当前位置： SCI文献检索 > Journal of NeuroInterventional Surgery期刊下所有文献 > Stent assisted coiling of the ruptured wide necked intracranial aneurysm.

Stent assisted coiling of the ruptured wide necked intracranial aneurysm.

Abstract：

BACKGROUND:Stent assisted coiling of unruptured wide necked intracranial aneurysms require antiplatelets to prevent stent thrombosis. The effect of the loading dose of antiplatelets prior to the stent coiling procedure in an unsecured wide necked ruptured intracranial aneurysm is not known. OBJECTIVE:To report any potential complication associated with the use of both aspirin and clopidogrel in stent assisted coiling of ruptured wide necked intracranial aneurysms. METHODS:Consecutive patients who underwent stent assisted coiling for ruptured wide necked intracranial aneurysm were enrolled from 2005 to 2009. Patients' demographics, including Hunt and Hess grade, Fisher scale, and location and size of aneurysms, were collected. Complications such as rupture of aneurysm, thromboembolic events, ventriculostomy associated or systemic hemorrhages were recorded. Additionally, a 90 day outcome measurement was obtained using the Glasgow Outcome Scale. RESULTS:22 patients with a mean age of 50±13 years underwent stent assisted coiling. A loading dose of clopidogrel 300 mg and aspirin 325 mg orally were given prior to stent placement. There was no intraoperative rupture of aneurysm, ventriculostomy associated hemorrhage or systemic hemorrhagic event. There were two episodes of stent thrombosis; one was an asymptomatic event which developed during the stent assisted coiling procedure and resolved spontaneously; the other was symptomatic which required intra-arterial administration of glycoprotein IIbIIIa receptor antagonist. There was no mortality and good outcome was observed in 82% of patients. CONCLUSION:In our series of carefully selected patients, therapeutic dual antiplatelet loading prior to stent assisted coiling of ruptured wide necked intracranial aneurysm was not associated with increased bleeding complications. However, thromboembolic events remain the main challenge. Further study is required to confirm the safety of antiplatelet loading in stent assisted ruptured intracranial aneurysm coiling.

journal_name

J Neurointerv Surg

journal_title

Journal of neurointerventional surgery

authors

Lodi YM,Latorre JG,El-Zammar Z,Swarnkar A,Deshaies E,Fessler RD

doi

10.1136/neurintsurg-2011-010035

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

281-6

issue

eissn

1759-8478

issn

1759-8486

pii

neurintsurg-2011-010035

journal_volume

pub_type

杂志文章

在线工具

Stent assisted coiling of the ruptured wide necked intracranial aneurysm.