当前位置： SCI文献检索 > HEART RHYTHM期刊下所有文献 > Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation.

Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation.

Abstract：

BACKGROUND:Arterial hypertension (HT) contributes to progression of atrial fibrillation (AF) via unknown mechanisms. OBJECTIVE:We aimed to characterize electrical and structural changes accounting for increased AF stability in a large animal model of rapid atrial pacing (RAP)-induced AF combined with desoxycorticosterone acetate (DOCA)-induced HT. METHODS:Eighteen pigs were instrumented with right atrial endocardial pacemaker leads and custom-made pacemakers to induce AF by continuous RAP (600 beats/min). DOCA pellets were subcutaneously implanted in a subgroup of 9 animals (AF+HT group); the other 9 animals served as controls (AF group). Final experiments included electrophysiology studies, endocardial electroanatomic mapping, and high-density mapping with epicardial multielectrode arrays. In addition, 3-dimensional computational modeling was performed. RESULTS:DOCA implantation led to secondary HT (median [interquartile range] aortic pressure 109.9 [100-137] mm Hg in AF+HT vs 82.2 [79-96] mm Hg in AF; P < .05), increased AF stability (55.6% vs 12.5% of animals with AF episodes lasting >1 hour; P < .05), concentric left ventricular hypertrophy, atrial dilatation (119 ± 31 cm2 in AF+HT vs 78 ± 23 cm2 in AF; P < .05), and fibrosis. Collagen accumulation in the AF+HT group was mainly found in non-intermyocyte areas (1.62 ± 0.38 cm3 in AF+HT vs 0.96 ± 0.3 cm3 in AF; P < .05). Left and right atrial effective refractory periods, action potential durations, endo- and epicardial conduction velocities, and measures of AF complexity were comparable between the 2 groups. A 3-dimensional computational model confirmed an increase in AF stability observed in the in vivo experiments associated with increased atrial size. CONCLUSION:In this model of secondary HT, higher AF stability after 2 weeks of RAP is mainly driven by atrial dilatation.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Manninger M,Zweiker D,van Hunnik A,Alogna A,Prassl AJ,Schipke J,Zeemering S,Zirngast B,Schönleitner P,Schwarzl M,Herbst V,Thon-Gutschi E,Huber S,Rohrer U,Ebner J,Brussee H,Pieske BM,Heinzel FR,Verheule S,Antoons G,

doi

10.1016/j.hrthm.2018.05.016

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1328-1336

issue

9

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(18)30503-4

journal_volume

15

pub_type

杂志文章

相关文献

HEART RHYTHM文献大全
  • Long-term survival after cardiac arrest in hypertrophic cardiomyopathy.

    abstract：BACKGROUND:Patients with hypertrophic cardiomyopathy (HCM) and aborted cardiac arrest are generally regarded as a high-risk subgroup susceptible to future major cardiac events and an unfavorable prognosis. However, outcome over extended time periods after major arrhythmic events is unresolved in such HCM patients. OBJ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2009.03.014

    authors： Maron BJ,Haas TS,Shannon KM,Almquist AK,Hodges JS

    更新日期：2009-07-01 00:00:00

  • Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: Basis for atrial-selective block by ranolazine.

    abstract：BACKGROUND:Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The antianginal agent ranolazine is a prototypic atrial-selective voltage-gated Na+ channel blocker but the mechanisms underlying its at...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2017.06.012

    authors： Caves RE,Cheng H,Choisy SC,Gadeberg HC,Bryant SM,Hancox JC,James AF

    更新日期：2017-11-01 00:00:00

  • Outcomes of long-standing persistent atrial fibrillation ablation: a systematic review.

    abstract：BACKGROUND:Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes. OBJECTIVE:The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2010.01.017

    authors： Brooks AG,Stiles MK,Laborderie J,Lau DH,Kuklik P,Shipp NJ,Hsu LF,Sanders P

    更新日期：2010-06-01 00:00:00

  • Nonspecific intraventricular conduction delay: Definitions, prognosis, and implications for cardiac resynchronization therapy.

    abstract：:Cardiac resynchronization therapy (CRT) is an electrical treatment of heart failure with reduced ejection fraction and wide QRS. It aims to correct the electrical dyssynchrony present in 30% to 50% of patients in this population. Dyssynchrony results in widening of the QRS complex on the electrocardiogram (ECG). CRT w...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2015.01.023

    authors： Eschalier R,Ploux S,Ritter P,Haïssaguerre M,Ellenbogen KA,Bordachar P

    更新日期：2015-05-01 00:00:00

  • Techniques for successful early retrieval of the Micra transcatheter pacing system: A worldwide experience.

    abstract：BACKGROUND:Experience with retrieval of the Micra transcatheter pacing system (TPS) is limited because of its relatively newer technology. Although abandonment of the TPS at end of life is recommended, certain situations such as endovascular infection or device embolization warrant retrieval. OBJECTIVE:The purpose of ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2018.02.008

    authors： Afzal MR,Daoud EG,Cunnane R,Mulpuru SK,Koay A,Hussain A,Omar R,Wei KK,Amin A,Kidwell G,Patel N,Love C,Lloyd M,Sterliński M,Goldbarg S,Leal MA,Gabriels J,Patel A,Jadonath R,Grubman E,Crossley G,Pepper C,Lakkire

    更新日期：2018-06-01 00:00:00

  • Sudden cardiac arrest in intercollegiate athletes: detailed analysis and outcomes of resuscitation in nine cases.

    abstract：BACKGROUND:Public access defibrillation programs have demonstrated a survival benefit in persons with out-of-hospital cardiac arrest. However, little is known about the effectiveness of early defibrillation in young competitive athletes with sudden cardiac arrest (SCA). OBJECTIVES:The purpose of this study was to inve...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2006.03.023

    authors： Drezner JA,Rogers KJ

    更新日期：2006-07-01 00:00:00

  • Application of noninvasive signal-averaged electrocardiogram analysis in predicting the requirement of epicardial ablation in patients with arrhythmogenic right ventricular cardiomyopathy.

    abstract：BACKGROUND:Signal-averaged electrocardiogram (SAECG) provides not only diagnostic information but also the prognostic implication of ablation in arrhythmogenic right ventricular cardiomyopathy (ARVC). OBJECTIVE:This study aimed to validate the role of SAECG in identifying arrhythmogenic substrates requiring an epicard...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.11.018

    authors： Chung FP,Lin CY,Lin YJ,Chang SL,Lo LW,Hu YF,Tuan TC,Chao TF,Liao JN,Chang TY,Tan VH,Kuo L,Wu CI,Liu CM,Vicera JJB,Chen CC,Chin CG,Liu SH,Cheng WH,Chou CY,Lugtu IC,Liu CH,Chen SA

    更新日期：2020-04-01 00:00:00

  • Left cardiac sympathetic denervation reduces skin sympathetic nerve activity in patients with long QT syndrome.

    abstract：BACKGROUND:Although left cardiac sympathetic denervation (LCSD) is an effective antiarrhythmic therapy for patients with long QT syndrome (LQTS), direct evidence of reduced sympathetic activity after LCSD in humans is limited. OBJECTIVE:The purpose of this study was to assess skin sympathetic nerve activity (SKNA) in ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.03.023

    authors： Han J,Ackerman MJ,Moir C,Cai C,Xiao PL,Zhang P,Briske KA,Zheng LR,Chen PS,Cha YM

    更新日期：2020-10-01 00:00:00

  • The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis.

    abstract：OBJECTIVE:The purpose of this study is to ascertain the effects of spatially variable ACh distributions on arrhythmogenesis in a morphologically realistic computer model of canine atria. BACKGROUND:Vagal stimulation releases acetylcholine (ACh), which causes a dose-dependent reduction in action potential duration (APD...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2004.03.077

    authors： Vigmond EJ,Tsoi V,Kuo S,Arevalo H,Kneller J,Nattel S,Trayanova N

    更新日期：2004-09-01 00:00:00

  • Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model.

    abstract：BACKGROUND:Pulmonary delivery of antiarrhythmic agents has the potential to increase rapidly targeted drug concentrations in pulmonary veins and left atrium to terminate atrial fibrillation (AF). OBJECTIVE:We evaluated the efficacy of flecainide administered via intratracheal instillation in terminating AF in a reliab...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2018.06.036

    authors： Verrier RL,Bortolotto AL,Silva BA,Marum AA,Stocco FG,Evaristo E,de Antonio VZ,Silva AC,Belardinelli L

    更新日期：2018-12-01 00:00:00

  • Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study.

    abstract：BACKGROUND:Autonomic regulation therapy (ART) with chronic vagus nerve stimulation improves ventricular function in patients with chronic heart failure, but its effects on quantitative T-wave alternans (TWA), ventricular tachycardia (VT), baroreflex sensitivity, and autonomic tone remained unknown. OBJECTIVE:Effects o...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.hrthm.2015.11.030

    authors： Libbus I,Nearing BD,Amurthur B,KenKnight BH,Verrier RL

    更新日期：2016-03-01 00:00:00

  • Long-term reduction of atrial tachyarrhythmia recurrences in patients paced for bradycardia-tachycardia syndrome.

    abstract：BACKGROUND:Atrial tachyarrhythmias (AT) are considered progressive diseases. Several rhythm control therapies for treatment of AT have been proposed. OBJECTIVES:The Italian AT500 Registry was designed to prospectively study long-term AT evolution in patients paced for the brady-tachy form of sinus node disease (BT-SND...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2005.07.011

    authors： Padeletti L,Santini M,Boriani G,Botto G,Gulizia M,Molon G,Luzzi G,Senatore G,Giraldi F,Zolezzi F,Pieragnoli P,Pro F,Desanto T,Grammatico A,Italian AT500 Registry Investigators.

    更新日期：2005-10-01 00:00:00

  • SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.

    abstract：BACKGROUND:The cardiac sodium channel (SCN5A) mutation R222Q neutralizes a positive charge in the domain I voltage sensor. Mutation carriers display very frequent ectopy and dilated cardiomyopathy. OBJECTIVES:To describe the effect of SCN5A R222Q on murine myocyte and Purkinje fiber electrophysiology, and identify und...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.05.017

    authors： Daniel LL,Yang T,Kroncke B,Hall L,Stroud D,Roden DM

    更新日期：2019-11-01 00:00:00

  • Of founder populations, long QT syndrome, and destiny.

    abstract：:Founder populations, characterized by a single ancestor affected by long QT syndrome (LQTS) and by a large number of individuals and families who all are related to the ancestor and thereby carry the same disease-causing mutation, represent the ideal human model for studying the role of "modifier genes" in LQTS. This ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2009.08.036

    authors： Brink PA,Schwartz PJ

    更新日期：2009-11-01 00:00:00

  • Association between atrial fibrillation and volumetric magnetic resonance imaging brain measures: Framingham Offspring Study.

    abstract：BACKGROUND:The increased risk of stroke and cognitive impairment associated with atrial fibrillation (AF) is well documented. However, there is a paucity of research investigating the relations between AF and brain morphology. OBJECTIVE:The purpose of this study was to investigate the association between AF and brain ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2016.07.004

    authors： Piers RJ,Nishtala A,Preis SR,DeCarli C,Wolf PA,Benjamin EJ,Au R

    更新日期：2016-10-01 00:00:00

  • Minimally invasive transtracheal cardiac plexus block for sympathetic neuromodulation.

    abstract：BACKGROUND:Bilateral thoracoscopic stellectomy has antiarrhythmic effects, but the procedure is invasive with associated morbidity. Sympathetic nerves from both stellate ganglia form the deep cardiac plexus (CP) in the aortopulmonary window, anterior to the trachea. OBJECTIVE:The purpose of this study was to demonstra...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2018.07.037

    authors： Assis FR,Yu DH,Zhou X,Sidhu S,Bapna A,Engelman ZJ,Misra S,Okada DR,Chrispin J,Berger R,Mandal K,Lee H,Tandri H

    更新日期：2019-01-01 00:00:00

  • Interatrial conduction can be accurately determined using standard 12-lead electrocardiography: validation of P-wave morphology using electroanatomic mapping in man.

    abstract：BACKGROUND:Different P-wave morphologies during sinus rhythm as displayed on standard ECGs have been postulated to correspond to differences in interatrial conduction. OBJECTIVE:The purpose of this study was to evaluate the hypothesis by comparing P-wave morphologies using left atrial activation maps. METHODS:Twenty-...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2007.12.017

    authors： Holmqvist F,Husser D,Tapanainen JM,Carlson J,Jurkko R,Xia Y,Havmöller R,Kongstad O,Toivonen L,Olsson SB,Platonov PG

    更新日期：2008-03-01 00:00:00

  • Inside-out access: a new method of lead placement for patients with central venous occlusions.

    abstract：BACKGROUND:Physicians will increasingly encounter patients who require rhythm management devices but have venous obstructions that prevent conventional access. Alternate access options, such as thoracotomy or transiliac approaches, exist but are associated with greater cost and morbidity. OBJECTIVE:The purpose of this...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.01.024

    authors： Elayi CS,Allen CL,Leung S,Lusher S,Morales GX,Wiisanen M,Aikat S,Kakavand B,Shah JS,Moliterno DJ,Gurley JC

    更新日期：2011-06-01 00:00:00

  • Clinical recognition of pure premature ventricular complex-induced cardiomyopathy at presentation.

    abstract：BACKGROUND:Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular (LV) systolic dysfunction. OBJECTIVE:The purpose of this study was to identify the clinical pattern of patients having a "pure PVC-induced" cardiomyopathy at presentation. METHODS:This prospective multicenter study includ...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2017.07.025

    authors： Penela D,Fernández-Armenta J,Aguinaga L,Tercedor L,Ordoñez A,Bisbal F,Acosta J,Rossi L,Borras R,Doltra A,Ortiz-Pérez JT,Bosch X,Perea RJ,Prat-González S,Soto-Iglesias D,Tolosana JM,Vassanelli F,Cabrera M,Linhart M,M

    更新日期：2017-12-01 00:00:00

  • Forward trafficking of ion channels: what the clinician needs to know.

    abstract：:Each heartbeat requires precisely orchestrated action potential propagation through the myocardium, achieved by coordination of about a million ion channels on the surface of each cardiomyocyte. Specific ion channels must occur within discrete subdomains of the sarcolemma to exert their electrophysiological effects wi...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2010.05.030

    authors： Smyth JW,Shaw RM

    更新日期：2010-08-01 00:00:00

  • Validation of a defibrillation lead ventricular volume measurement compared to three-dimensional echocardiography.

    abstract：BACKGROUND:There is increasing evidence that using frequent invasive measures of pressure in patients with heart failure results in improved outcomes compared to traditional measures. Admittance, a measure of volume derived from preexisting defibrillation leads, is proposed as a new technique to monitor cardiac hemodyn...

    journal_title：Heart rhythm

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.hrthm.2017.06.005

    authors： Haines DE,Wong W,Canby R,Jewell C,Houmsse M,Pederson D,Sugeng L,Porterfield J,Kottam A,Pearce J,Valvano J,Michalek J,Trevino A,Sagar S,Feldman MD

    更新日期：2017-10-01 00:00:00

  • hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms.

    abstract：BACKGROUND:The human ether-à-go-go-related gene (hERG 1a) potassium channel is critical for cardiac repolarization. hERG 1b, another variant subunit, co-assembles with hERG 1a, modulates channel biophysical properties and plays an important role in repolarization. Mutations of hERG 1a lead to type 2 long QT syndrome (L...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2016.01.012

    authors： Puckerin A,Aromolaran KA,Chang DD,Zukin RS,Colecraft HM,Boutjdir M,Aromolaran AS

    更新日期：2016-05-01 00:00:00

  • Admittance to detect alterations in left ventricular stroke volume.

    abstract：BACKGROUND:Implantable cardioverter-defibrillators monitor intracardiac electrograms (EGMs) to discriminate between ventricular and supraventricular tachycardias. The incidence of inappropriate shocks remains high because of misclassification of the tachycardia in an otherwise hemodynamically stable individual. Couplin...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2014.06.034

    authors： Larson ER,Porterfield JE,Sagar S,Marmol-Velez J,Panday M,Escobedo D,Michalek J,Ouyang Y,Valvano JW,Pearce JA,Feldman MD

    更新日期：2014-11-01 00:00:00

  • Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

    abstract：BACKGROUND:Vernakalant inhibits several potassium currents and causes a rate- and voltage-dependent inhibition of the sodium current. OBJECTIVE:The aim of this study was to evaluate the antiarrhythmic mechanism of vernakalant in normal and electrically remodeled atria. METHODS:Fourteen goats were instrumented with el...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2015.12.009

    authors： van Hunnik A,Lau DH,Zeemering S,Kuiper M,Verheule S,Schotten U

    更新日期：2016-04-01 00:00:00

  • Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing.

    abstract：BACKGROUND:Mutations in the RyR2-encoded cardiac ryanodine receptor/calcium release channel and in CASQ2-encoded calsequestrin cause catecholaminergic polymorphic ventricular tachycardia (CPVT1 and CPVT2, respectively). OBJECTIVES:The purpose of this study was to evaluate the extent of genotypic and phenotypic heterog...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2006.03.025

    authors： Tester DJ,Arya P,Will M,Haglund CM,Farley AL,Makielski JC,Ackerman MJ

    更新日期：2006-07-01 00:00:00

  • Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis.

    abstract：BACKGROUND:Early detection of cardiac involvement in sarcoidosis is difficult but essential to achieve optimal treatment. Signal-averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities termed late potentials (LPs) and would be useful for the early diagnosis of cardiac involvement. OBJEC...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2018.03.013

    authors： Yodogawa K,Seino Y,Ohara T,Iwasaki YK,Hayashi M,Miyauchi Y,Azuma A,Shimizu W

    更新日期：2018-06-01 00:00:00

  • Left ventricular endocardial pacing is less arrhythmogenic than conventional epicardial pacing when pacing in proximity to scar.

    abstract：BACKGROUND:Epicardial pacing increases risk of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) when pacing in proximity to scar. Endocardial pacing may be less arrhythmogenic as it preserves the physiological sequences of activation and repolarization. OBJECTIVE:The purpose of this study wa...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.03.021

    authors： Mendonca Costa C,Neic A,Gillette K,Porter B,Gould J,Sidhu B,Chen Z,Elliott M,Mehta V,Plank G,Rinaldi CA,Bishop MJ,Niederer SA

    更新日期：2020-08-01 00:00:00

  • Lack of regional association between atrial late gadolinium enhancement on cardiac magnetic resonance and atrial fibrillation rotors.

    abstract：BACKGROUND:The extent of left atrial (LA) late gadolinium enhancement (LGE), as a surrogate for fibrosis, has been associated with atrial fibrillation (AF) recurrence after catheter ablation. Furthermore, there is ex vivo evidence that islands of fibrosis may anchor fibrillatory rotors. OBJECTIVE:The purpose of this s...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2015.11.011

    authors： Chrispin J,Gucuk Ipek E,Zahid S,Prakosa A,Habibi M,Spragg D,Marine JE,Ashikaga H,Rickard J,Trayanova NA,Zimmerman SL,Zipunnikov V,Berger RD,Calkins H,Nazarian S

    更新日期：2016-03-01 00:00:00

  • Respiratory cycle-dependent atrial tachycardia: prevalence, electrocardiographic and electrophysiologic characteristics, and outcome after catheter ablation.

    abstract：BACKGROUND:Little is known about the tachyarrhythmias relating to respiration. Case reports presented patients with respiratory cycle-dependent atrial tachycardias (RCATs), which cyclically emerge after starting inspiration and cease during expiration. OBJECTIVE:The aim of the present study was to elucidate the preval...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.04.031

    authors： Yamamoto T,Hayashi M,Miyauchi Y,Murata H,Horie T,Igawa O,Kato T,Mizuno K

    更新日期：2011-10-01 00:00:00

  • Complete antral encirclement is not required for pulmonary vein isolation.

    abstract：BACKGROUND:Complete circumferential antral ablation may not be necessary for successful pulmonary vein (PV) isolation in patients with paroxysmal atrial fibrillation (AF). OBJECTIVE:We examined the feasibility of a noncircumferential approach limited to segments of the antra required for PV-atrial conduction. METHODS...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2010.09.069

    authors： Sy RW,Gula LJ,Leong-Sit P,Klein GJ,Yee R,Krahn AD,Bentley C,Razak S,Skanes AC

    更新日期：2011-01-01 00:00:00