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Increased expression of Akt2 and activity of PI3K and cell proliferation with the ascending of tumor grade of human gliomas.

Abstract：

OBJECTIVE:To study the expression of Akt2 and activation of PI3K in different grades of human gliomas and correlate the Akt2 expression with the proliferation activity of gliomas. METHODS:Akt2 expression and PI3K activity were examined in 48 different grades of human glioma specimens and six normal brain tissue samples by immunohistochemistry and Western blot analysis. The proliferation activity of tumors was evaluated by Ki-67 nuclear antigen labeling index (Ki-67 LI) using immunostaining. RESULTS:In contrast to the normal brain tissues, Akt2 expression and PI3K activity were greatly increased with the ascending of tumor grade and correlated positively with the proliferation activity of gliomas. CONCLUSION:Akt2 may play a critical role in the development of gliomas and present a potential therapeutic target for malignant gliomas.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Wang G,Kang C,Pu P

doi

10.1016/j.clineuro.2010.01.003

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

324-7

issue

4

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(10)00008-9

journal_volume

112

pub_type

杂志文章

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