Molecular Epidemiology of Rotavirus Strains in Under Five Children.

Abstract:

OBJECTIVES:To determine the prevalence and genotype distribution of rotaviruses in children presenting to authors' hospital in Middle Black Sea region of Turkey. The results may supply important information about vaccine studies in Turkey. METHODS:Rotavirus antigen was detected by latex agglutination test and rotavirus RNA was detected by RT-PCR test. On the other hand, rotavirus positive samples were genotyped by semi-nested multiplex polymerase chain reaction. RESULTS:The highest rate of rotavirus positivity (46.9%) was observed among children in the 13 to 24 mo age group. All the positive-strains were in G1-4, G8-9, P [4], P [8], and P [9] genotypes. The most common G and P combination in present study was G9P[8] (n = 24, 28.9%). CONCLUSIONS:The present results indicated that the most prevalent genotypes were G1, G9, P8, G9P[8] and G1P[8] in authors' region. Rotavirus vaccines used in this region must include mainly these genotypes.

journal_name

Indian J Pediatr

authors

Bulut Y,Yenişehirli G,Durmaz R

doi

10.1007/s12098-017-2540-9

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

364-368

issue

5

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-017-2540-9

journal_volume

85

pub_type

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