Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited Setting.

Abstract:

Background:Without early recognition and treatment, neonatal meningitis (NM) has a high mortality and morbidity. Although some neonates have features of NM, many do not. In many low-resource settings, the laboratory support to diagnose NM is not available, and bedside diagnostics are needed. Methods:This retrospective study was conducted in a neonatal unit in Uganda. Clear cerebrospinal fluid samples were routinely screened for glucose, protein and leukocytes on a Combur®-10 urinalysis reagent strip. A definitive diagnosis was made using laboratory analysis. The results of the screening and definitive tests were compared. Results:The reagent strip showed moderate sensitivity and high specificity for leukocytes ≥10×106 cells/l, high sensitivity for protein ≥100 mg/dl and high specificity for glucose <50 mg/dl. Conclusion:The use of reagent strips has the potential to improve and hasten the diagnosis of probable NM in settings where adequate or timely laboratory support is not available.

journal_name

J Trop Pediatr

authors

Burgoine K,Ikiror J,Naizuli K,Achom L,Akol S,Olupot-Olupot P

doi

10.1093/tropej/fmy003

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

9-13

issue

1

eissn

0142-6338

issn

1465-3664

pii

4829715

journal_volume

65

pub_type

杂志文章
  • Management of malnourished children with acute diarrhoea and sugar intolerance.

    abstract::A protocol of nutritional rehabilitation using fermented milk, vegetable oil, and castor sugar has been tested on 54 Senegalese children age 6-36 months admitted with acute diarrhoea and malnutrition. At time of admission, 39 per cent of children were dehydrated and 26 per cent had sugar intolerance. In the course of ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.6.281

    authors: Beau JP,Fontaine O,Garenne M

    更新日期:1989-12-01 00:00:00

  • Blood Procalcitonin Levels and Duration of Antibiotics in Neonatal Sepsis.

    abstract:OBJECTIVE:To determine the time to normalization of procalcitonin (PCT) levels and duration of antibiotics in neonatal sepsis. METHODS:A prospective observational study design was used. The participants included were neonates with sepsis. The primary outcome measure was time to normalization of PCT levels and duration...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmy053

    authors: Mathur NB,Behera B

    更新日期:2019-08-01 00:00:00

  • Renal function in acute malaria in children.

    abstract::Tests for renal function were performed in 75 smear positive children with acute malaria together with 10 control children. Plasmodium vivax and Plasmodium falciparum accounted for 52 and 46 per cent cases, respectively. Renal impairment in the form of decreased endogenous creatine clearance (less than 65 ml/min/m2) w...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.6.291

    authors: Ahmad SH,Danish T,Faridi MM,Ahmad AJ,Fakhir S,Khan AS

    更新日期:1989-12-01 00:00:00

  • Influence of health providers on pediatrics' immunization rate.

    abstract::To identify the immunization providers' characteristics associated with immunization rate in children younger than 2 years. A cohort and a cluster sampling design were implemented; 528 children between 18 and 70 months of age were sampled in five public health clinics in Mosul-Iraq. Providers' characterizations were o...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fms014

    authors: Al-lela OQ,Baidi Bahari M,Al-abbassi MG,Salih MR,Basher AY

    更新日期:2012-12-01 00:00:00

  • Ankle clonus and thiocyanate, linamarin, and inorganic sulphate excretion in school children in communities with Konzo, Mozambique.

    abstract::We examined 397 school children for ankle clonus in five communities in three districts affected by konzo, spastic paraparesis associated with cassava consumption. From a subsample of 131 children, we analysed urine specimens for urinary thiocyanate, linamarin, and inorganic sulphate. The proportion of children with c...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/45.3.139

    authors: Cliff J,Nicala D,Saute F,Givragy R,Azambuja G,Taela A,Chavane L,Gani A

    更新日期:1999-06-01 00:00:00

  • Changes in the prevalence of asthma and allergic diseases among Brazilian schoolchildren (13-14 years old): comparison between ISAAC Phases One and Three.

    abstract::The present study is aimed to describe the changes in the prevalence of symptoms of asthma, rhinitis and eczema among Brazilian adolescents (AD, 13-14 years old) between Phases 1 and 3 of the International Study of Asthma and Allergies in Childhood (ISAAC). The prevalence of self-reported symptoms of asthma, rhinitis ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fml044

    authors: Solé D,Melo KC,Camelo-Nunes IC,Freitas LS,Britto M,Rosário NA,Jones M,Fischer GB,Naspitz CK

    更新日期:2007-02-01 00:00:00

  • Preliminary assessment of breastfeeding practices in HIV 1-infected mothers (prior to weaning) under the Djoungolo programme on the prevention of mother-to-child transmission of HIV.

    abstract:BACKGROUND:Human Immunodeficiency virus (HIV) transmission in a breastfeeding population varies from 20% to 45%. OBJECTIVE:To evaluate breastfeeding practices and the early basic HIV transmission rate in HIV-exposed children in the Djoungolo health district (prevention of mother-to-child transmission HIV programme). ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq018

    authors: Nlend AE,Ekani BB

    更新日期:2010-12-01 00:00:00

  • Breastfeeding and supplemental feeding for neonates in Al-Ain, United Arab Emirates.

    abstract::A prospective cohort study was carried out to determine the factors affecting initiation of breastfeeding, and describe patterns of breastfeeding and supplemental feeding in the multiethnically and culturally diverse population of Al Ain, UAE. Two-hundred-and-twenty-one infants completed the 4 weeks of follow up. None...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/43.5.304

    authors: al-Mazroui MJ,Oyejide CO,Bener A,Cheema MY

    更新日期:1997-10-01 00:00:00

  • Vitamin D status of low birth weight infants in Delhi: a comparative study.

    abstract:OBJECTIVE:To evaluate vitamin D status of preterm and term low birthweight (LBW) and term normal birth weight (NBW; weight ≥ 2500 g) infants at birth and in early infancy. METHODS:We enrolled 220 LBW and 119 NBW infants along with their mothers. Blood samples of both infants and mothers were taken within 48 h of birth...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fms013

    authors: Agarwal R,Virmani D,Jaipal ML,Gupta S,Gupta N,Sankar MJ,Bhatia S,Agarwal A,Devgan V,Deorari A,Paul VK,Investigators of LBW Micronutrient Study Group, Departments of Pediatrics and Endocrinology.

    更新日期:2012-12-01 00:00:00

  • The Evolution of a Hospital-Based Cancer Registry in Northwest Cameroon from 2004 to 2015.

    abstract::Effective cancer registration is required for the development of cancer management policies, but is often deficient in the developing world. In 2008 cancer registration was set up Banso Baptist Hospital and Mbingo Baptist Hospital in the Northwest region of Cameroon, using the Pediatric Oncology Networked Database (PO...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmaa038

    authors: Afungchwi GM,Kruger M,Wharin PD,Bardin R,Kouya FN,Hesseling PB

    更新日期:2020-10-06 00:00:00

  • The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice.

    abstract::Increased bilirubin formation and decreased bilirubin conjugation play an important role in the pathogenesis of the newborn jaundice. Although physiologic jaundice is seen in most of the newborns, there are many risk factors that affect the severity and duration of hyperbilirubinemia. The latest studies showed that th...

    journal_title:Journal of tropical pediatrics

    pub_type: 信件

    doi:10.1093/tropej/fml067

    authors: Muslu N,Turhan AB,Eskandari G,Atici A,Ozturk OG,Kul S,Atik U

    更新日期:2007-02-01 00:00:00

  • Disseminated Cryptococcosis Presenting as Miliary Lung Shadows in an Immunocompetent Child.

    abstract::Disseminated cryptococcosis is infrequent in immunocompetent children. Pulmonary and central nervous system are the commonly involved sites of infection in an immunocompromised host. We report a fatal case of disseminated cryptococcosis in an immunocompetent host presenting as fever of unknown origin with miliary shad...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmx083

    authors: Ismail J,Chidambaram M,Sankar J,Agarwal S,Lodha R

    更新日期:2018-10-01 00:00:00

  • Weight, length, ponderal index, and intrauterine growth retardation in Brazil.

    abstract::The objective of this study was to classify intrauterine growth-retarded (IUGR) newborn babies from an urban region in Brazil into four different subtypes, according to their weight, length, and ponderal index (PI). Three hundred and fifty-six (356) babies were differentiated by this classification into IUGR subtypes ...

    journal_title:Journal of tropical pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1093/tropej/44.6.355

    authors: Rondó PH

    更新日期:1998-12-01 00:00:00

  • Attitudes towards end-of-life issues amongst pediatricians in a tertiary hospital in a developing country.

    abstract::To describe the perspectives of pediatricians from a tertiary care center from India on end-of-life (EOL) care issues, a standardized anonymous questionnaire was administered, which included questions regarding attitudes towards withdrawal/withholding of life-sustaining treatment in children and neonates at the EOL, a...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmn009

    authors: Guglani L,Lodha R

    更新日期:2008-08-01 00:00:00

  • Reasons for hospitalization due to abortion and pregnancy termination.

    abstract::The aim of this study was to identify the reasons for hospitalization associated with abortion and pregnancy termination among women attending the Maternity Unit of IMIP, Recife, Brazil. In a case-control study, 230 women who were hospitalized consecutively between August 1994 and June 1995 due to causes related to pr...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/45.1.31

    authors: de Souza AI,Cecatti JG,Ferreira LO,Santos LC

    更新日期:1999-02-01 00:00:00

  • Molecular analysis in two siblings African patients with severe form of Hunter Syndrome: identification of a novel (p.Y54X) nonsense mutation.

    abstract::Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and dermatan sulfates in the lysosomes. The heterogeneity of clinical phenotypes, ranging from mild-to-severe forms, is ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmm056

    authors: Mutesa L,Muganga N,Lissens W,Boemer F,Schoos R,Pierquin G,Bours V

    更新日期:2007-12-01 00:00:00

  • Prevention and early detection of leprosy in children.

    abstract::India with its 4 million cases of leprosy, accounts for one-third of the world's population of leprosy patients. One-fourth of them are below 15 years of age. We report a 5-year follow-up study of healthy children who were close contacts of leprosy patients, in order to: 1. detect subclinical infection and observe the...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/41.3.132

    authors: Dayal R,Bharadwaj VP

    更新日期:1995-06-01 00:00:00

  • Birthweight and gestational age as predictors of outcome in preterm deliveries for severe pre-eclampsia.

    abstract::The aim of this study was to compare the neonatal outcomes of babies with birthweights < 10th centile to those with birthweights > or = 10th centile with a gestational age of 28-34 weeks. This retrospective hospital-based study was performed at a tertiary referral centre. All women with early, severe pre-eclampsia, ma...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.3.178

    authors: Hall D

    更新日期:2003-06-01 00:00:00

  • Hypokalemic paralysis following severe vomiting in a child with intestinal obstruction due to round worms.

    abstract::Ascariasis is one of the most common helminthic infestations in humans. Massive infestation can give rise to serious complications such as intestinal obstruction. We present a 4-year-old boy, who presented with acute flaccid quadriparesis due to the hypokalemic alkalosis induced by severe vomiting. Severe vomiting was...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmp044

    authors: Nagotkar L,Shanbag P,Shenoy P

    更新日期:2010-02-01 00:00:00

  • Concurrent outbreak of leptospirosis and dengue in Mumbai, India, 2002.

    abstract::This prospective study was undertaken to investigate the possibility of a concurrent outbreak of leptospirosis and dengue and to describe the clinical illnesses. From 20 June to 14 November 2002, children who presented to our hospital with a suspected diagnosis of leptospirosis or dengue were admitted. In every child ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmh100

    authors: Karande S,Gandhi D,Kulkarni M,Bharadwaj R,Pol S,Thakare J,De A

    更新日期:2005-06-01 00:00:00

  • Clinical validation of a western blot assay for congenital toxoplasmosis and newborn screening in a hospital in Armenia (Quindio) Colombia.

    abstract::Congenital Toxoplasma infection can only be discovered or prevented by the appropriate serological screening and subsequent treatment of the mother and her offspring. In Colombia, there is no obligatory Toxoplasma screening for pregnant women and both the reporting and follow-up of congenital toxoplasmosis cases is li...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmi072

    authors: Gallego-Marín C,Henao AC,Gómez-Marín JE

    更新日期:2006-04-01 00:00:00

  • Circulating growth hormone (GH), insulin-like growth factor-I (IGF-I) and free thyroxine, GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle cell disease.

    abstract::Serum growth hormone (GH), cortisol, free thyroxine (FT4), thyroid-stimulating hormone (TSH), and insulin like growth factor I (IGF-I) concentrations were measured in 15 children with sickle cell disease (SCD) together with their heights < 5th percentile for age and gender, and in 15 healthy age-matched children who h...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/41.5.285

    authors: Soliman AT,Darwish A,Mohammed SH,Bassiony MR,el Banna N,Asfour M

    更新日期:1995-10-01 00:00:00

  • Causes of malnutrition in young children: Gilan, Iran.

    abstract::Causes of malnutrition were investigated in agricultural area of Gilan, Iran. Family food availability and adult food intakes were adequate, but intakes of young children were deficient, in all socioeconomic groups, reflected in growth deficits. Associated factors were: late introduction and small quantities of solid ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/36.4.165

    authors: Rabiee F,Geissler C

    更新日期:1990-08-01 00:00:00

  • Quality of survivals on conservative neonatal care.

    abstract::Quantity as well as quality of survivals determine the performance of a neonatal centre. Our centre has succeeded in improving survival with low cost technology without compromising the quality. Neurodevelopmental handicap was low on a 1-year follow-up. No baby had retinopathy of prematurity or hearing deficit. Dropou...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/37.5.250

    authors: Kadam SB,Daga SR,Daga AS

    更新日期:1991-10-01 00:00:00

  • A comparison of magnesium sulphate and sildenafil in the treatment of the newborns with persistent pulmonary hypertension: a randomized controlled trial.

    abstract::The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO₄) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO₄ group and 31 infants in the sildenafil group completed the s...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/tropej/fmq091

    authors: Uslu S,Kumtepe S,Bulbul A,Comert S,Bolat F,Nuhoglu A

    更新日期:2011-08-01 00:00:00

  • Tuberculous meningitis: barriers to adherence in home treatment of children and caretaker perceptions.

    abstract:INTRODUCTION:In-hospital treatment of children with tuberculous meningitis (TBM) is not a feasible option in many resource-poor countries. Home-based treatment has shown to be a viable alternative. Adherence is an important factor determining success of treatment. OBJECTIVE:Identify possible barriers to adherence of h...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmr095

    authors: van Elsland SL,Springer P,Steenhuis IH,van Toorn R,Schoeman JF,van Furth AM

    更新日期:2012-08-01 00:00:00

  • Cell-mediated immune responses in malnourished host.

    abstract::One hundred children in the age group 6 months to 5 years were investigated for cell-mediated immune response in relation to their nutrition. The nutritional status was assessed by the Wellcome classification. The majority (54 per cent) of children had marasmus. Absolute lymphocyte count was found to be significantly ...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/35.4.175

    authors: Fakhir S,Ahmad P,Faridi MA,Rattan A

    更新日期:1989-08-01 00:00:00

  • Healthcare-associated infections in a neonatal intensive care unit in Turkey in 2008: incidence and risk factors, a prospective study.

    abstract::In this study, we have prospectively recorded healthcare-associated infections (HAIs) in NICU and found incidence density as 18 infections per 1000 patient days. Of the infections, 51.3% was bacteriemia (BSI), and 45.1% was ventilator-associated pneumonia (VAP). Gram-negative microorganisms were predominant in VAP and...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/fmq060

    authors: Yapicioglu H,Ozcan K,Sertdemir Y,Mutlu B,Satar M,Narli N,Tasova Y

    更新日期:2011-06-01 00:00:00

  • The influence of clinical status on total bilirubin binding capacity in newborn infants.

    abstract::The relationship between total bilirubin binding capacity (TBBC) and clinical status was investigated in order to assess the risk of bilirubin toxicity in 83 infants with jaundice in this study. Infants with respiratory distress, acidosis, hypoglycaemia, sepsis, asphyxia-anoxia and hypercarbia were accepted as ill and...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/42.1.43

    authors: Satar M,Atici A,Oktay R

    更新日期:1996-02-01 00:00:00

  • Helicobacter pylori infection and recurrent abdominal pain in children.

    abstract::The association of Helicobacter pylori infection with recurrent abdominal pain (RAP) was studied in 65 children aged between 3 and 12 years. Cases with a specific cause for abdominal pain were excluded from the study. All the patients were subjected to upper gastrointestinal endoscopy and antral biopsy. The biopsy spe...

    journal_title:Journal of tropical pediatrics

    pub_type: 杂志文章

    doi:10.1093/tropej/49.4.250

    authors: Das BK,Kakkar S,Dixit VK,Kumar M,Nath G,Mishra OP

    更新日期:2003-08-01 00:00:00