Abstract:
:We examined two cases of primary lung cancer with sebaceous-like clear cells (SLCCs), defined as clear carcinoma cells with microvacuolated cytoplasm and centrally located nuclei, which were selected from among 281 surgical/autopsy cases of lung cancer (2/281, 0.7%). Both cases were higher stage (stage IIA and IIIA), and SLCCs were intermingled with adenocarcinoma cells of usual type. They showed minute mucin staining, no evidence of glycogen, diffuse positivity for epithelial membrane antigen and carcinoembryonic antigen, focal positivity for thyroid transcription factor-1, and negativity for Napsin A and gross cystic disease fluid protein-15. Oil red O stain and ultrastructural examination in both cases failed to reveal lipid in SLCCs. SLCCs could represent non-specific changes of lung adenocarcinoma with a relatively advanced stage, and should be discriminated from true sebaceous differentiation.
journal_name
Thorac Cancerjournal_title
Thoracic cancerauthors
Matsukuma S,Obara K,Kono T,Takeo H,Sato Kdoi
10.1111/1759-7714.12004subject
Has Abstractpub_date
2013-11-01 00:00:00pages
469-473issue
4eissn
1759-7706issn
1759-7714journal_volume
4pub_type
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