当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Longitudinal assessment of HLA and MIC-A antibodies in uneventful pregnancies and pregnancies complicated by preeclampsia or gestational diabetes.

Longitudinal assessment of HLA and MIC-A antibodies in uneventful pregnancies and pregnancies complicated by preeclampsia or gestational diabetes.

Abstract：

:The significance of antibodies directed against paternal epitopes in the context of obstetric disorders is discussed controversially. In this study anti-HLA and anti-MIC-A antibodies were analysed in sera of women with uneventful pregnancy (n = 101), preeclampsia (PE, n = 55) and gestational diabetes (GDM, n = 36) using antigen specific microbeads. While two thirds of the women with uneventful pregnancy or GDM were HLA and MIC-A antibody positive in gestational week 11 to 13 with a modest increase towards the end of pregnancy, women with PE showed an inverse kinetic: 90% were HLA antibody positive in gestational week 11 to 13 and only 10% showed HLA reactivities at the end of the pregnancy. HLA antibody binding strength was more pronounced in gestational week 14 to 17 in patients with PE compared to women with uneventful pregnancy (maximum median fluorescence intensity of the highest ranked positive bead 7403, IQR 2193-7938 vs. 1093, IQR 395-5689; p = 0.04) and was able to predict PE with an AUC of 0.80 (95% CI 0.67-0.93; p = 0.002). Our data suggest a pathophysiological involvement of HLA antibodies in PE. HLA antibody quantification in early pregnancy may provide a useful tool to increase diagnostic awareness in women prone to develop PE.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Küssel L,Herkner H,Wahrmann M,Eskandary F,Doberer K,Binder J,Pateisky P,Zeisler H,Böhmig GA,Bond G

doi

10.1038/s41598-017-13275-6

subject

Has Abstract

pub_date

2017-10-19 00:00:00

pages

13524

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13275-6

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Gene expression profiling gut microbiota in different races of humans.

    abstract：:The gut microbiome is shaped and modified by the polymorphisms of microorganisms in the intestinal tract. Its composition shows strong individual specificity and may play a crucial role in the human digestive system and metabolism. Several factors can affect the composition of the gut microbiome, such as eating habits...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23075

    authors： Chen L,Zhang YH,Huang T,Cai YD

    更新日期：2016-03-15 00:00:00

  • Density Functional Theory for Steady-State Nonequilibrium Molecular Junctions.

    abstract：:We present a density functional theory (DFT) for steady-state nonequilibrium quantum systems such as molecular junctions under a finite bias. Based on the steady-state nonequilibrium statistics that maps nonequilibrium to an effective equilibrium, we show that ground-state DFT (GS-DFT) is not applicable in this case a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15386

    authors： Liu S,Nurbawono A,Zhang C

    更新日期：2015-10-16 00:00:00

  • Combining molecular typing and spatial pattern analysis to identify areas of high tuberculosis transmission in a moderate-incidence county in Taiwan.

    abstract：:In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05674-6

    authors： Chen YY,Chang JR,Wu CD,Yeh YP,Yang SJ,Hsu CH,Lin MC,Tsai CF,Lin MS,Su IJ,Dou HY

    更新日期：2017-07-14 00:00:00

  • Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice.

    abstract：:Loss of regenerative capacity plays a critical role in age-related autoimmune hepatitis. Evidence implicates SIRT1 and p66shc in cell senescence, apoptosis, oxidative stress, and proliferation. This study investigated the effect of resveratrol on concanavalin A (Con A)-induced hepatitis in aged mice and the roles of S...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02881-z

    authors： Huang TH,Chen CC,Liu HM,Lee TY,Shieh SH

    更新日期：2017-06-02 00:00:00

  • Expression of NOTCH3 exon 16 differentiates Diffuse Large B-cell Lymphoma into molecular subtypes and is associated with prognosis.

    abstract：:Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with diverse clinical presentation and outcome. Bio-clinical prognostic models including oncogene expression and cell-of-origin phenotyping has been developed, however, approximately 30% of all patients still die from their disease, illustrating the need...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36680-x

    authors： Jespersen DS,Schönherz AA,Due H,Bøgsted M,Sondergaard TE,Dybkær K

    更新日期：2019-01-23 00:00:00

  • Influence of age and gender on sex steroid receptors in rat masticatory muscles.

    abstract：:The temporomandibular muscle dysfunction is characterized by myofascial pain and is more prevalent in women of reproductive age. Sex steroid hormones are hypothetically involved in the dysfunction, but few are the studies of steroid receptors in masticatory and mastication-related muscles. Our aim was to determine est...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54774-y

    authors： Galhardo APM,Mukai MK,Mori M,Carvalho KC,Baracat MCP,Simões MJ,Soares JM Jr,Baracat EC

    更新日期：2019-12-05 00:00:00

  • Ecosystem carbon storage in forest fragments of differing patch size.

    abstract：:Forest fragmentation threatens the ecosystem carbon (C) storage. The distribution patterns of ecosystem C density are poorly documented for fragmented forests of differing patch size. The objectives of this study were to examine C density in these forest ecosystems and the influence of edge effects on C density. Allom...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13598-4

    authors： Ma L,Shen C,Lou D,Fu S,Guan D

    更新日期：2017-10-13 00:00:00

  • Synergistic strengthening of polyelectrolyte complex membranes by functionalized carbon nanotubes and metal ions.

    abstract：:Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces, and surface engineering. However, a long-standing problem is that their mechanical properties usually deteriorate at high relative humidity (RH). Through the sim...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07782

    authors： Liu T,An QF,Zhao Q,Wu JK,Song YH,Zhu BK,Gao CJ

    更新日期：2015-01-14 00:00:00

  • Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial.

    abstract：:Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/s41598-017-04214-6

    authors： Baye E,de Courten MP,Walker K,Ranasinha S,Earnest A,Forbes JM,de Courten B

    更新日期：2017-06-23 00:00:00

  • Interplay between intra- and inter-nanowires dynamic dipolar interactions in the spin wave band structure of Py/Cu/Py nanowires.

    abstract：:We have studied both experimentally and theoretically the reprogrammable spin wave band structure in Permalloy(10 nm)/Cu(5 nm)/Permalloy(30 nm) nanowire arrays of width w = 280 nm and inter-wire separation in the range from 80 to 280 nm. We found that, depending on the inter-wire separation, the anti-parallel configur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40131-6

    authors： Gubbiotti G,Zhou X,Haghshenasfard Z,Cottam MG,Adeyeye AO,Kostylev M

    更新日期：2019-03-15 00:00:00

  • Studies of the oligomerisation mechanism of a cystatin-based engineered protein scaffold.

    abstract：:Engineered protein scaffolds are an alternative to monoclonal antibodies in research and drug design due to their small size, ease of production, versatility, and specificity for chosen targets. One key consideration when engineering such proteins is retaining the original scaffold structure and stability upon inserti...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45565-6

    authors： Zalar M,Indrakumar S,Levy CW,Tunnicliffe RB,Peters GHJ,Golovanov AP

    更新日期：2019-06-21 00:00:00

  • Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells.

    abstract：:Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFRα+Flk1- cardioblasts (PCBs), from mouse and human plurip...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41840

    authors： Hong SP,Song S,Cho SW,Lee S,Koh BI,Bae H,Kim KH,Park JS,Do HS,Im I,Heo HJ,Ko TH,Park JH,Youm JB,Kim SJ,Kim I,Han J,Han YM,Koh GY

    更新日期：2017-02-06 00:00:00

  • Drought and child mortality: a meta-analysis of small-scale surveys from Ethiopia.

    abstract：:Despite the intuitive connection between drought and mortality, we still lack a sound quantitative synthesis of evidence drawn from the available data. In this study, we estimate the pooled under-five death rates (U5DR) and assess the effect of drought on child death in Ethiopia. Small-scale mortality surveys were sea...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-02271-5

    authors： Delbiso TD,Altare C,Rodriguez-Llanes JM,Doocy S,Guha-Sapir D

    更新日期：2017-05-19 00:00:00

  • Down regulation of p-coumarate 3-hydroxylase in petunia uniquely alters the profile of emitted floral volatiles.

    abstract：:Petunia × hybrida cv 'Mitchell Diploid' floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis ultimately produces floral volatiles derived sequentially from phenylalanine, cinnamic acid, and p-coumaric acid. In an attempt to better understand biochemical steps after p-coumaric acid production, we cloned and ch...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45183-2

    authors： Kim JY,Swanson RT,Alvarez MI,Johnson TS,Cho KH,Clark DG,Colquhoun TA

    更新日期：2019-06-20 00:00:00

  • Noncanonical NF-κB mediates the Suppressive Effect of Neutrophil Elastase on IL-8/CXCL8 by Inducing NKRF in Human Airway Smooth Muscle.

    abstract：:Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44930

    authors： Ho SC,Wu SM,Feng PH,Liu WT,Chen KY,Chuang HC,Chan YF,Kuo LW,Lee KY

    更新日期：2017-03-21 00:00:00

  • Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism.

    abstract：:The peptide hormone oxytocin is an established regulator of social function in mammals, and dysregulated oxytocin signaling is implicated in autism spectrum disorder (ASD). Several clinical trials examining the effects of intranasal oxytocin for improving social and behavioral function in ASD have had mixed or inclusi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49617-9

    authors： Voinsky I,Bennuri SC,Svigals J,Frye RE,Rose S,Gurwitz D

    更新日期：2019-09-17 00:00:00

  • YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins.

    abstract：:E5 proteins are amongst the least understood of the Human Papillomavirus (HPV) encoded gene products. They are small, membrane-integrated proteins known to modulate a number of critical host pathways associated with pathogenesis including growth factor receptor signaling and immune evasion. Their role in the virus lif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12523

    authors： Müller M,Wasson CW,Bhatia R,Boxall S,Millan D,Goh GY,Haas J,Stonehouse NJ,Macdonald A

    更新日期：2015-08-03 00:00:00

  • Co-remediation of Pb Contaminated Soils by Heat Modified Sawdust and Festuca arundinacea.

    abstract：:This research aimed to explore the potential and mechanism of heat modified sawdust combined with Festuca arundinacea for the remediation of Pb-contaminated soil. We determined Pb concentration and biochemical indices in plants and soils, analyzed microbial communities in soil, and studied Pb distribution in subcellul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61668-x

    authors： Zhang Y,Wang X,Ji H

    更新日期：2020-03-13 00:00:00

  • Structural and electronic analysis of the atomic scale nucleation of Ag on α-Ag2WO4 induced by electron irradiation.

    abstract：:In this work, we utilise a combination of theory, computation and experiments to understand the early events related to the nucleation of Ag filaments on α-Ag2WO4 crystals, which is driven by an accelerated electron beam from an electron microscope under high vacuum. The growth process and the chemical composition and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05391

    authors： Andrés J,Gracia L,Gonzalez-Navarrete P,Longo VM,Avansi W Jr,Volanti DP,Ferrer MM,Lemos PS,La Porta FA,Hernandes AC,Longo E

    更新日期：2014-06-23 00:00:00

  • Tuneable pressure effects in graphene oxide layers.

    abstract：:Tuneable pressure effects associated with changing interlayer distances in two-dimensional graphene oxide (GO)/reduced GO (rGO) layers are demonstrated through monitoring the changes in the spin-crossover (SCO) temperature (T 1/2) of [Fe(Htrz)2(trz)](BF4) nanoparticles (NPs) incorporated in the interlayer spaces of th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12444-x

    authors： Sekimoto Y,Ohtani R,Nakamura M,Koinuma M,Lindoy LF,Hayami S

    更新日期：2017-09-22 00:00:00

  • Buffalo nasal odorant-binding protein (bunOBP) and its structural evaluation with putative pheromones.

    abstract：:Pheromones are odoriferous volatile chemical cues produced by animals for communication among conspecifics so as to regulate their social behaviors. In general, the odor compounds are recognized by receptors in the nasal cavity. Odorant-binding protein (OBP), a lipocalin family protein, mediates the air-borne odor cue...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27550-7

    authors： Muthukumar S,Rajesh D,Selvam RM,Saibaba G,Suvaithenamudhan S,Akbarsha MA,Padmanabhan P,Gulyas B,Archunan G

    更新日期：2018-06-19 00:00:00

  • The origin of sheep settlement in Western Mediterranean.

    abstract：:The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67246-5

    authors： Kandoussi A,Boujenane I,Auger C,Serranito B,Germot A,Piro M,Maftah A,Badaoui B,Petit D

    更新日期：2020-06-23 00:00:00

  • IgE-binding residues analysis of the house dust mite allergen Der p 23.

    abstract：:House dust mites (HDMs) are one of the major causes of allergies in the world. The group 23 allergen, Der p 23, from Dermatophagoides pteronyssinus, is a major allergen amongst HDM-sensitized individuals. This study aims to determine the specific immunoglobulin E (sIgE) binding frequency and IgE-binding residues of re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79820-y

    authors： Pang SL,Matta SA,Sio YY,Ng YT,Say YH,Ng CL,Chew FT

    更新日期：2021-01-13 00:00:00

  • A vacuolar sorting receptor-independent sorting mechanism for storage vacuoles in soybean seeds.

    abstract：:The seed storage proteins of soybean (Glycine max) are composed mainly of glycinin (11S globulin) and β-conglycinin (7S globulin). The subunits of glycinin (A1aB1b, A1bB2, A2B1a, A3B4, and A5A4B3) are synthesized as a single polypeptide precursor. These precursors are assembled into trimers with a random combination o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18697-w

    authors： Maruyama N,Matsuoka Y,Yokoyama K,Takagi K,Yamada T,Hasegawa H,Terakawa T,Ishimoto M

    更新日期：2018-01-18 00:00:00

  • On-Surface Synthesis within a Porphyrin Nanoring Template.

    abstract：:On-surface synthesis provides a route for the production of 1D and 2D covalently bonded polymeric structures. Such reactions are confined to the surface of a substrate and the catalytic properties of the substrate are often utilised to initiate the reaction. Recent studies have focused on the properties of various cry...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45359-w

    authors： Judd CJ,Kondratuk DV,Anderson HL,Saywell A

    更新日期：2019-06-27 00:00:00

  • Lath formation mechanisms and twinning as lath martensite substructures in an ultra low-carbon iron alloy.

    abstract：:Lath martensite is the dominant microstructural feature in quenched low-carbon Fe-C alloys. Its formation mechanism is not clear, despite extensive research. The microstructure of an Fe-0.05 C (wt.%) alloy water-quenched at various austenitizing temperatures has been investigated using transmission electron microscopy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32679-6

    authors： Ping DH,Guo SQ,Imura M,Liu X,Ohmura T,Ohnuma M,Lu X,Abe T,Onodera H

    更新日期：2018-09-24 00:00:00

  • Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.

    abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30943-3

    authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

    更新日期：2018-08-17 00:00:00

  • A Triplet Parallelizing Spiral Microfluidic Chip for Continuous Separation of Tumor Cells.

    abstract：:Inertial and deformability- based particles separations gradually attract more significant attentions. In this work, we present a hybrid chip by combining the advantages of inertial and deformability -based principle. The chip is a triplet parallelizing spiral inertial microfluidic chip interconnected with numerable t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22348-z

    authors： Chen H

    更新日期：2018-03-06 00:00:00

  • Author Correction: A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-74208-4

    authors： de Fabrègues CP,Bi S,Li H,Li G,Yang L,Xu X

    更新日期：2020-10-06 00:00:00

  • Ultralow-phase-noise millimetre-wave signal generator assisted with an electro-optics-modulator-based optical frequency comb.

    abstract：:Low-noise millimetre-wave signals are valuable for digital sampling systems, arbitrary waveform generation for ultra-wideband communications, and coherent radar systems. However, the phase noise of widely used conventional signal generators (SGs) will increase as the millimetre-wave frequency increases. Our goal has b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24621

    authors： Ishizawa A,Nishikawa T,Goto T,Hitachi K,Sogawa T,Gotoh H

    更新日期：2016-05-17 00:00:00