Abstract:
INTRODUCTION:This study addressed the following population, intervention, comparator, outcome, timing, study design and setting question: in patients with preoperative pain who undergo single-visit nonsurgical endodontic treatment, what is the comparative efficacy of corticosteroids compared with other analgesics or placebo in reducing postoperative pain and the incidence of adverse events. METHODS:Database/electronic searches were conducted using the PubMed/MEDLINE, Scopus, and Cochrane databases to identify published articles using included key words in various combinations. Manual searching of articles was performed, and the Clinicaltrials.gov site was also searched. Two independent reviewers assessed eligibility for inclusion, extracted data, and assessed quality using the risk of bias tool. Where applicable, meta-analysis was conducted on the pooled effect size. RESULTS:The database search identified 481 citations and 37 citations through the manual search. After removing duplicates and going through abstracts, 28 full-text articles were perused. Five articles met the inclusion criteria; qualitative analysis revealed 4 studies had unclear risk of bias, and 1 study had low risk of bias. Only 1 study had a sizable sample size; the others had lesser sample sizes. Meta-analysis showed that prednisolone administered preoperatively was able to reduce the incidence of postoperative pain at 6, 12, and 24 hours. The patients in the studies reported no adverse effects. CONCLUSIONS:Corticosteroids may be more effective than placebo for the relief of postoperative endodontic pain in patients with symptomatic pulpitis undergoing single-visit root canal treatment. However, more studies need to be conducted with greater sample sizes to validate the conclusions.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Suneelkumar C,Subha A,Gogala Ddoi
10.1016/j.joen.2018.05.015subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1347-1354issue
9eissn
0099-2399issn
1878-3554pii
S0099-2399(18)30375-3journal_volume
44pub_type
杂志文章,meta分析abstract:INTRODUCTION:Hydrogen peroxide tooth bleaching is claimed to cause alterations in dental tissue structures. This study investigated the influence of the number of bleaching sessions on pulp tissue in rats. METHODS:Male Wistar rats were studied in 5 groups (groups 1S-5S) of 10 each, which differed by the number (1-5) o...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.08.007
更新日期:2013-12-01 00:00:00
abstract::In the human dental pulp of five healthy premolars, we detected the presence of vesicles in the cytoplasm of macrophage-like cells. There were, in general, two types of vesicles, with regard to their size and content. The first was of smaller size (35 to 55 nm), and they were electron optically empty. The second type ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(98)80176-3
更新日期:1998-03-01 00:00:00
abstract:INTRODUCTION:Collagen dentin matrix may represent a suitable scaffold to be remineralized in the presence of bioactive materials. The purpose of this study was to determine if experimental resin cements containing bioactive fillers may modulate matrix metalloproteinase-mediated collagen degradation of etched dentin. M...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.011
更新日期:2012-09-01 00:00:00
abstract::Ocular complications after an inferior alveolar nerve anesthesia are rare. These complications, although temporary and benign, can be distressing to both the patient and the clinician. A 37-year-old male patient was administered an inferior alveolar nerve block for the root canal treatment of tooth #30. Immediately af...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2018.05.005
更新日期:2018-09-01 00:00:00
abstract::The purpose of this study was to evaluate the influence of Hero 642 rotary Ni-Ti instruments driven at 300, 400, or 600 rpm on root canal straightening, loss of working length, and instrument breakage. Sixty mesial root canals from extracted human mandibular molars were divided into 3 groups of 20 each and were instru...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200307000-00005
更新日期:2003-07-01 00:00:00
abstract::Calcium hydroxide is the "gold standard" endodontic medication, but it may fail to eliminate certain facultative bacteria and yeasts found in root canal systems. In this study, standardized bovine dentin blocks infected with Enterococcus faecalis were treated with an aqueous calcium hydroxide or bioactive glass S53P4 ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200404000-00009
更新日期:2004-04-01 00:00:00
abstract::Orthodontic tooth movement has been implicated in secondary changes to the dental pulp. The purpose of this study was to correlate the effects of orthodontic tooth movement on the dental pulp by histomorphometric parameters. Four groups, each consisting of 36 male adult Sprague-Dawley strain rats, were studied with di...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81034-4
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Optical coherence tomography (OCT) is a noninvasive modality to obtain in-depth images of biological structures. A dental OCT system has become available for chairside application. This in vitro study hypothesized that swept-source OCT can be used to measure the remaining dentin thickness (RDT) at the roof...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.03.016
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Resin-based dental materials contain various diluent monomers that can interfere with vascular function by causing vasodilation. In this study, we evaluated the vasoactive potential of hydroxyethyl methacrylate (HEMA) and triethylene glycol dimethacrylate (TEGDMA) and the possible mechanism of their vascul...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.11.038
更新日期:2011-03-01 00:00:00
abstract::The aim of this in vivo study was to find a way to conduct qualitative and quantitative evaluations of radicular apical third apposition in rats. Twenty rats were injected intraperitoneally with tetracycline at weight-adjusted doses. Mesio-distal sections of the first mandibular molar regions were prepared. The 60 to ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(99)80153-8
更新日期:1999-04-01 00:00:00
abstract::In this study, we examined the effects of TNF-alpha on Bone morphogenetic protein (BMP-2), Smads (which play intracellular signaling of BMPs) expression and alkaline phosphatase (ALP) activity of human dental pulp (HDP) cells to clarify the mechanism of tertiary dentin formation. The quantity of RT-PCR product for BMP...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2005.12.007
更新日期:2006-06-01 00:00:00
abstract::Nickel-titanium engine-driven rotary instruments are used increasingly in endodontic practice. One frequently mentioned problem is fracture of an instrument in the root canal. Very few studies have been conducted on torsional characteristics of these instruments, and none has been done under dynamic conditions. The pu...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200003000-00007
更新日期:2000-03-01 00:00:00
abstract::This study compared a tapered, calibrated spreader/plugger instrument (M-series) to noncalibrated spreaders and pluggers in achieving apical condensation of gutta-percha in 20 single-rooted human teeth. The distances between the tip of the instruments and the tip of the master gutta-percha were measured. Results showe...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80680-1
更新日期:1993-04-01 00:00:00
abstract:INTRODUCTION:Porphyromonas gingivalis and Tannerella forsythia are anaerobic bacteria commonly involved in root canal infections. Although previous investigations have assessed these species by strictly qualitative approaches, accurate determination of their cell levels by a sensitive quantitative technique may contrib...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.08.005
更新日期:2009-11-01 00:00:00
abstract::Dentinal chips and different biocompatible materials have been used in the past as apical plugs to enhance healing and simplify obturation. The purpose of this study was to evaluate bone reactions to implants of hydroxyapatite, collagen, and calcium hydroxide, alone or in different combinations. The materials were imp...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(07)80175-0
更新日期:1990-10-01 00:00:00
abstract::The mechanisms of odontogenic pain are complex and incompletely understood. Cases of irreversible pulpitis are thought to represent a localized inflammatory response to bacterial challenge in dental pulp tissue. The presenting symptoms are classically defined by exaggerated painful episodes to thermal stimuli that may...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.01.023
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin [IL]-1β, and IL-6) in human apical periodont...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2018.10.015
更新日期:2019-02-01 00:00:00
abstract::The purpose of this in vitro study was to investigate the canal configuration types, and the prevalence and location of anatomical variations in the mesiobuccal (MB) and mesial roots of permanent maxillary and mandibular first molars after instrumentation. The number and the type of canals were determined before instr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000145425.73364.91
更新日期:2005-05-01 00:00:00
abstract:INTRODUCTION:In this study, we investigated if apical periodontitis (AP) associated with diabetes influenced the levels of endogenous antioxidants, the total antioxidant capacity (TAC), and the oxidant parameter in the serum of Wistar rats. METHODS:Forty male rats were divided into 4 equal groups: normal rats (N), rat...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.05.014
更新日期:2017-10-01 00:00:00
abstract::Bisphosphonates are commonly used in medicine to maintain bone density in patients with certain nonneoplastic diseases or cancers. A serious adverse effect of bisphosphonates that has substantial dental significance is osteonecrosis that appears to uniquely affect the mandible and maxilla without occurring in other bo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000186481.96169.cd
更新日期:2005-11-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate and compare, clinically and radiographically, the effects of platelet-rich fibrin (PRF) and mineral trioxide aggregate (MTA) as pulpotomy agents in permanent teeth with incomplete root development. METHODS:A total number of 70 children requiring pulpotomy in 70 pe...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2014.01.009
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:External apical root resorption (EARR) is a frequent iatrogenic effect of orthodontic treatment. The way root-filled teeth respond to orthodontic forces with respect to EARR has been reported as varying widely between individuals. Genetic variants in the interleukin-1 gene have been associated with an incr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.12.022
更新日期:2012-03-01 00:00:00
abstract::In the present study, we used Fos expression as an index of nociceptive input to the spinal trigeminal nucleus after exposure of the coronal pulp tissue of maxillary right first molars and examined the effects of pretreatment with an opioid, a nonsteroidal anti-inflammatory drug or a local anesthetic before pulp expos...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000153844.61709.64
更新日期:2005-08-01 00:00:00
abstract:INTRODUCTION:Phentolamine mesylate has been reported to be an effective local anesthetic reversal agent for soft tissue but has not been studied regarding reversal of pulpal anesthesia. The authors conducted a prospective randomized, single-blind study comparing the reversal of pulpal and soft tissue anesthesia when ph...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2012.12.024
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:A number of factors affect the dimensional stability of a material. These factors include curing conditions, material solubility, leaching, and time. The aim of this study was to evaluate the restrained dimensional change in the vertical direction as a function of the ambient conditions, fluid uptake, solu...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.11.012
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Dentin regeneration could be an ideal treatment option to restore tissue function. This study was conducted to evaluate the ability of dental pulp stem cells (DPSCs) and dentin matrix protein 1 (DMP1) impregnated within a collagen scaffold to regenerate dentin. METHODS:Simulated perforations were created ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.05.019
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION:Squamous odontogenic tumor-like epithelial islands occurring in the walls of odontogenic cysts are histologically identical to the squamous odontogenic tumor (SOT). Microscopically, the squamous odontogenic tumor-like proliferations (SOTLPs) share certain histologic features with SOT, acanthomatous and des...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.02.010
更新日期:2011-05-01 00:00:00
abstract::No information could be found in the dental literature on the hardness or strength of the materials in root canal instruments. Hardness testing is a convenient method for examining these products, and strength properties can be deduced from available strength-hardness data. The Vickers hardness of cross-sections of st...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80274-3
更新日期:1996-02-01 00:00:00
abstract::There are no quantitative data on the mechanical efficacy of irrigation in the removal of bacteria from curved canals. This study quantitatively analyzed the effects of root canal curvature and preparation size on the mechanical efficacy of irrigation using 33 mandibular single-rooted bicuspids allocated to groups acc...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2006.04.011
更新日期:2006-11-01 00:00:00
abstract::A method is proposed for a three-dimensional visualization of the root canal system before and after the cleaning and shaping procedure to analyze the relationships of the root canal walls. The first part of the study provided cross-sections of the root perpendicular to the root canal. A system for remounting the sect...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81298-7
更新日期:1993-05-01 00:00:00