP is not necessarily elevated in adrenal hepatoid adenocarcinoma. NGS could be helpful in establishing the diagnosis and selecting treatments.


Medicine (Baltimore)




Lin J,Cao Y,Yu L,Lin L




Has Abstract


2018-09-01 00:00:00
















  • Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature.

    abstract:RATIONALE:Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagno...


    pub_type: 杂志文章,评审


    authors: Yang K,Jiang H,Li Q

    更新日期:2019-04-01 00:00:00

  • Coagulation markers and echocardiography predict atrial fibrillation, malignancy or recurrent stroke after cryptogenic stroke.

    abstract::We evaluated the utility of left atrial volume index (LAVI) and markers of coagulation and hemostatic activation (MOCHA) in cryptogenic stroke (CS) patients to identify those more likely to have subsequent diagnosis of atrial fibrillation (AF), malignancy or recurrent stroke during follow-up.Consecutive CS patients wh...


    pub_type: 杂志文章


    authors: Ellis D,Rangaraju S,Duncan A,Hoskins M,Raza SA,Rahman H,Winningham M,Belagaje S,Bianchi N,Mohamed GA,Obideen M,Sharashidze V,Belair T,Henriquez L,Nahab F

    更新日期:2018-12-01 00:00:00

  • Bacteremic and nonbacteremic pneumococcal pneumonia. A prospective study.

    abstract::We prospectively identified cases of pneumococcal pneumonia and used stringent criteria to stratify them into bacteremic and nonbacteremic cases. Although patients were distributed among racial groups in proportion to all patients seen at this medical center, the proportion of African-Americans with bacteremic disease...


    pub_type: 杂志文章


    authors: Musher DM,Alexandraki I,Graviss EA,Yanbeiy N,Eid A,Inderias LA,Phan HM,Solomon E

    更新日期:2000-07-01 00:00:00

  • Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: A case report.

    abstract:INTRODUCTION:Systemic Bartonella spp. infections are being increasingly reported in association with complex medical presentations. Individuals with frequent arthropod exposures or animal contact appear to be at risk for acquiring long standing infections with Bartonella spp. CASE REPORT:This case report describes inf...


    pub_type: 杂志文章


    authors: Mozayeni BR,Maggi RG,Bradley JM,Breitschwerdt EB

    更新日期:2018-04-01 00:00:00

  • The clinical effect of rehabilitation following arthroscopic rotator cuff repair: A meta-analysis of early versus delayed passive motion.

    abstract:BACKGROUND:The argument on the recommended rehabilitation protocol following arthroscopic rotator cuff repair remains to be resolved. So this meta-analysis was presented to evaluate the differences of clinical effects between the 2 distinct rehabilitation protocols after arthroscopic rotator cuff repair. METHODS:The P...


    pub_type: 杂志文章,meta分析,评审


    authors: Li S,Sun H,Luo X,Wang K,Wu G,Zhou J,Wang P,Sun X

    更新日期:2018-01-01 00:00:00

  • Role of immune cells in pancreatic cancer from bench to clinical application: An updated review.

    abstract:BACKGROUND:Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with P...


    pub_type: 杂志文章,评审


    authors: Chang JH,Jiang Y,Pillarisetty VG

    更新日期:2016-12-01 00:00:00

  • Effect of a serum lactate monitoring recommendation policy on patients treated with linezolid.

    abstract:ABSTRACT:Lactic acidosis is one of the most fatal adverse effects of linezolid, an antibiotic used to treat serious infections caused by antibiotic-resistant bacteria. However, the measures to prevent lactic acidosis have not been well established.We performed a retrospective study to analyze the impact of applying a s...


    pub_type: 杂志文章


    authors: Im JH,Lee JS,Chung MH,Kwon HY,Lee MJ,Baek JH

    更新日期:2021-01-08 00:00:00

  • Determination of the optimal target level of proteinuria in the management of patients with glomerular diseases by using different definitions of proteinuria.

    abstract::Proteinuria is a major determinant of adverse renal outcome, and its reduction slows renal progression in glomerular diseases. However, the optimal target of proteinuria in glomerular diseases is unclear, and discrepancies in the definition of proteinuria produce ambiguous findings. Here we investigated the optimal ta...


    pub_type: 杂志文章


    authors: Kee YK,Yoon CY,Kim SJ,Moon SJ,Kim CH,Park JT,Lim BJ,Chang TI,Kang EW,Kie JH,Yoo TH,Jeong HJ,Kang SW,Han SH

    更新日期:2017-11-01 00:00:00

  • Investigation and estimation of the prevalence of drug addicts in Xichang, china.

    abstract::To use a new method to estimate the prevalence of drug addicts in Xichang for the first time and to suggest that Chinese Center for Disease Control and Prevention should strengthen surveillance and intervention for them.The Capture-Mark-Recapture (CMR) method of 3 correlated sources under the simple random sampling an...


    pub_type: 杂志文章


    authors: Chen K,Bian C,Song B,Gao G

    更新日期:2019-01-01 00:00:00

  • Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty: A GRADE analysis and meta-analysis.

    abstract:BACKGROUND:The efficacy and safety of oral tranexamic acid (TXA) remain controversial because of the small number of clinical studies. The aim of the present study was to compare the efficacy and safety of oral TXA with intravenous TXA in patients undergoing total hip arthroplasty and total knee arthroplasty in a syste...


    pub_type: 杂志文章,meta分析


    authors: Sun C,Zhang X,Chen L,Deng J,Ma Q,Cai X,Yang H

    更新日期:2020-10-30 00:00:00

  • Sudden death due to ventricular double rupture as a complication of inferior acute myocardial infarction: A case report.

    abstract:RATIONALE:Ventricular double rupture (VDR) is a rare but lethal mechanical complication of acute myocardial infarction (AMI). The early identification and timely treatment of VDR remain challenging problems. We present a case of AMI with VDR and briefly review the characteristics and prognosis of this life-threatening ...


    pub_type: 杂志文章


    authors: Chen SJ,Zhang C,Meng QT,Peng Y,Chen M

    更新日期:2016-12-01 00:00:00

  • Strategic use of dual regimens of boosted protease inhibitors plus maraviroc in poorly adherent subjects in view of long-acting drugs: A retrospective study.

    abstract::In view of the forthcoming long-acting antiretrovirals, measures should be taken to prevent the selection of HIV drug resistance mutations. All subjects who had been switched to boosted protease inhibitors plus maraviroc (bPIs/MVC) with baseline HIV-1 RNA >50 copies/mL between June, 2014, and April, 2015, were retrosp...


    pub_type: 杂志文章


    authors: Capetti AF,Micale M,Carenzi L,Niero F,Landonio S,Vimercati S,Dedivitiis G,Rizzardini G

    更新日期:2017-02-01 00:00:00

  • Interferon-free regimens improve health-related quality of life and fatigue in HIV/HCV-coinfected patients with advanced liver disease: A retrospective study.

    abstract::Health-related quality of life (HRQoL) is impaired in HIV/HCV-coinfected patients (HIV/HCV) and further decreased by interferon (IFN)-based therapies. We aimed to investigate the impact of IFN- and ribavirin (RBV)-free therapies on HRQoL and fatigue.Thirty-three HIV/HCV-coinfected patients who underwent HCV therapy wi...


    pub_type: 杂志文章


    authors: Scheiner B,Schwabl P,Steiner S,Bucsics T,Chromy D,Aichelburg MC,Grabmeier-Pfistershammer K,Trauner M,Peck-Radosavljevic M,Reiberger T,Mandorfer M

    更新日期:2016-07-01 00:00:00

  • Prevalence of CD30 immunostaining in neoplastic mast cells: A retrospective immunohistochemical study.

    abstract::Mastocytosis is a rare disease characterized by clonal neoplastic proliferation of mast cells (MCs). It ranges from skin lesions as cutaneous mastocytosis (CM) which may spontaneously regress to highly aggressive neoplasms with multiorgan involvement corresponding to some aggressive systemic mastocytosis (ASM), mast c...


    pub_type: 杂志文章


    authors: Russano de Paiva Silva G,Tournier E,Sarian LO,Bulai-Livideanu C,Delsol G,Lamant L,Vassallo J,Brousset P,Laurent C

    更新日期:2018-05-01 00:00:00

  • Epidemiological evaluation of traumatic lower limb fractures in children: Variation with age, gender, time, and etiology.

    abstract::To investigate the age, gender, time, and etiology differences of traumatic lower limb fractures (TLLFs) in a population of children (≤18 years old), we retrospectively reviewed 936 children who had TLLFs and who came to our university-affiliated hospitals from 2001 to 2010. This study enrolled 657 males (70.2%) and 2...


    pub_type: 杂志文章


    authors: Liu H,Wang H,Shao B,Lu H,Zhang S,Ou L,Chen Y,Xiang L

    更新日期:2019-09-01 00:00:00

  • The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.

    abstract:BACKGROUND:CyclinD1 (CCND1) is a key cell cycle regulatory protein. A large number of epidemiological studies have assessed the potential correlation between the CCND1 G870A polymorphism and the risk of colorectal cancer (CRC), but their findings have been inconsistent. To obtain a more precise understanding of the ass...


    pub_type: 杂志文章,meta分析,评审


    authors: Xie M,Zhao F,Zou X,Jin S,Xiong S

    更新日期:2017-10-01 00:00:00

  • A retrospective study of in-hospital mortality in patients with idiopathic pulmonary fibrosis between 2015 and 2018.

    abstract::Hospitalizations are common in patients with idiopathic pulmonary fibrosis (IPF) and are associated with high mortality. We used data from the Premier Healthcare Database to determine in-hospital mortality rates and the factors associated with in-hospital mortality in patients with IPF in the era of approved antifibro...


    pub_type: 杂志文章


    authors: Durheim MT,Judy J,Bender S,Neely ML,Baumer D,Robinson SB,Conoscenti CS,Leonard TB,Lazarus HM,Palmer SM

    更新日期:2020-11-20 00:00:00

  • Differences of DNA methylation patterns in the placenta of large for gestational age infant.

    abstract::To investigate the molecular mechanisms of later metabolic health changes in large for gestational age (LGA) newborns by analyzing deoxyribonucleic acid (DNA) methylation patterns in the placenta of LGA and appropriate for gestational age (AGA) newborns.A total of 6 placentas of LGA and 6 placentas of AGA newborns wer...


    pub_type: 杂志文章


    authors: Shen Z,Tang Y,Song Y,Shen W,Zou C

    更新日期:2020-09-25 00:00:00

  • Differences of bleedings after percutaneous coronary intervention using femoral closure and radial compression devices.

    abstract::Bleedings represent most relevant complications being correlated with significant rates of adverse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). To reduce bleeding and improve prognosis various types of vascular closure devices (VCD) are frequently applied. This study aims to compa...


    pub_type: 杂志文章


    authors: Kim SH,Behnes M,Baron S,Shchetynska-Marinova T,Tekinsoy M,Mashayekhi K,Hoffmann U,Borggrefe M,Akin I

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  • Peripheral Arterial Disease and Spinal Cord Injury: A Retrospective Nationwide Cohort Study.

    abstract::The aim of this study was to elucidate the relationship between spinal cord injury (SCI) and the risk of peripheral arterial disease (PAD) in a cohort study with a large representative sample.The National Health Insurance Database was used to select patients who were diagnosed from 2000 to 2010. Patients with a histor...


    pub_type: 杂志文章


    authors: Su TW,Chou TY,Jou HJ,Yang PY,Lin CL,Sung FC,Hsu CY,Kao CH

    更新日期:2015-10-01 00:00:00

  • Antenatal infection and intraventricular hemorrhage in preterm infants: A meta-analysis.

    abstract:BACKGROUND:The aim of this study was to summarize current evidence evaluating the association between antenatal infection and intraventricular hemorrhage (IVH) in preterm infants. MATERIALS AND METHODS:We searched for published articles on antenatal infection and IVH in 3 English (PubMed, the Cochrane Library, and EBS...


    pub_type: 杂志文章,meta分析


    authors: Huang J,Meng J,Choonara I,Xiong T,Wang Y,Wang H,Qu Y,Mu D

    更新日期:2019-08-01 00:00:00

  • Relationship between ABO blood group and risk of venous thrombosis in cancer patients with peripherally inserted central catheters: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Peripherally inserted central catheter (PICC) is closely related to venous thromboembolism (VTE). It is a common complication of hospitalized patients, and its etiology is complex. How to prevent the occurrence of VTE is the focus of clinical work. In order to provide basis for individual prevention and accu...


    pub_type: 杂志文章


    authors: Liu F,Zhang Q,Rao L,Song J

    更新日期:2020-11-06 00:00:00

  • Fractures as a suicidal behavior risk factor: A nationwide population-based cohort study.

    abstract::This study aimed to evaluate the association between fracture history and sequential risk of suicidal behavior.A total of 82,804 patients with fractures and 82,804 control subjects without fractures were matched. The influence of fractures on the risk of suicidal behavior-related hospital visit was analyzed using a Co...


    pub_type: 杂志文章


    authors: Tsai CH,Cheng WJ,Muo CH,Lin TL

    更新日期:2019-01-01 00:00:00

  • Therapeutic effectiveness of neuromuscular electrical stimulation for treating patients with chronic low back pain.

    abstract::This retrospective study investigated the effectiveness and safety of neuromuscular electrical stimulation (NMES) for patients with chronic low back pain (CLBP).A total of 72 patients with CLBP were included in this retrospective study. All patients received usual care, and were assigned to a NMES group (n = 36) and a...


    pub_type: 杂志文章


    authors: Guo P,Wang JW,Tong A

    更新日期:2018-11-01 00:00:00

  • Intracoronary and peripheral blood levels of TNF-like Cytokine 1A (TL1A) in patients with acute coronary syndrome.

    abstract:BACKGROUND:TNF-like cytokine 1A (TL1A) is a subgroup of the tumor necrosis factor superfamily that exerts pleiotropic effects on cell proliferation, inflammation, activation, and differentiation of immune cells. The purpose of the current study is to investigate the clinical significance of TL1A expression in coronary ...


    pub_type: 杂志文章


    authors: Chen X,Guo Y,Lai L,Zhang S,Li Z

    更新日期:2020-05-29 00:00:00

  • Roentgenographic Evaluation of the Spine in Patients With Osteogenesis Imperfecta.

    abstract::Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder that leads to bone weakness and deformities, especially in the spine, which can lead to poor outcomes.The aim of this study was to find patterns and risk factors in spinal deformities in patients with OI.In a retrospective study, 70 patients with ...


    pub_type: 杂志文章


    authors: de Lima MV,de Lima FV,Akkari M,Resende VR,Santili C

    更新日期:2015-11-01 00:00:00

  • Procalcitonin-guided antibiotic therapy in acute exacerbation of chronic obstructive pulmonary disease: An updated meta-analysis.

    abstract:BACKGROUND:The benefit of a procalcitonin (PCT)-guided antibiotic strategy in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains uncertain. OBJECTIVES:This updated meta-analysis was performed to reevaluate the therapeutic potential of PCT-guided antibiotic therapy in AECOPD. DATA SOURCES:We ...


    pub_type: 杂志文章,meta分析


    authors: Li Z,Yuan X,Yu L,Wang B,Gao F,Ma J

    更新日期:2019-08-01 00:00:00

  • The Risk of Depressive Disorder Among Contacts of Tuberculosis Patients in a TB-endemic Area: A Population-based Cohort Study.

    abstract::Tuberculosis (TB) disease may be transmitted to close contacts of index cases, causing physical illness. No studies have investigated the risk of developing depressive disorder among TB contacts in a TB-endemic area.Adult participants with a new diagnosis of TB contact (ICD-9-CM codes V01.1 plus chest radiographic ord...


    pub_type: 杂志文章


    authors: Pan SW,Yen YF,Feng JY,Su VY,Kou YR,Su WJ

    更新日期:2015-10-01 00:00:00

  • Chronic obstructive pulmonary disease is independently associated with hypertension in men: A survey design analysis using nationwide survey data.

    abstract::Although studies have shown that chronic obstructive pulmonary disease (COPD) and hypertension are linked as comorbidities, it remains unclear whether COPD is independently associated with the risk of hypertension or is caused by common risk factors such as age and smoking. The objective of this study was to investiga...


    pub_type: 杂志文章


    authors: Kim SH,Park JH,Lee JK,Heo EY,Kim DK,Chung HS

    更新日期:2017-05-01 00:00:00

  • Prognostic significance of serum procalcitonin in patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization: A retrospective analysis of 509 cases.

    abstract::Although procalcitonin (PCT) is a valid marker for early diagnosis of bacterial infections, its accuracy in hepatocellular carcinoma (HCC) patients is unknown. The aim of this study was to investigate the prognostic significance of PCT in patients with unresectable HCC treated with transcatheter arterial chemoemboliza...


    pub_type: 杂志文章


    authors: Shen H,Zheng S,Chen R,Jin X,Xu X,Jing C,Lin J,Zhang J,Zhang M,Zhang L,Xie X,Guo K,Ren Z,Lin S,Zhang B

    更新日期:2017-07-01 00:00:00