Abstract:
RATIONALE:The optimal therapeutic regimen for chemotherapy-refractory and node-positive small-cell lung cancer (SCLC) is criticizable for the lack of evidence. PATIENT CONCERNS:A patient with locally advanced SCLC was insensitive to the first-line chemotherapy of etoposide, irinotecan, and cisplatin. DIAGNOSES:The patient was diagnosed as SCLC with mediastinal lymph node metastasis by pathological staining. INTERVENTIONS:Salvage pneumonectomy and systematic lymph node dissection combined with oral apatinib and mediastinal radiotherapy were performed for him. OUTCOMES:The patient survived for more than 2 years without recurrence after the operation and adjuvant therapy. LESSONS:For patients with chemotherapy-resistant but resectable SCLC, a timely resection combined with postoperative radiotherapy and apatinib might be effective.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Pan Y,Kong FW,Wang H,Wang X,Zhang H,Wu WB,Zhang Mdoi
10.1097/MD.0000000000008922subject
Has Abstractpub_date
2017-11-01 00:00:00pages
e8922issue
47eissn
0025-7974issn
1536-5964pii
00005792-201711270-00121journal_volume
96pub_type
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