Ankle clonus and thiocyanate, linamarin, and inorganic sulphate excretion in school children in communities with Konzo, Mozambique.

Abstract:

:We examined 397 school children for ankle clonus in five communities in three districts affected by konzo, spastic paraparesis associated with cassava consumption. From a subsample of 131 children, we analysed urine specimens for urinary thiocyanate, linamarin, and inorganic sulphate. The proportion of children with clonus varied between sites, ranging from 4 to 22 per cent. Geometric mean thiocyanate, linamarin, and inorganic sulphate concentrations were 163 and 60 mumol/l and 4.4 mmol/l, respectively. Children with ankle clonus had higher urinary thiocyanate concentrations. We recommend prevention to reduce cyanide exposure and further monitoring of cyanide exposure and neurological damage in these communities.

journal_name

J Trop Pediatr

authors

Cliff J,Nicala D,Saute F,Givragy R,Azambuja G,Taela A,Chavane L,Gani A

doi

10.1093/tropej/45.3.139

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

139-42

issue

3

eissn

0142-6338

issn

1465-3664

journal_volume

45

pub_type

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