The Sec61 translocon limits IRE1α signaling during the unfolded protein response.

abstract：:Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the parent. Lamina-associated domains (LADs) are regions of repressi...

journal_title：eLife

authors： Poleshko A,Smith CL,Nguyen SC,Sivaramakrishnan P,Wong KG,Murray JI,Lakadamyali M,Joyce EF,Jain R,Epstein JA

更新日期：2019-10-01 00:00:00

abstract：:Deinococcus radiodurans (DR) survives in the presence of hundreds of double-stranded DNA (dsDNA) breaks by efficiently repairing such breaks. RecO, a protein that is essential for the extreme radioresistance of DR, is one of the major recombination mediator proteins in the RecA-loading process in the RecFOR pathway. H...

journal_title：eLife

authors： Hwang J,Kim JY,Kim C,Park S,Joo S,Kim SK,Lee NK

更新日期：2020-04-16 00:00:00

abstract：:The piriform cortex (PCx) receives direct input from the olfactory bulb (OB) and is the brain's main station for odor recognition and memory. The transformation of the odor code from OB to PCx is profound: mitral and tufted cells in olfactory glomeruli respond to individual odorant molecules, whereas pyramidal neurons...

journal_title：eLife

authors： Kumar A,Schiff O,Barkai E,Mel BW,Poleg-Polsky A,Schiller J

更新日期：2018-12-21 00:00:00

abstract：:Synonymous codon usage (SCU) varies widely among human genes. In particular, genes involved in different functional categories display a distinct codon usage, which was interpreted as evidence that SCU is adaptively constrained to optimize translation efficiency in distinct cellular states. We demonstrate here that SC...

journal_title：eLife

authors： Pouyet F,Mouchiroud D,Duret L,Sémon M

更新日期：2017-08-15 00:00:00

abstract：:In the fruit fly optic lobe, T4 and T5 cells represent the first direction-selective neurons, with T4 cells responding selectively to moving brightness increments (ON) and T5 cells to brightness decrements (OFF). Both T4 and T5 cells comprise four subtypes with directional tuning to one of the four cardinal directions...

journal_title：eLife

authors： Haag J,Mishra A,Borst A

更新日期：2017-08-22 00:00:00

abstract：:Transposable elements (TEs), the movement of which can damage the genome, are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in the sperm companion cell - vegetative cell (VC) - of the flowering plant Arabidopsis thaliana. However, the extent and mechanism of this activation are unknown. Here w...

journal_title：eLife

authors： He S,Vickers M,Zhang J,Feng X

更新日期：2019-05-28 00:00:00

abstract：:Microbial fitness screens are a key technique in functional genomics. We present an all-in-one solution, pyphe, for automating and improving data analysis pipelines associated with large-scale fitness screens, including image acquisition and quantification, data normalisation, and statistical analysis. Pyphe is versat...

journal_title：eLife

authors： Kamrad S,Rodríguez-López M,Cotobal C,Correia-Melo C,Ralser M,Bähler J

更新日期：2020-06-16 00:00:00

abstract：:Evolution persistently undermines vector control programs through insecticide resistance. Here we propose a novel strategy which instead exploits evolution to generate and sustain new control tools. Effective spatial repellents are needed to keep vectors out of houses. Our approach generates such new repellents by com...

journal_title：eLife

authors： Lynch PA,Boots M

更新日期：2016-10-25 00:00:00

abstract：:Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H...

journal_title：eLife

authors： Johnson WL,Yewdell WT,Bell JC,McNulty SM,Duda Z,O'Neill RJ,Sullivan BA,Straight AF

更新日期：2017-08-01 00:00:00

abstract：:The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the spiral-shaped sensory epithelium. Aiding such precise cellular p...

journal_title：eLife

authors： Prajapati-DiNubila M,Benito-Gonzalez A,Golden EJ,Zhang S,Doetzlhofer A

更新日期：2019-06-12 00:00:00

abstract：:Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative trait loci (eQTLs) remain unidentified. We mapped eQTLs by transcriptome sequencing in 1012 yeast segregants. The resulting eQTLs accounted for over 70% of the h...

journal_title：eLife

authors： Albert FW,Bloom JS,Siegel J,Day L,Kruglyak L

更新日期：2018-07-17 00:00:00

abstract：:The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identif...

journal_title：eLife

authors： Xiong Z,Dankova G,Howe LJ,Lee MK,Hysi PG,de Jong MA,Zhu G,Adhikari K,Li D,Li Y,Pan B,Feingold E,Marazita ML,Shaffer JR,McAloney K,Xu SH,Jin L,Wang S,de Vrij FM,Lendemeijer B,Richmond S,Zhurov A,Lewis S,Sharp

更新日期：2019-11-26 00:00:00

abstract：:The time it takes a sound to travel from source to ear differs between the ears and creates an interaural delay. It varies systematically with spatial direction and is generally modeled as a pure time delay, independent of frequency. In acoustical recordings, we found that interaural delay varies with frequency at a f...

journal_title：eLife

authors： Benichoux V,Fontaine B,Franken TP,Karino S,Joris PX,Brette R

更新日期：2015-04-27 00:00:00

abstract：:Responses of sensory neurons are often modeled using a weighted combination of rectified linear subunits. Since these subunits often cannot be measured directly, a flexible method is needed to infer their properties from the responses of downstream neurons. We present a method for maximum likelihood estimation of subu...

journal_title：eLife

authors： Shah NP,Brackbill N,Rhoades C,Kling A,Goetz G,Litke AM,Sher A,Simoncelli EP,Chichilnisky EJ

更新日期：2020-03-09 00:00:00

abstract：:Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We fu...

journal_title：eLife

authors： Liu X,Wang X,Yang X,Liu S,Jiang L,Qu Y,Hu L,Ouyang Q,Tang C

更新日期：2015-01-14 00:00:00

abstract：:A key challenge in antibiotic stewardship is figuring out how to use antibiotics therapeutically without promoting the evolution of antibiotic resistance. Here, we demonstrate proof of concept for an adjunctive therapy that allows intravenous antibiotic treatment without driving the evolution and onward transmission o...

journal_title：eLife

authors： Morley VJ,Kinnear CL,Sim DG,Olson SN,Jackson LM,Hansen E,Usher GA,Showalter SA,Pai MP,Woods RJ,Read AF

更新日期：2020-12-01 00:00:00

abstract：:Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but the role of the ze...

journal_title：eLife

authors： Pelliccia JL,Jindal GA,Burdine RD

更新日期：2017-11-15 00:00:00

abstract：:The training of PhD students and early-career scientists is largely an apprenticeship in which the trainee associates with an expert to become an independent scientist. But when is a PhD student ready to graduate, a postdoctoral scholar ready for an independent position, or an early-career scientist ready for advanced...

journal_title：eLife

authors： Verderame MF,Freedman VH,Kozlowski LM,McCormack WT

更新日期：2018-05-31 00:00:00

abstract：:Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven by daily cues whose timing varies with the seasons. The principles that determine how circadian clocks align to these external cycles are not well u...

journal_title：eLife

authors： Leypunskiy E,Lin J,Yoo H,Lee U,Dinner AR,Rust MJ

更新日期：2017-07-07 00:00:00

abstract：:We analyzed 2898 scientific papers published between 1995 and 2017 in which two or more authors shared the first author position. For papers in which the first and second authors made equal contributions, mixed-gender combinations were most frequent, followed by male-male and then female-female author combinations. Fo...

journal_title：eLife

authors： Broderick NA,Casadevall A

更新日期：2019-01-29 00:00:00

abstract：:Dendritic spines are specialized postsynaptic structures that transduce presynaptic signals, are regulated by neural activity and correlated with learning and memory. Most studies of spine function have focused on the mammalian nervous system. However, spine-like protrusions have been reported in C. elegans (Philbrook...

journal_title：eLife

authors： Cuentas-Condori A,Mulcahy B,He S,Palumbos S,Zhen M,Miller DM 3rd

更新日期：2019-10-04 00:00:00

abstract：:During embryogenesis, chromatin accessibility profiles control lineage-specific gene expression by modulating transcription, thus impacting multipotent progenitor states and subsequent fate choices. Subsets of cardiac and pharyngeal/head muscles share a common origin in the cardiopharyngeal mesoderm, but the chromatin...

journal_title：eLife

authors： Racioppi C,Wiechecki KA,Christiaen L

更新日期：2019-11-20 00:00:00

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental mechanism of this lattice structure. We found that this structure emerged early during axon...

journal_title：eLife

authors： Zhong G,He J,Zhou R,Lorenzo D,Babcock HP,Bennett V,Zhuang X

更新日期：2014-12-23 00:00:00

abstract：:PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and long-term memory i...

journal_title：eLife

authors： Tsokas P,Hsieh C,Yao Y,Lesburguères E,Wallace EJC,Tcherepanov A,Jothianandan D,Hartley BR,Pan L,Rivard B,Farese RV,Sajan MP,Bergold PJ,Hernández AI,Cottrell JE,Shouval HZ,Fenton AA,Sacktor TC

更新日期：2016-05-17 00:00:00

abstract：:Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...

journal_title：eLife

authors： Leinwand SG,Yang CJ,Bazopoulou D,Chronis N,Srinivasan J,Chalasani SH

更新日期：2015-09-22 00:00:00

abstract：:Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation in vivo in murine pr...

journal_title：eLife

authors： Zhang S,Macias-Garcia A,Ulirsch JC,Velazquez J,Butty VL,Levine SS,Sankaran VG,Chen JJ

更新日期：2019-04-29 00:00:00

abstract：:Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission yeast that express o...

journal_title：eLife

authors： Yadav RK,Jablonowski CM,Fernandez AG,Lowe BR,Henry RA,Finkelstein D,Barnum KJ,Pidoux AL,Kuo YM,Huang J,O'Connell MJ,Andrews AJ,Onar-Thomas A,Allshire RC,Partridge JF

更新日期：2017-07-18 00:00:00

abstract：:Two different cell signals often affect transcription of the same gene. In such cases, it is natural to ask how the combined transcriptional response compares to the individual responses. The most commonly used mechanistic models predict additive or multiplicative combined responses, but a systematic genome-wide evalu...

journal_title：eLife

authors： Sanford EM,Emert BL,Coté A,Raj A

更新日期：2020-12-07 00:00:00

abstract：:Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...

journal_title：eLife

authors： Tikhonov M

更新日期：2016-06-16 00:00:00