Evaluation of the efficacy of Conbercept in the treatment of diabetic macular edema based on OCTA.

Abstract:

BACKGROUND:Diabetic macular edema (DME) can cause severe vision impairments for patients with diabetes. Recently, Conbercept has shown efficacy on DME with 3-monthly loading dose injection and pro re nata (PRN, 3+PRN) thereafter in retrospectivetrials. Furthermore, there are some other approaches have been recommended such as 2mg bimonthly (2q8) after 5 initial doses, or Conbercept 0.5mg treat-and-extend, however, some patients still have recurrence of the disease after treatment. Therefore, in order to identify more efficacy and safety approach on Conbercept inpatients with DME, a randomized controlled trial will be performed with 6-monthly loading dose injection and PRN (6+PRN) compared with 3+PRN treatments. METHODS:This study is a multicenter, randomized control trial of Conbecept treating DME in China. Patients with type 2 diabetes suffered from DEM who already planned to receive Conbercept treatment will be recruited. All subjects will be randomized divided into either a study agent treatment group (6+PRN) or a control group (3+PRN), and observes the subjects for 48 weeks after initiation of treatment. RESULTS:This study will provide a new powerful evidence of the efficacy and safety of Conbecept treating DME. DISCUSSION:This RTC study will determine whether multiple treatments of Conbercept provide better effectiveness in patients with DME. TRIAL REGISTRATION NUMBER:ChiCTR2000032728.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Ba T,Zhou L,Zhang H,Zhang X,Guo S,Li H,Tian H,Caihan Q,Bai G,Zhou J,Qi L,Zhang X,Zhang G

doi

10.1097/MD.0000000000021992

subject

Has Abstract

pub_date

2020-08-28 00:00:00

pages

e21992

issue

35

eissn

0025-7974

issn

1536-5964

pii

00005792-202008280-00093

journal_volume

99

pub_type

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