Abstract：
OBJECTIVES:Secondary caries at the tooth-restoration margins is a primary reason for restoration failure. Cracks at the margins lead to leakage which can trap bacteria, producing acids to cause caries. To date, there has been no report on developing an adhesive resin that has self-healing, antibacterial and remineralizing capabilities. The objectives of this study were to: (1) develop the first self-healing adhesive with antimicrobial and remineralizing capabilities, and (2) investigate the effects of incorporating microcapsules, dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) for the first time. METHODS:Self-healing microcapsules were synthesized with poly(urea-formaldehyde) (PUF) shells containing triethylene glycol dimethacrylate (TEGDMA) as the healing liquid. The new adhesive contained 7.5% microcapsules, 10% DMAHDM and 20% NACP. A single edge V-notched beam (SEVNB) method was used to measure the fracture toughness KIC and the autonomous crack-healing efficiency. An oral plaque microcosm biofilm model was tested. RESULTS:The new self-healing, antimicrobial and remineralizing dental adhesive matched the dentin bond strength of a commercial control (p > 0.1). The new adhesive achieved successful crack-healing, with an excellent KIC recovery of 67%. The new adhesive had strong antimicrobial activity, reducing biofilm colony-forming units by four orders of magnitude, and reducing biofilm acid production to 1/100th that of biofilms on the commercial control resin. CONCLUSIONS:A self-healing adhesive with antibacterial and remineralizing capabilities was developed for the first time. Excellent dentin bond strength, autonomous crack-healing and KIC recovery, and strong anti-biofilm properties were achieved for the new adhesive resin. CLINICAL SIGNIFICANCE:The novel method of using triple agents (self-healing microcapsules + DMAHDM + NACP) is promising for applications in dental adhesives, cements, sealants and composites to combat the two main challenges: fracture and secondary caries.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Yue S,Wu J,Zhang Q,Zhang K,Weir MD,Imazato S,Bai Y,Xu HHKdoi
10.1016/j.jdent.2018.05.009subject
Has Abstractpub_date
2018-08-01 00:00:00pages
48-57eissn
0300-5712issn
1879-176Xpii
S0300-5712(18)30126-Xjournal_volume
75pub_type
杂志文章abstract：OBJECTIVES:The aim of this study was to investigate the novel mesocellular siliceous foams (MCF) containing CaCO3 nanoparticles (denoted as CMCF) combined with phosphoric acid could occlude dentinal tubules through the formation of biomimetic crystal barrier. METHODS:Ultrastructures of MCF and CMCF were examined by tr...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2019.02.007
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVES:This clinical follow-up evaluated the long-term outcome of full-mouth rehabilitations with adhesively bonded all-ceramic restorations in patients suffering from amelogenesis imperfecta (AI) or affected by extensive tooth wear including a loss of the vertical dimension of occlusion. MATERIALS AND METHODS:Inc...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2017.12.011
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVES:This study concerned the temperature and linear dimensional change of heat-cured acrylic resin in the two-stage processing technique for complete dentures. METHODS:Thermocouples were incorporated in the acrylic resin for recording temperatures. Measurements between reference marks were made by a high-resolu...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)91190-x
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVES:The objectives of this study were to investigate: (1) the antibacterial activity of two antibacterial monomers, dimethylaminododecyl methacrylate (DMADDM) and dimethylammoniumethyl dimethacrylate (DMAEDM), against eight different species of oral pathogens for the first time; (2) the cytotoxicity of DMAEDM an...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.07.006
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:To measure the denaturation temperature (Td) of demineralised dentine matrix as a function of infiltration with water vs. polar solvents vs. adhesive resins. METHODS:Small discs of normal dentine were completely demineralised in 0.5M EDTA. Dried demineralised specimens were placed in water, methanol, ethano...
journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2007.10.003
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:This study investigated the effects of the surface conditioning of nano-zirconia fillers with 10-methacryloyloxydecyl dihydrogen phosphate (MDP) and dipentaerythritol penta-acrylate phosphate (PENTA) on the degree of conversion and mechanical properties of Bis-GMA- and UDMA-based resin composites containing ...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103306
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:Approximately 1.5 million panoramic radiographs are taken annually in the general dental service in England and Wales. The aim of this review was to assess the clinical role of panoramic radiology in the diagnosis of diseases associated with the teeth and to consider its value in routine screening of patient...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/0300-5712(95)00055-0
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:Following a successful 2005-2012 phase with three regional practice-based research networks (PBRNs), a single, unified national network called "The National Dental PBRN" was created in 2012 in the United States to improve oral health by conducting practice-based research and serving dental professionals throu...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.04.002
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:To compare the lifetime of Y-TZP/porcelain crowns under three different load conditions using step-stress accelerated lifetime testing. METHODS:The Y-TZP frameworks were milled using CAD/CAM, veneered with a porcelain and cemented onto dentine analogue dies. Specimens were divided according to the occlusal ...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2015.01.012
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVES:To compare the clinical performance of Scotchbond™ Universal Adhesive used in self- and total-etch modes and two-bottle Scotchbond™ Multi-purpose Adhesive in total-etch mode for Class 5 non-carious cervical lesions (NCCLs). METHODS:37 adults were recruited with 3 or 6 NCCLs (>1.5mm deep). Teeth were isolate...
journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2015.07.009
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:(1) To systematically review the clinical application and remineralization potentials of ozone in dentistry; (2) To summarize the available in vitro applications of ozone in dentistry. SOURCES:Ovid MEDLINE, CINAHL, etc. (up to April 2007). STUDY SELECTION:In vitro or in vivo English language publications, ...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/j.jdent.2007.11.008
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVES:The aetiology of orofacial pain (OFP) is not well understood. We aimed to determine the relationship between OFP and local mechanical factors in an unselected general population sample. METHODS:A cross-sectional population-based survey was conducted in the United Kingdom, involving 2504 participants (adjust...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(03)00108-8
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVES:This study investigated the in-vitro performance and fracture force of anterior implant-supported tooth-coloured fixed dental prosthesis (FDPs). Different material types with varying flexural strength and modulus of elasticity were compared with screw-retained or bonded application. MATERIALS AND METHODS:Id...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103326
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:This study aims to analyze the addition of niobium silicate particles to dental adhesive resins and evaluate its physicomechanical and biological properties. METHODS:The SiNb particles were produced by the sol-gel route and presented a mean particle size of 2.1 μm and a specific surface area of 616,96m2/g. A...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103449
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To compare a silver-reinforced glass ionomer material (cermet) with a resin-modified glass ionomer in minimal Class II preparations in primary teeth. METHODS:Matched pairs of primary molars with approximal caries that required operative treatment were used. Each cavity was filled with either Vitremer or Keta...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-5712(99)00004-4
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVES:The reason for high water absorption by room temperature vulcanizing (RTV) silicone denture soft lining materials has not been demonstrated previously. An experimental room-temperature vulcanizing (RTV) silicone soft lining material which had been shown to have good mechanical properties had high water absor...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)00032-1
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:This study aimed to evaluate the addition of copper nanoparticles (CuNp) on the clinical performance of a universal adhesive system used as etch-and-rinse (ER) and self-etch (SE). METHODS:216 restorations were randomly placed in 36 subjects according to the following groups: ERcu = etch-and-rinse with 0.1% C...
journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2019.103219
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was two-fold: (1) to monitor bacterial biofilm formation and bacteria-induced demineralization of dentine in situ by using electrochemical impedance spectrum (EIS); (2) to examine the relationship between EIS findings and changes in the chemical composition and ultrastructure of dent...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2009.09.013
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:Dentine modifies pulpward diffusion of monomers leaching from restorative materials. Thus, remaining dentine thickness must be taken into account during in vitro cytotoxicity tests. This in vitro study was designed to determine the influence of dentine permeability on the outcome of a cytotoxicity test. MET...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(98)00019-0
更新日期：1998-07-01 00:00:00
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journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)00102-6
更新日期：1996-11-01 00:00:00
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journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2005.02.001
更新日期：2005-10-01 00:00:00
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journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2014.02.011
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between leakage and microtensile bond strength in the same specimen of direct Class II composite restorations performed with two polymerization techniques. METHODS:Class II slot preparations were made in 40 non-carious human third molars and restored using Single Bond and P-60 (...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2005.01.001
更新日期：2005-08-01 00:00:00
abstract：:In the present study Class II resin composite restorations were placed under in vivo and in vitro conditions. For the in vivo part. Class II preparations were cut in teeth destined for extraction for orthodontic reasons. The preparations were completed with the gingival margin in enamel and restored using six differen...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(93)90026-m
更新日期：1993-06-01 00:00:00
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journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2019.01.012
更新日期：2019-03-01 00:00:00
abstract：:This satellite symposium was the fourth in a series for editors, publishers, reviewers and all those with an interest in scientific publishing. It was held on Wednesday 25th June 2014 at the IADR International meeting in Cape Town, South Africa. The symposium attracted more than 180 attendees. This symposium placed an...
journal_title：Journal of dentistry
pub_type：
doi：10.1016/j.jdent.2015.02.007
更新日期：2015-08-01 00:00:00
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journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2018.09.001
更新日期：2018-11-01 00:00:00
abstract：:The effect of various surface treatments on the shear bond strength of composite resin to a glass-ionomer cement has been studied. Acid etching with phosphoric acid and polyacrylic acid, roughening by way of grinding or air drying, the use of a dentine bonding system and a silane coupling agent were the variables. Aci...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(89)90004-3
更新日期：1989-02-01 00:00:00
abstract：:A dental source of infection remains the most common identifiable risk factor in infective endocarditis and this may be particularly important in patients at 'high risk'. We therefore performed a questionnaire survey of dental practitioners to assess acceptance of The British Society of Antimicrobial Chemotherapy (BSA...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(92)90032-8
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVES:The main objective is the characterisation of the setting reaction in glass ionomer cements based on experimental ionomer glasses with different fluorine content and a commercial glass ionomer cement liquid by using 13C CP/MAS-NMR, 29Si, 27Al and 31P MAS-NMR spectroscopy in order to receive information speci...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2005.08.006
更新日期：2006-09-01 00:00:00
