Abstract:
OBJECTIVE:To assess serum sclerostin levels in relation to severity of arthropathy and bone mineral density (BMD) in children with hemophilic arthropathy. METHODS:This cross-sectional study included 40 male children suffering from Hemophilia A, and 10 matched healthy controls. Assessment of factor VIII deficiency degree, frequency of bleeding, type of treatment, body mass index (BMI), disease severity using the Hemophilia Joint Health Score (HJHS) and lumbar spine (LS) Z score for bone mineral density (BMD) using dual-energy X-ray absorbiometry was done. Serum sclerostin levels were measured for all patients and controls. RESULTS:Significant difference of serum sclerostin levels between the patient and control groups with Mean ± SD (0.09 ± 0.07 ng/ml) and (0.04 ± 0.01 ng/ml) (P value = 0.028) respectively was found. Significant positive correlations between serum sclerostin levels and the patients' age, and HJHS (P value <0.05) were found, while it had negative correlation with DEXA Z score, not reaching a significant value. LS-BMD-Z score levels ranged from (-4.5 to 1.2), with 15 patients with low BMD Z score (less than -2) representing 37.5% of total patients. CONCLUSIONS:Serum sclerostin levels are elevated in hemophilic children denoting bone metabolism affection and correlates with increased age, and HJHS. Increased levels of serum sclerostin may identify hemophilic patients at high risk for developing osteoporosis.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
El-Mikkawy DME,Elbadawy MA,Abd El-Ghany SM,Samaha Ddoi
10.1007/s12098-019-02855-1subject
Has Abstractpub_date
2019-06-01 00:00:00pages
515-519issue
6eissn
0019-5456issn
0973-7693pii
10.1007/s12098-019-02855-1journal_volume
86pub_type
杂志文章abstract::Fainting attack or syncope in children is a common occurrence, with vasovagal syncope being the commonest cause for majority of pediatric syncope. The aim of emergency room evaluation is not to miss the rare serious underlying disorder causing syncope. A complete detailed history of the event followed by physical exam...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0497-7
更新日期:2012-03-01 00:00:00
abstract::Respiratory disease in childhood is common but not all children presenting to the paediatrician have an underlying organic cause for their symptoms. This article reviews the spectrum of non-organic somatization disorders that might be encountered and advises about the diagnosis and treatment of habit cough, laryngeal ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726188
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abstract::Disorders of sexual development (DSD) are a complex group of disorders to manage, not only because the diagnosis is difficult, but also because it involves many factors related to the psychosexual well being, the social stigma associated with the disorder, confusion and reluctance on the part of medical professionals ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-013-1168-7
更新日期:2014-01-01 00:00:00
abstract::The authors present 2 cases of dengue shock syndrome with unusual complications. In the first case, a 14-y-old boy with dengue shock syndrome who required aggressive fluid resuscitation, developed abdominal compartment syndrome (ACS). Patient developed severe shock, increased ventilator requirement and oliguria as a c...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0551-5
更新日期:2012-03-01 00:00:00
abstract::Microscopic polyangiitis (MPA) is a small vessel multisystemic disorder characterised by necrotising small vessel vasculitis without any immune deposits. Kidney and lung are the predominant organs affected in MPA. Skin, gastrointestinal and neurological findings are also described. Isolated pulmonary manifestations ar...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2379-0
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects generated by an intensivist in pediatric intensive care unit (PICU) on the process of care and patient outcomes. METHODS:This study was a retrospective observational study conducted in the 16-bedded PICU of a tertiary referral center. Two years (2013-2015) period of the PICU without a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-019-03154-5
更新日期:2020-04-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02760691
更新日期:2005-02-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-018-2651-y
更新日期:2019-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-008-0017-6
更新日期:2008-02-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02905736
更新日期:1996-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02722657
更新日期:2002-06-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-016-2030-5
更新日期:2016-07-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-013-1175-8
更新日期:2014-01-01 00:00:00
abstract::Incidence of allergic disorders in children has increased significantly over time due to environmental and life-style changes. These include allergic rhinitis, atopic dermatitis, allergic conjunctivitis, food allergies, bronchial asthma, drug allergies, insect bites and anaphylaxis; most being IgE-mediated type 1 hype...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-017-2436-8
更新日期:2018-01-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-010-0280-1
更新日期:2011-03-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02730822
更新日期:1996-09-01 00:00:00
abstract::Cefprozil is a novel third generation, broad-spectrum oral cephalosporin with activity against a spectrum of aerobic gram-negative and positive bacteria, as well as certain anaerobes. The beta-lactamase stability of cefprozil may exceed that of other oral cephalosporins for some important pathogens. Cefprozil may be a...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02723613
更新日期:2003-05-01 00:00:00
abstract::Integrated Management of Childhood Illness (IMCI), a strategy fostering holistic approach to child health and development, is built upon successful experiences gained from effective child health interventions like immunization, oral rehydration therapy, management of acute respiratory infections and improved infant fe...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02723776
更新日期:2002-01-01 00:00:00
abstract::"Hypertensive" variant of congenital adrenal hyperplasia is rare. The authors describe an interesting case of a 6-y-old boy who presented with an acute respiratory illness and progressive breathlessness since 1 y. Genital hyperpigmentation was noticed since 2 y of age; the onset of pubarche and increasing penile size ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-011-0649-9
更新日期:2012-09-01 00:00:00
abstract::Malignant tumours of the chest wall are rare in the pediatric age group. Askin tumour, a primitive neuroectodermal tumour with aggressive nature, is extremely rare. Clinico-pathological features make it quite distinct from Ewing's sarcoma. Aggressive nature of the tumour results in short clinical presentation of the p...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02726235
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:To evaluate the correlation between echocardiographic inferior vena cava (IVC) measurements and central venous pressure (CVP) in neonates. Also, to evaluate the correlation between IVC measurements and gestational age (GA) and body weight (BW). METHODS:This cross sectional analytical study was conducted fro...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-017-2382-5
更新日期:2017-10-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02724292
更新日期:2004-06-01 00:00:00
abstract::Incontinence disorders are an important group of problems that clinicians manage in children and adolescents. This paper reviews the physiology of micturition, the epidemiology of enuresis, etiologic concepts of incontinence disorders, a general clinical approach to enuretic patients, laboratory evaluation and general...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02845537
更新日期:1999-05-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-018-2695-z
更新日期:2018-11-01 00:00:00
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journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-020-03399-5
更新日期:2020-11-01 00:00:00
abstract::While Allergic bronchopulmonary aspergillosis (ABPA) is known to complicate asthma in adults, its association with childhood asthma is very rare. We present two patients, a four-and half year old boy who presented with severe asthma and a 12 year-old girl whose previous chest radiographs revealed fleeting opacities. B...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-009-0020-6
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the presentation, treatment and outcome of testicular tumors in undescended testes (UDT) in boys below 5 y of age. METHODS:Case records of boys below 5 y of age, diagnosed to have germ cell tumors (GCT) in the UDT were reviewed. RESULTS:Seven children in the age range of 05-54 mo (mean 26 mo) we...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s12098-014-1667-1
更新日期:2015-06-01 00:00:00
abstract::The estimated prevalence of food allergy amongst children in the west is around 6-8% but there is paucity of data in the Indian population. There is a complex interplay of environmental influences and genetic factors in the immuno-pathogenesis and manifestations of food allergy. A reliable thorough clinical history, c...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s12098-017-2535-6
更新日期:2018-05-01 00:00:00
abstract::A confirmed case of cholera in a 3-day-old neonate is being reported. Possible source of infection could be by holy water (Chamamrit) given to the baby, which is common ritual in India. Mother's milk has never been reported to transmit cholera, even though mother herself may be suffering from cholera. Contaminated wat...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02752426
更新日期:2001-08-01 00:00:00
abstract::The renal tubule plays an important role in fluid and electrolyte homeostasis. Renal tubular disorders may affect multiple ( e.g., Fanconi syndrome) or specific (e.g., nephrogenic diabetes insipidus, renal glucosuria) tubular functions. Most conditions are primary and monogenic but occasionally are secondary to other ...
journal_title:Indian journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF02734150
更新日期:2005-09-01 00:00:00