Brain and skull base MRI findings in patients with Ollier-Maffucci disease: A series of 12 patient-cases.

Abstract:

OBJECTIVES:To estimate the prevalence rate of silent cranial and intracranial lesions in a series of Ollier-Maffucci patients. PATIENTS AND METHODS:Cerebral MRI was routinely performed in Ollier-Maffucci patients followed-up in our tertiary centers. Patients with previous history of skull base or intracranial tumors were excluded from the study. Clinical and radiological datas were retrospectively collected. The occurrence rate and nature of abnormal cerebral MRIs were determined. RESULTS:Twelve patients were included. A glioma-looking lesion was found in one patient (8%), while skull base lesions were evidenced in 3 others (25%). A regular MRI follow-up was recommended for each patient, with a time interval varying between 1year and 3years depending on the likelihood of tumoral evolutivity, as infered from the MRI findings. CONCLUSION:All in all, the high rate of intracranial and skull base lesions with a malignant potential warrants to include cerebral MRI in the routine follow-up of Ollier-Maffucci patients.

journal_name

Clin Neurol Neurosurg

authors

Mandonnet E,Anract P,Martin E,Roujeau T,Spena G,Cormier-Daire V,Duffau H,Baujat G,Collaborators.

doi

10.1016/j.clineuro.2017.07.011

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

147-151

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(17)30206-8

journal_volume

160

pub_type

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