A recurrence-free survivor with chemotherapy-refractory small cell lung cancer after pneumonectomy: A case report and review of the literature.

Abstract:

RATIONALE:The optimal therapeutic regimen for chemotherapy-refractory and node-positive small-cell lung cancer (SCLC) is criticizable for the lack of evidence. PATIENT CONCERNS:A patient with locally advanced SCLC was insensitive to the first-line chemotherapy of etoposide, irinotecan, and cisplatin. DIAGNOSES:The patient was diagnosed as SCLC with mediastinal lymph node metastasis by pathological staining. INTERVENTIONS:Salvage pneumonectomy and systematic lymph node dissection combined with oral apatinib and mediastinal radiotherapy were performed for him. OUTCOMES:The patient survived for more than 2 years without recurrence after the operation and adjuvant therapy. LESSONS:For patients with chemotherapy-resistant but resectable SCLC, a timely resection combined with postoperative radiotherapy and apatinib might be effective.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Pan Y,Kong FW,Wang H,Wang X,Zhang H,Wu WB,Zhang M

doi

10.1097/MD.0000000000008922

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

e8922

issue

47

eissn

0025-7974

issn

1536-5964

pii

00005792-201711270-00121

journal_volume

96

pub_type

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