Cutaneous leukemic infiltration following varicella - a case of Wolf's isotopic response.

Abstract:

:Wolf's isotopic response designates the appearance of two subsequent unrelated dermatoses in the same anatomic location. We report the case of a 51-year-old man with a medical history of chronic lymphocytic leukemia without known extra-hematopoietic involvement. The patient developed a disseminated papulo-vesiculous eruption, diagnosed as varicella. Few days after recovering, an erythematous and violaceous papular dermatosis with histopathological examination compatible with leukemic infiltration appeared on the scars of previous herpetic lesions. Complete remission was obtained under systemic corticotherapy, without cutaneous recurrence or blastic transformation. Wolf's isotopic response is attributed to a localized immunologic imbalance following a certain stimulus. In this patient, herpetic infection acted as a local spur for inaugural cutaneous leukemic infiltration, with no impact on the prognosis for the underlying disease.

journal_name

An Bras Dermatol

authors

Brasileiro A,Lencastre A,João A,Fidalgo A

doi

10.1590/abd1806-4841.20164686

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

72-75

issue

5 suppl 1

eissn

0365-0596

issn

1806-4841

pii

S0365-05962016001100072

journal_volume

91

pub_type

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