What fertility specialists should know about the vaginal microbiome: a review.


:Our understanding of the composition of the microbial communities that inhabit the human body, known as the 'microbiome', is aided by the development of non-culture-dependent DNA sequencing. It is increasingly apparent that the balance of microbial species greatly affects the health of the host. Disturbances in the composition of bacterial communities have been shown to contribute to various disease states, and there is a growing body of evidence that the vaginal microbiota, which is unique to each woman, plays an important role in determining many facets of reproductive health. The purpose of this review is to investigate what is currently known about the composition of the vaginal microbiome, including what is considered 'normal' in terms of bacterial species and abundance. We will investigate the impact of vaginal microbiome composition on reproductive outcomes within the context of infertility treatments, and the implications this has been shown to have on assisted reproductive technology procedures.


Reprod Biomed Online


García-Velasco JA,Menabrito M,Catalán IB




Has Abstract


2017-07-01 00:00:00














  • Three concepts of cloning in human beings.

    abstract::Human cloning, organ cloning and tissue cloning are various types of cloning that occur at different levels with different methodologies. According to three standards of terminology for an embryo (fertilization through germ cells, development in the uterus and having the potential to produce a human life), tissue clon...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Cui KH

    更新日期:2005-07-01 00:00:00

  • Capacitation and acrosome reaction changes α-tubulin immunodistribution in human spermatozoa.

    abstract::Tubulin is a protein constituent of cytoskeletal microtubules, closely related to sperm motility. However, the changes in tubulin distribution following capacitation and acrosome reaction are poorly understood. This study immunolocalized and quantified the expression of α-tubulin in fresh, capacitated and acrosome-rea...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Francou MM,Ten J,Bernabeu R,De Juan J

    更新日期:2014-02-01 00:00:00

  • Efficiency of an automatic dehydrated carrier for the vitrification of human embryos derived from three pronuclei fertilized zygotes.

    abstract::The efficiency of a new vitrification technique using embryos obtained after abnormal fertilization was assesed. A total of 100 embryos were vitrified, 48 with the automatic dehydrated carrier (ADC) technique and 52 with cryotop. The survival rates in ADC and cryotop groups were similar (85.4% versus 92.3%). The loss ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Zhang X,Liu J,Huang G

    更新日期:2015-02-01 00:00:00

  • Morphokinetic parameters of ICSI tripronucleated embryos observed using time lapse.

    abstract::Time-lapse analysis of tripronucleated zygotes obtained in ICSI cycles showed that 75.4% cleaved into embryos. These embryos subsequently demonstrated slower developmental kinetics than normally fertilized embryos. ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Lammers J,Splingart C,Barrière P,Fréour T

    更新日期:2014-05-01 00:00:00

  • Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination.

    abstract::More than 17,000 intrauterine insemination (lUI) cycles were analysed retrospectively with respect to outcome according to differing aetiologies of infertility. The quantity and motility of spermatozoa in the final preparation used for insemination had a positive effect on the outcome, as classically observed in the p...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Belloc S,Cohen-Bacrie P,Benkhalifa M,Cohen-Bacrie M,De Mouzon J,Hazout A,Ménézo Y

    更新日期:2008-09-01 00:00:00

  • Development and characterization of an endometrial tissue culture system.

    abstract::A culture system has been developed for pieces of whole endometrium, comprising many different cell types. The system maintains the integrity of all compartments important for tissue function and allows functional studies of the human endometrium. Endometrial biopsy strips were collected from fertile women. The strips...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Stavreus-Evers A,Hovatta O,Eriksson H,Landgren BM

    更新日期:2003-09-01 00:00:00

  • Evaluation of syphilis serostatus on the safety of IVF treatment.

    abstract::An increasing number of infertile syphilis-infected individuals have turned to assisted reproductive technology; however, the safety of syphilis carrier serostatus on IVF and embryo transfer outcomes has not been evaluated. Data from 482 patients who delivered singletons were analysed. In the retrospective study, the ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Lin S,Li R,Huang S,Zhao L,Li M,Li J,Zhu J,Zheng X,Huang J,Liu P,Qiao J

    更新日期:2014-12-01 00:00:00

  • Strengths and pitfalls of Canadian gamete and embryo donor registries: searching for beneficent solutions.

    abstract::For the gamete and embryo donation community, it is well recognized that the implementation of a gamete and embryo donor registry (GEDR) represents a good initiative to ensure the best possible health conditions for donor-conceived individuals. Be they national, institutional or independent, GEDR can play a major role...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Couture V,Dubois MA,Drouin R,Moutquin JM,Bouffard C

    更新日期:2014-03-01 00:00:00

  • Male infertility: role of genetic background.

    abstract::Male infertility represents one of the clearest examples of a complex disease with a substantial genetic basis. Numerous male mouse models, mutation screening and association studies reported over the last few years reveal the high prevalence of genetic causes of spermatogenic impairment, accounting for 10-15% of seve...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: Ferlin A,Raicu F,Gatta V,Zuccarello D,Palka G,Foresta C

    更新日期:2007-06-01 00:00:00

  • Are Catholic universities giving up reproductive medicine?

    abstract::The Catholic Church has established a large number of universities worldwide. A dozen have schools of medicine and the impact of church doctrine on reproductive medicine appears widely disparate between some medical schools at Catholic universities in Europe and the rest of the world. The pressure of the Vatican on th...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Brosens I

    更新日期:2007-12-01 00:00:00

  • Emerging technologies for the molecular study of infertility, and potential clinical applications.

    abstract::The techniques currently used to treat infertility cases are quite limited in their capabilities, due to an incomplete understanding of the molecular activities of germ cells. Fortunately, several technologies are presently being researched that should aid the understanding of the various molecular causes of germ cell...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: Varghese AC,Goldberg E,Bhattacharyya AK,Agarwal A

    更新日期:2007-10-01 00:00:00

  • Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review.

    abstract::Gonadotrophin-releasing hormone (GnRH) antagonists suppress gonadotrophin secretion resulting in dramatic reduction in treatment cycle duration. Assuming comparable clinical outcomes, these benefits may justify changing the standard long GnRH agonist protocol to GnRH antagonist regimens. To evaluate the evidence, data...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: Al-Inany HG,Abou-Setta AM,Aboulghar M

    更新日期:2007-05-01 00:00:00

  • Patentability of time-lapse monitoring has nothing to do with human dignity: A response to Alain Pottage.

    abstract::In December 2017, Alain Pottage published an article denying the patentability of a technique called Time-Lapse Monitoring (TLM). His argument was that this procedure, like all other embryo selection procedures, fails to respect human dignity. Here, we argue that this statement is mistaken because assisted reproductiv...

    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章


    authors: Beriain IM,Sanz B

    更新日期:2018-10-01 00:00:00

  • Distinct changes in the proteome profile of endometrial tissues in polycystic ovary syndrome compared with healthy fertile women.

    abstract:RESEARCH QUESTION:What is the molecular basis of infertility related to uterine dysfunction in women with polycystic ovary syndrome (PCOS)? DESIGN:In this study, differences in protein expression between PCOS and normal endometrium were identified using a proteomic approach based on two-dimensional electrophoresis (2-...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Amjadi F,Mehdizadeh M,Ashrafi M,Nasrabadi D,Taleahmad S,Mirzaei M,Gupta V,Salekdeh GH,Aflatoonian R

    更新日期:2018-08-01 00:00:00

  • Removal of cervical mucus: effect on pregnancy rates in IVF/ICSI.

    abstract::Cervical mucus may cover the embryo transfer catheter during passage of the cervical canal, interfering with the correct placement of the embryo(s) into the uterine cavity. The effect of removal of cervical mucus prior to embryo transfer in IVF/ intracytoplasmic sperm injection (ICSI) on live birth rate was studied. T...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验


    authors: Visschers BA,Bots RS,Peeters MF,Mol BW,van Dessel HJ

    更新日期:2007-09-01 00:00:00

  • Perivitelline threads in cleavage-stage human embryos: observations using time-lapse imaging.

    abstract::Time-lapse imaging of the human preimplantation embryo in vitro has revealed a transient phenomenon involving the appearance of perivitelline threads, commonly observed at the two-cell stage. These threads span the perivitelline space, arising at the specific area where the cytoplasmic membrane contacts the zona pellu...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Kellam L,Pastorelli LM,Bastida AM,Senkbeil A,Montgomery S,Fishel S,Campbell A

    更新日期:2017-12-01 00:00:00

  • Fundamentals of cryobiology in reproductive medicine.

    abstract::The aim of this review will be to provide a basic understanding of the biophysical processes that accompany the application of cryopreservation in reproductive medicine. The ability to store cells in 'suspended animation' outside the body has become a keystone practice in the development of many modern clinical therap...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: Fuller B,Paynter S

    更新日期:2004-12-01 00:00:00

  • The role of in-vivo and in-vitro maturation time on ooplasmic dysmaturity.

    abstract::This study investigates whether the timing of in-vivo and in-vitro maturation influences ooplasmic dysmaturity. This is a retrospective comparison of intracytoplasmic sperm injection (ICSI) cycles (index cycles) complicated by complete fertilization failure (CFF) to cycles with successful fertilization in the same pat...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Pereira N,Neri QV,Lekovich JP,Palermo GD,Rosenwaks Z

    更新日期:2016-04-01 00:00:00

  • Outlook: Roles of FSH and LH during the follicular phase: insight into natural cycle IVF.

    abstract::A mounting interest in natural cycle IVF has challenged the medical community to better understand the mechanisms controlling the follicular phase and ovulation in particular, in an effort to optimize this procedure and its outcome. For practical reasons, the advancement of the follicular phase in the menstrual cycle ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: de Ziegler D,Fraisse T,de Candolle G,Vulliemoz N,Bellavia M,Colamaria S

    更新日期:2007-11-01 00:00:00

  • Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output: a randomized controlled study.

    abstract::In nature, HCG is secreted by the implanting embryo from peri-implantation and onwards. In contrast, LH is mandatory for steroidogenesis and follicular development during the follicular phase, working in synergy with FSH. Moreover, LH is mandatory for the function of the corpus luteum. Although LH and HCG bind to the ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验


    authors: Alsbjerg B,Elbaek HO,Laursen RJ,Povlsen BB,Haahr T,Yding Andersen C,Humaidan P

    更新日期:2017-08-01 00:00:00

  • Stem cell research policies: who's afraid of complicity?

    abstract::Countries that oppose embryo destruction for research purposes can forbid the production of human embryonic stem cell lines on their territory, but these cell lines are nevertheless produced abroad. Therefore, these countries also need to determine if their position on embryo destruction allows them to import and use ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Mertes H,Pennings G

    更新日期:2009-01-01 00:00:00

  • The Bertarelli Foundation's actions in the field of multiple gestations.

    abstract::The Bertarelli Foundation aims to promote understanding of infertility. Two international conferences in 1999 and 2002 have highlighted the importance of multiple gestations, which have been recognized as a major problem associated with assisted reproductive technologies and ovulation induction therapies. For this rea...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Germond M

    更新日期:2007-01-01 00:00:00

  • Seven out of 10 couples treated by IVF achieve parenthood following either treatment, natural conception or adoption.

    abstract::The aim of this study was to explore the achievement of parenthood 8 years after starting IVF, considering multiple pathways to parenthood during and after IVF treatment. Medical data on 6507 couples who began IVF between 2000 and 2002 were obtained from the databases of eight French IVF centres. Information on long-t...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Troude P,Santin G,Guibert J,Bouyer J,de La Rochebrochard E,DAIFI Group.

    更新日期:2016-11-01 00:00:00

  • Follitropin-alfa for ovarian stimulation during assisted reproduction treatment: a national collaborative study.

    abstract::This prospective, observational study investigated the efficacy and tolerability of follitropin-alfa for ovarian stimulation in routine clinical practice. The study involved a large, unselected population of women. Stimulation parameters and treatment outcomes were documented for 767 patients who underwent a total of ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Katzorke T,Verhoeven HC,Blechschmidt J,Köhler M,Kelly E

    更新日期:2001-01-01 00:00:00

  • Beyond the 'embryo question': human embryonic stem cell ethics in the context of biomaterial donation in the UK.

    abstract::Discussion about the ethics of human embryonic stem cell (ESC) research in the UK tends to be dominated by the divisive and potentially intractable issue of the moral status of the embryo. This can have the effect of silencing or marginalizing other concerns, especially in the context of public engagement with science...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审


    authors: Bahadur G,Morrison M,Machin L

    更新日期:2010-12-01 00:00:00

  • Anogenital distance in newborn infants conceived by assisted reproduction and natural conception.

    abstract:RESEARCH QUESTION:Does anogenital distance (AGD) differ in newborn infants conceived through assisted reproduction technology (ART) compared with those conceived naturally? DESIGN:This case-control study looked at anthropometric and anogenital measurements in 247 male and 200 female newborns born after ART (n = 121) o...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Ercin S,Ertas S,Dundar O,Oktem O,Yakin K

    更新日期:2020-09-01 00:00:00

  • Effect of phenobarbital on the induction of glutathione S-transferases in rat testis.

    abstract::Glutathione S-transferases are a family of multifunctional proteins involved in intracellular transport processes and drug detoxication. In rats, these enzymes are dimeric proteins, and exist as cytosolic and microsomal proteins. The affinity purified rat testicular glutathione S-transferases are comprised of four sub...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Thyagaraju K,Vasundhara K,Hemavathi B,Devi KN

    更新日期:2004-01-01 00:00:00

  • Moral attitudes and beliefs among couples pursuing PGD for sex selection.

    abstract::This article reports the results from a study of couples participating in a research protocol in which IVF/preimplantation genetic diagnosis (PGD) was available for non-medical sex selection. The study sought to characterize the moral attitudes and beliefs of couples actively pursuing IVF/PGD solely for purposes relat...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Sharp RR,McGowan ML,Verma JA,Landy DC,McAdoo S,Carson SA,Simpson JL,McCullough LB

    更新日期:2010-12-01 00:00:00

  • Early oocyte denudation does not compromise ICSI cycle outcome: a large retrospective cohort study.

    abstract::This retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were di...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Naji O,Moska N,Dajani Y,El-Shirif A,El-Ashkar H,Hosni MM,Khalil M,Khalaf Y,Bolton V,El-Toukhy T

    更新日期:2018-07-01 00:00:00

  • Gonadotrophins--filled-by-mass versus filled-by-bioassay.

    abstract::Application of recombinant technology to FSH in the early 1990s produced a highly purified preparation. Calibration of the product was dependent on the rat 'bioassay' based on measurement of ovarian weight after injection of FSH into rats. This test is associated with variability in the measurement of FSH bioactivity ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章


    authors: Hugues JN,Durnerin IC

    更新日期:2005-06-01 00:00:00