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Stentrievers versus other endovascular treatment methods for acute stroke: comparison of procedural results and their relationship to outcomes.

Abstract：

BACKGROUND AND PURPOSE:The use of stentrievers (ST) is rapidly growing due to several potential benefits over other available treatments. ST potentially restore flow before clot retrieval and reduce procedural time. We aimed to study the impact of these potential benefits. METHODS:Patients with acute stroke treated with endovascular procedures in two stroke centers were studied. According to device availability, patients were treated either with intra-arterial tissue plasminogen activator (IAT), Merci or ST. We defined time to initial flow restoration as time from symptom onset to first pass of contrast to previously occluded arteries either through the deployed device or after recanalization. Complete recanalization (Thrombolysis In Cerebral Infarction >2b), day 5 National Institute of Health Stroke Scale (NIHSS) score and favorable outcome at 3 months (modified Rankin Scale score≤2) were recorded. RESULTS:A total of 315 patients were studied: 127 IAT, 119 Merci, 69 ST (26 Trevo, 43 Solitaire). No major differences were observed in baseline characteristics between the treatment groups. The rate of complete recanalization was higher with ST (67.2%) than with IAT (50.8%) or Merci (57.3%) (p=0.05). Time from groin puncture to final recanalization was lower with ST (88±46 min) than with IAT (103±70 min) or Merci (128±62 min) (p<0.01) and time from groin puncture to initial flow restoration was shorter with ST (36±18 min) than with IAT (92±67 min) or Merci (114±57 min) (p<0.01). Discharge NIHSS was lower in the ST group (7, IQR 1-26) than in the IAT (14, 2-30) or Merci (12, 5-30) groups (p=0.05) and the rate of favorable outcome was higher: ST (52.9%) vs IAT (33.9%) and Merci (40%) (p=0.03). The use of a ST increased the odds of a favorable outcome (OR 1.9, 95% CI 1.04 to 3.39; p=0.037). CONCLUSIONS:In acute endovascular treatment of stroke, the use of ST may increase recanalization and reduce time to flow restoration leading to improved outcomes.

journal_name

J Neurointerv Surg

journal_title

Journal of neurointerventional surgery

authors

Ribo M,Molina CA,Jankowitz B,Tomasello A,Zaidi S,Jumaa M,Coscojuela P,Oakley J,Alvarez-Sabín J,Jovin T

doi

10.1136/neurintsurg-2013-010748

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

265-9

issue

eissn

1759-8478

issn

1759-8486

pii

neurintsurg-2013-010748

journal_volume

pub_type

杂志文章,多中心研究

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Stentrievers versus other endovascular treatment methods for acute stroke: comparison of procedural results and their relationship to outcomes.