Metastatic epithelioid trophoblastic tumor of the lung: A case report.

Abstract:

RATIONALE:Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS:Here we describe a 50-year-old woman with a metastatic ETT of the lung showing increasing tracer uptake at PET/CT. DIAGNOSIS:Hematoxylin-eosin staining showed a tumor composed of nests of epithelioid cells with necrotic debris and peritumoral hyaline-like material. Immunohistochemical staining of the tumor cells was positive for human chorionic gonadotropin (HCG) and cytokeratin 18. INTERVENTIONS:The patient underwent thoracoscopic lower left lobectomy combined with mediastinal lymphadenectomy. At surgery, a solid mass (size 3.0 × 3.0 cm) was found in the left lower lung. OUTCOMES:The patient was discharged on the tenth day postsurgery, following an uneventful recovery. Three months postsurgery, the patient was asymptomatic and is currently being managed with close follow-up. LESSONS:Metastatic ETT of lung is a very rare disease. Complete surgical resection and chemotherapy may be the critical therapeutic option.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Lei W,Zhang F,Zheng C,Zhao C,Tu S,Bao Y

doi

10.1097/MD.0000000000010306

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

e0306

issue

16

eissn

0025-7974

issn

1536-5964

pii

00005792-201804200-00006

journal_volume

97

pub_type

杂志文章

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