Cellular switches orchestrate rhythmic circuits.

Abstract:

:Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the circuit rhythms entirely rely on specific tunings of the synaptic connectivity, which makes them rigid, fragile, and difficult to control externally. We illustrate those properties on the much studied architecture of a small network controlling both the pyloric and gastric rhythms of crabs. The cellular switch is provided by a slow negative conductance often neglected in mathematical modeling of central pattern generators. We propose that this conductance is simple to model and key to computational studies of rhythmic circuit neuromodulation.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Drion G,Franci A,Sepulchre R

doi

10.1007/s00422-018-0778-6

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

71-82

issue

1-2

eissn

0340-1200

issn

1432-0770

pii

10.1007/s00422-018-0778-6

journal_volume

113

pub_type

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