Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.

Abstract:

RATIONALE:Adrenal hepatoid adenocarcinoma typically secretes alpha-fetoprotein (AFP). Here, we report a case of non-AFP-producing adrenal hepatoid adenocarcinoma. Next-generation sequencing (NGS) was conducted to identify gene mutations. PATIENT CONCERNS:A 64-year-old man presented with mild back pain and unexplained weight loss for 3 months. DIAGNOSES:Contrast-enhanced magnetic resonance imaging (MRI) showed a mass (9.9 × 9.7 × 9.1 mm) above the upper pole of the left kidney. The left renal artery and vein were compressed. The tumor was positive for CK8/18, CK19, CK7, hepatocyte marker (Hepatocyte), and Hep Par 1, but negative for AFP. Plasma AFP was 2.75 ng/mL (normal range: 0-7 ng/mL). NGS revealed mutations of the following genes: ATM, CDKN2A, EGFR, STK11, TP53, BIM, and MLH1. A diagnosis of adrenal hepatoid adenocarcinoma was established. INTERVENTIONS:The treatment included 4 cycles of the mFOLFOX6 regimen (oxaliplatin, leucovorin, and fluorouracil), transcatheter arterial chemoembolization, and apatinib. OUTCOMES:The patient died 9 months after the diagnosis. LESSONS:This case highlights the importance of thorough clinical, radiological, and immunohistochemical investigation for suspected adrenal hepatoid adenocarcinoma. Metastasis from other primary tumors should be ruled out. Furthermore, AFP is not necessarily elevated in adrenal hepatoid adenocarcinoma. NGS could be helpful in establishing the diagnosis and selecting treatments.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Lin J,Cao Y,Yu L,Lin L

doi

10.1097/MD.0000000000012336

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

e12336

issue

39

eissn

0025-7974

issn

1536-5964

pii

00005792-201809280-00032

journal_volume

97

pub_type

杂志文章,评审

相关文献

MEDICINE文献大全
  • Spectrum of cardiac lesions in Behçet disease: a series of 52 patients and review of the literature.

    abstract::Cardiac abnormalities in patients with Behçet disease (BD) include pericarditis, myocarditis, endocarditis with valvular regurgitation, intracardiac thrombosis, endomyocardial fibrosis, coronary arteritis with or without myocardial infarction, and aneurysms of the coronary arteries or sinus of Valsalva. Data regarding...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0b013e3182428f49

    authors: Geri G,Wechsler B,Thi Huong DL,Isnard R,Piette JC,Amoura Z,Resche-Rigon M,Cacoub P,Saadoun D

    更新日期:2012-01-01 00:00:00

  • Femoral nerve block vs adductor canal block after anterior cruciate ligament reconstruction under general anesthesia: A prospective randomized trial protocol.

    abstract:BACKGROUND:Femoral nerve block (FNB) is considered the preferred analgesia after anterior cruciate ligament reconstruction (ACLR), but leads to weakness in the quadriceps muscles. Adductor canal block (ACB) is a new sensory block technique that effectively relieves postoperative pain while preserving quadriceps strengt...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020776

    authors: Xue Q,Jiang W,Wang M,Sui J,Wang Y

    更新日期:2020-07-10 00:00:00

  • Application of point-of-care ultrasound for different types of esophageal foreign bodies: three case reports: A CARE-compliant article.

    abstract:RATIONALE:Esophageal point-of-care ultrasound (POCUS) has recently been reported as a useful, quick, safe, and simple technique to detect esophageal foreign bodies (FBs). However, case series to detect esophageal FB using POCUS have been rarely reported. Chicken bones and pills, especially, have not yet been reported a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018893

    authors: Ahn JH,Sohn Y

    更新日期:2020-01-01 00:00:00

  • Effects of traditional Chinese exercise on cognitive and psychological outcomes in older adults with mild cognitive impairment: A systematic review and meta-analysis.

    abstract:BACKGROUND:Mild cognitive impairment (MCI) can be a stage of pre-dementia. Although the traditional Chinese exercise (TCE) has benefits associated with cognitive functions, the effects of the TCE on cognitive functions of older patients with MCI remain controversial. This study performs a meta-analysis to quantify the ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014581

    authors: Zhang Q,Hu J,Wei L,Cao R,Ma R,Song H,Jin Y

    更新日期:2019-02-01 00:00:00

  • Spontaneous hemothorax. Report of 6 cases and review of the literature.

    abstract::We present 6 cases of spontaneous hemothorax and comprehensively review the medical literature on this subject. We categorize the reported causes and offer a rational diagnostic approach to patients with nontraumatic hemothorax. We recommend specific treatments for specific etiologies, and emphasize the importance of ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Martinez FJ,Villanueva AG,Pickering R,Becker FS,Smith DR

    更新日期:1992-11-01 00:00:00

  • Bullying experience of pupils in Nigerian primary schools.

    abstract::Childhood bullying leads to life-long scars and hinders adult development. Schoolchildren involved in bullying are at risk of developing behavioural difficulties, physical health problems and suicidal ideation. This research aimed to evaluate the bullying experience of pupils in Nigerian primary schools.The study is a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022409

    authors: Umoke PCI,Umoke M,Ugwuanyi CS,Okeke CIO,Eseadi C,Onuorah AR,Ugwu GC,Obiweluozo PE,Uzodinma UE,Uwakwe RC,Uba MBI,Ebizie EN,Onyeke NG,Otu MS

    更新日期:2020-09-25 00:00:00

  • Acupuncture for the treatment of allergic rhinitis: A systematic review protocol.

    abstract:BACKGROUND:Allergic rhinitis is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of allergic rhinitis (AR) is increasing, resulting in a large burden of disease. Desensitizing drugs such as nasal glucocorticoids and antihistam...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013772

    authors: Bao H,Si D,Gao L,Sun H,Shi Q,Yan Y,Damchaaperenlei D,Li C,Yu M,Li Y

    更新日期:2018-12-01 00:00:00

  • Transcatheter aortic valve implantation in the patients with chronic liver disease: A mini-review and meta-analysis.

    abstract:BACKGROUND:Chronic liver disease is traditionally conceived as a risk factor for cardiovascular surgery. Transcatheter aortic valve implantation (TAVI) has recently burgeoned to precede surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis at intermediate to high surgical risk. The evidence r...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000019766

    authors: Ma X,Zhao D,Li J,Wei D,Zhang J,Yuan P,Kong X,Ma J,Ma H,Sun L,Zhang Y,Jiao Q,Wang Z,Zhang H

    更新日期:2020-04-01 00:00:00

  • Accuracy and safety of ultrasound-guided percutaneous needle core biopsy of renal masses: A single center experience in China.

    abstract::Our aim is to determine the sufficiency, accuracy, and safety of ultrasound-guided percutaneous needle core biopsy of renal masses in Chinese patients.Patients who had undergone ultrasound-guided needle core renal mass biopsy from June 2012 to June 2016 at West China Hospital, China were retrospectively reviewed. The ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010178

    authors: Wang X,Lv Y,Xu Z,Aniu M,Qiu Y,Wei B,Li X,Wei Q,Dong Q,Lin T

    更新日期:2018-03-01 00:00:00

  • Treatment of lateral epicondylitis with acupuncture and glucocorticoid: A retrospective cohort study.

    abstract::Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown. The goal of this study is to examine whether acupuncture is more effective than injection of glucocorticoid in adults with LE.Adults with LE received either acupuncture or injection of glucocortic...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019227

    authors: Peng Z,Zhang M,Li Y,Feng Z

    更新日期:2020-02-01 00:00:00

  • Effect of hypertension on outcomes of high-risk patients after BCG-treated bladder cancer: a single-institution long follow-up cohort study.

    abstract::Immunotherapy with Bacillus Calmette-Guérin (BCG) is the most efficacious treatment for high-risk bladder cancer (BC) (Ta/T1 or carcinoma in situ) to reduce the risk of recurrence. Our aim was to evaluate whether hypertension and diabetes influence the outcome of patients with noninvasive BC treated with BCG instillat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000589

    authors: Dal Moro F,Bovo A,Crestani A,Vettor R,Gardiman MP,Zattoni F

    更新日期:2015-03-01 00:00:00

  • Traditional Chinese medicine enema for acute chronic liver failure: A protocol of systematic review and meta-analysis of randomized clinical trials.

    abstract:BACKGROUND:Acute chronic liver failure (ACLF) is the most common type of liver failure. The clinical symptoms are complex and changeable, the treatment is difficult and the fatality rate is high. It has become an urgent problem to actively seek effective treatment means and improve the clinical efficacy of ACLF patient...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022585

    authors: Chen Y,Luo Y,Wu F,Liao N,Shi Q,Mao D

    更新日期:2020-10-09 00:00:00

  • Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases.

    abstract::The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006575

    authors: Zhang Y,Liang G,Qin H,Li Y,Zeng X

    更新日期:2017-04-01 00:00:00

  • Comparison of the cuff pressure of a TaperGuard endotracheal tube and a cylindrical endotracheal tube after lateral rotation of head during middle ear surgery: A single-blind, randomized clinical consort study.

    abstract:BACKGROUND:Positional change affects the cuff pressure of an endotracheal tube (ETT) in treacheally intubated patients. We compared the cuff pressure of a TaperGuard ETT and a cylindrical ETT after lateral rotation of head during middle ear surgery. METHODS:Fifty-two patients aged 18-70 years underwent a tympanomastoi...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000006257

    authors: Choi E,Park Y,Jeon Y

    更新日期:2017-03-01 00:00:00

  • Cerebellar pilocytic astrocytomas with spontaneous intratumoral hemorrhage in the elderly: A case report and review of the literature.

    abstract:RATIONALE:Pilocytic astrocytoma (PA) is the most common pediatric central nervous system glial tumor. Adult occurrence is rare, especially in elderly adults. How to manage the pilocytic astrocytoma with spontaneous intratumoral hemorrhage in the elderly is still unfamiliar with clinician. PATIENT CONCERNS:Reports of t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000011329

    authors: Sun S,Zhou H,Ding ZZ,Shi H

    更新日期:2018-08-01 00:00:00

  • Effects of epinephrine for out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials.

    abstract:AIM:Our objective is to assess the effects of epinephrine for out of hospital cardiac arrest. BACKGROUND:Cardiac arrest was the most serious medical incidents with an estimated incidence in the United States of 95.7 per 100,000 person years. Though epinephrine improved coronary and cerebral perfusion, improving a retu...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000017502

    authors: Huan L,Qin F,Wu Y

    更新日期:2019-11-01 00:00:00

  • Tibial plateau fracture related to unicompartmental knee arthroplasty: Two case reports and literature review.

    abstract:RATIONALE:Unicompartmental knee arthroplasty (UKA) is an effective method to treat single compartment disease of the knee joint. Report about the complications of UKA, especially tibial plateau fractures, is rare. Given its rarity, its pathogenesis is not well described, and a standard of treatment is still not establi...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000017338

    authors: Lu C,Ye G,Liu W,Wu H,Wu G,Chen J

    更新日期:2019-10-01 00:00:00

  • Association between Helicobacter pylori infection and irritable bowel syndrome: A systematic review and meta-analysis.

    abstract:BACKGROUND:In recent years, the incidence of IBS has gradually increased, and it is considered as one of the most common functional gastrointestinal diseases. However, the etiology of IBS is still unclear, and expectations are rising for more targeted treatments. Many clinical trials have explored the link between Heli...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000022975

    authors: Li C,Shuai Y,Zhou X,Chen H

    更新日期:2020-12-11 00:00:00

  • Treatment of atypical gouty arthritis of the hip using total hip arthroplasty: A case report.

    abstract:RATIONALE:Gout and gouty arthritis typically involve peripheral and monoarticular joints, especially the first metatarsophalangeal joint and knees. Hip involvement in patients with gout is rare, and its diagnosis is very difficult, especially in the late stages of the disease. Total hip arthroplasty could be a surgical...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023027

    authors: Huang Y,Huang J,Luo C,Chen L,Huang B

    更新日期:2020-10-30 00:00:00

  • Poor prognosis of liver transplantation for acute liver failure with acute pancreatitis: Two case reports.

    abstract:INDUCTION:Liver transplantation (LT) is the only final therapy for patients with acute liver failure (ALF) that cannot be controlled by conservative treatment. Acute pancreatitis (AP) is a recognized complication of ALF. The pathogenesis of AP in ALF patients has not yet been elucidated. The appearance of AP complicate...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022934

    authors: Yan L,Qian C,Duan X,Ding J,Zhang W

    更新日期:2020-10-23 00:00:00

  • A 92-year-old man with primary cutaneous diffuse large B-cell non-Hodgkin's lymphoma manifesting as a giant scalp mass: A case report.

    abstract:RATIONALE:Primary cutaneous non-Hodgkin's lymphoma (NHL) is an uncommon entity, representing 10% of all extranodal NHLs. Among all cutaneous sites, the scalp is a rare site of representation. PATIENT CONCERNS:A 92-year-old Chinese man visited our hospital with a multiple-nodular huge scalp mass on the right parieto-oc...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006270

    authors: Liao C,Yang M,Liu P,Zhang W

    更新日期:2017-03-01 00:00:00

  • Prognostic value of serum zinc levels in patients with acute HC/zinc chloride smoke inhalation.

    abstract::Hexachloroethane (HC)/zinc chloride (ZnCl, smoke bomb) exposure in the military setting results in lung injury which is uncommon and has been rarely described in previous studies. The aim of this study is to investigate the correlation between the serum zinc in patients with HC/ZnCl smoke inhalation lung injury and di...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008156

    authors: Xie F,Zhang X,Xie L

    更新日期:2017-09-01 00:00:00

  • Successful treatment with rivaroxaban of cerebral venous thrombosis and bone marrow necrosis induced by pegaspargase: A case report and literature review.

    abstract:RATIONALE:Pegaspargase has been used in the treatment of acute lymphoblastic leukemia with promising results. However, it has also been associated with several potentially serious complications, including thrombosis. Pegaspargase-induced cerebral venous thrombosis and bone marrow necrosis are very rare. PATIENT CONCER...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008715

    authors: Sui J,Zhang Y,Yang L,Wang H,Xu J,Wei R,Hao Y,Wang X,Peng J,Ma J

    更新日期:2017-11-01 00:00:00

  • Ultrasound for postoperative surveillance after mastectomy in patients with breast cancer: A retrospective study.

    abstract::This study aimed to evaluate the clinical usefulness of postoperative surveillance by ultrasound (PSU) in patients after breast cancer surgery.In this retrospective study, 324 patients with breast cancer after mastectomy were included between January 2006 and December 2008. The final-positive lesions (FPL) were diagno...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009244

    authors: Liu YQ,Dong JN,Meng QX,Sun P,Zhang J

    更新日期:2017-12-01 00:00:00

  • Development and evaluation of a venous computed tomography radiomics model to predict lymph node metastasis from non-small cell lung cancer.

    abstract::The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020074

    authors: Cong M,Yao H,Liu H,Huang L,Shi G

    更新日期:2020-05-01 00:00:00

  • Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery: A retrospective study.

    abstract::In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion su...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008233

    authors: Ren Z,Li S,Sheng L,Zhuang Q,Li Z,Xu D,Chen X,Jiang P,Zhang X

    更新日期:2017-10-01 00:00:00

  • Cutaneous mycobacteriosis: analysis of 34 cases with a new classification of the disease.

    abstract::Several points can be made from analysis of the published cases of cutaneous mycobacteriosis and those in our series: 1) mycobacterial cutaneous infections are probably more common than is reported-we collected 34 cases over a 10-year period; 2) most patients with cutaneous infections caused by nontuberculous mycobact...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:

    authors: Beyt BE Jr,Ortbals DW,Santa Cruz DJ,Kobayashi GS,Eisen AZ,Medoff G

    更新日期:1981-03-01 00:00:00

  • Salivary lactate dehydrogenase and aminotransferases in diabetic patients.

    abstract::Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LD...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005211

    authors: Malicka B,Skoskiewicz-Malinowska K,Kaczmarek U

    更新日期:2016-11-01 00:00:00

  • Antiretroviral treatment and its impact on oral health outcomes in 5 to 7 year old Ugandan children: A 6 year follow-up visit from the ANRS 12174 randomized trial.

    abstract:BACKGROUND:Antiretroviral therapy for HIV in sub-Saharan Africa has transformed the highly infectious virus to a stable chronic condition, with the advent of Highly active antiretroviral therapy (HAART). The longterm effects of HAART on the oral health of children are understudied. OBJECTIVE:To compare the effect of l...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/MD.0000000000022352

    authors: Birungi N,Fadnes LT,Engebretsen IMS,Tumwine JK,Åstrøm AN,for ANRS 12174 AND 12341 study groups.

    更新日期:2020-09-25 00:00:00

  • A special superior cortex compressive fracture of femoral neck: Two case reports.

    abstract:RATIONALE:Garden type I femoral neck fractures are incomplete stable fractures with impaction in valgus fractures that the question of whether there exists Garden type I femoral neck fracture is currently uncertain. There is still disagreement on the existence of the Garden type I fractures. PATIENT CONCERNS:Herein we...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012876

    authors: Xian H,Zhang H,Lian K,Lin D

    更新日期:2018-10-01 00:00:00