Abstract：
:The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis-12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene interactions. Other upgrades from the past year include a command-line version of the Variant Annotation Integrator, support for Human Genome Variation Society variant nomenclature input and output, and a revised highlighting tool that now supports multiple simultaneous regions and colors.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Casper J,Zweig AS,Villarreal C,Tyner C,Speir ML,Rosenbloom KR,Raney BJ,Lee CM,Lee BT,Karolchik D,Hinrichs AS,Haeussler M,Guruvadoo L,Navarro Gonzalez J,Gibson D,Fiddes IT,Eisenhart C,Diekhans M,Clawson H,Barber GP,doi
10.1093/nar/gkx1020subject
Has Abstractpub_date
2018-01-04 00:00:00pages
D762-D769issue
D1eissn
0305-1048issn
1362-4962pii
4584624journal_volume
46pub_type
杂志文章abstract：:DNA primase has been partially purified from wheat germ. This enzyme, like DNA primases characterized from many procaryotic and eucaryotic sources, catalyses the synthesis of primers involved in DNA replication. However, the wheat enzyme differs from animal DNA primase in that it is found partially associated with a D...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/18.16.4867
更新日期：1990-08-25 00:00:00
abstract：:The vitamin D receptor mediates the signal of 1 alpha, 25-dihydroxyvitamin D3 by binding to vitamin D responsive elements in DNA as a homodimer or as a heterodimer composed of one vitamin D receptor subunit and one retinoid X receptor subunit. We have mapped the dimerization interfaces of the vitamin D receptor that i...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/23.4.606
更新日期：1995-02-25 00:00:00
abstract：:Light-inducible systems allow spatiotemporal control of a variety of biological activities. Here, we report newly optimized optogenetic tools to induce transcription with light in mammalian cells, using the Arabidopsis photoreceptor Flavin Kelch-repeat F-box 1 (FKF1) and its binding partner GIGANTEA (GI) as well as CR...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkx804
更新日期：2017-11-16 00:00:00
abstract：:Unlike short interfering RNAs (siRNAs), which are commonly designed to repress a single messenger RNA (mRNA) target through perfect base pairing, microRNAs (miRNAs) are endogenous small RNAs that have evolved to concurrently repress multiple mRNA targets through imperfect complementarity. MicroRNA target recognition i...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gku171
更新日期：2014-05-01 00:00:00
abstract：:Eucaryotic ribosome biogenesis involves many cis-acting sequences and trans-acting factors, including snoRNAS: We have used directed mutagenesis of rDNA plasmids in yeast to identify critical sequence and structural elements within and flanking the ITS2-proximal stem. This base paired structure, present in the mature ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/29.10.2106
更新日期：2001-05-15 00:00:00
abstract：:The deoxyoligonucleotide 5' AATCGGGCATGGATT (15-mer) was synthesized containing 12 phosphoramidate linkages derived from 2 primary and 2 secondary amines. The oligonucleotides were purified by reverse phase HPLC and characterized by PAGE. The thermal stability of the duplexes derived from these compounds, when hybridi...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/16.11.4831
更新日期：1988-06-10 00:00:00
abstract：:TRF1, a duplex telomeric DNA-binding protein, plays an important role in telomere metabolism. We have previously reported that a fraction of endogenous TRF1 can stably exist free of telomere chromatin when it is phosphorylated at T371 by Cdk1; however, the role of this telomere-free (pT371)TRF1 has yet to be fully cha...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt775
更新日期：2013-12-01 00:00:00
abstract：:Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin alpha-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin-ricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. The SRL interact...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq151
更新日期：2010-07-01 00:00:00
abstract：:Glucocorticoid (GC) signaling synchronizes the circadian rhythm of individual peripheral cells and induces the expression of circadian genes, including Period1 (Per1) and Period2 (Per2). However, no GC response element (GRE) has been reported in the Per2 promoter region. Here we report the molecular mechanisms of Per2...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt307
更新日期：2013-07-01 00:00:00
abstract：:Control of RNA processing plays a major role in HIV-1 gene expression. To explore the role of several hnRNP proteins in this process, we carried out a siRNA screen to examine the effect of depletion of hnRNPs A1, A2, D, H, I and K on HIV-1 gene expression. While loss of hnRNPs H, I or K had little effect, depletion of...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkr1238
更新日期：2012-04-01 00:00:00
abstract：:Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily, which act as transcription factors upon binding to specific DNA sequences called thyroid hormone (T3) response elements (TREs). Such elements are found in the upstream regulatory region of promoters as well as in intragenic sequen...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/25.9.1774
更新日期：1997-05-01 00:00:00
abstract：:Partial acid cleavage, comparative HPLC tryptic peptide mapping and amino acid sequencing of the C1 and C2 proteins of HeLa heterogeneous nuclear ribonucleoprotein (hnRNP) particles demonstrate that proteins C1 and C2 differ in primary structure by the presence of a 13 amino acid insert sequence in C2. This C2 insert ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/17.21.8441
更新日期：1989-11-11 00:00:00
abstract：:2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids. In particular, the 5-substituted-2-thiouridines (S2Us) present in tRNA play an important role in tuning the translation process through codon-anticodon interactions. The enhanced thermodynamic stability of S2U-cont...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkv109
更新日期：2015-03-11 00:00:00
abstract：:Corynebacterium diphtheriae is a Gram-positive, non-spore forming, non-motile, pleomorphic rod belonging to the genus Corynebacterium and the actinomycete group of organisms. The organism produces a potent bacteriophage-encoded protein exotoxin, diphtheria toxin (DT), which causes the symptoms of diphtheria. This pote...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkg874
更新日期：2003-11-15 00:00:00
abstract：:Modification of chromatin and related transcription factors by histone deacetylases (HDACs) is one of the major strategies for controlling gene expression in eukaryotes. The HDAC domains of class IIa HDACs repress the respective target genes by interacting with the C-terminal region of the silencing mediator for retin...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky926
更新日期：2018-12-14 00:00:00
abstract：:The NCBI has introduced two new web resources-LocusLink and RefSeq-that facilitate retrieval of gene-based information and provide reference sequence standards. These resources are designed to provide a non-redundant view of current knowledge about human genes, transcripts and proteins. Additional information about th...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/28.1.126
更新日期：2000-01-01 00:00:00
abstract：:Thermophilic viruses represent a novel source of genetic material and enzymes with great potential for use in biotechnology. We have isolated a number of thermophilic viruses from geothermal areas in Iceland, and by combining high throughput genome sequencing and state of the art bioinformatics we have identified a nu...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkg914
更新日期：2003-12-15 00:00:00
abstract：:In previous studies, we reported that fractionation of HeLa cell nuclear extracts on glycerol gradients revealed an endogenous ∼10S particle that contained galectin-3 and U1 snRNP and this particle was sufficient to load the galectin polypeptide onto a pre-mRNA substrate. We now document that this interaction between ...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkw303
更新日期：2016-07-27 00:00:00
abstract：:Single nucleotide polymorphisms (SNPs) are, together with copy number variation, the primary source of variation in the human genome. SNPs are associated with altered response to drug treatment, susceptibility to disease and other phenotypic variation. Furthermore, during genetic screens for disease-associated mutatio...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkm979
更新日期：2008-01-01 00:00:00
abstract：:APOBEC3G (A3G), a host protein that inhibits HIV-1 reverse transcription and replication in the absence of Vif, displays cytidine deaminase and single-stranded (ss) nucleic acid binding activities. HIV-1 nucleocapsid protein (NC) also binds nucleic acids and has a unique property, nucleic acid chaperone activity, whic...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkm750
更新日期：2007-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gks630
更新日期：2012-09-01 00:00:00
abstract：:The three-dimensional Poisson-Boltzmann equation for the distribution of counterion charge density around double helical DNA has been solved by an iterative procedure. These computations have been performed for 0.01M monovalent salt solutions. A systematic study of the ten possible sequences found among adjacent nucle...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/14.3.1479
更新日期：1986-02-11 00:00:00
abstract：:With recent advancements in techniques for cellular data acquisition, information on cellular processes has been increasing at a dramatic rate. Visualization is critical to analyzing and interpreting complex information; representing cellular processes or pathways is no exception. VISIBIOweb is a free, open-source, we...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkq352
更新日期：2010-07-01 00:00:00
abstract：:TATA-binding protein (TBP) is central to the regulation of eukaryotic transcription initiation. Recruitment of TBP to target genes can be positively regulated by one of two basal transcription factor complexes: SAGA or TFIID. Negative regulation of TBP promoter association can be performed by Mot1p or the NC2 complex....
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkr784
更新日期：2012-02-01 00:00:00
abstract：:AR9 is a giant Bacillus subtilis phage whose uracil-containing double-stranded DNA genome encodes distant homologs of β and β' subunits of bacterial RNA polymerase (RNAP). The products of these genes are thought to assemble into two non-canonical multisubunit RNAPs - a virion RNAP (vRNAP) that is injected into the hos...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkx264
更新日期：2017-06-02 00:00:00
abstract：:The effect of mutations in the highly conserved Y-GG/A motif of B-type DNA polymerases was studied in the DNA polymerase from the hyperthermophilic euryarchaeon Thermococcus aggregans. This motif plays a critical role in the balance between the synthesis and degradation of the DNA chain. Five different mutations of th...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/28.20.3910
更新日期：2000-10-15 00:00:00
abstract：:Many strains of E. coli K12 restrict DNA containing cytosine methylation such as that present in plant and animal genomes. Such restriction can severely inhibit the efficiency of cloning genomic DNAs. We have quantitatively evaluated a total of 39 E. coli strains for their tolerance to cytosine methylation in phage an...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/17.9.3469
更新日期：1989-05-11 00:00:00
abstract：:Retroviral particles contain a dimeric RNA genome, which serves as template for the generation of double-stranded DNA by reverse transcription. Transfer between RNA strands during DNA synthesis is governed by both sequence similarity between templates and structural features of the dimeric RNA. A kissing hairpin, beli...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkh159
更新日期：2004-01-09 00:00:00
abstract：:Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase failure by removing the abortive ligation product, i.e. the 5'-adenylate (5'-AMP) group, during DNA replication and repair. In the absence of APTX activity, blocked base excision repair (BER) intermediates containing the 5'...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkx654
更新日期：2017-09-29 00:00:00
abstract：:The phenotypic adjustments of Mycobacterium tuberculosis are commonly inferred from the analysis of transcript abundance. While mechanisms of transcriptional regulation have been extensively analysed in mycobacteria, little is known about mechanisms that shape the transcriptome by regulating RNA decay rates. The aim o...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkz251
更新日期：2019-06-20 00:00:00
