Rapid detection of urinary soluble intercellular adhesion molecule-1 for determination of lupus nephritis activity.

Abstract:

:The current methods of monitoring the activity of lupus nephritis (LN) may cause unnecessary hospital visits or delayed immunosuppressive therapy. We aimed to find a urinary biomarker that could be developed as a home-based test for monitoring the activity of LN.Urine samples were collected immediately before a renal biopsy from patients of suspected active LN, and also from patients with inactive LN, systemic lupus erythematous without LN or healthy controls. Biomarker search was conducted on a cytokine antibody array and confirmation was done by quantitative evaluation with enzyme-linked immunosorbent assay. The Mann-Whiney test or Student t test was used to compare the levels of 9 cytokines between different groups. The sensitivity and specificity of each cytokine for diagnosis of LN was evaluated by receiver operating characteristic curve. A rapid test based on colloidal gold immunochromatography was then developed for bedside or home use. Furthermore, an experimental e-healthcare system was constructed for recording and sharing the results of the rapid test a cloud-assisted internet of things (IoT) consisting of a sensing device, an IoT device and a cloud server.Adiponectin (Acrp30), soluble intercellular cell adhesion molecule-1 (sICAM-1), neural cell adhesion molecule 1 (NCAM-1), and CD26 were significantly higher in urine samples of active LN patients. sICAM-1 appeared more sensitive and specific among these candidates. When the cut-off value of sICAM-1 was set at 1.44 ng/mL, the sensitivity reached 98.33% with a specificity at 85.71%. The sICAM-1 strip test showed comparable sensitivity of 95% and a specificity of 83.3% for assessing the LN activity. Meanwhile, the e-healthcare system was able to conveniently digitize and share the sICAM-1 rapid test results.sICAM-1 appeared to be an excellent biomarker for monitoring LN activity. The e-healthcare system with cloud-assisted IoT could assist the digitalization and sharing of the bedside or home-based sICAM-1 test results.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wang Y,Tao Y,Liu Y,Zhao Y,Song C,Zhou B,Wang T,Gao L,Zhang L,Hu H

doi

10.1097/MD.0000000000011287

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

e11287

issue

26

eissn

0025-7974

issn

1536-5964

pii

00005792-201806290-00073

journal_volume

97

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.

    abstract::Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regardin...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000000679

    authors: Shen Y,Li D,Tian P,Shen K,Zhu J,Feng M,Wan C,Yang T,Chen L,Wen F

    更新日期:2015-04-01 00:00:00

  • Individual resection and reconstruction of pelvic tumor with three-dimensional printed customized hemi-pelvic prosthesis: A case report.

    abstract:RATIONALE:Pelvic tumor had great impact on patients' quality of life. After tumor resection, how to accurately fill bone defect remained challenging for orthopedic surgeons. Due to lack of individual design, high incidence of prosthetic mismatching, and loosening were reported in pelvic reconstruction surgery with conv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016658

    authors: Han Q,Zhang K,Zhang Y,Wang C,Yang K,Zou Y,Chen B,Wang J

    更新日期:2019-09-01 00:00:00

  • The Case for Adolescent HIV Vaccination in South Africa: A Cost-Effectiveness Analysis.

    abstract::Despite comprising 0.7% of the world population, South Africa is home to 18% of the global human immunodeficiency virus (HIV) prevalence. Unyielding HIV subepidemics among adolescents threaten national attempts to curtail the disease burden. Should an HIV vaccine become available, establishing its point of entry into ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002528

    authors: Moodley N,Gray G,Bertram M

    更新日期:2016-01-01 00:00:00

  • Intensive Periodontal Treatment Reduces Risk of Infection-Related Hospitalization in Hemodialysis Population: A Nationwide Population-Based Cohort Study.

    abstract::Periodontal disease (PD) is prevalent and correlated with malnutrition and inflammation in patients on hemodialysis (HD). Periodontal therapy improves systemic inflammatory and nutritional markers in HD population. The relationship between intensive PD therapy and clinical infectious outcomes in patients on HD remains...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001436

    authors: Huang ST,Lin CL,Yu TM,Wu MJ,Kao CH

    更新日期:2015-08-01 00:00:00

  • A Retrospective Cohort Study Comparing Stroke Recurrence Rate in Ischemic Stroke Patients With and Without Acupuncture Treatment.

    abstract::Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence. A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 wa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001572

    authors: Shih CC,Liao CC,Sun MF,Su YC,Wen CP,Morisky DE,Sung FC,Hsu CY,Lin JG

    更新日期:2015-09-01 00:00:00

  • Failed percutaneous kyphoplasty in treatment of stage 3 Kummell disease: A case report and literature review.

    abstract:RATIONALE:Albeit it is rare, the authors report a stage 3 Kummell disease case. It is diagnosed by dynamic thoracic magnetic resonance imaging (MRI). Because there is no established strategy on stage 3 Kummell disease, we performed percutaneous kyphoplasty at first, but unfortunately made a revision surgery to remove t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008895

    authors: Zhang C,Wang G,Liu X,Li Y,Sun J

    更新日期:2017-11-01 00:00:00

  • Combined endoscopic submucosal dissection and transanal minimally invasive surgery for the management of lower rectal adenoma extending above the dentate line: A case report.

    abstract:RATIONALE:Minimally invasive surgery is used to treat early colorectal tumors. Endoscopic submucosal dissection (ESD) for resection of tumors extending above the dentate line (particularly those with concomitant hemorrhoids) is technically difficult. We present a case of a patient with a lower rectal adenoma extending ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015289

    authors: Nepal P,Mori S,Kita Y,Tanabe K,Baba K,Sasaki F,Nasu Y,Ido A,Uchikado Y,Kurahara H,Arigami T,Sakoda M,Maemura K,Natsugoe S

    更新日期:2019-05-01 00:00:00

  • Clinical feature of infertile men carrying balanced translocations involving chromosome 10: Case series and a review of the literature.

    abstract:RATIONALE:Infertile male carrying balanced translocations can be broadly divided into two types: pregestational and gestational infertility. Chromosome and breakpoints involved translocation should be considered in genetic counselling for these patients. To date, > 100 cases have been described with carrying balanced t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000010452

    authors: Zhang H,Wang R,Li L,Jiang Y,Zhang H,Liu R

    更新日期:2018-04-01 00:00:00

  • Evaluation of the association between mammographic density and the risk of breast cancer using Quantra software and the BI-RADS classification.

    abstract::To determine the association between mammographic density (MD) and the risk of breast cancer (BC) in Chinese women and to investigate the role of fertility risk factors in regulating the relationship between MD and BC.We used Quantra software and the BI-RADS classification to assess MD in 466 patients and 932 controls...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023112

    authors: Wang JM,Zhao HG,Liu TT,Wang FY

    更新日期:2020-11-13 00:00:00

  • Effectiveness of moxibustion therapy in the treatment of urticaria: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Urticaria is a common skin disease in clinic. The main clinical symptoms are sudden attack, various forms, different sizes of wind, and erythema, accompanied by varying degrees of itching. At present, antihistamines, non-specific antiallergic agents, or glucocorticoids are the main treatment, with some side ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023481

    authors: Deng G,Ye W,Wan Q,Wang J

    更新日期:2020-12-04 00:00:00

  • E-cadherin expression is associated with susceptibility and clinicopathological characteristics of thyroid cancer: A PRISMA-compliant meta-analysis.

    abstract:BACKGROUND:Recently, many studies have been carried out to investigate the clinicopathological significance of E-cadherin expression in thyroid cancer. However, the results remained inconsistent. In the present study, we performed a meta-analysis to evaluate the associations of E-cadherin expression with susceptibility...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016187

    authors: Zhou C,Yang C,Chong D

    更新日期:2019-07-01 00:00:00

  • Comparison Between Digital and Manual Marking for Toric Intraocular Lenses: A Randomized Trial.

    abstract::To compare the clinical outcome of digital and manual marking for toric intraocular lens (IOL) alignment. This is a prospective clinical study that included 60 eyes of 60 patients undergoing cataract surgery with coexisting corneal astigmatism more than 1 diopter (D). The eyes were randomly assigned to either digital ...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000001618

    authors: Elhofi AH,Helaly HA

    更新日期:2015-09-01 00:00:00

  • Sequential development of multifocal recurrent non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue and diffuse large B-Cell lymphoma in a single patient: A case report.

    abstract:RATIONALE:Diffuse large B-cell lymphoma (DLBCL) and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) belong to Non-Hodgkin's lymphoma (NHL). DLBCL rarely involves the orbit. MALT lymphomas, which account for 8.0% of NHLs, rarely involve parotid gland, trachea and bronchus. PATIENT C...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010845

    authors: Yang X,Min X,He W

    更新日期:2018-05-01 00:00:00

  • Prognostic value of serum albumin for patients with acute aortic dissection: A retrospective cohort study.

    abstract::Serum albumin (SA) is associated with inflammation and thrombosis, which are involved in acute aortic dissection (AAD). Our aim was to investigate the effect of SA level on survival in patients with AAD.We analyzed 777 patients with AAD. The patients were divided into hypoalbuminemia and non-hypoalbuminemia groups acc...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014486

    authors: Gao Y,Li D,Cao Y,Zhu X,Zeng Z,Tang L

    更新日期:2019-02-01 00:00:00

  • Assessment of regional right ventricular systolic function in patients with obstructive sleep apnea syndrome using velocity vector imaging.

    abstract::Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep disorder which is associated with a series of cardiovascular disorders, including right ventricular (RV) dysfunction. However, it is difficult to assess the RV function systematically using a conventional echocardiography because RV has a complex...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004788

    authors: Li J,Wang Z,Li Y,Meng Y,Li R,Wang W,Fu X

    更新日期:2016-09-01 00:00:00

  • Laboratory epidemiology of respiratory viruses in a large children's hospital: A STROBE-compliant article.

    abstract::Acute respiratory tract infection (ARTI) is the most common causes of outpatient visit and hospital admission for children. The study aimed to report epidemiological data on respiratory viruses in a university-affiliated children's hospital.The study was a retrospective study conducted in a university affiliated child...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011385

    authors: Ye S,Wang T

    更新日期:2018-07-01 00:00:00

  • Effect of glycated hemoglobin index and mean arterial pressure on acute ischemic stroke prognosis after intravenous thrombolysis with recombinant tissue plasminogen activator.

    abstract::To determine whether glycated hemoglobin and mean arterial pressure (MAP) during thrombolysis are prognostic factors of intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke (AIS).A total of 125 AIS patients, who received rt-PA intravenous thrombolysis in our hospital...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013216

    authors: Liu SY,Cao WF,Wu LF,Xiang ZB,Liu SM,Liu HY,Pan Y,Nie F,Wu XM,Xie XF

    更新日期:2018-12-01 00:00:00

  • Metastatic epithelioid trophoblastic tumor of the lung: A case report.

    abstract:RATIONALE:Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS:Here we describe a 50-year-old woman with a meta...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010306

    authors: Lei W,Zhang F,Zheng C,Zhao C,Tu S,Bao Y

    更新日期:2018-04-01 00:00:00

  • Successful percutaneous stent implantation for isolated dismal transverse aortic arch kinking.

    abstract:RATIONALE:Isolated dismal transverse aortic arch kinking in adults is rare, and there is no recommended therapy at present. Percutaneous stent implantation may be an effective method to correct it and could be considered. PATIENT CONCERNS:We report a 46-year-old woman who suffered from recurrent migraine and refractor...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006089

    authors: Zuo ZL,Tsauo JY,Chen M,Feng Y

    更新日期:2017-03-01 00:00:00

  • Feasibility and safety of automated CO2 angiography in peripheral arterial interventions.

    abstract:ABSTRACT:Carbon dioxide (CO2) gas is an established alternative to iodine contrast during angiography in patients with risk of postcontrast acute kidney injury and in those with history of iodine contrast allergy. Different CO2 delivery systems during angiography are reported in literature, with automated delivery syst...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000024254

    authors: Thomas RP,Viniol S,König AM,Portig I,Swaid Z,Mahnken AH

    更新日期:2021-01-15 00:00:00

  • Capillary hemangioma arising from the lesser omentum in an adult: A case report.

    abstract:RATIONALE:Although capillary hemangiomas, common lesions involving the proliferation of small capillary vessels and a single layer of endothelial cells, can arise in any organ, they are rarely reported in the greater or lesser omentum. Here in, we report a case of capillary hemangioma arising from the lesser omentum in...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018693

    authors: Nagano H,Goi T,Taguchi S,Tsubaki T,Tsuchiyama T,Uematsu H,Noriki S

    更新日期:2020-01-01 00:00:00

  • Major influence of postoperative complications on costs of cytoreductive surgery and HIPEC in patients with colorectal peritoneal metastases.

    abstract::Complications after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) result in impaired short- and long-term outcomes. However, financial consequences of complications after CRS and HIPEC in a European health care setting are unknown. This study aims to assess the consequences of compl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010042

    authors: Simkens GA,Rovers KP,van Oudheusden TR,Nienhuijs SW,Rutten HJ,de Hingh IH

    更新日期:2018-03-01 00:00:00

  • The Impact of Admission Diagnosis on Recurrent or Frequent Hospitalizations in 3 Dementia Subtypes: A Hospital-Based Cohort in Taiwan with 4 Years Longitudinal Follow-Ups.

    abstract::Increasing numbers of patients with different types of dementia have resulted in the increasing medical care loads. It is not known whether explanatory factors for recurrent or prolong hospitalization were driven by the subtypes of dementia. We analyzed 203 dementia patients aged >65-year-old with a clinical diagnosis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002091

    authors: Chang CC,Lin PH,Chang YT,Chen NC,Huang CW,Lui CC,Huang SH,Chang YH,Lee CC,Lai WA

    更新日期:2015-11-01 00:00:00

  • Sero-survey of polio antibodies and quality of acute flaccid paralysis surveillance in Chongqing, China: A cross-sectional study.

    abstract::Serums were collected from people to assess whether polio immunity level was high enough to satisfy the polio vaccine immunization switch in Chongqing.People in 7 age groups (<1 year, 1-2 years, 3-4 years, 5-6 years, 7-14 years, 15-19 years, ≧20 years) were randomly selected in 3 areas by different geographical featur...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021298

    authors: Xu J,Kuang S,Rong R,Zhang Y,Tang W,Wang Q

    更新日期:2020-07-31 00:00:00

  • Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea: A meta-analysis.

    abstract:BACKGROUND:Exhaled nitric oxide (eNO) has been proposed as a noninvasive measure of airway inflammation. However, its value in patients with obstructive sleep apnea (OSA) is still controversial. The authors aim to assess the difference in eNO levels between patients with OSA and controls by a meta-analysis. METHODS:A ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000006429

    authors: Zhang D,Luo J,Qiao Y,Xiao Y,Huang R,Zhong X

    更新日期:2017-03-01 00:00:00

  • Risk factors and long-term outcome for postoperative intra-abdominal infection after hepatectomy for hepatocellular carcinoma.

    abstract::Intra-abdominal infection (IAI) after hepatectomy is an important morbidity. Identification of risk factors that could be avoided in the perioperative period may reduce the prevalence of IAI after hepatectomy for hepatocelluar carcinoma (HCC).Between January 1995 and December 2009, all patients with HCC who underwent ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006795

    authors: Tang H,Lu W,Yang Z,Jiang K,Chen Y,Lu S,Dong J

    更新日期:2017-04-01 00:00:00

  • Case report: The first case of Achromobacter xylosoxidans-related tunnel infection in a patient receiving peritoneal dialysis.

    abstract:RATIONALE:Achromobacter xylosoxidans infection is mostly reported in immunocompromised patients. Until now, it is still rarely reported in patients undergoing peritoneal dialysis. PATIENT CONCERNS:This is the 1st case of A xylosoxidans infection due to tunnel infection of a Tenckhoff catheter. DIAGNOSIS:The diagnosis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006654

    authors: Tsai JL,Tsai SF

    更新日期:2017-04-01 00:00:00

  • Hypoglycemic agents for non-alcoholic fatty liver disease with type 2 diabetes mellitus: A protocol for systematic review and network meta-analysis.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries, and strongly associated with type 2 diabetes mellitus (T2DM). Several studies have shown that hypoglycemic agents are effective for NAFLD combined with T2DM. However, there is still controversy o...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021568

    authors: Liu ST,Su KQ,Zhang LH,Liu MH,Zhao WX

    更新日期:2020-08-07 00:00:00

  • Measurement of Malrotation on Direct Radiography in Pediatric Distal Radius Fractures: Prospective Observational Study.

    abstract:UNLABELLED:The aim of this prospective study was to test a mathematical method of measuring the malrotation of pediatric distal radius fractures (PDRFs) from direct radiographs. A total of 70 pediatric patients who presented at the Emergency Department with a distal radius fracture were evaluated. For 38 selected patie...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003569

    authors: Duymus TM,Mutlu S,Komur B,Mutlu H,Yucel B,Parmaksizoglu AS

    更新日期:2016-05-01 00:00:00

  • The safety and efficacy of endobronchialvalve therapy in patients with advanced heterogeneous emphysema versus standard medical care: A meta-analysis.

    abstract:BACKGROUND:Endobronchial valves had been utilized for many years to treat patients with advanced emphysema, despite unfavorable results. In this meta-analysis, we aimed to assess the efficacy and safety of the use of endobronchial valves in patients with heterogeneous advanced emphysema. METHODS:We performed systemati...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000012062

    authors: Du Y,She D,Liang Z,Yang W,Chen L

    更新日期:2018-08-01 00:00:00