Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice.

abstract：RATIONALE:Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is a...

journal_title：American journal of respiratory and critical care medicine

authors： Khalyfa A,Gharib SA,Kim J,Dayyat E,Snow AB,Bhattacharjee R,Kheirandish-Gozal L,Goldman JL,Gozal D

更新日期：2010-05-15 00:00:00

abstract：RATIONALE:New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia vaccines are slow and costly, requiring tens of thousands of patients. Studies of pneumococcal vaccine efficacy against colonization have been proposed as a novel method to down-select between vac...

journal_title：American journal of respiratory and critical care medicine

authors： Collins AM,Wright AD,Mitsi E,Gritzfeld JF,Hancock CA,Pennington SH,Wang D,Morton B,Ferreira DM,Gordon SB

更新日期：2015-10-01 00:00:00

abstract：:Viral respiratory tract infections are associated with an acute increase in airway responsiveness in normal subjects and patients with asthma. Airway responsiveness is also increased at least transiently in animals during acute viral infections. In this article, we discuss possible mechanisms whereby viral infections ...

journal_title：American journal of respiratory and critical care medicine

authors： Hegele RG,Hayashi S,Hogg JC,Paré PD

更新日期：1995-05-01 00:00:00

abstract：:The number and significance of airway eosinophils in stable COPD is controversial. Aims of this study were to evaluate airway inflammation in patients with stable COPD compared with other groups, and to examine the correlations between inflammatory markers and functional indices of airway obstruction. Cellular analysi...

journal_title：American journal of respiratory and critical care medicine

authors： Balzano G,Stefanelli F,Iorio C,De Felice A,Melillo EM,Martucci M,Melillo G

更新日期：1999-11-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：:We previously found that weight lifters could generate greater inspiratory pressures and had more diaphragm mass than control subjects. We postulated that the weight-lifting activity itself provided a strength-training stimulus to the diaphragm. To evaluate the extent to which the diaphragm is recruited during strenuo...

journal_title：American journal of respiratory and critical care medicine

authors： Al-Bilbeisi F,McCOOL FD

更新日期：2000-08-01 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：:Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermore, as treatment response is variable, identifying optimal candidates for BT tre...

journal_title：American journal of respiratory and critical care medicine

authors： Goorsenberg AWM,d'Hooghe JNS,Srikanthan K,Ten Hacken NHT,Weersink EJM,Roelofs JJTH,Kemp SV,Bel EH,Shah PL,Annema JT,Bonta PI,TASMA research group.

更新日期：2021-01-15 00:00:00

abstract：:Poor adherence to medication regimens may be contributing to the recent increase in asthma morbidity and mortality. We examined patient characteristics that may influence adherence to twice-daily inhaled steroid regimens. Fifty adults with moderate to severe asthma completed questionnaires examining sociodemographics,...

journal_title：American journal of respiratory and critical care medicine

authors： Apter AJ,Reisine ST,Affleck G,Barrows E,ZuWallack RL

更新日期：1998-06-01 00:00:00

abstract：:We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary disease (COPD) through use of the multiple breath N2 washout test (MBW). From an alveolar slope analysis throughout the MBW, we derived two indices, S(cond) and S(acin), as a measure of ventilation inhomogeneity in conductive and ...

journal_title：American journal of respiratory and critical care medicine

authors： Verbanck S,Schuermans D,Van Muylem A,Melot C,Noppen M,Vincken W,Paiva M

更新日期：1998-05-01 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00

abstract：:It has long been known that there are cyclic changes in arterial pressure during mechanical ventilation. They are caused by cyclic changes in both the right and left ventricular stroke output, occurring in opposite phases. As a result, arterial pulse pressure is increased during inspiration and decreased during expira...

journal_title：American journal of respiratory and critical care medicine

authors： Vieillard-Baron A,Chergui K,Augarde R,Prin S,Page B,Beauchet A,Jardin F

更新日期：2003-09-15 00:00:00

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00

abstract：:Fibrosing alveolitis may occur alone (CFA) or in association with systemic sclerosis (FASSc). FASSc was recently shown to have a prognostic advantage over CFA. Because interleukin-8 (IL-8) is likely to be a major determinant of neutrophil alveolitis, we evaluated IL-8 expression in patients with CFA and FASSc and comp...

journal_title：American journal of respiratory and critical care medicine

authors： Southcott AM,Jones KP,Li D,Majumdar S,Cambrey AD,Pantelidis P,Black CM,Laurent GJ,Davies BH,Jeffery PK

更新日期：1995-05-01 00:00:00

abstract：:We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbating sepsis-induced lung inflammation. Liver and lung dysfunction were ...

journal_title：American journal of respiratory and critical care medicine

authors： Matuschak GM,Henry KA,Johanns CA,Lechner AJ

更新日期：2001-03-01 00:00:00

abstract：:In order to determine the long-term sequelae of prune belly syndrome (PBS) and whether the absence of abdominal wall musculature impairs exercise performance we studied nine patients 6 to 31 yr of age with PBS. Conventional spirometry, lung volumes, DLCO, and respiratory muscle strength were measured. A progressive 1-...

journal_title：American journal of respiratory and critical care medicine

authors： Ewig JM,Griscom NT,Wohl ME

更新日期：1996-04-01 00:00:00

abstract：:Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than women, which has been attributed to the historically higher rates of cigarette smoking in males. However, the increased rates of cigarette smoking in females within the last several decades have been associated with steadily increasi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman EK,Weiss ST,Drazen JM,Chapman HA,Carey V,Campbell EJ,Denish P,Silverman RA,Celedon JC,Reilly JJ,Ginns LC,Speizer FE

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Current classification of pulmonary hypertension (PH) is based on a relatively simple combination of patient characteristics and hemodynamics. This limits customization of treatment, and lacks the clarity of a more granular identification based on individual patient phenotypes. Rapid advances in mechanistic ...

journal_title：American journal of respiratory and critical care medicine

authors： Dweik RA,Rounds S,Erzurum SC,Archer S,Fagan K,Hassoun PM,Hill NS,Humbert M,Kawut SM,Krowka M,Michelakis E,Morrell NW,Stenmark K,Tuder RM,Newman J,ATS Committee on Pulmonary Hypertension Phenotypes.

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. OBJECTIVES:To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for no...

journal_title：American journal of respiratory and critical care medicine

authors： Jeong BH,Jeon K,Park HY,Kim SY,Lee KS,Huh HJ,Ki CS,Lee NY,Shin SJ,Daley CL,Koh WJ

更新日期：2015-01-01 00:00:00

abstract：:To determine whether the diagnostic yield of transbronchial needle aspiration (TBNA) improves over time and to obtain insights about factors influencing its performance, we reviewed our experience during a 3-yr period. After serial multifaceted educational interventions directed toward bronchoscopists and their techni...

journal_title：American journal of respiratory and critical care medicine

authors： Haponik EF,Cappellari JO,Chin R,Adair NE,Lykens M,Alford PT,Bowton DL

更新日期：1995-06-01 00:00:00

abstract：:At present there is some indirect evidence for increased nocturnal inflammation in patients suffering from nocturnal asthma: 1. Circulating eosinophil numbers and activation, as reflected by increased levels of ECP and EDN and low-density eosinophils, are increased at night. 2. Circulating histamine levels are increas...

journal_title：American journal of respiratory and critical care medicine

authors： Postma DS,Oosterhoff Y,van Aalderen WM,Kauffman HF,Wempe JB,Koëter GH

更新日期：1994-11-01 00:00:00

abstract：:Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributin...

journal_title：American journal of respiratory and critical care medicine

authors： Abdulai RM,Jensen TJ,Patel NR,Polkey MI,Jansson P,Celli BR,Rennard SI

更新日期：2018-02-15 00:00:00

abstract：RATIONALE:Patent foramen ovale (PFO) may be disadvantageous in chronic obstructive pulmonary disease (COPD). It is unknown whether right-to-left shunting through PFO increases during exercise impairing exercise performance. OBJECTIVES:To determine whether (1) PFO prevalence is greater in hypoxemic versus less hypoxemi...

journal_title：American journal of respiratory and critical care medicine

authors： Shaikh ZF,Kelly JL,Shrikrishna D,de Villa M,Mullen MJ,Hopkinson NS,Morrell MJ,Polkey MI

更新日期：2014-03-01 00:00:00

abstract：:Because inflammation stimulates the expression of inducible nitric oxide (NO) synthase (iNOS) with an associated increased local NO production, we hypothesized that patients with pneumonia would have increased excretion of NO into their airways. To test this hypothesis, NO was measured in the exhaled air and from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Adrie C,Monchi M,Dinh-Xuan AT,Dall'Ava-Santucci J,Dhainaut JF,Pinsky MR

更新日期：2001-04-01 00:00:00

abstract：:Collections of sputum from 105 patients with newly diagnosed pulmonary tuberculosis were made before and at 1 and 2 d after the start of chemotherapy with isoniazid (INH) alone given to groups of patients in doses of 600 mg, 300 mg, 150 mg, 75 mg, 37.5 mg, 18.75 mg, and 9 mg daily, as well as from an untreated group. ...

journal_title：American journal of respiratory and critical care medicine

authors： Donald PR,Sirgel FA,Botha FJ,Seifart HI,Parkin DP,Vandenplas ML,Van de Wal BW,Maritz JS,Mitchison DA

更新日期：1997-09-01 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA), a treatable sleep disorder that is associated with alterations in glucose metabolism in individuals without diabetes, is a highly prevalent comorbidity of type 2 diabetes. However, it is not known whether the severity of OSA is a predictor of glycemic control in patients with di...

journal_title：American journal of respiratory and critical care medicine

authors： Aronsohn RS,Whitmore H,Van Cauter E,Tasali E

更新日期：2010-03-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is caused by alterations in expression of proteins involved in multiple pathways, including matrix deposition, inflammation, injury, and repair. OBJECTIVES:To understand the pathogenic changes in lung protein expression in IPF and to evaluate apolipoprotein (Apo) A-I as a ...

journal_title：American journal of respiratory and critical care medicine

authors： Kim TH,Lee YH,Kim KH,Lee SH,Cha JY,Shin EK,Jung S,Jang AS,Park SW,Uh ST,Kim YH,Park JS,Sin HG,Youm W,Koh ES,Cho SY,Paik YK,Rhim TY,Park CS

更新日期：2010-09-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that both embryonic stem cells and adult bone marrow stem cells can participate in the regeneration and repair of diseased adult organs, including the lungs. However, the extent of airway epithelial remodeling with adult marrow stem cells is low, and there are no available in viv...

journal_title：American journal of respiratory and critical care medicine

authors： Sueblinvong V,Loi R,Eisenhauer PL,Bernstein IM,Suratt BT,Spees JL,Weiss DJ

更新日期：2008-04-01 00:00:00

abstract：RATIONALE:Matrix metalloproteinase-7 (MMP-7) has been implicated in interstitial lung disease pathobiology and proposed as a diagnostic and prognostic biomarker of idiopathic pulmonary fibrosis. OBJECTIVES:To test associations between serum MMP-7 and lung function, respiratory symptoms, interstitial lung abnormalities...

journal_title：American journal of respiratory and critical care medicine

authors： Armstrong HF,Podolanczuk AJ,Barr RG,Oelsner EC,Kawut SM,Hoffman EA,Tracy R,Kaminski N,McClelland RL,Lederer DJ

更新日期：2017-11-15 00:00:00