Abstract:
:Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models-using both xenografted material and genetically engineered mice-will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Mathew RK,Rutka JTdoi
10.3340/jkns.2018.0008subject
Has Abstractpub_date
2018-05-01 00:00:00pages
343-351issue
3eissn
2005-3711issn
1598-7876pii
jkns-2018-0008journal_volume
61pub_type
杂志文章,评审abstract:OBJECTIVE:We evaluated postoperative outcomes in patients who have lumbar foraminal or extraforaminal disc herniation (FELDH) and suggested the risk factors for poor outcomes. METHODS:A total of 234 patients were selected for this study. Pre- and post-operative Visual Analogue Scale (VAS) and Korean version Oswestry D...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.59.2.143
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. METHODS:We used a nationwide database managed by the Korean National Health Insurance Se...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2020.0013
更新日期:2020-11-01 00:00:00
abstract::Oblique basal skull fractures resulting from lateral crushing injuries involving both clivus and occipital condyle are rare due to their deep locations. Furthermore, these fractures may present clinically with multiple cranial nerve injuries because neural exit routes are restricted in this intricate region. The autho...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.51.5.305
更新日期:2012-05-01 00:00:00
abstract::Penetrating cerebral injuries caused by foreign bodies occur rarely due to the substantial mechanical protection offered by the skull. Throughout most of history, the brain, residing in a "closed box" of bone, has not been vulnerable to external aggression. Recently, we encountered a serious penetrating craniocerebral...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2014.56.6.537
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Outcome of gamma knife radiosurgery (GKS) in the consecutive 100 cases with cerebral arteriovenous malformations (AVMs) was analyzed. METHODS:Data from initial 100 patients treated with GKS in the authors' institute were reviewed retrospectively. Spetzler-Martin grade at diagnosis were I in 18 patients, II i...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.43.6.265
更新日期:2008-06-01 00:00:00
abstract::This case report describes the symptoms and clinical course of a 35-year-old female patient who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first present...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2015.57.4.298
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The objectives of the present study were to characterize the natural course of initially non-operated traumatic acute subdural hematoma (ASDH) and to identify the risk factors of hematoma progression. METHODS:Retrospective analysis was performed using sequential computed tomography (CT) images maintained in ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2013.54.3.211
更新日期:2013-09-01 00:00:00
abstract::The authors present a case of isolated dural arteriovenous fistula (DAVF) in the transverse sinus, which developed six years after microvascular decompression caused by hemifacial spasm via suboccipital craniectomy. The lesion was successfully treated by transarterial embolization using Onyx. We reviewed the related r...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.52.5.480
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Repair of sensorial nerve defect is an important issue on peripheric nerve surgery. The aim of the present study was to determine the effects of sensory-motor nerve bridging on the denervated dermatomal area, in rats with sensory nerve defects, using a neural cell adhesion molecule (NCAM). METHODS:We compare...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.1010.010
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to investigate good prognostic factors for an acute occlusion of a major cerebral artery using mechanical thrombectomy. METHODS:Between January 2013 to December 2014, 37 consecutive patients with acute occlusion of a major cerebral artery treated by mechanical thrombectomy with stent...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2015.58.3.192
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the different patterns of bone loss between the lumbar spine and the femur after ovariectomy in rats. METHODS:Twenty-four female Sprague-Dawley rats underwent a sham operation (the sham group) or bilateral ovariectomy (the ovariectomized group). Four and eight weeks ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2012.52.1.1
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestinpositive progenitor and/or stem cells (SC) isolated from pancrea...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2018.0035
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:In order to establish the role of Gamma Knife radiosurgery (GKS) in large intracranial arteriovenous malformations (AVMs), we analyzed clinical characteristics, radiological features, and radiosurgical outcomes. METHODS:Between March 1992 and March 2005, 28 of 33 patients with large AVMs (> 10 cm(3) in nidus...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2009.46.4.378
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To analyze the clinical courses and outcomes after anterior lumbar interbody fusion (ALIF) for the treatment of postoperative spondylodiscitis. METHODS:A total of 13 consecutive patients with postoperative spondylodiscitis treated with ALIF at our institute from January, 1994 to August, 2013 were included (9...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.56.4.310
更新日期:2014-10-01 00:00:00
abstract::We report a rare case of pronator teres syndrome in a young female patient. She reported that her right hand grip had weakened and development of tingling sensation in the first-third fingers two months previous. Thenar muscle atrophy was prominent, and hypoesthesia was also examined on median nerve territory. The pro...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2014.55.5.296
更新日期:2014-05-01 00:00:00
abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered as a low grade tumor of adolescents and young adults. Although this tumor often shows cystic component, the hemorrhage within the cyst is extremely rare. The authors report a rare case of cystic PXA with a hemorrhage within the cyst and the mural nodule in the le...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2007.42.5.410
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Cardiac dysfunction after aneurysmal subarachnoid hemorrhage (SAH) is associated with elevation of serum cardiac troponin I (cTnI) levels. Elevation of cTnI predicts cardiopulmonary and neurological complications, and poor outcome. METHODS:We retrospectively reviewed the medical and radiologic records of 114...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2009.46.2.99
更新日期:2009-08-01 00:00:00
abstract::The crossing Y-stent method is one of the indispensable techniques to achieve sufficient neck coverage during coil embolization of bifurcation aneurysms with a wide neck and/or branch incorporation. However, the inevitable hourglass-like expansion of the second stent at the crossing point can result in insufficient ve...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2019.0253
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the optimal volume of injected cement and its distribution when used to treat vertebral compression fractures, and to identify factors related to subsequent vertebral fractures. METHODS:A retrospective analysis of newly developing vertebral fractures after percutane...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2010.48.2.125
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:The goals of surgical intervention for metastatic spinal cord compression (MSCC) are prolonging survival and improving quality of life. Non-ambulatory paraplegic patients, either at presentation or after treatment, have a much shorter life expectancy than ambulatory patients. We therefore analyzed prognostic ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.5.434
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to determine the efficacy of indocyanine green (ICG) videoangiography for confirmation of vascular anastomosis patency in both extracranial-intracranial and intracranial-intracranial bypasses. METHODS:Intraoperative ICG videoangiography was used as a surgical adjunct for 56 bypasses i...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.1.23
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Clinical features of pituitary hemorrhage vary from asymptomatic to catastrophic. The purpose of this study was to evaluate the factors related to severity of hemorrhage of pituitary adenoma. METHODS:Pituitary hemorrhage was noted in 32 of 88 patients who underwent operations between January 2000 and Decembe...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2009.46.1.23
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Both endovascular coil embolization and microsurgical clipping are now firmly established as treatment options for the management of cerebral aneurysms. Moreover, they are sometimes used as complementary approaches each other. This study retrospectively analyzed our experience with endovascular and microsurgi...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.43.1.21
更新日期:2008-01-01 00:00:00
abstract::The stereotactic surgical target for dystonic tremor is the subject of ongoing debate. Targeting the subthalamic area using deep brain stimulation has been regaining interest as a therapy for various types of involuntary movements. We describe the efficacy of stimulation of the subthalamic area in a patient with intra...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2009.45.5.303
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy of endovascular therapy as a primary treatment for spinal dural arteriovenous fistula (DAVF). METHODS:The authors reviewed 18 patients with spinal DAVFs for whom endovascular therapy was considered as an initial treatment at a single institute between 1993 a...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.44.6.364
更新日期:2008-12-01 00:00:00
abstract::Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain ins...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章,评审
doi:10.3340/jkns.2015.57.6.428
更新日期:2015-06-01 00:00:00
abstract::We describe a rare case of intradural-extramedullary primary spinal cysticercosis. A 42-year-old man visited our institute for lower back pain. He denied having consumed raw meet. Magnetic resonance (MR) images revealed an intradural pure cystic mass at the L3-L4 level. A radiologic diagnosis of spinal arachnoid cyst ...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2014.55.4.226
更新日期:2014-04-01 00:00:00
abstract::Posttraumatic delayed vertebral collapse, known as Kummell's disease, is increasing in number of patients. This disease is already progressive kyphosis due to vertebral collapse at the time of diagnosis and it causes intractable pain or neurologic deficit due to intravertebral instability. Treatment is very difficult ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章,评审
doi:10.3340/jkns.2017.0505.010
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to confirm whether brain disease or brain trauma actually affect psychopathology in young male group in Korea. METHODS:The authors manually reviewed the result of Korean military multiphasic personal inventory (KMPI) in the examination of conscription in Korea from January 2008 t...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.2.114
更新日期:2011-08-01 00:00:00
abstract::Septic internal jugular vein-sigmoid sinus thrombosis (IJV-SST) associated with a malpositioned central venous catheter is a rare condition. It is potentially life-threatening and necessitates early diagnosis and rapid administration of appropriate medications. Unfortunately, it is difficult to diagnose due to vague c...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2013.53.3.183
更新日期:2013-03-01 00:00:00