Abstract：
OBJECTIVE:Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN). DESIGN:Cyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice. Mice were treated with ALN (26 μg/kg/day) or vehicle (VEH) for loading durations of 1, 2, or 6 weeks. Changes in articular cartilage and subchondral and epiphyseal cancellous bone were analyzed using histology and microcomputed tomography. RESULTS:FVB mice exhibited thicker cartilage, a thicker SCB plate, and higher epiphyseal cancellous bone mass and tissue mineral density than B6 mice. Loading induced cartilage pathology, osteophyte formation, and SCB changes; however, lower initial SCB mass and stiffness in B6 mice did not attenuate load-induced OA severity compared to FVB mice. By contrast, FVB mice exhibited less cartilage damage, and slower-growing and less mature osteophytes. In B6 mice, inhibiting bone remodeling via ALN treatment exacerbated cartilage pathology after 6 weeks of loading, while in FVB mice, inhibiting bone remodeling protected limbs from load-induced cartilage loss. CONCLUSIONS:Intrinsically lower SCB properties were not associated with attenuated load-induced cartilage loss. However, inhibiting bone remodeling produced differential patterns of OA pathology in animals with low compared to high SCB properties, indicating that these factors do influence load-induced OA progression.
journal_name
Osteoarthritis Cartilagejournal_title
Osteoarthritis and cartilageauthors
Adebayo OO,Ko FC,Wan PT,Goldring SR,Goldring MB,Wright TM,van der Meulen MCHdoi
10.1016/j.joca.2017.08.016subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2108-2118issue
12eissn
1063-4584issn
1522-9653pii
S1063-4584(17)31169-Xjournal_volume
25pub_type
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journal_title：Osteoarthritis and cartilage
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journal_title：Osteoarthritis and cartilage
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更新日期：2007-06-01 00:00:00
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更新日期：2017-10-01 00:00:00
abstract：OBJECTIVES:To determine the in vitro effects of oxygen tension on interleukin (IL)-1beta induced nitric oxide (*NO) and prostaglandin E(2) (PGE(2)) production by bovine chondrocytes. DESIGN:Enzymatically isolated bovine chondrocytes were cultured for different periods in suspension in 21 (atmospheric), 5 or 1% (low) o...
journal_title：Osteoarthritis and cartilage
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abstract：:Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors have been found to be strong determinants of the disease. Evidence of a genetic influence of OA comes from a number of sources, including epidemiological studies of family history and family clustering, twin studies, and expl...
journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,评审
doi：10.1016/j.joca.2003.09.005
更新日期：2004-01-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,评审
doi：10.1016/j.joca.2008.01.014
更新日期：2008-06-01 00:00:00
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更新日期：2013-09-01 00:00:00
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journal_title：Osteoarthritis and cartilage
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journal_title：Osteoarthritis and cartilage
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doi：10.1016/j.joca.2007.08.001
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joca.2006.04.009
更新日期：2006-11-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joca.2014.03.006
更新日期：2014-05-01 00:00:00
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.joca.2018.12.021
更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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更新日期：2017-04-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
doi：10.1016/j.joca.2011.08.011
更新日期：2011-11-01 00:00:00
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doi：10.1016/j.joca.2013.02.002
更新日期：2013-05-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
doi：10.1016/j.joca.2007.05.014
更新日期：2008-01-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
doi：10.1053/joca.1998.0141
更新日期：1998-11-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,多中心研究
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更新日期：2008-05-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,随机对照试验
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更新日期：2016-01-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
doi：10.1016/j.joca.2009.10.009
更新日期：2010-03-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章
doi：10.1016/j.joca.2013.01.004
更新日期：2013-04-01 00:00:00
abstract：:Animal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA. Mice are particularly useful due to the plethora of genetically modified or inbred mouse strains available. The majority of available mouse models of OA use a joint injury o...
journal_title：Osteoarthritis and cartilage
pub_type： 杂志文章,评审
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更新日期：2015-10-01 00:00:00
