Abstract:
:ComplexContact (http://raptorx2.uchicago.edu/ComplexContact/) is a web server for sequence-based interfacial residue-residue contact prediction of a putative protein complex. Interfacial residue-residue contacts are critical for understanding how proteins form complex and interact at residue level. When receiving a pair of protein sequences, ComplexContact first searches for their sequence homologs and builds two paired multiple sequence alignments (MSA), then it applies co-evolution analysis and a CASP-winning deep learning (DL) method to predict interfacial contacts from paired MSAs and visualizes the prediction as an image. The DL method was originally developed for intra-protein contact prediction and performed the best in CASP12. Our large-scale experimental test further shows that ComplexContact greatly outperforms pure co-evolution methods for inter-protein contact prediction, regardless of the species.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Zeng H,Wang S,Zhou T,Zhao F,Li X,Wu Q,Xu Jdoi
10.1093/nar/gky420subject
Has Abstractpub_date
2018-07-02 00:00:00pages
W432-W437issue
W1eissn
0305-1048issn
1362-4962pii
5001161journal_volume
46pub_type
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