Abstract:
:Akinematical model for excitable wave propagation is analyzed to describe the dynamics of a typical neurological symptom of migraine. The kinematical model equation is solved analytically for a linear dependency between front curvature and velocity. The resulting wave starts from an initial excitation and moves in the medium that represents the primary visual cortex. Due to very weak excitability the wave propagates only across a confined area and eventually disappears. This cortical excitation pattern is projected onto a visual hemifield by reverse retinotopic mapping. Weak excitability explains the confined appearance of aura symptoms in time and sensory space. The affected area in the visual field matches in growth and form the one reported by migraine sufferers. The results can be extended from visual to tactile and to other sensory symptoms. If the spatiotemporal pattern from our model can be matched in future investigations with those from introspectives, it would allow one to draw conclusions on topographic mapping of sensory input in human cortex.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Dahlem MA,Müller SCdoi
10.1007/s00422-003-0405-ykeywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
419-24issue
6eissn
0340-1200issn
1432-0770journal_volume
88pub_type
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