KampoDB, database of predicted targets and functional annotations of natural medicines.

abstract：:Disturbances in calcium metabolism are common in individuals with chronic kidney disease (CKD), but whether they are associated with subsequent kidney function decline is less clear. In a CKD 3-5 cohort of 15,755 adult citizens of Stockholm with creatinine tests taken during 2006-2011 and concurrent calcium testing at...

journal_title：Scientific reports

authors： Janmaat CJ,van Diepen M,Gasparini A,Evans M,Qureshi AR,Ärnlöv J,Barany P,Elinder CG,Rotmans JI,Vervloet M,Dekker FW,Carrero JJ

更新日期：2018-03-26 00:00:00

abstract：:Central nervous system-specific proteins (CSPs), transported across the damaged blood-brain-barrier (BBB) to cerebrospinal fluid (CSF) and blood (serum), might be promising diagnostic, prognostic and predictive protein biomarkers of disease in individual multiple sclerosis (MS) patients because they are not expected t...

journal_title：Scientific reports

authors： Raphael I,Mahesula S,Purkar A,Black D,Catala A,Gelfond JA,Forsthuber TG,Haskins WE

更新日期：2014-09-03 00:00:00

abstract：:A paper-based upconversion fluorescence resonance energy transfer assay device is proposed for sensitive detection of CEA. The device is fabricated on a normal filter paper with simple nano-printing method. Upconversion nanoparticles tagged with specific antibodies are printed to the test zones on the test paper, foll...

journal_title：Scientific reports

authors： Xu S,Dong B,Zhou D,Yin Z,Cui S,Xu W,Chen B,Song H

更新日期：2016-03-22 00:00:00

abstract：:The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...

journal_title：Scientific reports

authors： Chang ML,Lin YS,Pao LH,Huang HC,Chiu CT

更新日期：2017-02-13 00:00:00

abstract：:The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated genes have been ident...

journal_title：Scientific reports

authors： Salsman J,Stathakis A,Parker E,Chung D,Anthes LE,Koskowich KL,Lahsaee S,Gaston D,Kukurba KR,Smith KS,Chute IC,Léger D,Frost LD,Montgomery SB,Lewis SM,Eskiw C,Dellaire G

更新日期：2017-03-23 00:00:00

abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...

journal_title：Scientific reports

authors： Sun YB,Wang YZ,Wang JY,Luo F

更新日期：2015-12-09 00:00:00

abstract：:Passive immunotherapy may have particular benefits for the treatment of severe influenza infection in at-risk populations, however little is known of the impact of passive immunotherapy on the formation of memory responses to the virus. Ideally, passive immunotherapy should attenuate the severity of infection while st...

journal_title：Scientific reports

authors： Stevens NE,Hatjopolous A,Fraser CK,Alsharifi M,Diener KR,Hayball JD

更新日期：2016-07-06 00:00:00

abstract：:Superfluidity and superconductivity have been widely studied since the last century in many different contexts ranging from nuclear matter to atomic quantum gases. The rigidity of these systems with respect to external perturbations results in frictionless motion for superfluids and resistance-free electric current fl...

journal_title：Scientific reports

authors： Paris-Mandoki A,Shearring J,Mancarella F,Fromhold TM,Trombettoni A,Krüger P

更新日期：2017-08-22 00:00:00

abstract：:By moving the alkoxy group on the spacer from position 5 to position 4 to add another protocol for the algorithm for intermolecular and intramolecular hydrogen bonding interactions, highly regioselectivity of noncovalent synthesis of the hydrazide-based cyclic hexamers was achieved: one out of thirteen possible isomer...

journal_title：Scientific reports

authors： Yang Y,Huang F,Chen CF,Xia M,Cai Q,Qian FJ,Xiang J

更新日期：2013-01-01 00:00:00

abstract：:Osteoporosis is the most common age-related bone disease worldwide and is usually clinically asymptomatic until the first fracture happens. MicroRNAs are critical molecular regulators in bone remodelling processes and are stabilised in the blood. The aim of this project was to identify circulatory microRNAs associated...

journal_title：Scientific reports

authors： Mandourah AY,Ranganath L,Barraclough R,Vinjamuri S,Hof RV,Hamill S,Czanner G,Dera AA,Wang D,Barraclough DL

更新日期：2018-05-30 00:00:00

abstract：:Fundamental interest for 2D electron gas (2DEG) systems has been recently renewed with the advent of 2D materials and their potential high-impact applications in optoelectronics. Here, we investigate a 2DEG created by the electron transfer from a Ag adatom gas deposited on a Si(111) [Formula: see text]-Ag surface to a...

journal_title：Scientific reports

authors： Cheynis F,Curiotto S,Leroy F,Müller P

更新日期：2017-09-06 00:00:00

abstract：:Fitness-related costs of evolving insecticide resistance have been reported in a number of insect species, but the interplay between evolutionary adaptation to insecticide pressure and variable environmental conditions has received little attention. We provisioned nymphs from three German cockroach (Blattella germanic...

journal_title：Scientific reports

authors： Jensen K,Ko AE,Schal C,Silverman J

更新日期：2016-06-27 00:00:00

abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...

journal_title：Scientific reports

authors： Tao H,Zhou M,Wang K,Cheng S,Jiang K

更新日期：2017-03-03 00:00:00

abstract：:Ecological adaptations to seasonal changes are often observed in the phenotypic traits of plants and animals, and these adaptations are usually expressed through the production of different biochemical end products. In this study, ecological adaptations are observed in a biochemical pathway without alteration of the e...

journal_title：Scientific reports

authors： Hirata H,Ohnishi T,Tomida K,Ishida H,Kanda M,Sakai M,Yoshimura J,Suzuki H,Ishikawa T,Dohra H,Watanabe N

更新日期：2016-02-01 00:00:00

abstract：:Studies of the molecular mechanisms involved in the formation of the albino leaf cells are important for understanding the development of chimera leaves in Ananas comosus var. bracteatus. In this study, we identified a total of 163 novel miRNAs involved in the development of complete white (CWh) and complete green (CG...

journal_title：Scientific reports

authors： Xiong YY,Ma J,He YH,Lin Z,Li X,Yu SM,Li RX,Jiang FX,Li X,Huang Z,Sun LX

更新日期：2018-01-31 00:00:00

abstract：:The Paraná delta, growing at a rate of c. 2 km(2) yr(-1) since 6,000 yrs, is one of the most complete records of the Late Holocene in southern South America. The evolution of this 17,400 km(2) delta enclosed in Plata estuary, can be tracked by a series of 343 successive coastal-ridges showing a c.11 years period, in c...

journal_title：Scientific reports

authors： Milana JP,Kröhling D

更新日期：2015-08-06 00:00:00

abstract：:The domestic dog (Canis familiaris) is a promising animal model. Yet, the canine neuroscience literature is predominantly comprised of studies wherein (semi-)invasive methods and intensive training are used to study awake dog behavior. Given prior findings with humans and/or dogs, our goal was to assess, in 16 family ...

journal_title：Scientific reports

authors： Bunford N,Reicher V,Kis A,Pogány Á,Gombos F,Bódizs R,Gácsi M

更新日期：2018-05-08 00:00:00

abstract：:Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...

journal_title：Scientific reports

authors： Harada K,Akashi T,Niitsu K,Shimada K,Ono YA,Shindo D,Shinada H,Mori S

更新日期：2018-01-17 00:00:00

abstract：:The development of scalable synthesis techniques for optically transparent, electrically conductive coatings is in great demand due to the constantly increasing market price and limited resources of indium for indium tin oxide (ITO) materials currently applied in most of the optoelectronic devices. This work pioneers ...

journal_title：Scientific reports

authors： Mohl M,Dombovari A,Vajtai R,Ajayan PM,Kordas K

更新日期：2015-09-03 00:00:00

abstract：:Transformation optics (TO) concept well known for its huge possibility in patterning the path of electromagnetic waves is exploited to design a beam steering lens. The broadband directive in-phase emission in a desired off-normal direction from an array of equally fed radiators is numerically and experimentally report...

journal_title：Scientific reports

authors： Yi J,Burokur SN,Piau GP,de Lustrac A

更新日期：2016-01-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cencetti G,Clusella P,Fanelli D

更新日期：2020-02-18 00:00:00

abstract：:F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and ...

journal_title：Scientific reports

authors： Ikenoue T,Terakado Y,Zhu C,Liu X,Ohsugi T,Matsubara D,Fujii T,Kakuta S,Kubo S,Shibata T,Yamaguchi K,Iwakura Y,Furukawa Y

更新日期：2018-01-31 00:00:00

abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

journal_title：Scientific reports

authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

更新日期：2020-12-01 00:00:00

abstract：:Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...

journal_title：Scientific reports

authors： Bura VL,Kawahara AY,Yack JE

更新日期：2016-08-11 00:00:00

abstract：:Structural materials used for safety critical applications require high strength and simultaneously high resistance against crack growth, referred to as damage tolerance. However, the two properties typically exclude each other and research efforts towards ever stronger materials are hampered by drastic loss of fractu...

journal_title：Scientific reports

authors： Hohenwarter A,Völker B,Kapp MW,Li Y,Goto S,Raabe D,Pippan R

更新日期：2016-09-14 00:00:00

abstract：:The placenta is an essential organ that is formed during pregnancy and its proper development is critical for embryonic survival. While several animal models have been shown to exhibit some of the pathological effects present in human preeclampsia, these models often do not represent the physiological aspects that hav...

journal_title：Scientific reports

authors： Albers RE,Kaufman MR,Natale BV,Keoni C,Kulkarni-Datar K,Min S,Williams CR,Natale DRC,Brown TL

更新日期：2019-02-26 00:00:00

abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...

journal_title：Scientific reports

authors： Harter AK,Saxena A,Joglekar YN

更新日期：2018-08-13 00:00:00

abstract：:Due to their convergent evolution, dogs have been suggested as a good model for the evolution of human social skills, such as tolerance and cooperativeness. However, recent studies have revealed that wolves (dogs' closest undomesticated relatives) are more tolerant and cooperative with conspecifics than dogs. It is st...

journal_title：Scientific reports

authors： Range F,Marshall-Pescini S,Kratz C,Virányi Z

更新日期：2019-03-07 00:00:00

abstract：:Erythropoiesis is regulated by the erythropoietin receptor (EpoR) binding to its ligand. The transmembrane domain (TMD) and the juxtamembrane (JM) regions of the EpoR are important for signal transduction across the cell membrane. We report a solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising t...

journal_title：Scientific reports

authors： Li Q,Wong YL,Yueqi Lee M,Li Y,Kang C

更新日期：2015-08-28 00:00:00

abstract：:Fatty acid oxidation and subsequent ketogenesis is one of the major mechanisms to maintain hepatic lipid homeostasis under fasting conditions. Fasting hormone glucagon has been shown to stimulate ketone body production through activation of PPARα; however, the signal pathway linking glucagon to PPARα is largely undisc...

journal_title：Scientific reports

authors： Zhang ZN,Gong L,Lv S,Li J,Tai X,Cao W,Peng B,Qu S,Li W,Zhang C,Luan B

更新日期：2016-03-17 00:00:00