Abstract：
OBJECTIVES:The objectives of this study were to investigate: (1) the antibacterial activity of two antibacterial monomers, dimethylaminododecyl methacrylate (DMADDM) and dimethylammoniumethyl dimethacrylate (DMAEDM), against eight different species of oral pathogens for the first time; (2) the cytotoxicity of DMAEDM and DMADDM. METHODS:DMAEDM and DMADDM were synthesized by reacting a tertiary amine group with an organo-halide. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against eight species of bacteria were tested. Time-kill determinations were performed to examine the bactericidal kinetics. Cytotoxicity of monomers on human gingival fibroblasts (HGF) was assessed using a methyl thiazolyltetrazolium assay and live/dead viability assay. RESULTS:DMADDM showed strong bactericidal activity against all bacteria, with MIC of 1.2-9.8μg/mL. DMAEDM had MIC of 20-80mg/mL. Time-kill determinations indicated that DMADDM and DMAEDM had rapid killing effects against eight species of bacteria, and eliminated all bacteria in 30min at the concentration of 4-fold MBC. Median lethal concentration for DMADDM and DMAEDM was between 20 and 40μg/mL, which was 20-fold higher than 1-2μg/mL for BisGMA control. CONCLUSIONS:DMAEDM and DMADDM were tested in time-kill assay against eight species of oral bacteria for the first time. Both were effective in bacteria-inhibition, but DMADDM had a higher potency than DMAEDM. Different killing efficacy was found against different bacteria species. DMAEDM and DMADDM had much lower cytotoxicity than BisGMA. Therefore, DMADDM and DMAEDM are promising for use in bonding agents and other restorative/preventive materials to combat a variety of oral pathogens.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Li F,Weir MD,Fouad AF,Xu HHdoi
10.1016/j.jdent.2013.07.006subject
Has Abstractpub_date
2013-10-01 00:00:00pages
881-91issue
10eissn
0300-5712issn
1879-176Xpii
S0300-5712(13)00178-4journal_volume
41pub_type
杂志文章abstract：OBJECTIVES:This meta-analysis was performed to evaluate the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment. DATA, SOURCES AND STUDY SELECTION:An electronic systematic literature search was conducted in Cochrane Center Register of Controlled Trials, MEDLINE (P...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jdent.2015.03.015
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:This study investigated whether novel liposome formulations loaded with transforming growth factor β1 (TGF-β1) could promote the odontogenic differentiation of human dental pulp stem cells (hDPSCs) for dentine-pulp regeneration. METHODS:0-100 ng/mL of liposomal TGF-β1 was prepared using the thin-film hydrat...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103501
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:The fracture of bonded ceramic to metal restorations remains a problem in clinical dental practice. The use of resin based composites to repair such fractures is generally unsatisfactory. Tribochemical technology creates a surface layer of small silica particles fused to the surface substrate. Such a layer po...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(00)00006-3
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVES:Mutans streptococci and Lactobacilli on impressions of teeth and caries tests were used to identify caries prone subjects. METHODS:Twenty-seven dental students were examined for caries initially and after 4 years. At the initial examination plaque index; saliva flow, buffering capacity and lysozyme; sucrose...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2008.07.004
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:The purpose of the study was to evaluate the intra- and inter-examiner variability of a panel of examiners using a 'glance and grade' marking system when assessing Class II preparations. METHODS:The examination panel consisted of five university staff with varying clinical and teaching experience. The panel...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(97)00033-x
更新日期：1998-11-01 00:00:00
abstract：:The effects of gamma radiation at therapeutic dosage levels on the physical properties of three anterior (two light-cured and one autocure) composites and a light-cured posterior composite were studied. Gamma radiation had no effect on the autocured composite but had varied effects on the light-cured systems. The diam...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(89)90071-7
更新日期：1989-08-01 00:00:00
abstract：OBJECTIVE:To investigate whether bleaching prior to placement of a composite veneer had an effect on the final shade of the restoration and whether this was affected by the thickness or shade of the veneer. METHODS:Twenty bovine teeth were collected, sectioned and divided into two groups. One group was the non-bleache...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2008.04.004
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis, derived from a previous short-term (7-day) assessment, that the absence of conventional pulp protection is not responsible for long-term pulp complications of composite resin restorations with self-etching adhesives. METHODS:All 150 patients who received the restorations with self-etc...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2007.02.005
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:To integrate items from two widely used oral health-related quality of life (OHRQoL) questionnaires, the General Oral Health Assessment Index (GOHAI) and the Oral Impacts on Daily Performances (OIDP), as well as culturally-specific items of the Oral Health Impact Profile (OHIP) into a four-dimensional OHRQoL...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2016.06.006
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:Recently, a novel device to generate dental plaque in situ on a removable human enamel surface was described. The device permitted the recovery of plaque intact and undisturbed on its enamel substrate. The aim of this investigation was to determine the utility and robustness of this model for analysis of the...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-5712(01)00033-1
更新日期：2001-08-01 00:00:00
abstract：OBJECTIVES:Three activated organofunctional silane coupling agents alone and blended with a non-functional cross-linker silane were evaluated as adhesion promoters in an experiment where a bis-GMA (bis-phenol-A-diglycidyldimethacrylate) resin was bonded to silicatized titanium. The adhesive performances of the silanes ...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2006.01.008
更新日期：2006-11-01 00:00:00
abstract：:Twenty healthy volunteers entered a study to assess cardiopulmonary responses, as measured by pulse oximetry, following changes in posture in the dental chair and the administration of Diazemuls (diazepam) in doses sufficient to instill sedation (up to a maximum dose of 20 mg) in the volunteers to a degree such that p...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(92)90080-v
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVES:The concept of Cervical Margin Relocation (CMR) consists on placing a base layer of direct resin composite to elevate supra-gingivally the proximal indirect bonded restorations. The aims of this clinical study were to evaluate 1. Bleeding on Probing (BoP) on posterior indirect restorations with one interprox...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章
doi：10.1016/j.jdent.2017.10.008
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:The development of a micro plate assay for cytotoxicity testing of dental materials based on a bioassay using brine shrimp larvae (artemia salina) as sensitive organisms. METHODS:Brine shrimp larvae are commonly used for cytotoxicity assays in pharmacology. These larvae are sensitive to toxic substances. Th...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(00)00007-5
更新日期：2000-07-01 00:00:00
abstract：:Ultrasound in the kHz frequency range is used widely in clinical dentistry. The most common uses are in the fields of periodontology and endodontics. The ultrasonic scaler works by the vibratory chipping action of the oscillating tip and is assisted by the presence of cavitational activity in the associated cooling wa...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/0300-5712(92)90003-u
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVES:To measure aspects of fizzy drink consumption in a social environment to inform the development of a laboratory testing regime. METHODS:This was an observational study in which participants were invited to attend one of four pizza and soft drink parties. All such foods and drinks were served in an air condi...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2015.08.008
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:Chlorhexidine (CHX) is a commonly used antiseptic mouthwash, used by dental practitioners and the public, due to its antimicrobial effects. The aim of this article was to provide a narrative review of current antimicrobial uses of CHX relevant to dentistry in the context of oral diseases, highlighting need f...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/j.jdent.2020.103497
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVES:Purpose of this study was to determine the influence of grey-scale reversal of digital radiographic images on the detection of proximal caries. METHODS:Five observers assessed digital bitewing radiographs (Sidexis((R)), Sirona) of 320 unrestored surfaces of extracted posterior teeth embedded in 20 models, s...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2004.08.003
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:Probiotics might be beneficial to prevent or treat caries, gingivitis or periodontitis. We aimed to appraise trials assessing probiotics for managing caries and periodontal disease. DATA:We included randomized controlled trials comparing the efficacy of probiotics versus (placebo) control with regards to St...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jdent.2016.03.002
更新日期：2016-05-01 00:00:00
abstract：:OBJECTIVES.: To compare the safety and plaque removal efficacy of two oscillating/rotating/pulsating toothbrushes (Oral-B ProfessionalCaretrade mark 7000 [PC 7000] and Oral-B 3D Excel [3DE]) and a high-frequency toothbrush (Sonicare(R) Advance, Philips Oral Healthcare; SA) in a single-use, examiner-blind, three period...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:An accurate evaluation of the extent of dental caries and possible progress of the lesion from enamel into dentin is very important in clinical dentistry. Dentists need an imaging technology that can noninvasively and reliably quantify the extent of caries. This study aimed to evaluate the effectiveness of no...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2012.10.007
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the kinetics of protein interactions with a novel hydroxyapatite-polylactide (HA-PLA) composite membrane material. METHODS:Trilayer PLA and HA-PLA composite membranes reinforced with PLA fibres were used to absorb and release protein which was measured by a BioRad as...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2009.06.014
更新日期：2009-11-01 00:00:00
abstract：:The bacteriological contamination of pumice slurry in polishing units in a dental clinical area (high risk), a production laboratory (medium risk), and a non-clinical teaching laboratory (low risk), was investigated. Slurry samples taken from all three areas were found to be heavily contaminated with pathogenic organi...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(90)90030-i
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVE:This study aims to analyze the addition of niobium silicate particles to dental adhesive resins and evaluate its physicomechanical and biological properties. METHODS:The SiNb particles were produced by the sol-gel route and presented a mean particle size of 2.1 μm and a specific surface area of 616,96m2/g. A...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103449
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between leakage and microtensile bond strength in the same specimen of direct Class II composite restorations performed with two polymerization techniques. METHODS:Class II slot preparations were made in 40 non-carious human third molars and restored using Single Bond and P-60 (...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2005.01.001
更新日期：2005-08-01 00:00:00
abstract：:A dental source of infection remains the most common identifiable risk factor in infective endocarditis and this may be particularly important in patients at 'high risk'. We therefore performed a questionnaire survey of dental practitioners to assess acceptance of The British Society of Antimicrobial Chemotherapy (BSA...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(92)90032-8
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:There is no consensus on whether incisal coverage is a risk or a protective factor in preparations for ceramic veneers. OBJECTIVE:The aim of this systematic review and meta-analysis was to evaluate the survival rates of preparation designs for ceramic veneers with and without incisal coverage. METHODS:Prim...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jdent.2016.06.004
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the behavior of two new, low-shrinkage hybrid composites (Aelite LS and Inten-S) with a microfilled (Heliomolar) and a hybrid composite (Filtek Z250), in terms of polymerization contraction stress and microleakage. METHODS:Maximum contraction stress after 10 min was recor...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2004.01.014
更新日期：2004-07-01 00:00:00
abstract：:An even fitting surface is essential to obtain and maintain a healthy oral mucosa in denture wearers. The present study was designed to clarify the relationship between the surface roughness of oral mucosa and its reproduction in the corresponding fitting surface of acrylic dentures. A silicone elastomer/epoxy replica...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(94)90201-1
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:The aim of this in vivo study was to investigate the influence of age on optical properties of pure enamel and enamel-dentine complex. METHODS:A spectrophotometric study was performed on two different age groups: young (10-35 years old) and adult (36-60 years old). In both groups, the tooth's total area of t...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.09.005
更新日期：2013-12-01 00:00:00
