Pathophysiological mechanisms of altered transmembrane potentials in diseased human atria.


:The pathophysiological mechanisms of altered transmembrane potentials in diseased human atria were investigated in 20 patients who were divided into group A (normal) and group B (diseased). The electrophysiological data of right atrial tissues measured with glass microelectrodes included maximum diastolic potentials (MDP), action potential amplitudes (APA) and action potential durations at the time required for 50% repolarization (ADP 50%) and 75% repolarization (APD 75%). The sarcolemma isolated from atrial tissues was used for determination of the sarcolemmal Na+-K+ ATPase activities. Anionic molecular sites distributed in the sarcolemmal complex were characterized by cationized ferritins (CF). The electrophysiological data in groups A and B were: MDP -80.74 +/- 1.94 mV and -44.54 +/- 6.24 mV, APA 92.72 +/- 9.25 mV and 57.74 +/- 10.85 mV, APD 50% 42.48 +/- 6.63 msec and 210.34 +/- 36.38 msec and APD 75% 56.47 +/- 8.55 msec and 281.66 +/- 42.18 msec respectively. The difference in the Na+-K+ ATPase activities between groups A (15.37 +/- 0.46 mumole Pi/mg/hr) and B (12.55 +/- 0.4 mumole Pi/mg/hr) was highly significant. CF molecules were frequently seen to be more irregularly and loosely distributed in the sarcolemmal surfaces of group B atrial myocytes. Based on these results we conclude that depression of the sarcolemmal Na+-K+ ATPase activity and derangement of the anionic binding sites in the sarcolemmal surfaces play an important role in altering transmembrane potentials in diseased human atria.


J Electrocardiol


Lee YS




Has Abstract


1986-01-01 00:00:00












  • Arrhythmogenic inherited heart muscle diseases in children.

    abstract::The left ventricle (LV) plays a central role in the maintenance of health of children and adults due to its role as the major pump of the heart. In cases of LV dysfunction, a significant percentage of affected individuals develop signs and symptoms of congestive heart failure, leading to the need for therapeutic inter...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章,评审


    authors: Towbin JA,Bowles NE

    更新日期:2001-01-01 00:00:00

  • Superficial accessory pathway in the Wolff-Parkinson-White syndrome--electrophysiological, surgical and histologic demonstration.

    abstract::A superficial accessory pathway was demonstrated by electrophysiologic techniques and surgical histopathology in 30-year-old male with Wolff-Parkinson-White syndrome, severe mitral valve disease and medically uncontrollable arrhythmias. In this patient, electrode catheter studies in the cardiac catheterization laborat...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Untereker WJ,Litwak RS,Mindich BP,Wiemann G,Goldberg S,Gorlin R,Kupersmith J

    更新日期:1980-10-01 00:00:00

  • Effect of changes in left ventricular anatomy and conduction velocity on the QRS voltage and morphology in left ventricular hypertrophy: a model study.

    abstract:UNLABELLED:The increased QRS voltage is considered to be a specific electrocardiogram (ECG) sign of left ventricular hypertrophy (LVH), and it is expected that the QRS voltage reflects the increase in left ventricular mass (LVM). However, the increased QRS voltage is only one of QRS patterns observed in patients with L...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Bacharova L,Szathmary V,Kovalcik M,Mateasik A

    更新日期:2010-05-01 00:00:00

  • Arrhythmia analysis by successive RR plotting.

    abstract::A successive RR interval plot was developed to analyze arrhythmia. The plot consisted of a set of points with the x-value of (N)th RR interval and the y-value of (N + 1)th RR interval. This method was applied in the arrhythmia analysis of Holter electrocardiograms obtained from 35 patients. In the analysis of ventricu...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Anan T,Sunagawa K,Araki H,Nakamura M

    更新日期:1990-07-01 00:00:00

  • Differences between supine and sitting Frank-lead electrocardiograms.

    abstract::Frank-lead electrocardiograms (ECGs) were recorded from 59 adult males with suspected coronary artery disease. Three records were recorded consecutively on frequency modulated tape for each patient in (1) supine position, (2) sitting position with arms relaxed, and (3) sitting position on bicycle with arms on bicycle ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Shapiro W,Berson AS,Pipberger HV

    更新日期:1976-01-01 00:00:00

  • Successful epicardial ablation for ventricular tachycardia originating from the true apex of apical aneurysm associated with hypertrophic cardiomyopathy.

    abstract::Hypertrophic cardiomyopathy (HCM) with apical aneurysm (AA) is rare, but has been reported to be associated with refractory ventricular tachycardias (VTs). Majority of such cases had a central isthmus of the reentry circuit on the border zone of AA. In this report, we describe a rare case of the successful epicardial ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Nakao M,Watanabe M,Kamada R,Hagiwara H,Takahashi Y,Koya T,Kadosaka T,Koizumi T,Hirose M,Anzai T

    更新日期:2020-01-01 00:00:00

  • Effects of supernormal capture on directly measured nonmodulated parasystolic cycles.

    abstract::Pacemaker capture during the supernormal period was seen in a case of modulated parasystole where ectopic cycles occurred without any interposed nonparasystolic beat. This contrasts with previous clinical reports, since, in the latter, the parasystolic cycle length could not be measured directly. As in experimental st...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Castellanos A,De La Hera A,Luceri RM,Mendoza IJ,Myerburg RJ

    更新日期:1989-10-01 00:00:00

  • ST-segment deviation pattern of takotsubo cardiomyopathy similar to acute pericarditis: diffuse ST-segment elevation.

    abstract:BACKGROUND:Possible similarities or differences in the ST- and PR-segment deviations in the electrocardiogram of takotsubo cardiomyopathy (TTC) and acute pericarditis (AP) are not well defined. METHODS:We compared different parameters of the admission electrocardiogram in eight patients with TTC and eight patients wit...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Zhong-qun Z,Chong-quan W,Sclarovsky S,Nikus KC,Chao-rong H,Shan M

    更新日期:2013-03-01 00:00:00

  • Abnormal atrial activation is common in patients with arrhythmogenic right ventricular cardiomyopathy.

    abstract:INTRODUCTION:Structural right atrial abnormalities have been described in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, little is known about electrocardiographic signs of atrial involvement in ARVC because no systematic studies have been conducted. METHODS:P-wave-triggered signal-aver...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Platonov PG,Christensen AH,Holmqvist F,Carlson J,Haunsø S,Svendsen JH

    更新日期:2011-03-01 00:00:00

  • Exercise training slows down heart rate and improves deceleration and acceleration capacity in patients with heart failure.

    abstract::Controlled physical training has been shown to be a valuable therapeutic addition to a pharmacological treatment in patients with chronic heart failure (CHF). It is speculated that repeated physical training can improve the autonomic modulation of the cardiovascular system in patients with CHF. The present study evalu...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章,随机对照试验


    authors: Ricca-Mallada R,Migliaro ER,Piskorski J,Guzik P

    更新日期:2012-05-01 00:00:00

  • CSE (common standards for quantitative electrocardiography) data testing in Japan.

    abstract::The authors comment on the present status of computerized electro-cardiogram (ECG) works in Japan and demonstrate the preliminary tentative results of CSE (common standards for quantitative electrocardiography) data analysis using the Nagoya program. The more detailed results of the performance of several programs in ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Okamoto N,Ohsawa N

    更新日期:1988-01-01 00:00:00

  • Paroxysmal supraventricular tachycardia caused by 1:2 atrioventricular conduction in the presence of dual atrioventricular nodal pathways.

    abstract::One-to-two atrioventricular conduction, ie, the double response to a single sinus or atrial impulse, resulting in two QRS complexes for one P wave, is a rare manifestation of dual atrioventricular (AV) nodal pathways. This report describes the case of a 61-year-old woman with continuous episodes of supraventricular ta...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Fraticelli A,Saccomanno G,Pappone C,Oreto G

    更新日期:1999-10-01 00:00:00

  • Intermittent ventricular parasystolic bigeminy accompanied by reentrant ventricular extrasystoles.

    abstract::An extremely rare case of intermittent ventricular parasystolic bigeminy is presented, in which coexisting reentrant ventricular extrasystoles of sinus origin, showing mainly trigeminy, and those of ventricular parasystolic origin, showing a close coupling to the ventricular parasystolic beat, are demonstrated. Such a...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Izumi K

    更新日期:1990-04-01 00:00:00

  • Holter ECG study of the electrocardiographic phenomena in Prinzmetal angina attacks with emphasis on the study of ventricular arrhythmias.

    abstract::The ECG phenomena in 20 outpatients (121 episodes) suffering from variant angina with transient ST segment elevation greater than 1.5 mm. (Prinzmetal angina) were studied by Holter monitoring. The most important changes in the ECG morphology were: a) increased height of the R wave in all cases, b) the S wave decreased...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Bayes de Luna A,Carreras F,Cladellas M,Oca F,Sagues F,Garcia Moll M

    更新日期:1985-07-01 00:00:00

  • Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies.

    abstract::The objective of this article is to present a set of methods for constructing realistic computational models of cardiac structure from high-resolution structural and diffusion tensor magnetic resonance images and to demonstrate the applicability of the models in simulation studies. The structural image is segmented to...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Vadakkumpadan F,Rantner LJ,Tice B,Boyle P,Prassl AJ,Vigmond E,Plank G,Trayanova N

    更新日期:2009-03-01 00:00:00

  • Possible role of a ventricular conduction disturbance in the electrogenesis of the ECG-VCG signs of myocardial infarction.

    abstract::The typical QRS patterns of myocardial infarction (MI-QRS) are commonly attributed to myocardial cellular death. However, observation of a transient appearance of MI-QRS during coronary insufficiency, the disappearance of MI-QRS after coronary by-pass surgery and the appearance of MI-QRS after intracranial hemorrhage ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Piccolo E,Delise P,Raviele A,D'Este D,Lucangeli F,Pascotto P,Dainese F,Di Pede F

    更新日期:1983-10-01 00:00:00

  • Electrocardiogram voltage discordance: Interpretation of low QRS voltage only in the precordial leads.

    abstract:OBJECTIVES:To define clinical correlates of low voltage isolated to precordial leads on the surface electrocardiogram (ECG). INTRODUCTION:Low voltage (V) on the ECG is defined as QRS V<5mm in all limb leads and <10mm in all precordial leads. The diagnostic use of ECGs with low voltage isolated to the precordial leads ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Kim DH,Verdino RJ

    更新日期:2017-01-01 00:00:00

  • The value of transtelephonic electrocardiogram monitoring system during the "Blanking Period" after ablation of atrial fibrillation.

    abstract:OBJECTIVE:The aim of our study was to investigate the value of the transtelephonic electrocardiogram (TTECG) monitoring system during a "blanking period" of 3 months after ablation by analyzing the frequency of atrial arrhythmias episodes and the relationship between the frequency of atrial fibrillation (AF) attacks an...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Liu J,Fang PH,Hou Y,Li XF,Liu Y,Wang YS,Zhang S

    更新日期:2010-11-01 00:00:00

  • Spatial characteristics of atrial fibrillation electrocardiograms.

    abstract:BACKGROUND:The present study investigates spatial properties of atrial fibrillation (AF) by analyzing vectorcardiogram loops synthesized from 12-lead electrocardiograms (ECGs). METHODS:After atrial signal extraction, spatial properties are characterized through analysis of successive, fixed-length signal segments and ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Richter U,Stridh M,Bollmann A,Husser D,Sörnmo L

    更新日期:2008-03-01 00:00:00

  • Isolated spontaneous septal myocardial infarction.

    abstract::Isolated occlusion of the septal perforating branch of the left anterior descending coronary artery is extremely rare. As a result, little is known about its electrocardiographic manifestations compared with those of an anteroseptal myocardial infarction. We present the case of an isolated septal myocardial infarction...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Tomcsanyi J,Bozsik B,Zsoldos A,Simor T

    更新日期:2012-05-01 00:00:00

  • Does the abnormal signal-averaged electrocardiogram predict future appropriate therapy in patients with implantable cardioverter-defibrillators?

    abstract:BACKGROUND:Several studies have documented the prognostic significance of the signal-averaged electrocardiogram (SAECG) both after myocardial infarction and nonischemic cardiomyopathy. However, whether the SAECG can identify patients with implantable cardioverter-defibrillator (ICD) who receive appropriate therapy has ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Haghjoo M,Arya A,Parsaie M,Dehghani MR,Sadr-Ameli MA

    更新日期:2006-04-01 00:00:00

  • High-resolution ECG on a standard ECG cart.

    abstract::High-resolution (HI-RES) ECG analysis software and a new front end have been designed for a standard 12-lead ECG cart, MAC-12. The front end acquires orthogonal ECG at 1,000 samples/sec and 1.2 microV/bit and transmits to the cart. The HI-RES software delineates QRS complexes and correlates them with a template in fre...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Reddy BR,Christenson DW,Rowlandson GI

    更新日期:1988-01-01 00:00:00

  • Transient left posterior hemiblock during myocardial ischemia-eliciting exercise treadmill testing: a report of a case and a critical analysis of the literature.

    abstract::We describe a 75-year-old male patient with two-vessel coronary artery disease, who developed transient left posterior hemiblock (LPH) while undergoing an exercise treadmill test (ETT). The intraventricular conduction abnormality initially had the features of alternating LPH, which evolved to stable LPH prior to dissi...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章,评审


    authors: Madias JE,Knez P

    更新日期:1999-01-01 00:00:00

  • A device for producing high frequency electrocardiograms on a conventional direct writing electrocardiograph.

    abstract::A device has been developed which can be used in conjunction with a direct-writing electrocardiograph to record the high frequency electrocardiogram (ECG) including notches and slurs in the waveform. The device operates on the principle of temporarily storing the QRS complex and then reproducing it at a rate 10 times ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Geselowitz DB,Balogh J,Bishop RR

    更新日期:1975-07-01 00:00:00

  • Distorted T-vector loop and increased heart rate are associated with ventricular fibrillation in a porcine ischemia-reperfusion model.

    abstract:BACKGROUND:The ventricular repolarization (VR) response to short-lasting coronary occlusion has been characterized by 3-dimensional vectorcardiography during angioplasty in humans; the T-vector loop becomes distorted (increased T(avplan)) and more circular (decreased T(eigenvalue)), but these changes have not been rela...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Odenstedt J,Rubulis A,Grip L,Bergfeldt L

    更新日期:2009-05-01 00:00:00

  • Rate dependent variation in concealed bigeminy.

    abstract::A 63 year old man with angina pectoris was found to have frequent extrasystoles separated by odd as well as even numbers of conducted sinus beats. Analysis of 935 conducted sinus beats showed that premature ventricular beats without interpolation were separated by odd numbers of conducted sinus beats in 117 sequences ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Bissett JK,Watson JW,Wanta-Matthews M,Ozemek H

    更新日期:1982-01-01 00:00:00

  • Ventricular flutter triggered by fever in a patient with Brugada syndrome.

    abstract::Brugada syndrome is a clinical-electrocardiographic entity predisposing to malignant ventricular arrhythmias. The typical arrhythmia is polymorphic ventricular tachycardia, which can potentially degenerate to ventricular fibrillation. Monomorphic ventricular tachycardia is uncommon. Our group is reporting the case of ...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: McIntyre WF,Femenía F,Arce M,Trucco E,Palazzolo J,Pérez-Riera AR,Baranchuk A

    更新日期:2012-05-01 00:00:00

  • Ablation of nonparoxysmal A-V nodal tachycardia.

    abstract::The present study describes the successful radiofrequency ablation of an uncommon type of A-V nodal tachycardia. Electroanatomical mapping of the right atria was used to locate the region of the earliest atrial activation and allowed for positioning of the ablation catheter and a successful 25-watt radiofrequency burn...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Pollak SJ,Dreifus LS

    更新日期:2002-01-01 00:00:00

  • A completely automated activation-repolarization interval algorithm for directly coupled unipolar electrograms and its three-dimensional correlation with refractory periods.

    abstract::Sintered Ag-AgCl needle electrodes were used to record unipolar directly coupled (DC) electrograms transmurally from right and left ventricular myocardium. Direct coupling yields unfiltered low-frequency signal content, preserving repolarization waveform morphology. These electrograms were analyzed using completely au...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Witkowski FX,Penkoske PA

    更新日期:1988-08-01 00:00:00

  • The value of both ST-segment and QRS complex changes during acute coronary occlusion for prediction of reperfusion-induced myocardial salvage in a canine model.

    abstract:BACKGROUND:Analysis of ST-segment elevation for assessment of patients with suspected acute coronary occlusion is in widespread use for diagnostic and prognostic purposes. In this study, changes in the QRS complex also were analyzed to determine if these changes that are seldom used clinically can provide additional pr...

    journal_title:Journal of electrocardiology

    pub_type: 杂志文章


    authors: Weston P,Johanson P,Schwartz LM,Maynard C,Jennings RB,Wagner GS

    更新日期:2007-01-01 00:00:00