Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.

abstract：:Lipid droplet proteins (LDPs) coat the surface of triglyceride-rich lipid droplets and regulate their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld) mice, a unique model of neonatal hepatic steatosis that predictably resolves between postnatal day 14 (P14) and P17. Western ...

journal_title：Journal of lipid research

authors： Hall AM,Brunt EM,Chen Z,Viswakarma N,Reddy JK,Wolins NE,Finck BN

更新日期：2010-03-01 00:00:00

abstract：:An elevated plasma concentration of lipoprotein (a) [Lp(a)] is an independent risk factor for cardiovascular disease. Life style modification and currently available drugs either fail to effectively lower plasma Lp(a) levels or do not result in clinical benefit. However, lipoprotein apheresis is very efficient in decr...

journal_title：Journal of lipid research

authors： Waldmann E,Parhofer KG

更新日期：2016-10-01 00:00:00

abstract：:Alcohol consumption markedly increases the hepatic output of very low density lipoprotein (VLDL), whereas it decreases the resulting low density lipoprotein (LDL) levels and apolipoprotein B. As ethylation of apoB-lysine renders LDL immunogenic and accelerates their clearance, and as alcoholics develop antibodies agai...

journal_title：Journal of lipid research

authors： Wehr H,Rodo M,Lieber CS,Baraona E

更新日期：1993-07-01 00:00:00

abstract：:Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation through their capacity to be converted to potent inflammatory mediators. We assessed associations of FADS gene cluster polymorphisms and fasting serum PUFA concentrations in a fully ascertained, geographically isolated founder populati...

journal_title：Journal of lipid research

authors： Mathias RA,Vergara C,Gao L,Rafaels N,Hand T,Campbell M,Bickel C,Ivester P,Sergeant S,Barnes KC,Chilton FH

更新日期：2010-09-01 00:00:00

abstract：:This study aimed at measuring the influence of a low salt diet on the development of experimental atherosclerosis in moderately hyperlipidemic mice. Experiments were carried out on LDL receptor (LDLR) knockout (KO) mice, or apolipoprotein E (apoE) KO mice on a low sodium chloride diet (LSD) as compared with a normal s...

journal_title：Journal of lipid research

authors： Catanozi S,Rocha JC,Passarelli M,Guzzo ML,Alves C,Furukawa LN,Nunes VS,Nakandakare ER,Heimann JC,Quintão EC

更新日期：2003-04-01 00:00:00

abstract：:ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC) transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is known to be expressed in numerous cell types and tissues, whereas ABCG4 expression is limited to the central nervous system (CNS). Here, we show sig...

journal_title：Journal of lipid research

authors： Bojanic DD,Tarr PT,Gale GD,Smith DJ,Bok D,Chen B,Nusinowitz S,Lövgren-Sandblom A,Björkhem I,Edwards PA

更新日期：2010-01-01 00:00:00

abstract：:The phospholipase A2(PLA2) activity of peroxiredoxin (Prdx)6 has important physiological roles in the synthesis of lung surfactant and in the repair of peroxidized cell membranes. These functions require the activity of a lysophospholipid acyl transferase as a critical component of the phospholipid remodeling pathway....

journal_title：Journal of lipid research

authors： Fisher AB,Dodia C,Sorokina EM,Li H,Zhou S,Raabe T,Feinstein SI

更新日期：2016-04-01 00:00:00

abstract：:Zinc Finger Protein 202 (ZNF202) is a transcriptional repressor that binds elements found predominantly in genes involved in HDL metabolism. We tested the following hypotheses: 1) frequencies of single-nucleotide polymorphisms (SNPs) and haplotypes in ZNF202 differ between individuals with low and high HDL cholesterol...

journal_title：Journal of lipid research

authors： Stene MC,Frikke-Schmidt R,Nordestgaard BG,Tybjaerg-Hansen A

更新日期：2006-05-01 00:00:00

abstract：:The transport of LDL-derived cholesterol from lysosomes to peroxisomes is facilitated by membrane contacts formed between the lysosomal protein synaptotagmin VII and the peroxisomal lipid phosphatidylinositol 4, 5-bisphosphate [PI(4,5)P2]. Here, we used RNA interference to search for regulators of PI(4,5)P2 and to stu...

journal_title：Journal of lipid research

authors： Hu A,Zhao XT,Tu H,Xiao T,Fu T,Wang Y,Liu Y,Shi XJ,Luo J,Song BL

更新日期：2018-03-01 00:00:00

abstract：:Neuroinflammation, caused by 6 days of intracerebroventricular infusion of a low dose of lipopolysaccharide (LPS; 0.5 ng/h), stimulates brain arachidonic acid (AA) metabolism in rats, but 6 weeks of lithium pretreatment reduces this effect. To further understand this action of lithium, we measured concentrations of ei...

journal_title：Journal of lipid research

authors： Basselin M,Kim HW,Chen M,Ma K,Rapoport SI,Murphy RC,Farias SE

更新日期：2010-05-01 00:00:00

abstract：:An improved preparation of proteolipid from bovine brain white matter is described. The product obtained by repeated acetone precipitation is completely soluble in chloroform-methanol and has a fairly constant composition: 35% protein, 40% galactocerebroside, and about 25% phospholipid. ...

journal_title：Journal of lipid research

authors： Cavanna R,Rapport MM

更新日期：1967-01-01 00:00:00

abstract：:Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the ...

journal_title：Journal of lipid research

authors： Bahn YJ,Lee KP,Lee SM,Choi JY,Seo YS,Kwon KS

更新日期：2015-02-01 00:00:00

abstract：:The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous xanthomatosis. To gain insight into the roles of CYP27A in the r...

journal_title：Journal of lipid research

authors： Dubrac S,Lear SR,Ananthanarayanan M,Balasubramaniyan N,Bollineni J,Shefer S,Hyogo H,Cohen DE,Blanche PJ,Krauss RM,Batta AK,Salen G,Suchy FJ,Maeda N,Erickson SK

更新日期：2005-01-01 00:00:00

abstract：:Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their influence on the cholesterol nucleation time has not been compared. W...

journal_title：Journal of lipid research

authors： Jüngst D,Lang T,Huber P,Lange V,Paumgartner G

更新日期：1993-09-01 00:00:00

abstract：:Three 14C-labeled 22-carbon polyunsaturated fatty acids, 7,10,13,16-[14C]docosatetraenoic acid (22:4(n-6)), 7,10,13,16,19-[14C]docosapentaenoic acid (22:5(n-3)), and 4,7,10,13,16,19-[14C]docosahexaenoic acid (22:6(n-3)), were compared with [3H]arachidonic acid (20:4(n-6] and [14C]linoleic acid (18:2(n-6)) to character...

journal_title：Journal of lipid research

authors： Masuzawa Y,Okano S,Waku K,Sprecher H,Lands WE

更新日期：1986-11-01 00:00:00

abstract：:In humans, peroxisomes harbor a complex set of enzymes acting on various lipophilic carboxylic acids, organized in two basic pathways, alpha-oxidation and beta-oxidation; the latter pathway can also handle omega-oxidized compounds. Some oxidation products are crucial to human health (primary bile acids and polyunsatur...

journal_title：Journal of lipid research

authors： Van Veldhoven PP

更新日期：2010-10-01 00:00:00

abstract：:Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. Diet-induced changes in elongase activity correlate wi...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Christian B,Busik J,Xu J,Jump DB

更新日期：2005-04-01 00:00:00

abstract：:Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of ...

journal_title：Journal of lipid research

authors： Nakashima Y,Yuasa S,Hukamizu Y,Okuyama H,Ohhara T,Kameyama T,Nabeshima T

更新日期：1993-02-01 00:00:00

abstract：:Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied to determine whether these v...

journal_title：Journal of lipid research

authors： Latsuzbaia A,Jaddoe VW,Hofman A,Franco OH,Felix JF

更新日期：2016-12-01 00:00:00

abstract：:The extent of oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in bile acids during the enterohepatic circulation in man was studied with the use of [3 beta-3H]-labeled deoxycholic acid and cholic acid, [7 beta-3H]-labeled cholic acid, and [12 beta-3H]-labeled deoxycholic acid and cholic acid. Eac...

journal_title：Journal of lipid research

authors： Björkhem I,Liljeqvist L,Nilsell K,Einarsson K

更新日期：1986-02-01 00:00:00

abstract：:Immunological tolerance is one of the fundamental aspects of the immune system. The CD4(+)CD25(+) regulatory T (Treg) cells have emerged as key players in the development of tolerance to self and foreign antigens. However, little is known about the endogenous factors and mechanisms controlling their suppressive capaci...

journal_title：Journal of lipid research

authors： Yessoufou A,Plé A,Moutairou K,Hichami A,Khan NA

更新日期：2009-12-01 00:00:00

abstract：:Previous in vitro studies have revealed that oxidized low density lipoprotein (OxLDL) has negative effects on the proliferation and activity of endothelial progenitor cells (EPCs). Here, we evaluated the effect of OxLDL on the therapeutic potential of EPCs in ischemia-induced neovascularization. EPCs derived from mobi...

journal_title：Journal of lipid research

authors： Zhou B,Ma FX,Liu PX,Fang ZH,Wang SL,Han ZB,Poon MC,Han ZC

更新日期：2007-03-01 00:00:00

abstract：:To identify novel fatty acid diol synthases, putative candidate sequences from Penicillium species were analyzed, and hydroxy fatty acid production by crude Penicillium enzyme extracts was assessed. Penicillium chrysogenum was found to produce an unknown dihydroxy fatty acid, a candidate gene implicated in this produc...

journal_title：Journal of lipid research

authors： Shin KC,Seo MJ,Oh DK

更新日期：2016-02-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:The LDL receptor-related protein-1 (LRP1) is highly expressed in numerous cell types, and its impairment is associated with obesity, diabetes, and fatty liver disease. However, the mechanisms linking LRP1 to metabolic disease are not completely understood. Here, we compared the metabolic phenotype of C57BL/6J wild typ...

journal_title：Journal of lipid research

authors： Jaeschke A,Haller A,Cash JG,Nam C,Igel E,Roebroek AJM,Hui DY

更新日期：2020-12-09 00:00:00

abstract：:Several recent reports have examined whether there is a correlation between the presence of some minor alleles of the highly polymorphic apolipoprotein B gene and atherosclerosis and premature heart disease. The present study extends this investigation. A high-resolution method was used to study the allele frequencies...

journal_title：Journal of lipid research

authors： Friedl W,Ludwig EH,Paulweber B,Sandhofer F,McCarthy BJ

更新日期：1990-04-01 00:00:00

abstract：:Lipid hydroperoxide may react with protein or amino phospholipid without secondary decomposition. We prepared a polyclonal antibody to lipid hydroperoxide-modified proteins using 13S-hydroperoxy-9Z, 11E-octadecadienoic acid-modified keyhole limpet hemocyanin (13-HPODE-KLH) as immunogen. The antibody recognized 13-HPOD...

journal_title：Journal of lipid research

authors： Kato Y,Makino Y,Osawa T

更新日期：1997-07-01 00:00:00

abstract：:The effects of polyunsaturated fatty acids (PUFA) on the structure of recombinant high density lipoprotein (rHDL) was investigated using homogeneous particles containing phosphatidylcholine (PC), [3H]cholesterol, and apolipoprotein A-I (apoA-I). The PC component of the rHDL contained sn -1 16:0 and sn -2 18:1 (POPC), ...

journal_title：Journal of lipid research

authors： Huggins KW,Curtiss LK,Gebre AK,Parks JS

更新日期：1998-12-01 00:00:00

abstract：:We have previously demonstrated the potential usefulness of capillary columns coated with a high temperature polarizable phenylmethylsilicone liquid phase in plasma lipid profiling (Kuksis, A., J.J. Myher, and P. Sandra. 1990. J. Chromatogr. 500: 427-441). The present study reports improved operating conditions along ...

journal_title：Journal of lipid research

authors： Kuksis A,Myher JJ,Geher K

更新日期：1993-06-01 00:00:00

abstract：:Human apolipoprotein (apo) E occurs as three common isoforms (apoE4, E3, and E2), all of which influence plasma cholesterol levels. Although both apoE4 and E3 bind with equal effectiveness to the low density lipoprotein receptor, they associate preferentially with different classes of plasma lipoproteins: apoE4 with v...

journal_title：Journal of lipid research

authors： Weisgraber KH

更新日期：1990-08-01 00:00:00