Abstract:
:The aim of this prospective, randomized and controlled study was to compare the clinical efficacy of intravenous magnesium sulfate (MgSO₄) and oral sildenafil therapies with persistent pulmonary hypertension of the newborn. A total of 34 infants in the MgSO₄ group and 31 infants in the sildenafil group completed the study. The time to reach the adequate clinical response [defined as oxygen index (OI) level of <15, a pulmonary artery pressure of < 20 mmHg) was significantly shorter in the sildenafil group (p = 0.002). Duration of mechanical ventilation was longer and the number of the patients requiring inotropic support was higher in the MgSO₄ group (p = 0.001 and p = 0.002, respectively). Although among two groups the difference in OI > 5 as speculated in our hypothesis could only be found at 36 h of the treatment, sildenafil was more effective than MgSO₄ in the treatment of persistent pulmonary hypertension of the newborns with regard to time to adequate clinical response, duration of mechanical ventilation and support requirement with inotropic agents.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Uslu S,Kumtepe S,Bulbul A,Comert S,Bolat F,Nuhoglu Adoi
10.1093/tropej/fmq091subject
Has Abstractpub_date
2011-08-01 00:00:00pages
245-50issue
4eissn
0142-6338issn
1465-3664pii
fmq091journal_volume
57pub_type
杂志文章,随机对照试验abstract::We surveyed the clinical presentation, initial management and subsequent course of a prospectively registered cohort of 60 children with insulin-dependent diabetes mellitus (IDDM) diagnosed before age 15 years in the Sultanate of Oman between January 1990 and December 1993. Clinical details from the time of diagnosis ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/43.3.128
更新日期:1997-06-01 00:00:00
abstract:Objectives:To evaluate pediatric intensive care unit (PICU) needs, outcome and predictors of mortality in post-neonatal tetanus. Materials and methods:Review of 30 consecutive post-neonatal tetanus cases aged 1 months to 12 years admitted to a PICU in north India over a period of 10 years (January 2006 to December 201...
journal_title:Journal of tropical pediatrics
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abstract::The objective of this study was to classify intrauterine growth-retarded (IUGR) newborn babies from an urban region in Brazil into four different subtypes, according to their weight, length, and ponderal index (PI). Three hundred and fifty-six (356) babies were differentiated by this classification into IUGR subtypes ...
journal_title:Journal of tropical pediatrics
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更新日期:1998-12-01 00:00:00
abstract::This study was carried out to determine the vitamin A status and nutritional intake of carotenoids of 213 children between the ages of 6 months and 6 years in a rural community in Nigeria. There were 109 males and 104 females. A total of 57 (26.8 per cent) children were deficient in serum retinol levels (< 10 microg/d...
journal_title:Journal of tropical pediatrics
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abstract::Hunter syndrome (or Mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder due to the deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in the accumulation of heparan and dermatan sulfates in the lysosomes. The heterogeneity of clinical phenotypes, ranging from mild-to-severe forms, is ...
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abstract::Determination of lead, cadmium, nickel, chromium, manganese and copper levels in colostrum samples (n = 30), collected from middle-class mothers, was carried out by electrothermal atomic absorption spectrophotometer (ETAAS) with Zeeman effect background correction using a tungsten-palladium-citric acid chemical modifi...
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章
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更新日期:2005-04-01 00:00:00
abstract::Tests for renal function were performed in 75 smear positive children with acute malaria together with 10 control children. Plasmodium vivax and Plasmodium falciparum accounted for 52 and 46 per cent cases, respectively. Renal impairment in the form of decreased endogenous creatine clearance (less than 65 ml/min/m2) w...
journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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更新日期:2020-12-27 00:00:00
abstract::Congenital anomalies exist all over the world. The management and outcome, however, vary considerably between the developed and the developing countries. This study looks at the impediments to the management of surgically correctable anomalies in South-east Nigeria. A prospective study was undertaken on 223 children w...
journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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journal_title:Journal of tropical pediatrics
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abstract::In this article, we will describe the presence of metabolic syndrome and its components in a group of hypertensive and obese adolescents. The study presented here was conducted on 20 patients (10 boys) presented with complaints of obesity and hypertension who were diagnosed as metabolic syndrome. In 20 patients who we...
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