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Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.

Abstract：

:The transcriptional regulator CpxR mediates an adaptive response to envelope stress, tightly linked to virulence and antibiotics resistance in several Gammaproteobacteria pathogens. In this work, we integrated crystallographic and small-angle X-ray scattering data to gain insights into the structure and conformational plasticity of CpxR from Escherichia coli. CpxR dimerizes through two alternative interaction surfaces. Moreover, widely different CpxR conformations coexist in solution, from compact to fully extended ones. The possible functional implications of these structural features are discussed.

journal_name

J Struct Biol

journal_title

Journal of structural biology

authors

Mechaly AE,Haouz A,Sassoon N,Buschiazzo A,Betton JM,Alzari PM

doi

10.1016/j.jsb.2018.08.001

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

165-171

issue

2

eissn

1047-8477

issn

1095-8657

pii

S1047-8477(18)30196-5

journal_volume

204

pub_type

杂志文章

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