Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics.


:Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models-using both xenografted material and genetically engineered mice-will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.


J Korean Neurosurg Soc


Mathew RK,Rutka JT




Has Abstract


2018-05-01 00:00:00














  • Delayed Retroperitoneal Hemorrhage due to Lumbar Artery Pseudoaneurysm after Lumbar Posterolateral Fusion.

    abstract::A 55-year-old female patient presented with lower back pain and neurogenic intermittent claudication and underwent L3-L4 posterolateral fusion. To prepare the bone fusion bed, the transverse process of L3 and L4 was decorticated with a drill. On the 9th post-operative day, the patient complained of a sudden onset of s...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Oh YM,Choi HY,Eun JP

    更新日期:2013-10-01 00:00:00

  • Novel Noncrossing Y-Stent Technique Using Tapered Proximal End of a Solitaire AB Stent for Coil Embolization of Wide-Neck Bifurcation Aneurysms.

    abstract::The crossing Y-stent method is one of the indispensable techniques to achieve sufficient neck coverage during coil embolization of bifurcation aneurysms with a wide neck and/or branch incorporation. However, the inevitable hourglass-like expansion of the second stent at the crossing point can result in insufficient ve...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Kwon HJ,Lim JW,Byoun HS,Koh HS

    更新日期:2021-01-01 00:00:00

  • Analyses Using Micro-CT Scans and Tissue Staining on New Bone Formation and Bone Fusion According to the Timing of Cranioplasty via Frozen Autologous Bone Flaps in Rabbits : A Preliminary Report.

    abstract:OBJECTIVE:The timing of cranioplasty and method of bone flap storage are known risk factors of non-union and resorption of bone flaps. In this animal experimental study, we evaluated the efficacy of cranioplasty using frozen autologous bone flap, and examined whether the timing of cranioplasty after craniectomy affects...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Shin HS,Lee DW,Lee SH,Koh JS

    更新日期:2015-04-01 00:00:00

  • Clinical features of wrist drop caused by compressive radial neuropathy and its anatomical considerations.

    abstract:OBJECTIVE:Posture-induced radial neuropathy, known as Saturday night palsy, occurs because of compression of the radial nerve. The clinical symptoms of radial neuropathy are similar to stroke or a herniated cervical disk, which makes it difficult to diagnose and sometimes leads to inappropriate evaluations. The purpose...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Han BR,Cho YJ,Yang JS,Kang SH,Choi HJ

    更新日期:2014-03-01 00:00:00

  • Surgical obliteration in superior petrosal sinus dural arteriovenous fistula.

    abstract::Superior petrosal sinus (SPS) dural arteriovenous fistula (DAVF) is one of tentorial DAVFs with significant morbidity, which usually drains into the petrosal vein and its tributaries. Unless there is a connection with venous sinus, surgical obliteration is required. We present two cases of SPS DAVF which were successf...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Hwang G,Kang HS,Oh CW,Kwon OK

    更新日期:2011-04-01 00:00:00

  • Inflammatory pseudotumor in the lateral ventricle with repeated bleeding-case report-.

    abstract::Inflammatory pseudotumor is an uncommon lesion with unknown etiology characterized by sclerosing inflammation which clinically and radiographically mimics a neoplastic lesion. A 47-year-old man presented with sudden headache and dysarthria. Brain CT scan revealed a 2.6x2.2 cm sized, round, and hyperdense mass in the a...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Park JH,Nam TK,Hwang SN,Park SW

    更新日期:2009-02-01 00:00:00

  • Bone cement augmentation of short segment fixation for unstable burst fracture in severe osteoporosis.

    abstract:OBJECTIVE:The purpose of this study was to determine the efficacy of short segment fixation following postural reduction for the re-expansion and stabilization of unstable burst fractures in patients with osteoporosis. METHODS:Twenty patients underwent short segment fixation following postural reduction using a soft r...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Kim HS,Park SK,Joy H,Ryu JK,Kim SW,Ju CI

    更新日期:2008-01-01 00:00:00

  • Multimodal therapy for patients with acute ischemic stroke : outcomes and related prognostic factors.

    abstract:OBJECTIVE:The objectives of this study were to analyze the recanalization rates and outcomes of multimodal therapy that consisted of sequential intravenous (IV)/intra-arterial (IA) thrombolysis, mechanical thrombolysis including mechanical clot disruption using microcatheters and microwires, balloon angioplasty, and st...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Jeong SY,Park SS,Koh EJ,Eun JP,Choi HY

    更新日期:2009-06-01 00:00:00

  • Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population.

    abstract:Objective:To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods:This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology a...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Yang X,Xu H,Liu D,Ma R,Zhang Y,Wang G

    更新日期:2020-11-24 00:00:00

  • Spinal schwannoma; analysis of 40 cases.

    abstract:OBJECTIVE:This study is to report our experience of 40 cases of spinal schwannoma. METHODS:From 1995 to 2006, medical records were retrospectively reviewed in 40 cases of spinal schwannoma. RESULTS:We treated 40 spinal schwannomas in 38 (22 male and 16 female) patients. The mean age was 50.2. Four cases were sited in...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Jeon JH,Hwang HS,Jeong JH,Park SH,Moon JG,Kim CH

    更新日期:2008-03-01 00:00:00

  • Quantitative analysis of developmental process of cranial suture in korean infants.

    abstract:OBJECTIVE:The purpose of this study was to elucidate the anatomical development of physiologic suture closure processes in infants using three dimensional reconstructed computed tomography (CT). METHODS:A consecutive series of 243 infants under 12 months of age who underwent three dimensional CT were included in this ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Sim SY,Yoon SH,Kim SY

    更新日期:2012-01-01 00:00:00

  • Cerebrospinal fluid rhinorrhea and seizure caused by temporo-sphenoidal encephalocele.

    abstract::This case report describes the symptoms and clinical course of a 35-year-old female patient who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first present...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Hammer A,Baer I,Geletneky K,Steiner HH

    更新日期:2015-04-01 00:00:00

  • The role of computed tomography in the presurgical diagnosis of foraminal entrapment of lumbosacral junction.

    abstract:OBJECTIVE:On the basis of preoperative computed tomography (CT) scans, we studied the change of the size of anterior primary division (APD) of the L5 spinal root in the presence of foraminal/extraforaminal entrapment of the L5 spinal root. METHODS:Two independent radiologists retrospectively reviewed the preoperative ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Moon KH,Jang JS,Lee SH,Lee SC,Lee HY

    更新日期:2010-01-01 00:00:00

  • Sole stenting technique for treatment of complex aneurysms.

    abstract:OBJECTIVE:Complex aneurysms such as fusiform and very small aneurysms (< 3 mm) are challenging in neurovascular and endovascular surgery. Author reports follow-up results of 9 cases treated by sole stent technique with pertinent literature review. METHODS:A retrospective study was made of 9 patients who were treated b...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Kim YJ

    更新日期:2009-12-01 00:00:00

  • Combined endovascular and microsurgical procedures as complementary approaches in the treatment of a single intracranial aneurysm.

    abstract:OBJECTIVE:Both endovascular coil embolization and microsurgical clipping are now firmly established as treatment options for the management of cerebral aneurysms. Moreover, they are sometimes used as complementary approaches each other. This study retrospectively analyzed our experience with endovascular and microsurgi...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Lim YC,Shin YS,Chung J

    更新日期:2008-01-01 00:00:00

  • Comparative analysis of cervical arthroplasty using mobi-c(r) and anterior cervical discectomy and fusion using the solis(r) -cage.

    abstract:OBJECTIVE:Although anterior cervical discectomy and fusion (ACDF) is the standard treatment for degenerative cervical disc disease, concerns regarding adjacent level degeneration and loss of motion have suggested that arthroplasty may be a better alternative. We have compared clinical and radiological results in patien...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Park JH,Roh KH,Cho JY,Ra YS,Rhim SC,Noh SW

    更新日期:2008-10-01 00:00:00

  • Spinal intradural extramedullary cavernoma presenting with intracranial superficial hemosiderosis.

    abstract::A case of intradural extramedullary cavernous angioma is presented with headache, dizziness, and bilateral sensorineural hearing loss caused by an intracranial superficial hemosiderosis. It was incidentally found in a patient with a 3-month history of sustained headache, dizziness and a 3-year history of hearing diffi...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Jin YJ,Chung SB,Kim KJ,Kim HJ

    更新日期:2011-06-01 00:00:00

  • Analysis According to Characteristics of 18 Cases of Brachial Plexus Tumors : A Review of Surgical Treatment Experience.

    abstract:OBJECTIVE:Because the anatomical structure of the brachial plexus is very complex, surgical treatment of tumors in this region is challenging. Therefore, a lot of clinical and surgical experience is required for successful treatment; however, many neurosurgeons have difficulty accumulating this experience owing to the ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Jung IH,Yoon KW,Kim YJ,Lee SK

    更新日期:2018-09-01 00:00:00

  • Dural arteriovenous fistula involving an isolated sinus treated using transarterial onyx embolization.

    abstract::The authors present a case of isolated dural arteriovenous fistula (DAVF) in the transverse sinus, which developed six years after microvascular decompression caused by hemifacial spasm via suboccipital craniectomy. The lesion was successfully treated by transarterial embolization using Onyx. We reviewed the related r...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Ihn YK,Kim MJ,Shin YS,Kim BS

    更新日期:2012-11-01 00:00:00

  • Lymphomatosis cerebri.

    abstract::Lymphomatosis cerebri is considered a diffuse form of primary central nervous system lymphoma and very rare. It is not well recognized and may be misdiagnosed with infiltrating tumors, degenerative disorders, ischemic diseases, and infectious diseases developed in the brain. Awareness of the possibility of this rare d...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Choi CY,Lee CH,Joo M

    更新日期:2013-11-01 00:00:00

  • Change of Pyogenic and Tuberculous Spondylitis between 2007 and 2016 Year : A Nationwide Study.

    abstract:OBJECTIVE:We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. METHODS:We used a nationwide database managed by the Korean National Health Insurance Se...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Kim YJ,Hong JB,Kim YS,Yi J,Choi JM,Sohn S

    更新日期:2020-11-01 00:00:00

  • Anatomical Variants of "Short Head of Biceps Femoris Muscle" Associated with Common Peroneal Neuropathy in Korean Populations : An MRI Based Study.

    abstract:Objective:In Asians, kneeling and squatting are the postures that are most often induce common peroneal neuropathy. However, we could not identify a compatible compression site of the common peroneal nerve (CPN) during hyper-flexion of knees. To evaluate the course of the CPN at the popliteal area related with compress...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Yang J,Cho Y,Cho J,Choi H,Jeon J,Kang S

    更新日期:2018-07-01 00:00:00

  • Indocyanine green videoangiography for confirmation of bypass graft patency.

    abstract:OBJECTIVE:The aim of the study is to determine the efficacy of indocyanine green (ICG) videoangiography for confirmation of vascular anastomosis patency in both extracranial-intracranial and intracranial-intracranial bypasses. METHODS:Intraoperative ICG videoangiography was used as a surgical adjunct for 56 bypasses i...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Schuette AJ,Dannenbaum MJ,Cawley CM,Barrow DL

    更新日期:2011-07-01 00:00:00

  • Surgical Treatment of a Life-Threatening Large Retropharyngeal Hematoma after Minor Trauma : Two Case Reports and a Literature Review.

    abstract::Only a few cases of anterior longitudinal ligament (ALL) injury related with retropharyngeal hematoma without fracture have previously been reported. The treatment of choice for retropharyngeal hematoma is generally considered to be conservative care, but we believe that early surgery of this pathology would be better...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Park JH,Jeong EK,Kang DH,Jeon SR

    更新日期:2015-09-01 00:00:00

  • Sacral insufficiency fracture, usually overlooked cause of lumbosacral pain.

    abstract::Sacral insufficiency fractures are usually known to develop in elderly patients with osteoporosis without definite trauma history. It is difficult to diagnose the sacral insufficiency fracture at an early stage because lower lumbar diseases, concurrently or not, may also be presented with similar symptoms and signs. W...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Lee YJ,Bong HJ,Kim JT,Chung DS

    更新日期:2008-09-01 00:00:00

  • Analysis of failed spinal cord stimulation trials in the treatment of intractable chronic pain.

    abstract:OBJECTIVE:The purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal cord stimulation (SCS) trial. METHODS:A retrospective review of the failed trials (44 patients, 36.1%) among the patients (n=122) who underwent...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Jang HD,Kim MS,Chang CH,Kim SW,Kim OL,Kim SH

    更新日期:2008-02-01 00:00:00

  • Cardiac troponin I elevation in patients with aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:Cardiac dysfunction after aneurysmal subarachnoid hemorrhage (SAH) is associated with elevation of serum cardiac troponin I (cTnI) levels. Elevation of cTnI predicts cardiopulmonary and neurological complications, and poor outcome. METHODS:We retrospectively reviewed the medical and radiologic records of 114...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Jeon IC,Chang CH,Choi BY,Kim MS,Kim SW,Kim SH

    更新日期:2009-08-01 00:00:00

  • Alveolar soft part sarcoma metastasized to both the skull and the brain.

    abstract::Alveolar soft part sarcoma (ASPS) with skull and brain metastases is extremely rare. A 53-year-old patient diagnosed as skull metastasis of ASPS visited our clinic complaining of an outgrowing scalp mass in spite of radiation therapy. Past medical history revealed that the patient had been diagnosed and treated for AS...

    journal_title:Journal of Korean Neurosurgical Society



    authors: Shin TH,Jung YJ,Kim OL,Kim MS

    更新日期:2012-07-01 00:00:00

  • Characteristics and management of residual or slowly recurred intracranial aneurysms.

    abstract:OBJECTIVE:Residual aneurysm from incomplete clipping or slowly recurrent aneurysm is associated with high risk of subarachnoid hemorrhage. We describe complete treatment of the lesions by surgical clipping or endovascular treatment. METHODS:We analyzed 11 patients of residual or recurrent aneurysms who had undergone s...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Ihm EH,Hong CK,Shim YS,Jung JY,Joo JY,Park SW

    更新日期:2010-10-01 00:00:00

  • Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis.

    abstract::The demineralized bone matrix (DBM) as the bone graft material to increase the fusion rate was widely used in spinal fusion. The current study aimed to compare the fusion rate of DBM to the fusion rate of autograft in lumbar spine fusion via meta-analysis of published literature. After systematic search, comparative s...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章


    authors: Han S,Park B,Lim JW,Youm JY,Choi SW,Kim DH,Ahn DK

    更新日期:2020-11-01 00:00:00