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Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging.

Abstract：

OBJECTIVE:To characterise longitudinal changes in joint integrity and cartilage volume in vivo in the guinea pig spontaneous osteoarthritis (OA) model by magnetic resonance imaging (MRI). METHODS:Guinea pigs knee were imaged in vivo by high-resolution three-dimensional (3D) MRI between the ages of 3 and 12 months. Image analysis was performed to assess qualitative knee joint changes between 3 and 12 months (n=16) and quantitative volumetric changes of the medial tibial cartilage between 9 and 12 months (n=7). After imaging, animals were killed and knees were assessed macroscopically and histologically. RESULTS:From 3 to 6 months qualitative observation by MRI and histopathology indicated localised cartilage swelling on the medial tibial plateau. At 6 months, bone cysts had developed in the epiphysis. At 9 months, we observed by MRI and histopathology, fragmentation of the medial tibial cartilage in areas not protected by the meniscus. Cartilage degeneration had intensified at 12 months with evidence of widespread loss of cartilage throughout the tibial plateau. Segmentation of the MR cartilage images showed a 36% loss of volume between 9 and 12 months. CONCLUSIONS:We have achieved 3D image acquisition and segmentation of knee cartilage in a guinea pig model of chronic OA, which permits measurements previously only possible in man. High resolution and short acquisition time allowed qualitative longitudinal characterisation of the entire knee joint and enabled us to quantify for the first time longitudinal tibial cartilage volume loss associated with disease progression.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Tessier JJ,Bowyer J,Brownrigg NJ,Peers IS,Westwood FR,Waterton JC,Maciewicz RA

doi

10.1016/s1063-4584(03)00162-6

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

845-53

issue

12

eissn

1063-4584

issn

1522-9653

pii

S1063458403001626

journal_volume

11

pub_type

杂志文章

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