The effect of metilpheniydate, risperidone and combination therapy on ECG in children with attention-deficit hyperactivity disorder.

Abstract:

INTRODUCTION:This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy. METHODS:A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and combined therapy for minimum 3months and an untreated ADHD group (n=76) was consecutively included in the study. Twelve lead ECG parameters including mean QT, QTc, T-peak to T-end (TpTe) intervals, TpTe dispersion and TpTe/QT ratio were compared. RESULTS:QT interval, and QTc, TpTe interval, TpTe dispersion and TpTe/QTc ratio values for groups receiving RIS, MPH and combined therapy were found to be significantly higher than other groups. Moreover, in the combined therapy group TpTe and TpTe/QTc values were higher than the single drug administration groups (p<0.05). TpTe and TpTe/QT ratio was significantly higher in the RIS group compared to that of the MPH group. CONCLUSION:These results suggested that combined therapy of these drugs had a more prominent impact on the T wave and RIS could be strongly associated with it.

journal_name

J Electrocardiol

authors

Karpuz D,Hallioglu O,Toros F,Tasdelen B

doi

10.1016/j.jelectrocard.2017.02.012

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

410-415

issue

4

eissn

0022-0736

issn

1532-8430

pii

S0022-0736(17)30059-6

journal_volume

50

pub_type

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