Intrinsic variability of latency to first-spike.

Abstract:

:The assessment of the variability of neuronal spike timing is fundamental to gain understanding of latency coding. Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distribution of latency, together with an explicit expression for its variance. Consequences in terms of information processing are studied with Fisher information in the Morris-Lecar model. A competition between sensitivity to input and precision is responsible for favoring two distinct regimes of latencies.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Wainrib G,Thieullen M,Pakdaman K

doi

10.1007/s00422-010-0384-8

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

43-56

issue

1

eissn

0340-1200

issn

1432-0770

journal_volume

103

pub_type

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