Abstract:
:Neuropeptide Y (NPY) is a 36 amino-acid amidated peptide of the pancreatic polypeptide (PP) family, which plays an important role in appetite regulation and energy expenditure in mammals. Although several teleost NPY have been identified, its roles remain unclear in fish. We herein reported on the molecular cloning, tissue distribution and the effect of fasting on the expression of NPY in Channa argus, and designated as CaNPY. It consisted of a 300 bp open reading frame predicted to encode a prepro-NPY of 99 amino acids. Sequence analysis revealed that CaNPY was highly conserved (>60%) with other vertebrate NPY. Phylogenetic analysis highly supported CaNPY was closely related to piscine NPY. In addition, except for muscle and spleen tissues, CaNPY was found to extensively expressed in all other detected tissues, with the highest level in brain. Futhermore, the CaNPY transcript was found to significantly increase after short-term and long-term food deprivation, and dramatically decrease following refeeding. These findings suggested that CaNPY might be involved in food intake regulation and it could be as a potential target locus to improve commercial production of this kind of fish.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Yang S,Wen ZY,Zou YC,Qin CJ,Wang J,Yuan DY,Li Rdoi
10.1016/j.ygcen.2017.11.017subject
Has Abstractpub_date
2018-04-01 00:00:00pages
147-153eissn
0016-6480issn
1095-6840pii
S0016-6480(17)30531-2journal_volume
259pub_type
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