Preliminary outcomes of single antiplatelet therapy for surface-modified flow diverters in an animal model: analysis of neointimal development and thrombus formation using OCT.

Abstract:

OBJECTIVE:To evaluate the rate of neointimal development and thrombus formation of surface-modified flow diverters in single antiplatelet therapy (SAPT) using optical coherence tomography (OCT) in a porcine model. METHODS:We divided 10 experimental pigs into two groups. One group (n=6) received dual antiplatelet therapy (DAPT) and the other group (n=4) received SAPT. Four stents (two per carotid artery) were implanted in both groups. The stents used were the Pipeline Flex embolization device (PED Flex), Pipeline Flex with Shield technology (PED Shield), and the Solitaire AB stent. All animals underwent weekly angiography and OCT. The OCT data were analyzed using the following measurements: neointimal ratio ((stent - lumen area)/stent area), stent-coverage ratio (number of stent struts covered by neointima/total stent struts), and the presence or absence of thrombus formation per 1 mm cross-section. RESULTS:PED Flex and Shield in the SAPT group had higher neointimal ratios than in the DAPT group (P<0.001, respectively). In the DAPT group, the speed of endothelial growth on day 7 in the PED Shield group was higher than that in the PED Flex group (P<0.001). In the SAPT group, PED Flex demonstrated significantly more thrombus formation on day 7 than PED Shield (P<0.001). CONCLUSIONS:The PED Shield stent showed faster endothelial growth than the other devices and comparable neointimal volume. There was significantly less thrombus formation on PED Shield than PED Flex when using SAPT in a porcine model.

journal_name

J Neurointerv Surg

authors

Matsuda Y,Jang DK,Chung J,Wainwright JM,Lopes D

doi

10.1136/neurintsurg-2018-013935

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

74-79

issue

1

eissn

1759-8478

issn

1759-8486

pii

neurintsurg-2018-013935

journal_volume

11

pub_type

杂志文章
  • DynaCT evaluation of in-stent restenosis following Wingspan stenting of intracranial stenosis.

    abstract:OBJECTIVE AND IMPORTANCE:To describe the use of DynaCT angiographic imaging for the evaluation of Wingspan in-stent restenosis (ISR). METHODS:Two patients were treated with Wingspan stenting and percutaneous transluminal angioplasty (Patient 1 had treatment of a severe stenosis of the right middle cerebral artery and ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/jnis.2009.000505

    authors: Moskowitz SI,Kelly ME,Haynes J,Fiorella D

    更新日期:2010-03-01 00:00:00

  • Venous waveform morphological changes associated with treatment of symptomatic venous sinus stenosis.

    abstract:INTRODUCTION:Venous outflow obstruction is recognized as a contributing factor in a subset of patients with idiopathic intracranial hypertension (IIH). Little is known about venous sinus waveform morphology or how it changes after stenting. METHODS:Fifteen patients with IIH underwent waveform recording during catheter...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2018-013858

    authors: West JL,Garner RM,Greeneway GP,Traunero JR,Aschenbrenner CA,Singh J,Wolfe SQ,Fargen KM

    更新日期:2018-11-01 00:00:00

  • Yield of diagnostic imaging in atraumatic convexity subarachnoid hemorrhage.

    abstract:INTRODUCTION:Atraumatic convexity subarachnoid hemorrhage is a subtype of spontaneous subarachnoid hemorrhage that often presents a diagnostic challenge. Common etiologies include cerebral amyloid angiopathy, vasculopathies, and coagulopathy; however, aneurysm is rare. Given the broad differential of causes of convexit...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2019-014781

    authors: Dakay K,Mahta A,Rao S,Reznik ME,Wendell LC,Thompson BB,Potter NS,Saad A,Gandhi CD,Santarelli J,Al-Mufti F,MacGrory B,Burton T,Jayaraman MV,McTaggart RA,Furie K,Yaghi S,Cutting S

    更新日期:2019-12-01 00:00:00

  • Onyx embolization of an extensive mandibular arteriovenous malformation via a dual lumen balloon catheter: a technical case report.

    abstract:SUMMARY:The first known use of Onyx delivered via a dual lumen balloon catheter is reported. A mandibular arteriovenous malformation was successfully embolized with Onyx via an Ascent balloon catheter. CASE PRESENTATION:A teenage girl presented with facial deformity and episodes of oral bleeding. Angiogram showed an e...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2011-010179

    authors: Fifi J,Niimi Y,Berenstein A

    更新日期:2013-03-01 00:00:00

  • Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms.

    abstract:BACKGROUND AND PURPOSE:Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. MAT...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2018-013756

    authors: Brinjikji W,Chung B,Yong-Hong D,Wald JT,Mut F,Kadirvel R,Kallmes DF,Rouchaud A,Lanzino G,Cebral JR

    更新日期:2018-11-01 00:00:00

  • Effect of stenting on progressive occlusion of small unruptured saccular intracranial aneurysms with residual sac immediately after coil embolization: a propensity score analysis.

    abstract:BACKGROUND:To examine the effect of stenting on progressive occlusion of small and incompletely occluded unruptured intracranial aneurysms (UIAs) ≤10 mm in size using a propensity score matched case controlled analysis. METHODS:715 small UIAs consecutively treated by coiling between 2008 and 2010 were eligible for stu...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2015-011947

    authors: Jeon JP,Cho YD,Rhim JK,Park JJ,Cho WS,Kang HS,Kim JE,Han MH

    更新日期:2016-10-01 00:00:00

  • Infectious intracranial aneurysms: a systematic review of epidemiology, management, and outcomes.

    abstract::Infectious intracranial aneurysms (IIAs) are a rare cerebrovascular complication of systemic infections induced by microbial infiltration and degradation of the arterial vessel wall. Studies on the epidemiology and management of IIAs are limited to case reports and retrospective single-center studies, and report a lar...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审

    doi:10.1136/neurintsurg-2017-013603

    authors: Alawieh A,Chaudry MI,Turner RD,Turk AS,Spiotta AM

    更新日期:2018-07-01 00:00:00

  • Quantification of speed-up and accuracy of multi-CPU computational flow dynamics simulations of hemodynamics in a posterior communicating artery aneurysm of complex geometry.

    abstract:BACKGROUND:Towards the translation of computational fluid dynamics (CFD) techniques into the clinical workflow, performance increases achieved with parallel multi-central processing unit (CPU) pulsatile CFD simulations in a patient-derived model of a bilobed posterior communicating artery aneurysm were evaluated while ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2012-010586

    authors: Karmonik C,Yen C,Gabriel E,Partovi S,Horner M,Zhang YJ,Klucznik RP,Diaz O,Grossman RG

    更新日期:2013-11-01 00:00:00

  • Endovascular stroke therapy may be safe in patients with elevated international normalized ratio.

    abstract:INTRODUCTION:Endovascular therapy in acute ischemic stroke is safe and efficient. However, patients receiving oral anticoagulation were excluded in the larger trials. OBJECTIVE:To analyze the safety of endovascular therapy in patients with acute ischemic stroke and elevated international normalized ratio (INR) values....

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2016-012757

    authors: Mundiyanapurath S,Tillmann A,Möhlenbruch MA,Bendszus M,Ringleb PA

    更新日期:2017-12-01 00:00:00

  • Combined proximal balloon occlusion and distal aspiration: a new approach to prevent distal embolization during neurothrombectomy.

    abstract:BACKGROUND AND PURPOSE:Embolization of thrombus fragments in a new vascular territory is a potential adverse event in neurothrombectomy. This study was performed to evaluate the safety and feasibility of a novel approach combining proximal balloon occlusion and distal aspiration to prevent distal thrombembolic complica...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2015-012208

    authors: Stampfl S,Pfaff J,Herweh C,Pham M,Schieber S,Ringleb PA,Bendszus M,Möhlenbruch MA

    更新日期:2017-04-01 00:00:00

  • Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition.

    abstract:BACKGROUND:Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clot...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2020-016966

    authors: Fitzgerald S,Rossi R,Mereuta OM,Jabrah D,Okolo A,Douglas A,Molina Gil S,Pandit A,McCarthy R,Gilvarry M,Dunker D,Nordanstig A,Ceder E,Redfors P,Jood K,Dehlfors N,Magoufis G,Tsivgoulis G,Brinjikji W,Kallmes DF,O'Har

    更新日期:2020-12-09 00:00:00

  • Middle meningeal artery embolization as an adjuvant treatment to surgery for symptomatic chronic subdural hematoma: a pilot study assessing hematoma volume resorption.

    abstract:BACKGROUND:Chronic subdural hematoma (CSDH) is a common condition requiring surgical treatment; however, recurrence occurs in 15% of cases at 1 year. Middle meningeal artery (MMA) embolization has recently emerged as a promising treatment to prevent CSDH recurrence. OBJECTIVE:To investigate the effect of MMA embolizat...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/neurintsurg-2019-015421

    authors: Ng S,Derraz I,Boetto J,Dargazanli C,Poulen G,Gascou G,Lefevre PH,Molinari N,Lonjon N,Costalat V

    更新日期:2020-07-01 00:00:00

  • Angiographic cerebral venous sinus calibers and drainage patterns in patients with normal intracranial pressure and idiopathic intracranial hypertension.

    abstract:BACKGROUND:Normative venous sinus diameters are not well established. This study seeks to compare two-dimensional digital subtraction cerebral angiographic (DSA) venous sinus calibers for patients with normal intracranial pressure (ICP) and with idiopathic intracranial hypertension (IIH). METHODS:Patients who underwen...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2020-016976

    authors: Peterson KA,Kittel C,Lee KE,Garner R,Nechtman CM,Brown P,Wolfe SQ,Fargen KM

    更新日期:2020-12-15 00:00:00

  • Association between hemodynamic conditions and occlusion times after flow diversion in cerebral aneurysms.

    abstract:BACKGROUND:Evaluation of flow diversion treatment of intracranial aneurysms is difficult owing to lack of knowledge of the target hemodynamic environment. OBJECTIVE:To identify hemodynamic conditions created after flow diversion that induce fast aneurysm occlusion. METHODS:Two groups of aneurysms treated with flow di...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2013-011080

    authors: Mut F,Raschi M,Scrivano E,Bleise C,Chudyk J,Ceratto R,Lylyk P,Cebral JR

    更新日期:2015-04-01 00:00:00

  • Mechanical thrombectomy of M1 and M2 middle cerebral artery occlusions.

    abstract:BACKGROUND:Over half of patients who receive intravenous tissue plasminogen activator for middle cerebral artery division (MCA-M2) occlusion do not recanalize, leaving a large percentage of patients who may need mechanical thrombectomy (MT). However, the outcomes of MT for M2 occlusion have not been well characterized....

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1136/neurintsurg-2017-013159

    authors: Salahuddin H,Ramaiah G,Slawski DE,Shawver J,Buehler M,Zaidi SF,Jumaa M

    更新日期:2018-04-01 00:00:00

  • Picture-to-puncture time in acute stroke endovascular intervention: are we getting faster?

    abstract:BACKGROUND:In acute stroke management, time efficiency in the continuum of patient management is critical. We aimed to determine if implementation of system improvements at our institution translated to reduced picture-to-puncture (P2P) times over a 6-year period. METHODS:We conducted a single-center retrospective ana...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2014-011177

    authors: van Heerden J,Yan B,Churilov L,Dowling RJ,Mitchell PJ

    更新日期:2015-08-01 00:00:00

  • Contrast-enhanced time-resolved MRA for pre-angiographic evaluation of suspected spinal dural arterial venous fistulas.

    abstract:BACKGROUND:Spinal digital subtraction angiography (DSA) is the gold standard for diagnosis of spinal dural arterial venous fistulas (SDAVFs), but can require extensive time, radiation exposure and contrast dose. We hypothesize that contrast-enhanced time-resolved MR angiography (CE-TR MRA) will have utility for the non...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2013-010981

    authors: Saindane AM,Boddu SR,Tong FC,Dehkharghani S,Dion JE

    更新日期:2015-02-01 00:00:00

  • Clinical, morphological, and hemodynamic independent characteristic factors for rupture of posterior communicating artery aneurysms.

    abstract:OBJECTIVE:To identify clinical, morphological, and hemodynamic independent characteristic factors that discriminate posterior communicating artery (PCoA) aneurysm rupture status. METHODS:173 patients with single PCoA aneurysms (108 ruptured, 65 unruptured) between January 2012 and June 2014 were retrospectively collec...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2015-011865

    authors: Zhang Y,Jing L,Liu J,Li C,Fan J,Wang S,Li H,Yang X

    更新日期:2016-08-01 00:00:00

  • Use of the pCONus HPC as an adjunct to coil occlusion of acutely ruptured aneurysms: early clinical experience using single antiplatelet therapy.

    abstract:BACKGROUND:Coil occlusion has become the standard treatment for many ruptured aneurysms. However, specific aneurysm structures pose technical difficulties and may require the use of adjunctive neck-bridging devices, which necessitate the use of dual antiplatelet therapy. The hydrophilic polymer coating (pHPC, phenox) i...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2019-015746

    authors: Aguilar Perez M,AlMatter M,Hellstern V,Wendl C,Ganslandt O,Bäzner H,Henkes H

    更新日期:2020-09-01 00:00:00

  • Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture - a systematic review and novel parameter-ranking tool.

    abstract:BACKGROUND:Intracranial aneurysms (IAs) are vascular dilations on cerebral vessels that affect between 1%-5% of the general population, and can cause life-threatening intracranial hemorrhage when ruptured. Computational fluid dynamics (CFD) has emerged as a promising tool to study IAs in recent years, particularly for ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2018-014246

    authors: Liang L,Steinman DA,Brina O,Chnafa C,Cancelliere NM,Pereira VM

    更新日期:2019-02-01 00:00:00

  • NBCA embolization of a ruptured intraventricular distal anterior choroidal artery aneurysm in a patient with moyamoya disease.

    abstract::Occasionally an aneurysm is the cause of hemorrhage in patients with moyamoya disease (MMD). We present a case of a ruptured intraventricular distal anterior choroidal artery (AChA) aneurysm treated with n-butyl cyanoacrylic acid (nBCA) (Trufill nBCA Liquid Embolic, Codman Neurovascular, Raynham, Massachusetts, USA) e...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/jnis.2010.002253

    authors: Choulakian A,Drazin D,Alexander MJ

    更新日期:2010-12-01 00:00:00

  • Endovascular treatment of intracranial aneurysms with the LVIS device: a systematic review.

    abstract:OBJECTIVE:Despite promising initial results, current knowledge regarding the use of the Low-profile Visualized Intraluminal Support (LVIS) device to treat wide-necked intracranial aneurysms is still limited. Our aim is to evaluate the feasibility, efficacy, and safety of the LVIS device in stent-assisted coiling of int...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审

    doi:10.1136/neurintsurg-2016-012403

    authors: Zhang X,Zhong J,Gao H,Xu F,Bambakidis NC

    更新日期:2017-06-01 00:00:00

  • Flow changes in the posterior communicating artery related to flow-diverter stents in carotid siphon aneurysms.

    abstract:BACKGROUND:Flow-diverter stent (FDS) placement for treatment of intracranial aneurysms can cause flow changes in the covered branches. OBJECTIVE:To assess the impact of the treatment of carotid siphon aneurysms with FDS on the posterior communicating artery (PComA) flow. MATERIALS AND METHODS:Between February 2011 an...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2016-012443

    authors: de Carvalho FM,Caroff J,Pereira Dos Santos Neto E,Chalumeau V,Abdel Khalek H,Neki H,Saliou G,Rouchaud A,Moret J,Spelle L

    更新日期:2017-07-01 00:00:00

  • Flow diversion of large internal carotid artery aneurysms with the surpass device: impressions and technical nuance from the initial North American experience.

    abstract:BACKGROUND:Flow diversion is an important tool for treatment of cerebral aneurysms, particularly large and giant aneurysms. The Surpass flow diverter is a new system under evaluation in the USA. OBJECTIVE:To report our initial experience of 20 cases with the Surpass flow diverter to demonstrate its basic properties, t...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2015-011769

    authors: Colby GP,Lin LM,Caplan JM,Jiang B,Michniewicz B,Huang J,Tamargo RJ,Coon AL

    更新日期:2016-03-01 00:00:00

  • Intracranial bailout stenting with the Acclino (Flex) Stent/NeuroSpeed Balloon Catheter after failed thrombectomy in acute ischemic stroke: a multicenter experience.

    abstract:BACKGROUND AND PURPOSE:To report on the feasibility, safety, and outcome of acute intracranial stenting (ICS) with the Acclino (Flex) Stent and NeuroSpeed Balloon Catheter in cases of failed mechanical thrombectomy (MT) for acute ischemic stroke (AIS). METHODS:We retrospectively reviewed the data of patients treated w...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1136/neurintsurg-2019-014957

    authors: Stracke CP,Meyer L,Fiehler J,Leischner H,Bester M,Buhk JH,Thomalla G,Krause LU,Lowens S,Rothaupt J,Chapot R,Hanning U

    更新日期:2020-01-01 00:00:00

  • Early detachment of the Solitaire stent during thrombectomy retrieval: an in vitro investigation.

    abstract:OBJECTIVE:To elucidate the early detachment of the Solitaire stent during mechanical thrombectomy, we tested the stent in vitro under various conditions and evaluated with microscopy. METHODS:A total of five stents were tested. Using a dynamic mechanical analysis machine, we calculated the tensile force needed for sep...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2013-010942

    authors: Kwon HJ,Chueh JY,Puri AS,Koh HS

    更新日期:2015-02-01 00:00:00

  • Embolization of palpebral and orbito-frontal fistulas: technical and anatomical considerations in treating high-flow superficial skin lesions with liquid embolics.

    abstract::The treatment of palpebral and periorbital fistulas may be challenging due to the presence of multiple anastomosis with eloquent ophthalmic and intracranial vascular territories. Moreover, cosmetic and functional characteristics of this area pose unique challenges to open surgical approaches and endovascular therapy. ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2017-013239

    authors: Samaniego EA,Fisher M,Hasan D,Guerrero WR,Fifi JT,Bottani L,Ortega-Gutierrez S

    更新日期:2018-03-01 00:00:00

  • De novo pseudoaneurysm formation after angioplasty and stenting of posterior circulation intracranial atherosclerotic disease: mechanism, characterization with intravascular ultrasound and management considerations.

    abstract:BACKGROUND:The formation of de novo pseudoaneurysms after stent implantation has not been well characterized after stenting of intracranial vessels. Its clinical significance is unknown, resulting in a difficult decision making process with regard to its treatment. METHODS:The database of patients treated at the Bapti...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2012-010443

    authors: Dabus G,Linfante I,Samaniego EA

    更新日期:2013-09-01 00:00:00

  • p64 Flow Modulation Device in the treatment of intracranial aneurysms: initial experience and technical aspects.

    abstract:BACKGROUND:Experience with the endovascular treatment of cerebral aneurysms by flow diverter devices (FDDs) is limited to four devices (Pipeline, Covidien; FRED, Microvention; Silk, Balt Extrusion; Surpass, Stryker), as reported in different studies. OBJECTIVE:To describe the initial experience and the technical innov...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2015-011743

    authors: Briganti F,Leone G,Marseglia M,Cicala D,Caranci F,Maiuri F

    更新日期:2016-02-01 00:00:00

  • Disposition to home or acute rehabilitation is associated with a favorable clinical outcome in the SENTIS trial.

    abstract:OBJECTIVE:To explore the impact of stroke severity and discharge disposition on 90-day outcomes in US patients enrolled in the SENTIS trial. METHODS:SENTIS is a previously published prospective randomized controlled trial. We analyzed the demographic information, National Institutes of Health Stroke Scores (NIHSS) on ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章

    doi:10.1136/neurintsurg-2014-011132

    authors: Belagaje SR,Zander K,Thackeray L,Gupta R

    更新日期:2015-05-01 00:00:00