Endometrial cancer and antidepressants: A nationwide population-based study.

Abstract:

:To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the analysis were derived from National Health Insurance Research Database. We identified 8392 cases with a diagnosis of endometrial cancer and 82,432 matched controls. A conditional logistic regression model was used, with adjusting for potentially confounding variables (e.g., comorbid psychiatric diseases, comorbid physical diseases, and other medications). Risk for endometrial cancer in the population-based study sample was categorized by, and assessed as a function of, antidepressant prescription and cumulative dosage.We report no association between endometrial cancer incidence and antidepressant prescription, including those prescribed either selective serotonin reuptake inhibitors (adjusted odds ratio [OR] = 0.98; 95% confidence interval [CI], 0.84-1.15) or serotonin norepinephrine reuptake inhibitors (adjusted OR = 1.14; 95% CI, 0.76-1.71). We also did not identify an association between higher cumulative doses of antidepressant prescription and endometrial cancer.There was no association between antidepressant prescription and endometrial cancer.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Lin CF,Chan HL,Hsieh YH,Liang HY,Chiu WC,Huang KY,Lee Y,McIntyre RS,Chen VC

doi

10.1097/MD.0000000000004178

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

e4178

issue

29

eissn

0025-7974

issn

1536-5964

pii

00005792-201607190-00010

journal_volume

95

pub_type

杂志文章

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