当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Inflammation is a key contributor to ovarian cancer cell seeding.

Inflammation is a key contributor to ovarian cancer cell seeding.

Abstract：

:The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary. However, the events and conditions that lead to cancer cell implantation are unknown. To quantify which conditions are conducive to the seeding of cancer cells in an immunocompetent mouse model, we surgically implanted mouse ovarian cancer cells into the oviducts of syngeneic mice and simulated conditions associated with ovulatory wound repair, incessant ovulation, ovarian surface scarring, and aging. We found that the dominant site of cancer cell seeding was not the ovary but the nearby surgical wound site, which was associated with a strong and persistent inflammatory reaction. Conditions in the ovary associated with inflammation, such as acute ovulatory wound repair, active healing of the scarred ovarian surface, and mouse aging, contributed to increased seeding of the cancer cells to the surgical wound site and tissues surrounding the ovary. Changes in the ovary not accompanied by inflammation, such as completed ovulatory cycles and fully-healed scars on the ovarian surface, did not contribute to increased cancer cell seeding. We conclude that inflammation is the most likely mechanism by which ovulation and postmenopausal events contribute to the increased risk of ovarian cancer.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Jia D,Nagaoka Y,Katsumata M,Orsulic S

doi

10.1038/s41598-018-30261-8

subject

Has Abstract

pub_date

2018-08-17 00:00:00

pages

12394

issue

1

issn

2045-2322

pii

10.1038/s41598-018-30261-8

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Testing for consistency in the impacts of a burrowing ecosystem engineer on soil and vegetation characteristics across biomes.

    abstract：:The impacts of ecosystem engineers may be expected to vary along environmental gradients. Due to some resources being more limited in arid than in mesic environments, disturbances created by burrowing mammals are expected to have a greater ameliorating effect in arid environments, with larger differences in microhabit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55917-x

    authors： Louw MA,Haussmann NS,le Roux PC

    更新日期：2019-12-18 00:00:00

  • Novel thymoquinone lipidic core nanocapsules with anisamide-polymethacrylate shell for colon cancer cells overexpressing sigma receptors.

    abstract：:The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67748-2

    authors： Ramzy L,Metwally AA,Nasr M,Awad GAS

    更新日期：2020-07-03 00:00:00

  • Author Correction: Past continental shelf evolution increased Antarctic ice sheet sensitivity to climatic conditions.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-67554-w

    authors： Colleoni F,De Santis L,Montoli E,Olivo E,Sorlien CC,Bart PJ,Gasson EGW,Bergamasco A,Sauli C,Wardell N,Prato S

    更新日期：2020-06-25 00:00:00

  • Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.

    abstract：:Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to the canonical G protein-activation pathway, GIRK channels are activated by small molecules but less is...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04681-x

    authors： Glaaser IW,Slesinger PA

    更新日期：2017-07-04 00:00:00

  • Diplosporous development in Boehmeria tricuspis: Insights from de novo transcriptome assembly and comprehensive expression profiling.

    abstract：:Boehmeria tricuspis includes sexually reproducing diploid and apomictic triploid individuals. Previously, we established that triploid B. tricuspis reproduces through obligate diplospory. To understand the molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46043

    authors： Tang Q,Zang G,Cheng C,Luan M,Dai Z,Xu Y,Yang Z,Zhao L,Su J

    更新日期：2017-04-06 00:00:00

  • No supplementary evidence of attention to a spatial cue when saccadic facilitation is absent.

    abstract：:Attending a location in space facilitates responses to targets at that location when the time between cue and target is short. Certain types of exogenous cues - such as sudden peripheral onsets - have been described as reflexive and automatic. Recent studies however, have been showing many cases where exogenous cues a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31633-w

    authors： MacInnes WJ,Bhatnagar R

    更新日期：2018-09-05 00:00:00

  • Statistical modeling and optimization of heterogeneous Fenton-like removal of organic pollutant using fibrous catalysts: a full factorial design.

    abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72401-z

    authors： Morshed MN,Pervez MN,Behary N,Bouazizi N,Guan J,Nierstrasz VA

    更新日期：2020-09-30 00:00:00

  • Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus.

    abstract：:Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00496-y

    authors： Li XJ,Ma QY,Jiang YM,Bai XH,Yan ZY,Liu Q,Pan QX,Liu YY,Chen JX

    更新日期：2017-03-23 00:00:00

  • Single genetic locus improvement of iron, zinc and β-carotene content in rice grains.

    abstract：:Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07198-5

    authors： Singh SP,Gruissem W,Bhullar NK

    更新日期：2017-07-31 00:00:00

  • Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention.

    abstract：:Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00933-y

    authors： Mölzer C,Wallner M,Kern C,Tosevska A,Zadnikar R,Doberer D,Marculescu R,Wagner KH

    更新日期：2017-04-07 00:00:00

  • Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line.

    abstract：:The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53509-3

    authors： Yen HY,Tsao CW,Lin YW,Kuo CC,Tsao CH,Liu CY

    更新日期：2019-11-21 00:00:00

  • Sum uncertainty relations for arbitrary N incompatible observables.

    abstract：:We formulate uncertainty relations for arbitrary N observables. Two uncertainty inequalities are presented in terms of the sum of variances and standard deviations, respectively. The lower bounds of the corresponding sum uncertainty relations are explicitly derived. These bounds are shown to be tighter than the ones s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14238

    authors： Chen B,Fei SM

    更新日期：2015-09-15 00:00:00

  • Extraction of Multi-Labelled Movement Information from the Raw HD-sEMG Image with Time-Domain Depth.

    abstract：:In contemporary muscle-computer interfaces for upper limb prosthetics there is often a trade-off between control robustness and range of executable movements. As a very low movement error rate is necessary in practical applications, this often results in a quite severe limitation of controllability; a problem growing ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43676-8

    authors： Olsson AE,Sager P,Andersson E,Björkman A,Malešević N,Antfolk C

    更新日期：2019-05-10 00:00:00

  • Author Correction: A global mass budget for positively buoyant macroplastic debris in the ocean.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-58755-4

    authors： Lebreton L,Egger M,Slat B

    更新日期：2020-01-30 00:00:00

  • Managing peatland vegetation for drinking water treatment.

    abstract：:Peatland ecosystem services include drinking water provision, flood mitigation, habitat provision and carbon sequestration. Dissolved organic carbon (DOC) removal is a key treatment process for the supply of potable water downstream from peat-dominated catchments. A transition from peat-forming Sphagnum moss to vascul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36751

    authors： Ritson JP,Bell M,Brazier RE,Grand-Clement E,Graham NJ,Freeman C,Smith D,Templeton MR,Clark JM

    更新日期：2016-11-18 00:00:00

  • A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence.

    abstract：:Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41662-8

    authors： Roberts R,Yee PTI,Mujawar S,Lahiri C,Poh CL,Gatherer D

    更新日期：2019-04-01 00:00:00

  • Continuous leaky-wave scanning using periodically modulated spoof plasmonic waveguide.

    abstract：:The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29600

    authors： Kong GS,Ma HF,Cai BG,Cui TJ

    更新日期：2016-07-12 00:00:00

  • Selective capturing of phenolic derivative by a binary metal oxide microcubes for its detection.

    abstract：:Development of highly efficient and potential material for toxic p-nitrophenol is an important design for sensitive detection of hazardous species from ecology and environment. Here it is developed, an efficient as well as selective of p-nitrophenol using binary material by electrochemical performances, including good...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55891-4

    authors： Rahman MM

    更新日期：2019-12-17 00:00:00

  • Extraction technique of trap states based on transient photo-voltage measurement.

    abstract：:This article puts forward a technique for extracting the density of trap states (DOST) distribution based on the transient photo-voltage (TPV) measurement result. We prove that when the TPV result is linear, the DOST distribution is exponential type and vice versa. Compared to the approach based on the space charge li...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69914-y

    authors： Lin Z

    更新日期：2020-07-30 00:00:00

  • Chemokine receptor 7 overexpression promotes mesenchymal stem cell migration and proliferation via secreting Chemokine ligand 12.

    abstract：:Great interest has been shown in mesenchymal stem cell (MSC) therapy in a wide variety of clinical domains. However, the therapeutic efficiency depends on the proliferation and migration of MSCs. Chemokine receptors are involved in regulating the proliferation and migration to the specific organs of MSCs in different ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18509-1

    authors： Liu L,Chen JX,Zhang XW,Sun Q,Yang L,Liu A,Hu S,Guo F,Liu S,Huang Y,Yang Y,Qiu HB

    更新日期：2018-01-09 00:00:00

  • Maximum limit to the number of myosin II motors participating in processive sliding of actin.

    abstract：:In this work, we analysed processive sliding and breakage of actin filaments at various heavy meromyosin (HMM) densities and ATP concentrations in IVMA. We observed that with addition of ATP solution, the actin filaments fragmented stochastically; we then determined mean length and velocity of surviving actin filament...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32043

    authors： Rastogi K,Puliyakodan MS,Pandey V,Nath S,Elangovan R

    更新日期：2016-08-24 00:00:00

  • Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite.

    abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46333-2

    authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

    更新日期：2019-07-15 00:00:00

  • Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

    abstract：:Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigge...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40900-3

    authors： Becker Y,Loignon RC,Julien AS,Marcoux G,Allaeys I,Lévesque T,Rollet-Labelle E,Benk-Fortin H,Cloutier N,Melki I,Eder L,Wagner É,Pelletier M,Hajj HE,Tremblay MÈ,Belleannée C,Hébert MJ,Dieudé M,Rauch J,Fortin PR,Boil

    更新日期：2019-03-14 00:00:00

  • Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs.

    abstract：:Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine. Production of transgenic pigs, however, is a lengthy and inefficient process that hinders research using pig models. Recent application...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14253

    authors： Ruan J,Li H,Xu K,Wu T,Wei J,Zhou R,Liu Z,Mu Y,Yang S,Ouyang H,Chen-Tsai RY,Li K

    更新日期：2015-09-18 00:00:00

  • A Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study.

    abstract：:Current chemical markers based quality assessment methods largely fail to reflect intrinsic chemical complexity and multiple mechanisms of action of botanical drugs (BD). The development of novel quality markers is greatly needed. Here we propose bioactive chemical markers (BCM), defined as a group of chemo-markers th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02305-y

    authors： Yang Z,Shao Q,Ge Z,Ai N,Zhao X,Fan X

    更新日期：2017-05-25 00:00:00

  • SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells.

    abstract：:LMNA gene encodes lamins A and C, two major components of the nuclear lamina, a network of intermediate filaments underlying the inner nuclear membrane. Most of LMNA mutations are associated with cardiac and/or skeletal muscles defects. Muscle laminopathies include Emery-Dreifuss Muscular Dystrophy, Limb-Girdle Muscul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23918-x

    authors： Janin A,Bauer D,Ratti F,Valla C,Bertrand A,Christin E,Chopin E,Streichenberger N,Bonne G,Gache V,Cohen T,Méjat A

    更新日期：2018-04-04 00:00:00

  • Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance.

    abstract：:In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33538-0

    authors： Inzaule SC,Kityo CM,Siwale M,Akanmu AS,Wellington M,de Jager M,Ive P,Mandaliya K,Stevens W,Boender TS,Ondoa P,Sigaloff KCE,Naniche D,Rinke de Wit TF,Hamers RL

    更新日期：2018-10-25 00:00:00

  • Freestanding flexible, pure and composite form of reduced graphene oxide paper for ammonia vapor sensing.

    abstract：:Metal oxides based graphene nanocomposites were used for ammonia vapour sensing. The self-assembly process was adopted to prepare freestanding flexible pure rGO, CeO2-rGO and SnO2-rGO composite papers. The structural studies confirmed the formation of rGO composite papers. The ammonia vapor sensing was demonstrated us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45408-4

    authors： Selvakumar D,Sivaram H,Alsalme A,Alghamdi A,Jayavel R

    更新日期：2019-06-19 00:00:00

  • Experimental interference of uncorrelated photons.

    abstract：:The distinguishing of the multiphoton quantum interference effect from the classical one forms one of the most important issues in modern quantum mechanics and experimental quantum optics. For a long time, the two-photon interference (TPI) of correlated photons has been recognized as a pure quantum effect that cannot ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54504-4

    authors： Kim H,Kwon O,Moon HS

    更新日期：2019-12-05 00:00:00

  • Stainless steel bipolar plate coated with polyaniline/Zn-Porphyrin composites coatings for proton exchange membrane fuel cell.

    abstract：:The proton exchange membrane fuel cells are the promising sustainable energy sources. The present study focuses on the enhancement the fuel cell performance and the protection of the stainless steel bipolar plate from the corrosion using polyaniline/Zn-Porphyrin composites coatings. The electrochemical properties (pol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60288-9

    authors： Deyab MA,Mele G

    更新日期：2020-02-24 00:00:00