当前位置： SCI文献检索 > HEART RHYTHM期刊下所有文献 > Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness.

Abstract：

BACKGROUND:Vernakalant inhibits several potassium currents and causes a rate- and voltage-dependent inhibition of the sodium current. OBJECTIVE:The aim of this study was to evaluate the antiarrhythmic mechanism of vernakalant in normal and electrically remodeled atria. METHODS:Fourteen goats were instrumented with electrodes on both atria. Drug effects on refractory period (ERP), conduction velocity (CV), and atrial fibrillation cycle length (AFCL) were determined in normal goats (control) and after 2 (2dAF) or 11 (11dAF) days of pacing-induced atrial fibrillation (AF) in awake goats. To evaluate the contribution of changes in conduction and ERP, the same experiments were performed with flecainide and AVE0118. In a subset of goats, monophasic action potentials were recorded during anesthesia. RESULTS:Vernakalant dose-dependently prolonged ERP and decreased CV in CTL experiments. Both effects were maintained after 2dAF and 11dAF. After 11dAF, conduction slowed down by 8.2 ± 1.5 cm/s and AFCL increased by 55 ± 3 ms, leading to AF termination in 5 out of 9 goats. Monophasic action potential measurements revealed that ERP prolongation was due to enhanced postrepolarization refractoriness. During pacing, vernakalant had comparable effects on CV as flecainide, while effect on ERP was comparable to AVE0118. During AF, all compounds had comparable effects on median AFCL and ERP despite differences in their effects on CV during pacing. CONCLUSION:The antiarrhythmic effect of vernakalant in the goat, at clinically relevant plasma concentrations, is based on both conduction slowing and ERP prolongation due to postrepolarization refractoriness. These electrophysiological effects were not affected by long-term electrical remodeling of the atria.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

van Hunnik A,Lau DH,Zeemering S,Kuiper M,Verheule S,Schotten U

doi

10.1016/j.hrthm.2015.12.009

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

964-72

issue

4

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(15)01522-2

journal_volume

13

pub_type

杂志文章

相关文献

HEART RHYTHM文献大全
  • Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea.

    abstract：BACKGROUND:Negative tracheal pressure (NTP) during tracheal obstruction in obstructive apnea increases vagal tone and causes pronounced shortening of the atrial effective refractory period (AERP), thereby perpetuating atrial fibrillation (AF). The role of different atrial potassium channels under those conditions has n...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.07.018

    authors： Linz D,Schotten U,Neuberger HR,Böhm M,Wirth K

    更新日期：2011-12-01 00:00:00

  • Magnitude of increase in QTc interval after initiation of dofetilide in patients with persistent atrial fibrillation is associated with increased rates of pharmacological cardioversion and long-term freedom from recurrent atrial fibrillation.

    abstract：BACKGROUND:Dofetilide is a class III antiarrhythmic drug approved for the treatment of atrial fibrillation (AF). Dofetilide-induced corrected QT (QTc) interval prolongation is a surrogate for the degree of drug effect, but the relationships between drug-induced QTc interval prolongation, pharmacological cardioversion (...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2016.02.016

    authors： Huang HD,Waks JW,Steinhaus DA,Zimetbaum P

    更新日期：2016-07-01 00:00:00

  • Locating the right phrenic nerve by imaging the right pericardiophrenic artery with computerized tomographic angiography: implications for balloon-based procedures.

    abstract：BACKGROUND:Phrenic nerve (PN) injury, a known complication of radiofrequency (RF) catheter ablation of atrial fibrillation (AF), has been more commonly reported with balloon-based pulmonary vein isolation. OBJECTIVE:We present a novel approach to locating the PN and predicting patients at higher risk of this complicat...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2010.03.027

    authors： Horton R,Di Biase L,Reddy V,Neuzil P,Mohanty P,Sanchez J,Nguyen T,Mohanty S,Gallinghouse GJ,Bailey SM,Zagrodzky JD,Burkhardt JD,Natale A

    更新日期：2010-07-01 00:00:00

  • Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation.

    abstract：BACKGROUND:A considerable rate of atrial fibrillation (AF) recurrence is one of the major limitations of pulmonary vein isolation (PVI). Although endothelin-1 (ET-1) is involved in atrial remodeling, it is unknown whether plasma ET-1 level before PVI can be used as a predictive factor for AF recurrence. OBJECTIVE:The ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2009.02.027

    authors： Nakazawa Y,Ashihara T,Tsutamoto T,Ito M,Horie M

    更新日期：2009-06-01 00:00:00

  • Clinical and electrocardiographic features of complete heart block after blunt cardiac injury: A systematic review of the literature.

    abstract：:The underlying mechanisms and temporal course of complete heart block (CHB) after blunt cardiac injuries (BCIs) are poorly understood, and a systematic analysis of available data is lacking. In this systematic review, PubMed was searched for publications of reported cases of CHB-BCI analyzing clinical findings, electr...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2017.05.040

    authors： Ali H,Furlanello F,Lupo P,Foresti S,De Ambroggi G,Epicoco G,Semprini L,Fundaliotis A,Cappato R

    更新日期：2017-10-01 00:00:00

  • Adaptive cardiac resynchronization therapy is associated with decreased risk of incident atrial fibrillation compared to standard biventricular pacing: A real-world analysis of 37,450 patients followed by remote monitoring.

    abstract：BACKGROUND:The AdaptivCRT algorithm (aCRT) automatically adjusts atrioventricular delays each minute to achieve ventricular fusion through left ventricular (LV) or biventricular (BiV) pacing. aCRT is associated with superior clinical outcomes compared to standard BiV pacing, but the association of aCRT and subsequent a...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.05.012

    authors： Hsu JC,Birnie D,Stadler RW,Cerkvenik J,Feld GK,Birgersdotter-Green U

    更新日期：2019-07-01 00:00:00

  • Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart.

    abstract：BACKGROUND:Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) in the mouse is expressed in the developing cardiac conduction system (CCS). In the sinoatrial node (SAN), HCN4 is the predominant isoform responsible for the funny current. To date, no data are available on HCN4 expression during chicken C...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.03.043

    authors： Vicente-Steijn R,Passier R,Wisse LJ,Schalij MJ,Poelmann RE,Gittenberger-de Groot AC,Jongbloed MR

    更新日期：2011-08-01 00:00:00

  • Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients.

    abstract：BACKGROUND:There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE:The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2018.06.019

    authors： Milman A,Gourraud JB,Andorin A,Postema PG,Sacher F,Mabo P,Conte G,Giustetto C,Sarquella-Brugada G,Hochstadt A,Kim SH,Juang JJM,Maeda S,Takahashi Y,Kamakura T,Aiba T,Leshem E,Michowitz Y,Rahkovich M,Mizusawa Y,Arbe

    更新日期：2018-10-01 00:00:00

  • Incidence and predictors of atrial fibrillation progression: A systematic review and meta-analysis.

    abstract：BACKGROUND:More sustained forms of atrial fibrillation (AF) are less amenable to treatment and associated with worse outcomes, but the incidence and predictors of AF progression are not well defined. OBJECTIVE:The purpose of this study was to perform a systematic review and meta-analysis assessing the incidence and pr...

    journal_title：Heart rhythm

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.hrthm.2018.10.022

    authors： Blum S,Meyre P,Aeschbacher S,Berger S,Auberson C,Briel M,Osswald S,Conen D

    更新日期：2019-04-01 00:00:00

  • Increasing hazard of Sprint Fidelis implantable cardioverter-defibrillator lead failure.

    abstract：BACKGROUND:The Medtronic Sprint Fidelis defibrillator lead is prone to fracture and was recalled in 2007 after 665 failures and five reported deaths. Approximately 150,000 patients at risk for sudden death in the United States have Sprint Fidelis leads. The rate of Sprint Fidelis lead failure may be increasing, and phy...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2009.02.024

    authors： Hauser RG,Hayes DL

    更新日期：2009-05-01 00:00:00

  • Outcomes of catheter ablation of anteroseptal and midseptal accessory pathways in pediatric patients.

    abstract：BACKGROUND:Outcomes for catheter ablation of accessory pathways in pediatric patients have steadily improved, with the exception of pathways located in the anteroseptal (AS) and midseptal (MS) regions, where success is limited by the close proximity of normal atrioventricular conduction. OBJECTIVE:The purpose of this ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.12.008

    authors： Kovach JR,Mah DY,Abrams DJ,Alexander ME,Cecchin F,Triedman JK,Walsh EP

    更新日期：2020-05-01 00:00:00

  • Differential diagnosis of regular, narrow-QRS tachycardias.

    abstract：:We present an update on clinical and electrophysiological criteria used for the differential diagnosis of regular supraventricular tachycardias. Although several electrocardiographic clues may assist in the differential diagnosis, this is usually accomplished at electrophysiology study, and most often, the differentia...

    journal_title：Heart rhythm

    pub_type： 杂志文章,评审

    doi：10.1016/j.hrthm.2015.03.046

    authors： Katritsis DG,Josephson ME

    更新日期：2015-07-01 00:00:00

  • Interatrial conduction can be accurately determined using standard 12-lead electrocardiography: validation of P-wave morphology using electroanatomic mapping in man.

    abstract：BACKGROUND:Different P-wave morphologies during sinus rhythm as displayed on standard ECGs have been postulated to correspond to differences in interatrial conduction. OBJECTIVE:The purpose of this study was to evaluate the hypothesis by comparing P-wave morphologies using left atrial activation maps. METHODS:Twenty-...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2007.12.017

    authors： Holmqvist F,Husser D,Tapanainen JM,Carlson J,Jurkko R,Xia Y,Havmöller R,Kongstad O,Toivonen L,Olsson SB,Platonov PG

    更新日期：2008-03-01 00:00:00

  • Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice.

    abstract：BACKGROUND:Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy. OBJECTIVE:The purpose of this study was to (1) determine the value of ECG criteria to predict an epicardial SoO of clinical...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2014.03.001

    authors： Piers SR,Silva Mde R,Kapel GF,Trines SA,Schalij MJ,Zeppenfeld K

    更新日期：2014-06-01 00:00:00

  • Electrophysiologic and clinical consequences of linear catheter ablation to transect the anterior left atrium in patients with atrial fibrillation.

    abstract：OBJECTIVES:To evaluate the feasibility and outcome of ablation to transect the anterior left atrium (LA) in patients with atrial fibrillation (AF). BACKGROUND:While the Maze procedure is effective in maintaining sinus rhythm in patients with AF, it is associated with significant morbidity. This prospective clinical st...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2004.03.072

    authors： Sanders P,Jaïs P,Hocini M,Hsu LF,Scavée C,Sacher F,Rotter M,Takahashi Y,Pasquié JL,Shah DC,Garrigue S,Clémenty J,Haïssaguerre M

    更新日期：2004-07-01 00:00:00

  • Race/ethnicity and the incidence of new-onset atrial fibrillation after isolated coronary artery bypass surgery.

    abstract：BACKGROUND:Atrial fibrillation (AF) is more prevalent in Caucasians than in persons of other racial/ethnic groups. OBJECTIVE:The purpose of this study was to examine the association between race/ethnicity and new-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG). METHODS:Data...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2010.06.037

    authors： Nazeri A,Razavi M,Elayda MA,Lee VV,Massumi A,Wilson JM

    更新日期：2010-10-01 00:00:00

  • Endocardial (Watchman) vs epicardial (Lariat) left atrial appendage exclusion devices: Understanding the differences in the location and type of leaks and their clinical implications.

    abstract：BACKGROUND:Watchman and Lariat left atrial appendage (LAA) occlusion devices are associated with LAA leaks postdeployment. OBJECTIVE:The purpose of this study was to compare the incidence, characteristics, and clinical significance of these leaks. METHODS:We performed a multicenter prospective observational study of ...

    journal_title：Heart rhythm

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.hrthm.2015.03.020

    authors： Pillarisetti J,Reddy YM,Gunda S,Swarup V,Lee R,Rasekh A,Horton R,Massumi A,Cheng J,Bartus K,Badhwar N,Han F,Atkins D,Bommana S,Earnest M,Nath J,Ferrell R,Bormann S,Dawn B,Di Biase L,Mansour M,Natale A,Lakkired

    更新日期：2015-07-01 00:00:00

  • Pediatric survivors of out-of-hospital ventricular fibrillation: Etiologies and outcomes.

    abstract：BACKGROUND:In general, the prognosis is poor for pediatric patients who experience out-of-hospital (OOH) cardiac arrest, with survival rates of 12% to 29%. OBJECTIVE:The purpose of this study was to describe the causes and outcomes of pediatric patients with documented ventricular fibrillation (VF) at resuscitation fr...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2017.08.014

    authors： Silka MJ,Kobayashi RL,Hill AC,Bar-Cohen Y

    更新日期：2018-01-01 00:00:00

  • Genetic testing and cascade screening in pediatric long QT syndrome and hypertrophic cardiomyopathy.

    abstract：BACKGROUND:The efficacy of cascade screening for the inherited heart conditions long QT syndrome (LQTS) and hypertrophic cardiomyopathy (HCM) is incompletely characterized. OBJECTIVE:The purpose of this study was to examine the use of genetic testing and yield of cascade screening across diverse regions in the United ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.06.015

    authors： Knight LM,Miller E,Kovach J,Arscott P,von Alvensleben JC,Bradley D,Valdes SO,Ware SM,Meyers L,Travers CD,Campbell RM,Etheridge SP

    更新日期：2020-01-01 00:00:00

  • Subcutaneous versus transvenous implantable defibrillator: An updated meta-analysis.

    abstract：BACKGROUND:Implantable cardioverter-defibrillator (ICD) placement is a well-established therapy for prevention of sudden cardiac death. The subcutaneous implantable cardioverter-defibrillator (S-ICD) was specifically designed to overcome some of the complications related to the transvenous implantable cardioverter-defi...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.11.013

    authors： Rordorf R,Casula M,Pezza L,Fortuni F,Sanzo A,Savastano S,Vicentini A

    更新日期：2020-11-16 00:00:00

  • Radiofrequency ablation of atrial fibrillation under therapeutic international normalized ratio: a safe and efficacious periprocedural anticoagulation strategy.

    abstract：BACKGROUND:The best periprocedural anticoagulation strategy at the time of pulmonary vein isolation (PVI) is not known. Most centers stop administering warfarin (Coumadin) and use bridging with heparin or enoxaparin. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of PVI under therapeutic i...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2009.07.007

    authors： Hussein AA,Martin DO,Saliba W,Patel D,Karim S,Batal O,Banna M,Williams-Andrews M,Sherman M,Kanj M,Bhargava M,Dresing T,Callahan T,Tchou P,Di Biase L,Beheiry S,Lindsay B,Natale A,Wazni O

    更新日期：2009-10-01 00:00:00

  • Antitachycardia pacing reduces appropriate and inappropriate shocks in children and congenital heart disease patients.

    abstract：BACKGROUND:Antitachycardia pacing (ATP) can reduce implantable cardioverter-defibrillator shocks, but its use in children and patients with congenital heart disease (CHD) is not well described. OBJECTIVE:To review the efficacy of ATP in children and patients with CHD. METHODS:We reviewed implantable cardioverter-defi...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2012.06.042

    authors： Kalra Y,Radbill AE,Johns JA,Fish FA,Kannankeril PJ

    更新日期：2012-11-01 00:00:00

  • Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations.

    abstract：BACKGROUND:Carvedilol and its analogues suppress delayed afterdepolarizations (DADs) and catecholaminergic polymorphic ventricular tachycardias by direct action on the cardiac ryanodine receptor type 2 (RyR2). OBJECTIVE:To test a hypothesis that carvedilol analogue may also prevent triggered activities (TAs) through t...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2012.09.006

    authors： Maruyama M,Xiao J,Zhou Q,Vembaiyan K,Chua SK,Rubart-von der Lohe M,Lin SF,Back TG,Chen SR,Chen PS

    更新日期：2013-01-01 00:00:00

  • Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation.

    abstract：BACKGROUND:The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE:The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients a...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2020.11.028

    authors： Blum S,Aeschbacher S,Meyre P,Kühne M,Rodondi N,Beer JH,Ammann P,Moschovitis G,Bonati LH,Blum MR,Kastner P,Baguley F,Sticherling C,Osswald S,Conen D,BEAT-AF and Swiss-AF Investigators.

    更新日期：2020-12-03 00:00:00

  • A retrospective analysis of proceduralist-directed, nurse-administered propofol sedation for implantable cardioverter-defibrillator procedures.

    abstract：BACKGROUND:There is controversy whether proceduralist-directed, nurse-administered propofol sedation (PDNAPS) is safe. OBJECTIVE:To assess the frequency of adverse events when PDNAPS is used for implantable cardioverter-defibrillator (ICD)-related procedures and to determine the patient and procedural characteristics ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.10.009

    authors： Sayfo S,Vakil KP,Alqaqa'a A,Flippin H,Bhakta D,Yadav AV,Miller JM,Groh WJ

    更新日期：2012-03-01 00:00:00

  • Complications arising from catheter ablation of atrial fibrillation: temporal trends and predictors.

    abstract：BACKGROUND:The reported complication rate of catheter ablation of atrial fibrillation (AF) varies. OBJECTIVE:Our goal was to assess temporal trends and the effect of both institutional and individual operators' experience on the incidence of complications. METHODS:All patients undergoing AF ablation at Johns Hopkins ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2011.07.025

    authors： Hoyt H,Bhonsale A,Chilukuri K,Alhumaid F,Needleman M,Edwards D,Govil A,Nazarian S,Cheng A,Henrikson CA,Sinha S,Marine JE,Berger R,Calkins H,Spragg DD

    更新日期：2011-12-01 00:00:00

  • Patient plus partner trial: A randomized controlled trial of 2 interventions to improve outcomes after an initial implantable cardioverter-defibrillator.

    abstract：BACKGROUND:Interventions to improve physical and psychological outcomes in recipients with an initial implantable cardioverter-defibrillator (ICD) and their intimate partners are largely unstudied, though likely to have a major impact on adjustment to the ICD and general well-being. OBJECTIVE:The purpose of this study...

    journal_title：Heart rhythm

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.hrthm.2018.10.011

    authors： Dougherty CM,Thompson EA,Kudenchuk PJ

    更新日期：2019-03-01 00:00:00

  • Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles.

    abstract：OBJECTIVES:This study was designed to determine whether ionic currents in right ventricular myocytes from explanted human transplant recipient hearts are related to right ventricular histopathology and function. BACKGROUND:Cardiac action potential duration (APD) is prolonged in ventricular tissues/cells from patients ...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2004.06.003

    authors： Li GR,Lau CP,Leung TK,Nattel S

    更新日期：2004-10-01 00:00:00

  • Ten-year ablation outcomes of patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation.

    abstract：BACKGROUND:Pulmonary vein isolation (PVI) is commonly performed in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF). However, the very long-term follow-up result is limited. OBJECTIVE:We aimed to investigate 10-year ablation outcomes in patients with PAF and long-term follow-up results af...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2019.03.028

    authors： Cheng WH,Lo LW,Lin YJ,Chang SL,Hu YF,Hung Y,Chung FP,Liao JN,Tuan TC,Chao TF,Tsai TY,Liu SH,Chen SA

    更新日期：2019-09-01 00:00:00

  • Spatial correlation of action potential duration and diastolic dysfunction in transgenic and drug-induced LQT2 rabbits.

    abstract：BACKGROUND:Enhanced dispersion of action potential duration (APD) is a major contributor to long QT syndrome (LQTS)-related arrhythmias. OBJECTIVE:To investigate spatial correlations of regional heterogeneities in cardiac repolarization and mechanical function in LQTS. METHODS:Female transgenic LQTS type 2 (LQT2; n =...

    journal_title：Heart rhythm

    pub_type： 杂志文章

    doi：10.1016/j.hrthm.2013.07.038

    authors： Odening KE,Jung BA,Lang CN,Cabrera Lozoya R,Ziupa D,Menza M,Relan J,Franke G,Perez Feliz S,Koren G,Zehender M,Bode C,Brunner M,Sermesant M,Föll D

    更新日期：2013-10-01 00:00:00