Abstract：
OBJECTIVES:Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in residual PPT's. PATIENTS AND METHODS:Between 2006-2016, fourteen patients with residual PPT's were treated with adjuvant radiotherapy (12 with 3D conformal RT). Eight had pineocytomas (PC), 4 pineal parenchymal tumors with intermediate differentiation (PPID) and 2 pineoblastomas (PB). Doses of 45-54 Gy was delivered in 1.8-2 Gy per fraction. Cranio-spinal irradiation(CSI) was given to one case of PB and PPID each, with drop lesions at presentation. Patients were followed up at regular intervals. RESULTS:The average Planning Target Volume (PTV) was 279.4cc. Clinico-radiological response was noted in all with complete disappearance of tumor in 4 patients with PC and 2 with PPID. Delayed recurrence (36-72 months later, median 42.5 months) was seen in 3 patients with PC and early recurrence in both with PB (median 28 months). Overall median follow-up for PC and PB was 54 and 31.5 months respectively. Two patients with PC and 2 with PB expired. The median follow-up for PPID was 21.5 months with no deaths or recurrences. CONCLUSIONS:Some PC and PPID may behave aggressively and recur or spread along neural axes requiring close follow up. Radiotherapy appears to be effective in patients with residual PC, PPID. Re-irradiation or radiosurgery may help in recurrences.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Kumar N,Srinivasa GY,Madan R,Salunke Pdoi
10.1016/j.clineuro.2018.01.027subject
Has Abstractpub_date
2018-03-01 00:00:00pages
91-98eissn
0303-8467issn
1872-6968pii
S0303-8467(18)30033-7journal_volume
166pub_type
杂志文章abstract：BACKGROUND/AIMS:Previous studies have suggested that diabetes mellitus (DM) could be a protective factor against amyotrophic lateral sclerosis (ALS) although the results are inconsistent. This study aimed to comprehensively investigate this relationship by identifying all available studies and summarizing their results...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2020.106248
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To describe demographic and clinical characteristics in a group of Parkinson's disease (PD) patients with non-motor fluctuations (NMF) and to evaluate the management of medications proposed to treat NMF. METHODS:Three hundred and three PD patients (mean age, 66 ± 10.3 years; mean disease duration, 10.1 ± 6.5...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2014.10.006
更新日期：2014-12-01 00:00:00
abstract：:The motor response of the Glasgow 'coma' scale is readily learned by nurses and doctors. It can be used as a reliable indicator of changes in the state of a comatose patient, as there is a high agreement rate between different observers. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(78)80067-5
更新日期：1977-01-01 00:00:00
abstract：OBJECTIVE:A thorough follow-up study in which the same clinic presents the change in the surgical outcomes of acromegaly over the years, is still lacking in the endoscopic era. In this study, we intended to evaluate the clinical characteristics, radiological features, surgical and late remission rates of newly diagnose...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2020.106201
更新日期：2020-11-01 00:00:00
abstract：:Contrast-enhanced ultrasound (CEUS) is a real-time, feasible technique. Both intraoperatively and bedside, it satisfies the need for serial assessment and easy performability. Initially employed in neuro-oncology, it has recently overcome this first application. We aimed to evaluate the literature and give a comprehen...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.clineuro.2020.106105
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To study the expression of Akt2 and activation of PI3K in different grades of human gliomas and correlate the Akt2 expression with the proliferation activity of gliomas. METHODS:Akt2 expression and PI3K activity were examined in 48 different grades of human glioma specimens and six normal brain tissue sample...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2010.01.003
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To obtain information on functional integrity of the facial nerve by transcranial electrical motor evoked potentials independent of nerve visualization and to improve prediction of postoperative function. PATIENTS AND METHODS:In a prospective clinical study, 68 patients with cerebello-pontine angle tumors an...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2011.06.011
更新日期：2011-12-01 00:00:00
abstract：:The efficacy of perioperative seizure prophylaxis in seizure-naïve glioma patients is still controversial. Thus we conducted this meta-analysis to assess the effectiveness of perioperative prophylactic antiepileptic drugs (AEDs) on postoperative seizures in seizure-naïve glioma for the first time. We systematically se...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.clineuro.2019.105529
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The objective of this communication was to study the incidence and course of ICD and the long term outcome of this severe disease. The second goal was to analyze the different endovascular treatment modalities according to their long term results. METHODS:It is a retrospective analysis of 14 patients with IC...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.03.017
更新日期：2012-11-01 00:00:00
abstract：:Although there is accepted criteria for migrainous infarction, the pathophysiology of this disease process remains poorly defined. Delineation of MRI characteristics of migrainous infarction may improve our understanding of the pathophysiology, diagnosis, and prognosis of this disorder. We present a case of a migraino...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2007.04.005
更新日期：2007-09-01 00:00:00
abstract：:We present a 67-year-old non-diabetic male who presented with muscle cramps, paresis, atrophy and fasciculations in the left leg, followed by rapidly progressive muscle stiffness and superimposed spasms which subsequently also affected the right leg and the trunk. GAD65 autoantibodies were elevated in serum and CSF, c...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.06.005
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:Mean platelet volume (MPV) determined shortly after the onset of acute ischemic stroke represents the pre-stroke values. Data on its relationship to stroke severity/outcome have been conflicting. We related MPV to infarct volume on CT brain scans and risk of death/dependence 7 days and 3 months post-stroke. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.04.002
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Surgery for medically resistant epilepsy is safe and effective. However, when noninvasive techniques are insufficient, then consideration is given to invasive electrocorticography (EcoG). OBJECTIVE:The aim of the study was to analyze results and complications of subdural electrodes placement in the treatmen...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2012.10.007
更新日期：2013-07-01 00:00:00
abstract：:A 63-year-old man developed a severe left frontal headache followed by an acute change of mentality 6 days later. Magnetic resonance imaging revealed bilateral thalamic ischemia. Angiography confirmed the occlusion of deep cerebral veins. Proton magnetic resonance spectroscopy (1H-MRS) of the thalami showed normal N-a...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(97)00026-7
更新日期：1998-03-01 00:00:00
abstract：:The results of the combination of CW-Doppler ultrasonography and OPG-Gee are described in 68 patients. The Doppler examination had a sensitivity of 92% and a specificity of 89%, the percentages for the OPG-Gee were 69 en 79. The combination of the Doppler examination with the OPG-Gee improves our positive predictive v...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(88)90026-1
更新日期：1988-01-01 00:00:00
abstract：:The histopathological, immunologic, and ultrastructural findings of neurenteric cysts support an endodermal derivation. These developmental cystic lesions are generally located in the posterior mediastinum, abdomen, and pelvis and may also contain some mesodermal and neuroectodermal elements. In contrast, neurenteric ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2009.11.001
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:Remote ischemic preconditioning (RIPC) is a powerful endogenous mechanism whereby a brief period of ischemia is capable of protecting remote tissues from subsequent ischemic insult. While this phenomenon has been extensively studied in the heart and brain in animal models, little work has been done to explor...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2013.07.038
更新日期：2013-10-01 00:00:00
abstract：:Sarcoidosis of the central nervous system has been variously reported in 5-15% of all sarcoid patients. However, presentation of sarcoidosis as an isolated 'intracranial tumor' is rare. A 35-year-old African-American woman presented with intractable headaches. Neuroimaging revealed a tumor that was suggestive of a gli...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(02)00012-4
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To investigate imaging findings, risk factors and outcome in patients with cerebral venous thrombosis (CVT). METHODS:Records of all patients with diagnosis of CVT between 1992 and 2002 were reviewed. Patients with CNS infection and with CVT secondary to invasive procedures were excluded. Inherited and acquired...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2004.10.004
更新日期：2005-08-01 00:00:00
abstract：:A patient is presented who developed a frontal intracerebral hemorrhage, which proved to be due to a metastasis of a choriocarcinoma. The patient's uterus and adnexa had been removed two years previously for a non-malignant disorder. two years previously for a non-malignant disorder. The authors stress the importance ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(85)90137-4
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVES:To describe the clinical and radiological findings in a consecutive series of patients diagnosed with fibrous dysplasia of the skull. PATIENTS AND METHODS:A retrospective analysis of collected data for 36 patients with histopathologically confirmed fibrous dysplasia involving the skull is presented. The dem...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2011.10.026
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To determine the frequency of symptomatic and asymptomatic herniated discs and root compression in patients with lumbosacral radicular syndrome (LRS) and to correlate clinical localization with MRI findings. METHODS:Fifty-seven patients with unilateral LRS were included in the study. Using the visual analogu...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2005.10.003
更新日期：2006-09-01 00:00:00
abstract：:Three cases of spinal cord compression due to solitary osteochondroma of the spine are reported. The rarity and benign nature of the tumour is stressed. Other reported cases are reviewed. ...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/0303-8467(85)90113-1
更新日期：1985-01-01 00:00:00
abstract：:Two patients presenting a relapsing form of sporadic brachial plexus neuropathy, the so-called Parsonage Turner syndrome, are reported. The diagnosis is based on clinical and electromyographic features. Recurrent attacks, although infrequently encountered, have been well described in the past. Sporadic cases of this s...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/s0303-8467(88)80014-3
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Seizures occur more frequently in patients with an intracerebral haematoma (ICH) than in those with a cerebral infarct. However, the risk factors for seizures in association with an ICH are less well known. PURPOSE:The characteristics of medically treated patients with spontaneous ICHs, who developed seizur...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2007.04.001
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To analyse the prevalence and incidence of dementia in a population of community-dwelling elderly (aged 75-80), living in socio-economically differing districts of Antwerp (Belgium), taking into account possible gender and educational differences. METHODS:A longitudinal cohort study (N=825) with a 3-year fol...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2011.07.030
更新日期：2011-11-01 00:00:00
abstract：:We explored the feasibility of using subcutaneous low-molecular-weight-heparin (LMWH) injections in place unfractionated heparin (UFH) while anticoagulating patients with cerebral ischemia. In this open-labeled, prospective study, patients admitted to our hospital with transient ischemic attacks or stroke requiring an...
journal_title：Clinical neurology and neurosurgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0303-8467(98)00039-0
更新日期：1998-09-01 00:00:00
abstract：:Ependymomas account for 3-9% of all neuroepithelial tumors. A peculiar variant of ependymoma known as "giant cell ependymoma" ("GCE") is especially rarely reported, it may pose some difficulties for the diagnosing neuropathologist. Here we present a case of a giant cell ependymoma occuring in a 17-year-old patient wit...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2007.09.018
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:Vascular cognitive impairment associated with small vessel disease (sVCI) may manifest as both cognitive and motor dysfunctions. However, few instruments exist for systematically assessing motor symptoms in sVCI, even though many neuropsychological tests exist to evaluate cognitive function. We developed a ne...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2010.11.001
更新日期：2011-04-01 00:00:00
abstract：:This study aims to achieve the complete removal of trigeminal schwannoma (TS) while preserving cranial nerve function. We focused on the outcomes of different surgical approaches and address the contributions of different operative techniques. Forty-two TS cases, treated surgically in Qilu Hospital during a 12-year pe...
journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
doi：10.1016/j.clineuro.2008.10.014
更新日期：2009-04-01 00:00:00
