Periodic acid‑Schiff staining method for function detection of liver cells is affected by 2% horse serum in induction medium.

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Aberrantly expressed microRNAs (miRs) are implicated in the regulation of osteosarcoma (OS) onset and development. Therefore, key miRs in OS must be identified to develop promising and effective therapeutic targets for patients with OS. In the present study, reverse transcription‑quantitative polymerase chain reaction...

journal_title：Molecular medicine reports

authors： Zhou G,Jiang H,Ma L

更新日期：2018-09-01 00:00:00

abstract：:Systemic lupus erythematosus is a connective tissue disease characterized by autoimmune inflammation, which leads to specific and nonspecific immune disorders with the formation of various autoantibodies by activated B cells. B‑cell‑activating factor (BAFF) is secreted by macrophages and activated T cells, and is resp...

journal_title：Molecular medicine reports

authors： Ge F,Wang F,Yan X,Li Z,Wang X

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of hepatitis B virus X protein (HBx) on the expression of DNA methyltransferase (DNMT)3A/3B and suppressors of cytokine signaling‑1 (SOCS‑1), as well as promoter CpG island methylation of the SOCS‑1 gene. Stable hepatocyte cell lines expressing the HBx gene (p...

journal_title：Molecular medicine reports

authors： Fu X,Song X,Li Y,Tan D,Liu G

更新日期：2016-01-01 00:00:00

abstract：:Oxidative stress serves important roles in cardiac injury during the process of ischemia/reperfusion (I/R). Y‑box protein 1 (YB1), a member of the highly conserved Y‑box protein family, is closely associated with inflammation and stress responses by regulating gene transcription, RNA splicing and mRNA translation. How...

journal_title：Molecular medicine reports

authors： Wang S,He F,Li Z,Hu Y,Huangfu N,Chen X

更新日期：2019-06-01 00:00:00

abstract：:Saikosaponin‑d (SSd), a triterpene saponin compound derived from Bupleurum radix, has been shown to have a cytotoxic effect on various cancer cell lines. However, its effect on prostate cancer cells has remained unexplored. The present study reports the apoptosis‑inducing effect of SSd on the DU145 human prostate carc...

journal_title：Molecular medicine reports

authors： Yao M,Yang J,Cao L,Zhang L,Qu S,Gao H

更新日期：2014-07-01 00:00:00

abstract：:Reamed intramedullary nailing (RIN) is a surgical method of choice for treatment of diaphyseal fractures. This procedure affects the biological environment of bone tissue locally and systemically. This study investigated the influence of RIN on mesenchymal stem cells (MSCs) in patients with long bone fractures. The ax...

journal_title：Molecular medicine reports

authors： Sperelakis I,Tsitoura E,Koutoulaki C,Mastrodimou S,Tosounidis TH,Dimitriou H,Spandidos DA,Antoniou KM,Kontakis G

更新日期：2020-09-01 00:00:00

abstract：:Cadmium (Cd) is a heavy metal that can accumulate and cause damage to a variety of tissues and organs. The kidney is the primary target organ for Cd accumulation and toxic damage. Autophagy, which is a critical intracellular process, serves an important role in maintaining the homeostasis of the intracellular environm...

journal_title：Molecular medicine reports

authors： Liu G,Zhang K,Dong W,Tan Y,Long M,Zou H,Liu Z

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to compare the expression levels of excitatory amino acid transporters (EAATs) and growth status of piglets weaned at 10‑20 days after birth with suckling piglets. A total of 40 hybrid piglets (Landrace x Large White x Duroc) born to 40 different sows, with similar body weight were selected for...

journal_title：Molecular medicine reports

authors： Wang QJ,Cui YZ,Zhang XY,Su J

更新日期：2017-11-01 00:00:00

abstract：:Chronic hypoxia can be observed in the heart under physiological or pathophysiological states, including embryonic development or cyanotic congenital heart disease. The aim of the present study was to examine gene expression profiles of chronically hypoxic myocardium and to explore the pathophysiological mechanisms by...

journal_title：Molecular medicine reports

authors： Wu F,Gao F,He S,Xiao Y

更新日期：2019-05-01 00:00:00

abstract：:Alpinetin is a natural flavonoid widely distributed in Zingiberaceae. Previous studies have demonstrated that alpinetin markedly inhibits tumour growth. However, the molecular mechanisms underlying the antitumour effects of alpinetin are unclear. Bcl‑2‑associated X protein (Bax) tra...

journal_title：Molecular medicine reports

authors： Wang Z,Lu W,Li Y,Tang B

更新日期：2013-03-01 00:00:00

abstract：:Thyroid cancer (TC) is a frequently occurring malignant tumor with a rising steadily incidence. microRNA (miRNA/miR)‑193a‑3p is an miRNA that is associated with tumors, playing a crucial role in the genesis and progression of various cancers. However, the expression levels of miR‑193a‑3p and its molecular mechanisms i...

journal_title：Molecular medicine reports

authors： Li XJ,Wen R,Wen DY,Lin P,Pan DH,Zhang LJ,He Y,Shi L,Qin YY,Lai YH,Lai JN,Yang JL,Lai QQ,Wang J,Ma J,Yang H,Pang YY

更新日期：2020-09-01 00:00:00

abstract：:Pioglitazone (PIO) has been reported to be effective for nonalcoholic fatty liver disease (NAFLD) and alogliptin (ALO) may have efficacy against NAFLD progression in patients with type 2 diabetes mellitus (T2DM). The present study examined the effectiveness of ALO in a rodent model of NAFLD and diabetes mellitus. KK‑A...

journal_title：Molecular medicine reports

authors： Tobita H,Sato S,Yazaki T,Mishiro T,Ishimura N,Ishihara S,Kinoshita Y

更新日期：2018-05-01 00:00:00

abstract：:It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin...

journal_title：Molecular medicine reports

authors： Zhang F,Liu C,Wang L,Cao X,Wang YY,Yang JK

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymeras...

journal_title：Molecular medicine reports

authors： Zhang Y,Li Y,Wang J,Lei P

更新日期：2018-11-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is associated with an aggressive clinical history, high risk of recurrence and metastasis, and shorter patient survival due to lack of targeted therapy. In the present study, UNC0638, a chemical G9a inhibitor, was identified to suppress TNBC cell invasion and migration in vitro at ...

journal_title：Molecular medicine reports

authors： Liu XR,Zhou LH,Hu JX,Liu LM,Wan HP,Zhang XQ

更新日期：2018-02-01 00:00:00

abstract：:Induction of cardiomyocyte proliferation, the most promising approach to reverse myocardial attrition, has been gaining importance as a therapy for cardiovascular disease. Hypoxia and macrophages were previously independently reported to promote cardiomyocyte proliferation in mice. However, whether hypoxia promotes ca...

journal_title：Molecular medicine reports

authors： Liu B,Zhang HG,Zhu Y,Jiang YH,Luo GP,Tang FQ,Jian Z,Xiao YB

更新日期：2017-06-01 00:00:00

abstract：:Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic...

journal_title：Molecular medicine reports

authors： Guo J,Lin Q,Shao Y,Rong L,Zhang D

更新日期：2017-08-01 00:00:00

abstract：:Aloperine (Alo), as a quinolizidine alkaloid extracted from S. alopecuroide, has the positive activities of anti-inflammatory, anti-allergenic, antitumor and anti-viral. However, the role and mechanism of Alo in breast cancer have not been studied yet. In the present study, Alo markedly inhibited the proliferation and...

journal_title：Molecular medicine reports

authors： Tian D,Li Y,Li X,Tian Z

更新日期：2018-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:Connexin 43 (Cx43) is the main gap junction protein in astrocytes and exerts the same effects on growth inhibition in astrocytoma and glioma as microRNA-146a (miR-146a) in glioma. β2-adrenergic receptor (AR) signaling modulates Cx43 expression in myocytes via components downstream of protein kinase A (PKA) and exchang...

journal_title：Molecular medicine reports

authors： Khaksarian M,Mostafavi H,Soleimani M,Karimian SM,Ghahremani MH,Joghataee MT,Khorashadizadeh M,Aligholi H,Attari F,Hassanzadeh G

更新日期：2015-08-01 00:00:00

abstract：:Prostate cancer (PCa) is the second most common cancer amongst males worldwide. In the current study, microarray datasets GSE3325 and GSE6919 from the Gene Expression Omnibus database were screened to identify candidate genes that are associated with the progression of PCa. A total of 273 differentially expressed gene...

journal_title：Molecular medicine reports

authors： Li S,Hou J,Xu W

更新日期：2020-01-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is a key event in the development of in‑stent restenosis. Evodiamine is an indole alkaloid extracted from the Chinese medicine, evodia, and has been shown to inhibit tumor cell proliferation and protect the cardiovascular system. However, whether evodiamine affects VSMC...

journal_title：Molecular medicine reports

authors： Ge X,Chen SY,Liu M,Liang TM,Liu C

更新日期：2016-11-01 00:00:00

abstract：:LEOPARD syndrome (LS) is an autosomal dominant inherited disorder primarily caused by mutations in the PTPN11, RAF1 and BRAF genes. Characteristic features include lentigines, craniofacial dysmorphism, myocardium or valve abnormalities, eletrocardiographic conduction defects and deafness. LS, neurofibromatosis type 1,...

journal_title：Molecular medicine reports

authors： Zhang J,Shen J,Cheng R,Ni C,Liang J,Li M,Yao Z

更新日期：2016-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder, which is characterized by the selective and progressive death of dopaminergic (DA) neurons in the substantia nigra. Increasing evidence suggests that inflammation is important in the degeneration of DA neurons. The purinergic receptor subtype P2X7 recept...

journal_title：Molecular medicine reports

authors： Wang XH,Xie X,Luo XG,Shang H,He ZY

更新日期：2017-02-01 00:00:00

abstract：:A limited number of studies have revealed that adding kidneys to liver perfusion may maintain an improved physiological balance; however, the underlying mechanism remains to be elucidated. The preset study confirmed the protective role of this new model and investigated the underlying mechanisms. Methods: A total of 1...

journal_title：Molecular medicine reports

authors： Li J,Jia J,He N,Jiang L,Yu H,Li H,Peng Y,Xie H,Zhou L,Zheng S

更新日期：2019-08-01 00:00:00

abstract：:The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction...

journal_title：Molecular medicine reports

authors： Zhong QL,Liu FR,Liu DW,Peng Y,Zhang XR

更新日期：2011-03-01 00:00:00

abstract：:Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to...

journal_title：Molecular medicine reports

authors： Zhao W,Lu M,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:The impact of rare and damaging variants in genes associated with platelet function in large‑vessel ischemic stroke (LVIS) remains unknown. The aim of this study was to investigate the contribution of some of these variants to the genetic susceptibility to LVIS in Polish patients using a deep re‑sequencing of 54 selec...

journal_title：Molecular medicine reports

authors： Janicki PK,Eyileten C,Ruiz-Velasco V,Pordzik J,Czlonkowska A,Kurkowska-Jastrzebska I,Sugino S,Imamura Kawasawa Y,Mirowska-Guzel D,Postula M

更新日期：2019-04-01 00:00:00

abstract：:Cervical cancer (CC) is a frequently occurring cancer in women with a high mortality rate. Despite improvements to therapeutic strategies, the survival outcome for patients with CC remains poor. Therefore, the present study aimed to investigate the molecular mechanism underlying CC inhibition involving microRNA (miR)‑...

journal_title：Molecular medicine reports

authors： Guo Y,Luo S

更新日期：2020-12-01 00:00:00