ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.

abstract：:In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics...

journal_title：Scientific reports

authors： Giddey AD,de Kock E,Nakedi KC,Garnett S,Nel AJ,Soares NC,Blackburn JM

更新日期：2017-03-06 00:00:00

abstract：:Technological advances have made it possible to examine dental resin composites using 3D nanometer resolution. This investigation aims to characterize existing dental nano-hybrid and micro-hybrid resin composites through comparing and contrasting nano-computed tomography (nano-CT) with micro-CT and high-resolution SEM...

journal_title：Scientific reports

authors： Haugen HJ,Qasim SB,Matinlinna JP,Vallittu P,Nogueira LP

更新日期：2020-09-23 00:00:00

abstract：:The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...

journal_title：Scientific reports

authors： Cho SH,Choe YS,Park S,Kim YJ,Kim HJ,Jang H,Kim SJ,Kim JP,Jung YH,Kim BC,Na DL,Moon SH,Seo SW

更新日期：2020-09-11 00:00:00

abstract：:High-k dielectric oxides are supposedly ideal gate-materials for ultra-high doping in graphene and other 2D-crystals. Here, we report a temperature-dependent electronic transport study on chemical vapor deposited-graphene gated with SrTiO₃ (STO) thin film substrate. At carrier densities away from charge neutrality poi...

journal_title：Scientific reports

authors： Saha S,Kahya O,Jaiswal M,Srivastava A,Annadi A,Balakrishnan J,Pachoud A,Toh CT,Hong BH,Ahn JH,Venkatesan T,Özyilmaz B

更新日期：2014-08-22 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:The relationship between the grain size of as-cast and cold rolled 16%Cr ferritic stainless steel and the surface roughness defect, called ridging during forming was investigated. The ridging height corresponded to the grain size of the as-cast sample. The nitrogen content of 140 ppm yielded the minimum grain size and...

journal_title：Scientific reports

authors： Lee MH,Kim R,Park JH

更新日期：2019-04-24 00:00:00

abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...

journal_title：Scientific reports

authors： Ostanin I,Safonov A,Oseledets I

更新日期：2017-12-11 00:00:00

abstract：:The first instar larva of a species of the Australian endemic genus Aenigmetopia Malloch is described for the first time, along with the first instar larvae of three other Australian species representing the genera Amobia Robineau-Desvoidy and Protomiltogramma Townsend. Larval morphology was analysed using a combinati...

journal_title：Scientific reports

authors： Szpila K,Walczak K,Johnston NP,Pape T,Wallman JF

更新日期：2021-01-29 00:00:00

abstract：:Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. However, searching for mutually ex...

journal_title：Scientific reports

authors： Pulido-Tamayo S,Weytjens B,De Maeyer D,Marchal K

更新日期：2016-11-03 00:00:00

abstract：:In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240-360 in total number as estimated by scanning electron microscopy (SEM). There is not an easy way to visualize all taste buds in chickens. Here, we report a highly efficient method for labeling chicken taste buds in...

journal_title：Scientific reports

authors： Rajapaksha P,Wang Z,Venkatesan N,Tehrani KF,Payne J,Swetenburg RL,Kawabata F,Tabata S,Mortensen LJ,Stice SL,Beckstead R,Liu HX

更新日期：2016-11-17 00:00:00

abstract：:Wave propagation is an important characteristic for pattern formation and pattern dynamics. To date, various waves in homogeneous media have been investigated extensively and have been understood to a great extent. However, the wave behaviors in heterogeneous media have been studied and understood much less. In this w...

journal_title：Scientific reports

authors： Cui X,Huang X,Hu G

更新日期：2016-05-04 00:00:00

abstract：:Fiber lasers with flexible spectral manipulation property could provide a flexible tool for scenes where the temporal coherence property accounts, for example, coherent sensing/communication and nonlinear frequency conversion. Due to the good laser performance and relative simplicity of implementation, random fiber la...

journal_title：Scientific reports

authors： Ye J,Xu J,Song J,Wu H,Zhang H,Wu J,Zhou P

更新日期：2018-02-01 00:00:00

abstract：:TET aminopeptidases are dodecameric particles shared in the three life domains involved in various biological processes, from carbon source provider in archaea to eye-pressure regulation in humans. Each subunit contains a dinuclear metal site (M1 and M2) responsible for the enzyme catalytic activity. However, the role...

journal_title：Scientific reports

authors： Colombo M,Girard E,Franzetti B

更新日期：2016-02-08 00:00:00

abstract：:Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), a green tea extract, was found to inhibit hIAPP fibrillation. However, the inhibition mechanism and the conformational distribution of the s...

journal_title：Scientific reports

authors： Mo Y,Lei J,Sun Y,Zhang Q,Wei G

更新日期：2016-09-13 00:00:00

abstract：:Membrane-embedded proteins are critical to the establishment, survival and persistence in the host of the Lyme disease bacterium Borrelia burgdorferi (Bb), but to date, there are no solved structures of transmembrane proteins representing these attractive therapeutic targets. All available structures from the genus Bo...

journal_title：Scientific reports

authors： Robertson KE,Truong CD,Craciunescu FM,Yang JH,Chiu PL,Fromme P,Hansen DT

更新日期：2019-11-26 00:00:00

abstract：:Ocean acidification is predicted to have detrimental effects on many marine organisms and ecological processes. Despite growing evidence for direct impacts on specific species, few studies have simultaneously considered the effects of ocean acidification on individuals (e.g. consequences for energy budgets and resourc...

journal_title：Scientific reports

authors： Harvey BP,McKeown NJ,Rastrick SP,Bertolini C,Foggo A,Graham H,Hall-Spencer JM,Milazzo M,Shaw PW,Small DP,Moore PJ

更新日期：2016-01-29 00:00:00

abstract：:Pressure therapy has been proved to be an effective treatment for hypertrophic scars in a clinical setting. However, evidence-based data are controversial and the precise mechanism of action of this technique remains unknown. The aim of this study was to investigate the potential molecular mechanisms of pressure thera...

journal_title：Scientific reports

authors： Liu B,Liu Y,Wang L,Hou C,An M

更新日期：2018-08-07 00:00:00

abstract：:Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. ...

journal_title：Scientific reports

authors： Liu J,Li R,Liu T,Rausch-Fan X,Wang M

更新日期：2017-08-01 00:00:00

abstract：:Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...

journal_title：Scientific reports

authors： Mackenzie LE,Goode JA,Vakurov A,Nampi PP,Saha S,Jose G,Millner PA

更新日期：2018-01-18 00:00:00

abstract：:We performed a systematic investigation on the dynamic behavior of conduction filaments (CFs) in WO₃-x-based devices. It was found that the electric forming produced an electric structure consisted of a conductive channel (virtual cathode) started from cathode and an insulating band surrounding anode. Both the virtual...

journal_title：Scientific reports

authors： Hong DS,Chen YS,Li Y,Yang HW,Wei LL,Shen BG,Sun JR

更新日期：2014-02-11 00:00:00

abstract：:The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...

journal_title：Scientific reports

authors： Gutiérrez JS,Sabat P,Castañeda LE,Contreras C,Navarrete L,Peña-Villalobos I,Navedo JG

更新日期：2019-11-26 00:00:00

abstract：:We fabricated multi-layered graphene/MoS2 heterostructured devices by positioning mechanically exfoliated bulk graphite and single-crystalline 2H-MoS2 onto Au metal pads on a SiO2/Si substrate via a contamination-free dry transfer technique. We also studied the electrical transport properties of Au/MoS2 junction devic...

journal_title：Scientific reports

authors： Qiu D,Kim EK

更新日期：2015-09-03 00:00:00

abstract：:Concurrent generation and mixing phenomenon of thermoacoustic (TA) and magnetoacoustic (MA) waves in water are predicted and observed. A theory unifying TA and MA is further put forward to analyze it. By scaling down the radio frequency in thermoacoustics to the low mega Hertz range and by incorporating appropriately ...

journal_title：Scientific reports

authors： Feng X,Gao F,Kishor R,Zheng Y

更新日期：2015-06-26 00:00:00

abstract：:Triazophos (TAP) is a widely used phosphorus pesticide in China that possesses a potential risk for water pollution. We have studied the removal efficiency of TAP using pilot-scale horizontal subsurface flow constructed wetlands (HSCWs) as well as the contribution of plants, substrates and other pathways to its remova...

journal_title：Scientific reports

authors： Wu J,Li Z,Wu L,Zhong F,Cui N,Dai Y,Cheng S

更新日期：2017-07-14 00:00:00

abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...

journal_title：Scientific reports

authors： Harter AK,Saxena A,Joglekar YN

更新日期：2018-08-13 00:00:00

abstract：:Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...

journal_title：Scientific reports

authors： Sakuma T,Ochiai H,Kaneko T,Mashimo T,Tokumasu D,Sakane Y,Suzuki K,Miyamoto T,Sakamoto N,Matsuura S,Yamamoto T

更新日期：2013-11-29 00:00:00

abstract：:Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue da...

journal_title：Scientific reports

authors： Garcia-Gonzalez D,Race NS,Voets NL,Jenkins DR,Sotiropoulos SN,Acosta G,Cruz-Haces M,Tang J,Shi R,Jérusalem A

更新日期：2018-07-06 00:00:00

abstract：:Smoking aggravates HIV-1 pathogenesis and leads to decreased responses to antiretroviral therapy. In this study, we aim to find a molecular mechanism that would explain smoking-induced HIV-1 replication. Benzo(a)pyrene (BaP), a major carcinogen in cigarette, requires metabolic activation through cytochrome P450s (CYPs...

journal_title：Scientific reports

authors： Ranjit S,Sinha N,Kodidela S,Kumar S

更新日期：2018-07-10 00:00:00

abstract：:The methylotrophic yeast Komagataella phaffii (Pichia pastoris) has been developed into a highly successful system for heterologous protein expression in both academia and industry. However, overexpression of recombinant protein often leads to severe burden on the physiology of K. phaffii and triggers cellular stress....

journal_title：Scientific reports

authors： Yu XW,Sun WH,Wang YZ,Xu Y

更新日期：2017-11-24 00:00:00

abstract：:Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...

journal_title：Scientific reports

authors： Pelz PM,Qiu WX,Bücker R,Kassier G,Miller RJD

更新日期：2017-08-29 00:00:00