Abstract：
:Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models-using both xenografted material and genetically engineered mice-will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Mathew RK,Rutka JTdoi
10.3340/jkns.2018.0008subject
Has Abstractpub_date
2018-05-01 00:00:00pages
343-351issue
3eissn
2005-3711issn
1598-7876pii
jkns-2018-0008journal_volume
61pub_type
杂志文章,评审abstract：:Epilepsy surgery revealed dramatically improved seizure outcomes over medical therapy in drug-resistant epilepsy patients. Children with epilepsy, however, have multiple epileptic focuses which require multilobar resection for better seizure outcome. Multilobar resection has not only the several severe surgical compli...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2019.0031
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of posterior implant rigidity on spinal kinematics at adjacent levels by utilizing a cadaveric spine model with simulated physiological loading. METHODS:Five human lumbar spinal specimens (L3 to S1) were obtained and checked for abnormalities. The fresh specimens were stripped of m...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.58.5.412
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:Microvascular decompression (MVD) for hemifacial spasm (HFS) involving the vertebral artery (VA) can be technically challenging. We investigated the therapeutic effects of a bioglue-coated Teflon sling technique on the VA during MVD in 42 cases. METHODS:A bioglue-coated Teflon sling was crafted by the surgeo...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2016.59.5.505
更新日期：2016-09-01 00:00:00
abstract：:Spinal epidural hematoma is a rare complication associated with pain control procedures such as facet block, acupuncture, epidural injection, etc. Although it is an uncommon cause of acute myelopathy, and it may require surgical evacuation. We report four patients with epidural hematoma developed after pain control pr...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.48.3.281
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal cord stimulation (SCS) trial. METHODS:A retrospective review of the failed trials (44 patients, 36.1%) among the patients (n=122) who underwent...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.43.2.85
更新日期：2008-02-01 00:00:00
abstract：:The authors present a case of isolated dural arteriovenous fistula (DAVF) in the transverse sinus, which developed six years after microvascular decompression caused by hemifacial spasm via suboccipital craniectomy. The lesion was successfully treated by transarterial embolization using Onyx. We reviewed the related r...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2012.52.5.480
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:The objectives of this study were to determine the frequency of symptomatic postdiscectomy pseudocyst (PP) after endoscopic discectomy and to compare the results of surgical and conservative management of them. METHODS:Initial study participants were 1,503 cases (1,406 patients) receiving endoscopic lumbar d...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2011.49.1.31
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:To analyze the clinical courses and outcomes after anterior lumbar interbody fusion (ALIF) for the treatment of postoperative spondylodiscitis. METHODS:A total of 13 consecutive patients with postoperative spondylodiscitis treated with ALIF at our institute from January, 1994 to August, 2013 were included (9...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.56.4.310
更新日期：2014-10-01 00:00:00
abstract：:Chordoid glioma of the third ventricle is a rare and challenging tumor to surgery because of its unique anatomical location and its close juxtaposition to the neurovascular structures and hypothalamus. The authors report a case of chordoid glioma of the third ventricle in a 43-year-old woman, who presented with headac...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2016.59.6.643
更新日期：2016-11-01 00:00:00
abstract：:Gas pseudocysts are a rare cause of lumbar radiculopathy and most symptomatic gas pseudocysts are found within the confines of the spinal canal. A gas pseudocyst in the foramen causing lumbar radiculopathy is very rare. We present a case of a 67-year-old woman suffering from severe pain in the right leg. Computed tomo...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.47.3.232
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Discal cyst is rare and causes indistinguishable symptoms from lumbar disc herniation. The clinical manifestations and pathological features of discal cyst have not yet been completely known. Discal cyst has been treated with surgery or with direct intervention such as computed tomography (CT) guided aspirati...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.51.4.208
更新日期：2012-04-01 00:00:00
abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma is one of the most common lymphomas and accounts for about 7% of all newly diagnosed non-Hodgkin's lymphoma (NHL). The clinical course of MALT lymphoma is relatively indolent and, in the majority of cases (50%), the lymphoma arises within the stomach. Primary central n...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2012.51.6.377
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Several surgical procedures have been reported for the treatment of chronic subdural hematoma (CSDH). We compared the results of treatments for CSDH obtained from one burr-hole craniostomy with closed system drainage with or without irrigation, two burr-hole craniostomy with closed system drainage with irriga...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2009.46.3.210
更新日期：2009-09-01 00:00:00
abstract：:The authors present a case of multiple intracranial calcifications after the procedure of external ventricular drain placement in a 50-year-old man with pericallosal artery aneurysm. We believe that calcifications formed dust that had fallen into the track during the external ventricular drain procedure. The clinical ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.47.2.158
更新日期：2010-02-01 00:00:00
abstract：:Sympathetic dysfunction is one of the possible complications of anterior spine surgery; however, it has been underestimated as a cause of complications. We report two successful experiences of treating severe dysesthetic pain occurring after anterior spine surgery, by performing a sympathetic block. The first patient ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.56.1.66
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Outcome of gamma knife radiosurgery (GKS) in the consecutive 100 cases with cerebral arteriovenous malformations (AVMs) was analyzed. METHODS:Data from initial 100 patients treated with GKS in the authors' institute were reviewed retrospectively. Spetzler-Martin grade at diagnosis were I in 18 patients, II i...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.43.6.265
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:The present study aims to investigate 1) the risk factors for hydrocephalus and subdural hygroma (SDG) occurring after decompressive craniectomy (DC), and 2) the association between the type of SDG and hydrocephalus. METHODS:We retrospectively reviewed the clinical and radiological features of 92 patients wh...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.58.3.254
更新日期：2015-09-01 00:00:00
abstract：:Alveolar soft part sarcoma (ASPS) with skull and brain metastases is extremely rare. A 53-year-old patient diagnosed as skull metastasis of ASPS visited our clinic complaining of an outgrowing scalp mass in spite of radiation therapy. Past medical history revealed that the patient had been diagnosed and treated for AS...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2012.52.1.55
更新日期：2012-07-01 00:00:00
abstract：:Owing to the focal wall defect covered with thin fibrous tissues, an aneurysm arising from the dorsal wall of the internal carotid artery (ICA) is difficult to manage either surgically or endovascularly and is often associated with high morbidity and mortality. Unfortunately, the definitive treatment modality of such ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.56.6.496
更新日期：2014-12-01 00:00:00
abstract：:We report a rare case of pronator teres syndrome in a young female patient. She reported that her right hand grip had weakened and development of tingling sensation in the first-third fingers two months previous. Thenar muscle atrophy was prominent, and hypoesthesia was also examined on median nerve territory. The pro...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.55.5.296
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:Retrospective analysis to compare the effect and complication of epidural patient-controlled analgesia (epidural PCA) with intravenous patient-controlled analgesia (IV PCA) for the treatment of the post-operative pain after posterior lumbar instrumented fusion. METHODS:Sixty patients who underwent posterior ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2011.50.3.205
更新日期：2011-09-01 00:00:00
abstract：:Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by sudden-onset headache with focal neurologic deficit and prolonged but reversible multifocal narrowing of the distal cerebral arteries. Stroke, either hemorrhagic or ischemic, is a relatively frequent presentation in RCVS, but progressive manifest...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.56.5.419
更新日期：2014-11-01 00:00:00
abstract：:Traumatic brainstem hemorrhage after blunt head injury is an uncommon event. The most frequent site of hemorrhage is the midline rostral brainstem. The prognosis of these patients is poor because of its critical location. We experienced a case of traumatic brainstem hemorrhage. A 41-year-old male was presented with dr...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2009.45.3.176
更新日期：2009-03-01 00:00:00
abstract：Objective:Morphometric data for the lumbar posterior longitudinal ligament (PLL) was investigated to identify whether there is a difference in the morphometry of the PLL of the lumbar spine at each level with respect to the pattern of intervertebral disc displacement. Methods:In 14 formalin-fixed adult cadavers (12 ma...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2017.0257
更新日期：2018-01-01 00:00:00
abstract：:GBM is the most common primary brain tumor, but intraventricular GBM is rare and only few cases have been reported in the literature. The authors report a case of 64-year-old man who had a remote history of previous periventricular intracerebral hemorrhage. Brain computed tomography (CT) and magnetic resonance (MR) im...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2008.44.6.405
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Posterior lumbar interbody fusion (PLIF) is considered to have the best theoretical potential in promoting bony fusion of unstable vertebral segments by way of a load sharing effect of the anterior column. This study was undertaken to investigate the efficacy of PLIF with cages in chronic degenerative disc di...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2009.46.4.322
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To report a minimally invasive treatment option using percutaneous pedicle screw fixation with adjuvant treatment for metastatic thoraco-lumbar and lumbar spinal tumors. METHODS:This is a retrospective study of charts of patients with spinal metastases. All were older than 18 years of age and were considered...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.57.2.100
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC). METHODS:Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 +/- 13 years, and 17 (85.0%) were men. Sevente...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2010.47.5.325
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:The purpose of the present study is to assess the long-term results of microsurgical dorsal root entry zonotomy (MDT) for the treatment of medically intractable upper-extremity spasticity. METHODS:The records of nine adult patients who underwent MDT by one operating neurosurgeon from March 1999 to June 2004 ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.43.4.182
更新日期：2008-04-01 00:00:00
abstract：:Acute subdural hematoma (SDH) of arterial origin is rare, especially SDH associated with an arteriovenous malformation (AVM) is extremely rare. The authors report a case of acute spontaneous SDH due to rupture of a tiny cortical AVM. A 51-year-old male presented with sudden onset headache and mentality deterioration w...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2015.58.6.547
更新日期：2015-12-01 00:00:00
