Characterization of early pregnancy placental progesterone production by use of dydrogesterone in programmed frozen-thawed embryo transfer cycles.

Abstract:

RESEARCH QUESTION:When and how does the gradual transition of the endocrine control of early pregnancy from the corpus luteum to the placenta, termed luteoplacental shift, take place? DESIGN:Prospective analysis of serum progesterone levels in pregnancies (n = 88) resulting from programmed frozen-thawed embryo transfer cycles in which ovulation was suppressed and no corpus luteum was present. Dydrogesterone, which does not cross-react with progesterone in immunoassay or spectrometric assay, was used for luteal phase and early pregnancy support. Progesterone, oestradiol and hCG were measured at regular intervals from before pregnancy achievement until +65 to 71 days after embryo transfer by Roche Elecsys electrochemiluminescence immunoassay (Elecsys ECLIA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). RESULTS:Serum progesterone remained at baseline levels on first blood analysis +9 to 15 days after embryo transfer and increased only marginally independently from the type of pregnancy up to +16 to 22 days after embryo transfer. From +23 to 29 days after embryo transfer, progesterone increased non-linearly above 1.0 ng/ml and increased further throughout the first trimester with elevated levels in multiples. Oestradiol levels increased in parallel with progesterone; hCG plateaued around +37 to 43 days. Progesterone levels were significant predictors for pregnancy viability from +23 to 29 days after embryo transfer onwards with best accuracy +37 to 43 days after embryo transfer (receiver operator characteristic analysis area under the curve 0.98; 95% CI 0.94 to 1; P = 0.0009). CONCLUSIONS:The onset of substantial progesterone production is the 7th gestational week. Progesterone increase is non-linear, depends on chorionicity and zygosity, and may have predictive potential on the outcome of pregnancies originating from frozen embryo transfer cycles.

journal_name

Reprod Biomed Online

authors

Neumann K,Depenbusch M,Schultze-Mosgau A,Griesinger G

doi

10.1016/j.rbmo.2020.01.019

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

743-751

issue

5

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(20)30072-9

journal_volume

40

pub_type

杂志文章
  • Very early prenatal diagnosis on coelomic cells using quantitative fluorescent polymerase chain reaction.

    abstract::Quantitative fluorescent PCR (QF-PCR) has been shown to be an accurate assay for the rapid prenatal diagnosis of chromosome disorders. The extra-embryonic coelom develops during week 4 of gestation and it can be aspirated from the following week, making coelocentesis the earliest possible method of prenatal diagnosis ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)62173-6

    authors: Jauniaux E,Cirigliano V,Adinolfi M

    更新日期:2003-06-01 00:00:00

  • Circulatory metastin/kisspeptin-1 in polycystic ovary syndrome: a systematic review and meta-analysis with diagnostic test accuracy.

    abstract:RESEARCH QUESTION:A close association between Kisspeptin-1 (KISS-1) and reproductive physiology has been reported, but the results on circulatory KISS-1 are ambiguous in patients with polycystic ovary syndrome (PCOS). A systematic review and meta-analysis were conducted to evaluate the association between KISS-1 and PC...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.rbmo.2019.04.018

    authors: Varikasuvu SR,Prasad VS,Vamshika VC,Satyanarayana MV,Panga JR

    更新日期:2019-10-01 00:00:00

  • Capacitation and acrosome reaction changes α-tubulin immunodistribution in human spermatozoa.

    abstract::Tubulin is a protein constituent of cytoskeletal microtubules, closely related to sperm motility. However, the changes in tubulin distribution following capacitation and acrosome reaction are poorly understood. This study immunolocalized and quantified the expression of α-tubulin in fresh, capacitated and acrosome-rea...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2013.10.001

    authors: Francou MM,Ten J,Bernabeu R,De Juan J

    更新日期:2014-02-01 00:00:00

  • Comparison of the psychological evaluation test and classical psychoanalysis in infertile women.

    abstract::This study aims to compare a psychological evaluation test to classical psychoanalysis in infertile women. Two hundred women were submitted to the Psychological Evaluation Test (PET). The sum of the scores for the responses ranged from 15 to 60 points, with scores >/=30 points being defined as 'psycho-emotional maladj...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)60492-0

    authors: Franco JG Jr,Silva PG,Achê RS,Baruffi RR,Mauri AL,Petersen CG,Felipe V,Vagnini L,Oliveira JB

    更新日期:2004-01-01 00:00:00

  • A critical assessment of the impact of the European Union Tissues and Cells Directive (2004) on laboratory practices in assisted conception.

    abstract::The European Union's Tissues and Cells Directive (2004) establishes an extensive framework of standards for all tissue banks throughout the EU. This article considers how the requirements of the Directive might be expected to achieve the stated goals of promoting the safety of assisted conception treatments and/or fac...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)60954-6

    authors: Mortimer D

    更新日期:2005-08-01 00:00:00

  • Cross-border reproductive care: market forces in action or market failure? An economic perspective.

    abstract::From an economist's perspective, cross-border reproductive care (CBRC) reflects a global market economy bringing together the needs of patients and skills of doctors at an agreed price. From this perspective CBRC is neither wrong nor right, rather it reflects rational economic behaviour of couples to maximize their we...

    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章

    doi:10.1016/j.rbmo.2011.09.006

    authors: Connolly M

    更新日期:2011-12-01 00:00:00

  • The status of global DNA methylation in the spermatozoa of smokers and non-smokers.

    abstract:RESEARCH QUESTION:Does regular smoking affect semen quality and the levels of DNA methylation in mature human spermatozoa? DESIGN:Spermatozoa from 109 men were evaluated (55 smokers and 54 non-smokers). DNA was extracted from purified spermatozoa, and DNA methylation was quantified by enzyme-linked immunosorbent assay...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2018.08.016

    authors: Hamad MF,Dayyih WAA,Laqqan M,AlKhaled Y,Montenarh M,Hammadeh ME

    更新日期:2018-11-01 00:00:00

  • Induction of ovulation in idiopathic premature ovarian failure: a randomized double-blind trial.

    abstract::In this prospective randomized study, women with idiopathic karyotypically normal premature ovarian failure (POF) were treated with gonadotrophin-releasing hormone (GnRH) agonist and gonadotrophins with and without the addition of corticosteroids in an attempt to restore ovarian function. The study comprised 58 women ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/s1472-6483(10)60711-0

    authors: Badawy A,Goda H,Ragab A

    更新日期:2007-08-01 00:00:00

  • Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies.

    abstract::The clinical implications of congenital uterine anomalies (CUA), and the benefits of hysteroscopic resection of a uterine septum, were evaluated. Studies comparing reproductive and obstetric outcome of patients with and without CUA and of patients who had and had not undergone hysteroscopic resection of a uterine sept...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.rbmo.2014.09.006

    authors: Venetis CA,Papadopoulos SP,Campo R,Gordts S,Tarlatzis BC,Grimbizis GF

    更新日期:2014-12-01 00:00:00

  • Intra-cycle fluctuations of anti-Müllerian hormone in normal women with a regular cycle: a re-analysis.

    abstract::Anti-Müllerian hormone (AMH) has emerged as an important marker of ovarian reserve. Its variation throughout the cycle, however, may still be a matter of debate. The objective of this study was to re-evaluate the intra-cycle fluctuations of AMH in individuals in a prospective clinical study with focus on the age-relat...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2012.02.023

    authors: Overbeek A,Broekmans FJ,Hehenkamp WJ,Wijdeveld ME,van Disseldorp J,van Dulmen-den Broeder E,Lambalk CB

    更新日期:2012-06-01 00:00:00

  • In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation.

    abstract::This study tested in-vitro maturation (IVM) as a complementary strategy to improve the mature oocyte yield of breast cancer patients undergoing ovarian stimulation for fertility preservation. Secondary analysis of prospectively collected data is performed for 32 breast cancer patients undergoing oocyte or embryo cryop...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2010.01.012

    authors: Oktay K,Buyuk E,Rodriguez-Wallberg KA,Sahin G

    更新日期:2010-05-01 00:00:00

  • IVF versus ICSI for the fertilization of in-vitro matured human oocytes.

    abstract::Traditional dogma suggests that intracytoplasmic sperm injection (ICSI) should be performed to ensure successful oocyte fertilization in an in-vitro maturation (IVM) cycle. This study postulated that there would be no difference in the fertilization rate when ICSI was compared with IVF. This hypothesis was tested in a...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.rbmo.2012.08.001

    authors: Walls M,Junk S,Ryan JP,Hart R

    更新日期:2012-12-01 00:00:00

  • Quantifying the effectiveness and cost-efficiency of food supplementation with antioxidants for male infertility.

    abstract::In male infertility, complementary treatment with antioxidant-containing food supplements quadruples the spontaneous pregnancy rate and reduces the cost per pregnancy by 60%. ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2011.05.009

    authors: Comhaire F,Decleer W

    更新日期:2011-09-01 00:00:00

  • Redefining advanced maternal age as an indication for preimplantation genetic screening.

    abstract::In this retrospective study, the utility of preimplantation genetic screening (PGS) in patients with advanced maternal age is evaluated. The patient population consisted of women aged 38-44years and included in a regular IVF programme with or without PGS analysis. Transfer rate, ongoing implantation rate and ongoing p...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2010.06.020

    authors: Milán M,Cobo AC,Rodrigo L,Mateu E,Mercader A,Buendía P,Peinado V,Delgado A,Mir P,Simón C,Remohí J,Pellicer A,Rubio C

    更新日期:2010-11-01 00:00:00

  • Physiology of gamete and embryo transport through the fallopian tube.

    abstract::A great deal is now known about the migration of spermatozoa within the female reproductive tract, and how they interact with the oocyte and achieve fertilization in a variety of species. The process involves a series of complex features. It is a mixture of active and passive transport and active migration, with drast...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)61935-9

    authors: Croxatto HB

    更新日期:2002-03-01 00:00:00

  • Scientific aspects of preconception gender selection.

    abstract::Although numerous methods have been promoted as having an influence on the gender of offspring, most lack credible scientific evidence of effectiveness. Preconception gender selection has an important application in reducing the risk of having children with X-linked disease. A preconception, flow cytometric sperm sort...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)62217-1

    authors: Schulman JD,Karabinus DS

    更新日期:2005-03-01 00:00:00

  • Prediction of pituitary down-regulation by evaluation of endometrial thickness in an IVF programme.

    abstract::The aim of this retrospective study was to determine whether pituitary down-regulation after gonadotrophin-releasing hormone analogue (GnRHa) administration can be accurately predicted by transvaginal ultrasonographic measurement of endometrial thickness in the presence of menstruation. All cycles of an IVF/intracytop...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)61109-1

    authors: Dogan MM,Uygur D,Alkan RN,Batioglu S,Mollamahmutoglu L

    更新日期:2004-05-01 00:00:00

  • Observations on intrauterine oxygen tension measured by fibre-optic microsensors.

    abstract::Understanding the biology of reproductive organs is essential for the development of assisted reproductive techniques. There is at present no direct evidence for either the concentration and dynamics of intrauterine oxygen tension at the endometrial surface, nor its importance for the receptiveness of the endometrium....

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)61443-5

    authors: Ottosen LD,Hindkaer J,Husth M,Petersen DE,Kirk J,Ingerslev HJ

    更新日期:2006-09-01 00:00:00

  • Cost-effectiveness of treatment strategies in women with PCOS who do not conceive after six cycles of clomiphene citrate.

    abstract::This study evaluated the cost-effectiveness of treatments for women with polycystic ovary syndrome (PCOS) who ovulate on clomiphene citrate but do not conceive after six cycles. A decision-analytic framework was developed for six scenarios: (1) three cycles of IVF; (2) continuation of clomiphene citrate for six cycles...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2014.01.014

    authors: Moolenaar LM,Nahuis MJ,Hompes PG,van der Veen F,Mol BW

    更新日期:2014-05-01 00:00:00

  • Early oocyte denudation does not compromise ICSI cycle outcome: a large retrospective cohort study.

    abstract::This retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were di...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2018.03.014

    authors: Naji O,Moska N,Dajani Y,El-Shirif A,El-Ashkar H,Hosni MM,Khalil M,Khalaf Y,Bolton V,El-Toukhy T

    更新日期:2018-07-01 00:00:00

  • Comparative protein expression profiling in human cumulus cells in relation to oocyte fertilization and ovarian stimulation protocol.

    abstract::Comparative profiling was performed on proteins synthesized in human cumulus cells (CC) from individual oocytes recovered after two different ovarian stimulation protocols for classical IVF (cIVF). Using high-resolution two-dimensional protein electrophoresis after metabolic labelling with [35S]-methionine, protein ex...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)61028-0

    authors: Hamamah S,Matha V,Berthenet C,Anahory T,Loup V,Dechaud H,Hedon B,Fernandez A,Lamb N

    更新日期:2006-12-01 00:00:00

  • Placental disorders of pregnancy in subsequent IVF pregnancies - a sibling cohort.

    abstract:RESEARCH QUESTION:To assess whether the incidence of placental disorders of pregnancy decreases with increasing parity in repeat IVF pregnancies, in the same way as natural pregnancies. DESIGN:This was a retrospective cohort of deliveries between November 2008 and January 2020, in a single university-affiliated medica...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2020.11.018

    authors: Ganer Herman H,Mizrachi Y,Farhadian Y,Shevach Alon A,Gluck O,Bar J,Kovo M,Raziel A

    更新日期:2020-11-29 00:00:00

  • Follicle recruitment determines IVF productivity rate via the number of embryos frozen and subsequent transfers.

    abstract::IVF productivity rate is an index defined as the sum of all live births from either fresh or frozen embryo transfers arising from a single oocyte collection. This retrospective analysis over 9 continuous years used this index to understand the potential impact on pregnancy rates of milder stimulation regimens with ass...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2013.05.015

    authors: Stanger JD,Yovich JL

    更新日期:2013-09-01 00:00:00

  • Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

    abstract::The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a nega...

    journal_title:Reproductive biomedicine online

    pub_type: 评论,杂志文章

    doi:10.1016/j.rbmo.2016.02.004

    authors: Markoff A,Kurahashi H,Grandone E,Bogdanova N

    更新日期:2016-05-01 00:00:00

  • The role of in-vivo and in-vitro maturation time on ooplasmic dysmaturity.

    abstract::This study investigates whether the timing of in-vivo and in-vitro maturation influences ooplasmic dysmaturity. This is a retrospective comparison of intracytoplasmic sperm injection (ICSI) cycles (index cycles) complicated by complete fertilization failure (CFF) to cycles with successful fertilization in the same pat...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2016.01.007

    authors: Pereira N,Neri QV,Lekovich JP,Palermo GD,Rosenwaks Z

    更新日期:2016-04-01 00:00:00

  • The treatment of infertility and its historical context.

    abstract::The objective of this review is to analyse and integrate into a semi-historical background the alternative treatments available for the alleviation of infertility. Data are presented on their causes and success, using compilations of data reported in the literature along with personal experience. Results are expressed...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)61601-x

    authors: Da Motta EL,Serafini P

    更新日期:2002-07-01 00:00:00

  • Role of the endocrine profile for the achievement of pregnancy with IVF.

    abstract::The predictive value of pre-ovulatory hormones for achievement of pregnancy has been extensively evaluated in assisted reproductive technologies. Currently, no high-quality evidence exists to support or deny an association between oestradiol levels on the day of human chorionic gonadotrophin (HCG) administration and p...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)60447-6

    authors: Kolibianakis EM,Venetis CA,Tarlatzis BC

    更新日期:2009-01-01 00:00:00

  • Predicting pregnancy rate following multiple embryo transfers using algorithms developed through static image analysis.

    abstract::Single-embryo image assessment involves a high degree of inaccuracy because of the imprecise labelling of the transferred embryo images. In this study, we considered the entire transfer cycle to predict the implantation potential of embryos, and propose a novel algorithm based on a combination of local binary pattern ...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/j.rbmo.2017.02.002

    authors: Tian Y,Wang W,Yin Y,Wang W,Duan F,Zhao S

    更新日期:2017-05-01 00:00:00

  • Imaging meiotic spindles by polarization light microscopy: principles and applications to IVF.

    abstract::Meiotic spindles tether the chromosomes of oocytes and have been found to be structurally abnormal in older women. Conventional methods to image the meiotic spindle, such as immunostaining or transmission electron microscopy, require prior fixation, so they cannot be used clinically, and their utility in developmental...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章,评审

    doi:10.1016/s1472-6483(10)61724-5

    authors: Keefe D,Liu L,Wang W,Silva C

    更新日期:2003-07-01 00:00:00

  • Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies.

    abstract::Over the past decade, the number of reported live births resulting from oocyte cryopreservation has rapidly increased. To appreciate the true number of children born, verified live births were tabulated and assessed. A literature search was performed; authors were then contacted to verify birth outcomes and provide up...

    journal_title:Reproductive biomedicine online

    pub_type: 杂志文章

    doi:10.1016/s1472-6483(10)60025-9

    authors: Noyes N,Porcu E,Borini A

    更新日期:2009-06-01 00:00:00