Preparation and in vitro release kinetics of ivermectin sustained-release bolus optimized by response surface methodology.

abstract：:Okinawa is the largest and most populated island of the Ryukyu Archipelago in southern Japan and is renowned for its natural resources and beauty. Similar as to what has been happening in the rest of the country, Okinawa Island has been affected by an increasing amount of development and construction work. The trend h...

journal_title：PeerJ

authors： Masucci GD,Reimer JD

更新日期：2019-09-06 00:00:00

abstract：BACKGROUND:This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of ...

journal_title：PeerJ

authors： Notter RH,Gupta R,Schwan AL,Wang Z,Shkoor MG,Walther FJ

更新日期：2016-10-27 00:00:00

abstract：:Earthworms enrich the soil and protect the health of their ecological environment. Previous studies on these invertebrates determined their protein content, hormone secretions, medicinal value, and ecological habits, but their whole genomic sequence remains incomplete. We performed whole genome sequencing of Metaphire...

journal_title：PeerJ

authors： Jin F,Zhou Z,Guo Q,Liang Z,Yang R,Jiang J,He Y,Zhao Q,Zhao Q

更新日期：2020-11-12 00:00:00

abstract：BACKGROUND:Amoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic approach. Serine-rich Entamoeba histolyticaprotein (SREHP...

journal_title：PeerJ

authors： Manochitra K,Parija SC

更新日期：2017-06-28 00:00:00

abstract：:Rearing coral fragments in nurseries and subsequent transplantation onto a degraded reef is a common approach for coral reef restoration. However, if barnacles and other biofouling organisms are not removed prior to transplantation, fish will dislodge newly cemented corals when feeding on biofouling organisms. This be...

journal_title：PeerJ

authors： Frias-Torres S,van de Geer C

更新日期：2015-09-29 00:00:00

abstract：:Many of the major locomotor transitions during the evolution of Archosauria, the lineage including crocodiles and birds as well as extinct Dinosauria, were shifts from quadrupedalism to bipedalism (and vice versa). Those occurred within a continuum between more sprawling and erect modes of locomotion and involved dras...

journal_title：PeerJ

authors： Otero A,Allen V,Pol D,Hutchinson JR

更新日期：2017-11-24 00:00:00

abstract：:Vitellogenin has been proposed to regulate division of labor and social organization in social insects. The red imported fire ant (Solenopsis invicta) harbors four distinct, adjacent vitellogenin genes (Vg1, Vg2, Vg3, and Vg4). Contrary to honey bees that have a single Vg ortholog as well as potentially fertile nurses...

journal_title：PeerJ

authors： Hawkings C,Tamborindeguy C

更新日期：2018-05-28 00:00:00

abstract：:We describe a new species of Oligodon from the highlands of the Langbian Plateau, southern Truong Son Mountains, Vietnam, based on morphological and molecular phylogenetic analyses. The new species, Oligodon rostralissp. nov is distinguished from its congeners by the following morphological characters: medium size in ...

journal_title：PeerJ

authors： Nguyen HN,Tran BV,Nguyen LH,Neang T,Yushchenko PV,Poyarkov NA

更新日期：2020-01-06 00:00:00

abstract：Background:As the most frequently occurred tumor in biliary tract, cholangiocarcinoma (CCA) is mainly characterized by its late diagnosis and poor outcome. It is therefore urgent to identify specific genes and pathways associated with its progression and prognosis. Materials and Methods:The differentially expressed ge...

journal_title：PeerJ

authors： Liu J,Liu W,Li H,Deng Q,Yang M,Li X,Liang Z

更新日期：2019-10-31 00:00:00

abstract：:The potential of soils to naturally suppress inherent plant pathogens is an important ecosystem function. Usually, pathogen infection assays are used for estimating the suppressive potential of soils. In natural soils, however, co-occurring pathogens might simultaneously infect plants complicating the estimation of a ...

journal_title：PeerJ

authors： Rall BC,Latz E

更新日期：2016-11-03 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in HCC through multidimensional methods and revealed potential mole...

journal_title：PeerJ

authors： Liu ZK,Zhang RY,Yong YL,Zhang ZY,Li C,Chen ZN,Bian H

更新日期：2019-08-08 00:00:00

abstract：:Sound production is a widespread phenomenon among animals. Effective sound use for mate or species recognition requires some acoustic differentiation at an individual or species level. Several species of caudate amphibians produce underwater sounds, but information about intra- and interspecific variation in their aco...

journal_title：PeerJ

authors： Hubáček J,Šugerková M,Gvoždík L

更新日期：2019-03-28 00:00:00

abstract：Background:Lumbar spinal stenosis (LSS) is a common cause of low back pain with degenerative spinal change in older adults. Telomeres are repetitive nucleoprotein DNA sequences of TTAGGG at the ends of chromosomes. Oxidative stress originates from an imbalance in pro-oxidant and antioxidant homeostasis that results in ...

journal_title：PeerJ

authors： Dechsupa S,Yingsakmongkol W,Limthongkul W,Singhatanadgige W,Honsawek S

更新日期：2018-08-09 00:00:00

abstract：:A large body of evidence suggests that female Old World monkeys maintain selective long-term grooming interactions with fitness benefits. The last two decades have produced evidence that the regulation of social interactions among primates can be, in part, explained by the Biological Markets theory, with grooming beha...

journal_title：PeerJ

authors： Pereira AS,Rebelo ID,Casanova C,Lee PC,Louca V

更新日期：2019-01-25 00:00:00

abstract：Background:Larval settlement and intra-specific interactions during the recruitment phase are crucial in determining the distribution and density of sessile marine populations. Marine caves are confined and stable habitats. As such, they provide a natural laboratory to study the settlement and recruitment processes in ...

journal_title：PeerJ

authors： Costantini F,Rugiu L,Cerrano C,Abbiati M

更新日期：2018-05-21 00:00:00

abstract：Background:Acipenser dabryanus, an endemic Chinese species, has been listed as a first-class protected animal in China. Sturgeons are among the oldest and most primitive group of existing fish in the world and occupy a special place in the evolutionary history of fish. Thus, a study of the reproduction and sex differen...

journal_title：PeerJ

authors： Chen Y,Liu Y,Gong Q,Lai J,Song M,Du J,Deng X

更新日期：2018-07-27 00:00:00

abstract：:Quantitative morphometric analyses, particularly ontogenetic allometry, are common methods used in quantifying shape, and changes therein, in both extinct and extant organisms. Due to incompleteness and the potential for restricted sample sizes in the fossil record, palaeobiological analyses of allometry may encounter...

journal_title：PeerJ

authors： Brown CM,Vavrek MJ

更新日期：2015-03-10 00:00:00

abstract：:Several data loggers deployed to monitor temperature and humidity of Crocodylus acutus (American crocodile) nests in South Florida could not be located after hatching. One badly damaged data logger was retrieved, providing insight into the possible fate of the others. Using a taphonomic approach, we identified numerou...

journal_title：PeerJ

authors： Drumheller SK,Nestler JH,Hackett Farris CE,Farris SC,Mazzotti FJ

更新日期：2020-02-17 00:00:00

abstract：Background and Purpose:Oxidative stress is involved in normal and pathological functioning of skeletal muscle. Protection of myoblasts from oxidative stress may improve muscle contraction and delay aging. Here we studied the effect of R. coriaria sumac fruit extract on human myoblasts and zebrafish embryos in condition...

journal_title：PeerJ

authors： Najjar F,Rizk F,Carnac G,Nassar R,Jabak S,Sobolev AP,Bou Saada Y,El Sabban M,Hamade A

更新日期：2017-12-12 00:00:00

abstract：:It is assumed that the sequencing of ribosomes better reflects the active microbial community than the sequencing of the ribosomal RNA encoding genes. Yet, many studies exploring microbial communities in various environments, ranging from the human gut to deep oceans, questioned the validity of this paradigm due to th...

journal_title：PeerJ

authors： Šťovíček A,Cohen-Chalamish S,Gillor O

更新日期：2019-10-25 00:00:00

abstract：:Single-cell analysis has the potential to provide us with a host of new knowledge about biological systems, but it comes with the challenge of correctly interpreting the biological information. While emerging techniques have made it possible to measure inter-cellular variability at the transcriptome level, no consensu...

journal_title：PeerJ

authors： Kippner LE,Kim J,Gibson G,Kemp ML

更新日期：2014-06-24 00:00:00

abstract：:MicoRNAs (miRNAs), usually as gene regulators, participate in various biological processes, including stress responses. The hypothalamus-pituitary-adrenal axis (HPA axis) is an important pathway in regulating stress response. Although the mechanism that HPA axis regulates stress response has been basically revealed, t...

journal_title：PeerJ

authors： Luo W,Fang M,Xu H,Xing H,Fu J,Nie Q

更新日期：2016-02-18 00:00:00

abstract：:Palythoa caribaeorum is a zoanthid often dominant in shallow rocky environments along the west coast of the Atlantic Ocean, from the tropics to the subtropics. This species has high environmental tolerance and is a good space competitor in reef environments. Considering current and future scenarios in the global clima...

journal_title：PeerJ

authors： Durante LM,Cruz ICS,Lotufo TMC

更新日期：2018-05-17 00:00:00

abstract：:Secondary cavity nesting (SCN) birds breed in holes that they do not excavate themselves. This is possible where there are large trees whose size and age permit the digging of holes by primary excavators and only rarely happens in forest plantations, where we expected a deficit of both breeding holes and SCN species. ...

journal_title：PeerJ

authors： Cuatianquiz Lima C,Macías Garcia C

更新日期：2016-03-15 00:00:00

abstract：:Populations undergoing rapid climate-driven range expansion experience distinct selection regimes dominated both by increased dispersal at the leading edges and steep environmental gradients. Characterisation of traits associated with such expansions provides insight into the selection pressures and evolutionary const...

journal_title：PeerJ

authors： Taylor-Cox ED,Macgregor CJ,Corthine A,Hill JK,Hodgson JA,Saccheri IJ

更新日期：2020-11-19 00:00:00

abstract：:The ability to accurately identify and label emotions in the self and others is crucial for successful social interactions and good mental health. In the current study we tested the longitudinal relationship between early language skills and recognition of facial and vocal emotion cues in a representative UK populatio...

journal_title：PeerJ

authors： Griffiths S,Goh SKY,Norbury CF,the SCALES team.

更新日期：2020-05-12 00:00:00

abstract：Aim:We aimed to translate and cross-culturally adapt the International Knee Documentation Committee-subjective knee form (IKDC) in Romanian. Method:The original (US) IKDC-subjective knee form was translated according to recommended guidelines. Validity was tested using Spearmans's correlation coefficient between score...

journal_title：PeerJ

authors： Todor A,Vermesan D,Haragus H,Patrascu JM Jr,Timar B,Cosma DI

更新日期：2020-02-03 00:00:00

abstract：:Understanding how structural and functional alterations of individual tissues impact on whole-joint function is challenging, particularly in humans where direct invasive experimentation is difficult. Finite element (FE) computational models produce quantitative predictions of the mechanical and physiological behaviour...

journal_title：PeerJ

authors： Peters AE,Akhtar R,Comerford EJ,Bates KT

更新日期：2018-01-25 00:00:00

abstract：:Cell immobilization is an alternative to microencapsulation for the maintenance of cells in a liquid medium. However, artificial immobilization carriers are expensive and pose a high safety risk. Okara, a food-grade byproduct from soymilk production, is rich in prebiotics. Lactobacilli could provide health enhancing e...

journal_title：PeerJ

authors： Xiudong X,Ying W,Xiaoli L,Ying L,Jianzhong Z

更新日期：2016-11-10 00:00:00

abstract：Background:KIAA1199 is a recently identified novel gene that is upregulated in various human cancers with poor survival, but its role and the underlying mechanisms in laryngeal squamous cell carcinoma (LSCC) remain unknown. Here, we collected tissues from 105 cases of LSCC to investigate the relationships between KIAA1...

journal_title：PeerJ

authors： Huang M,Liao F,Song Y,Zuo G,Tan G,Chu L,Wang T

更新日期：2020-09-07 00:00:00