Abstract:
:The first step in gene expression, transcription, is modulated by the interaction of transcription factors with their corresponding binding sites on the DNA sequence. Pscan is a software tool that scans a set of sequences (e.g. promoters) from co-regulated or co-expressed genes with motifs describing the binding specificity of known transcription factors and assesses which motifs are significantly over- or under-represented, providing thus hints on which transcription factors could be common regulators of the genes studied, together with the location of their candidate binding sites in the sequences. Pscan does not resort to comparisons with orthologous sequences and experimental results show that it compares favorably to other tools for the same task in terms of false positive predictions and computation time. The website is free and open to all users and there is no login requirement. Address: http://www.beaconlab.it/pscan.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Zambelli F,Pesole G,Pavesi Gdoi
10.1093/nar/gkp464subject
Has Abstractpub_date
2009-07-01 00:00:00pages
W247-52issue
Web Server issueeissn
0305-1048issn
1362-4962pii
gkp464journal_volume
37pub_type
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