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Venous waveform morphological changes associated with treatment of symptomatic venous sinus stenosis.

Abstract：

INTRODUCTION:Venous outflow obstruction is recognized as a contributing factor in a subset of patients with idiopathic intracranial hypertension (IIH). Little is known about venous sinus waveform morphology or how it changes after stenting. METHODS:Fifteen patients with IIH underwent waveform recording during catheter venography and manometry. Ten patients (Group A) with venous sinus stenosis and pressure gradient ≥7 mm Hg underwent waveform recording during awake venography and during stenting under general anesthesia. Five control IIH patients (Group B) without a gradient underwent awake recording only. RESULTS:Group A patients underwent successful stenting with reduction of their gradient from 15.1±6.19 mm Hg to 1.2±0.60 mm Hg. This resulted in an amplitude reduction from 8.3 mm Hg to 2.8 mm Hg (P=0.02). Qualitative evaluation of the waveform yielded a number of novel findings. In Group A before stenting, the observed waveform progressed from an intracranial pressure (ICP)-dominated to central venous pressure (CVP)-dominated waveform. Stenting abolished the high amplitude waveform and smoothed the transition from the intracranial to central venous measurement points. Group B displayed primarily CVP-influenced waveforms distal and proximal to the transverse-sigmoid junction along with respiratory variability of the waveform, absent in 8/10 Group A patients. General anesthesia appeared to blunt the waveform in 5/10 Group A patients. CONCLUSION:The cerebral venous waveform appears to be influenced by both the ICP and CVP waveforms. As measurement moves proximally, the waveform progressively changes to mirror the CVP waveform. Venous sinus stenosis results in a high amplitude waveform which improves with treatment of the stenosis.

journal_name

J Neurointerv Surg

journal_title

Journal of neurointerventional surgery

authors

West JL,Garner RM,Greeneway GP,Traunero JR,Aschenbrenner CA,Singh J,Wolfe SQ,Fargen KM

doi

10.1136/neurintsurg-2018-013858

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1108-1113

issue

eissn

1759-8478

issn

1759-8486

pii

neurintsurg-2018-013858

journal_volume

pub_type

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Venous waveform morphological changes associated with treatment of symptomatic venous sinus stenosis.