Abstract：
:The development of large-scale network models that infer the effective (directed) connectivity among neuronal populations from neuroimaging data represents a key challenge for computational neuroscience. Dynamic causal models (DCMs) of neuroimaging and electrophysiological data are frequently used for inferring effective connectivity but are presently restricted to small graphs (typically up to 10 regions) in order to keep model inversion computationally feasible. Here, we present a novel variant of DCM for functional magnetic resonance imaging (fMRI) data that is suited to assess effective connectivity in large (whole-brain) networks. The approach rests on translating a linear DCM into the frequency domain and reformulating it as a special case of Bayesian linear regression. This paper derives regression DCM (rDCM) in detail and presents a variational Bayesian inversion method that enables extremely fast inference and accelerates model inversion by several orders of magnitude compared to classical DCM. Using both simulated and empirical data, we demonstrate the face validity of rDCM under different settings of signal-to-noise ratio (SNR) and repetition time (TR) of fMRI data. In particular, we assess the potential utility of rDCM as a tool for whole-brain connectomics by challenging it to infer effective connection strengths in a simulated whole-brain network comprising 66 regions and 300 free parameters. Our results indicate that rDCM represents a computationally highly efficient approach with promising potential for inferring whole-brain connectivity from individual fMRI data.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Frässle S,Lomakina EI,Razi A,Friston KJ,Buhmann JM,Stephan KEdoi
10.1016/j.neuroimage.2017.02.090subject
Has Abstractpub_date
2017-07-15 00:00:00pages
406-421eissn
1053-8119issn
1095-9572pii
S1053-8119(17)30201-Xjournal_volume
155pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:Reward and punishment shape behavior, but the mechanisms underlying their effect on skill learning are not well understood. Here, we tested whether the functional connectivity of premotor cortex (PMC), a region known to be critical for learning of sequencing skills, is altered after training when reward or punishment ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.01.009
更新日期：2019-04-01 00:00:00
abstract：:Recent animal studies have suggested that cortical areas may play a greater role in the modulation of abnormal oscillatory activity in Parkinson's disease (PD) than previously recognized. We investigated task and medication-dependent, EEG-based directional cortical connectivity in the θ (4-7Hz), α (8-12Hz), β (13-30Hz...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.03.018
更新日期：2011-06-15 00:00:00
abstract：:Some individuals are more distracted by pain during a cognitive task than others, representing poor pain coping. We have characterized individuals as A-type (attention dominates) or P-type (pain dominates) based on how pain interferes with task speed. The ability to optimize behavior during pain may relate to the flex...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.06.005
更新日期：2017-08-15 00:00:00
abstract：:Divergent thinking tests have been used extensively in neuroscientific studies of creativity. However, output from tests of divergent thinking can be scored in different ways, and those scores can influence assessments of divergent thinking performance and its relationship with brain activation. Here we sought to inve...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.117325
更新日期：2020-12-01 00:00:00
abstract：:Disease in the brain is often associated with subtle, spatially diffuse, or complex tissue changes that may lie beneath the level of gross visual inspection, even on magnetic resonance imaging (MRI). Unfortunately, current computer-assisted approaches that examine pre-specified features, whether anatomically-defined (...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.11.006
更新日期：2018-02-15 00:00:00
abstract：:The current study used a magnetoencephalogram to investigate the relationship between high-gamma (52-100 Hz) activity within an attention network and individual differences in behavioral performance among healthy elderly adults. We analyzed brain activity in 41 elderly subjects performing a 3-stimulus visual oddball t...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.06.037
更新日期：2014-10-15 00:00:00
abstract：:In this study, we examined the impact of goal-directed processing on the response to emotional pictures and the impact of emotional pictures on goal-directed processing. Subjects (N=22) viewed neutral or emotional pictures in the presence or absence of a demanding cognitive task. Goal-directed processing disrupted the...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.11.048
更新日期：2007-03-01 00:00:00
abstract：:The ability to select and integrate relevant information in the presence of competing irrelevant information can be enhanced by advance information to direct attention and guide response selection. Attentional preparation can reduce perceptual and response conflict, yet little is known about the neural source of confl...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.06.058
更新日期：2009-11-01 00:00:00
abstract：:Proton magnetic resonance spectroscopy (1H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.03.031
更新日期：2017-05-15 00:00:00
abstract：:Ultra High Field (UHF) MRI requires improved gradient and shim performance to fully realize the promised gains (SNR as well as spatial, spectral, diffusion resolution) that higher main magnetic fields offer. Both the more challenging UHF environment by itself, as well as the higher currents used in high performance co...
journal_title：NeuroImage
pub_type： 杂志文章,评审
doi：10.1016/j.neuroimage.2016.11.033
更新日期：2018-03-01 00:00:00
abstract：:A fundamental component of brain development is the formation of large-scale networks across the cortex. One such network, the default network, undergoes a protracted development, displaying weak connectivity in childhood that strengthens in adolescence and becomes most robust in adulthood. Little is known about the g...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.10.030
更新日期：2012-02-01 00:00:00
abstract：:Macroscopic models of brain networks typically incorporate assumptions regarding the characteristics of afferent noise, which is used to represent input from distal brain regions or ongoing fluctuations in non-modelled parts of the brain. Such inputs are often modelled by Gaussian white noise which has a flat power sp...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.11.034
更新日期：2017-02-01 00:00:00
abstract：:Discovering functional connectivity between and within brain regions is a key concern in neuroscience. Due to the noise inherent in fMRI data, it is challenging to characterize the properties of individual voxels, and current methods are unable to flexibly analyze voxel-level connectivity differences. We propose a new...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.07.046
更新日期：2012-11-15 00:00:00
abstract：:Depression is one of the leading causes of disability worldwide. Immense heterogeneity in symptoms of depression causes difficulty in diagnosis, and to date, there are no established biomarkers or imaging methods to examine depression. Unpredictable chronic mild stress (CMS) induced anhedonia is considered to be a rea...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.07.001
更新日期：2016-11-15 00:00:00
abstract：:Previous studies have suggested the importance of bilateral anterior temporal regions in face-name associations, but there is little evidence concerning their precise role. In this fMRI study, we investigated the effects of person-related semantics (PS) and repeated learning (R) on activations in these regions during ...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.09.043
更新日期：2006-04-01 00:00:00
abstract：:Current theories of cognitive dysfunction in schizophrenia emphasize an impairment in the ability of individuals suffering from this disorder to monitor their own performance, and adjust their behavior to changing demands. Detecting an error in performance is a critical component of evaluative functions that allow the...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.09.046
更新日期：2011-01-15 00:00:00
abstract：:Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigat...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.04.022
更新日期：2014-08-15 00:00:00
abstract：:The impulse to act for immediate reward often conflicts with more deliberate evaluations that support long-term benefit. The neural architecture that negotiates this conflict remains unclear. One account proposes a single neural circuit that evaluates both immediate and delayed outcomes, while another outlines separat...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.12.071
更新日期：2015-04-01 00:00:00
abstract：:In the social neuroscience of face processing, multiple roles are attributed to amygdala: signalling of fear/threat-stimuli, of emotional expression, and general salience. The current study aimed at a direct comparison of amygdala activation attributable to these conditions by contrasting amygdala responses to matched...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.11.024
更新日期：2011-02-14 00:00:00
abstract：:An influential framework suggests that the central nucleus of the amygdala (CeA) is involved in phasic responses to threat, while the bed nucleus of the stria terminalis (BNST) mediates sustained anxiety. However, this model has been questioned, proposing that the role of the BNST is not limited to sustained threat co...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.10.054
更新日期：2018-02-01 00:00:00
abstract：:While we have a fair understanding of how and where forelimb-hand manipulative movements are controlled by the neocortex, due to functional imaging studies, we know little about the control of bipedal movements such as walking because of technical difficulties. We succeeded in visualizing cortical activation patterns ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2001.0905
更新日期：2001-11-01 00:00:00
abstract：:In human functional magnetic resonance imaging (fMRI), a characteristic pattern of frontal and parietal activity is produced by many different cognitive demands. Although frontoparietal cortex has been shown to represent a variety of task features in different contexts, little is known about detailed representation of...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.04.035
更新日期：2011-05-15 00:00:00
abstract：:Multi-slice perfusion-based functional magnetic resonance imaging (p-fMRI) is demonstrated with a color-word Stroop task as an established cognitive paradigm. Continuous arterial spin labeling (CASL) of the blood in the left common carotid artery was applied for all repetitions of the functional run in a quasi-continu...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.04.040
更新日期：2005-10-01 00:00:00
abstract：:Functional imaging studies consistently support the role of the medial prefrontal cortex to be a part of a functional network of reflective self-awareness. The current study introduces a new linguistic task which (1) directly compares self-reference and other-reference, and (2) separates pre-reflective from reflective...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.01.060
更新日期：2008-08-01 00:00:00
abstract：:Current resting-state network analysis often looks for coherent spontaneous BOLD signal fluctuations at frequencies below 0.1 Hz in a multiple-minutes scan. However hemodynamic signal variation can occur at a faster rate, causing changes in functional connectivity at a smaller time scale. In this study we proposed to ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.10.015
更新日期：2013-01-15 00:00:00
abstract：:Conditioned pain-related fear may contribute to hyperalgesia and central sensitization, but this has not been tested for interoceptive, visceral pain. The underlying ability to accurately predict pain is based on predictive cue properties and may alter the sensory processing and cognitive-emotional modulation of pain ...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2016.01.064
更新日期：2016-04-15 00:00:00
abstract：:The modulation of repetition effects by the lag between first and second presentations of a visual object during a speeded semantic judgment task was examined using both scalp event-related potentials (ERPs) and event-related functional magnetic resonance imaging (efMRI). Four levels of lag were used within a single s...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2003.12.020
更新日期：2004-04-01 00:00:00
abstract：:A new rotation-invariant spherical harmonic decomposition (SHD) method is proposed in this paper for analyzing high angular resolution diffusion (HARD) imaging. Regular SHD methods have been used to characterize the features of the apparent diffusion coefficient (ADC) profile measured by the HARD technique. However, t...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.08.045
更新日期：2006-02-15 00:00:00
abstract：:The association between white matter hyperintensities (WMH) and amyloid accumulation over time in cognitively normal, amyloid-negative elderly people remains largely unexplored. In order to study whether baseline WMH were associated with longitudinal subthreshold amyloid accumulation, 159 cognitively normal participan...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2020.116944
更新日期：2020-09-01 00:00:00
abstract：:In this work, we propose to use fiber tracking in order to analyze and quantify the state of the pyramidal tracts in patients affected by tumors. We introduce a framework that includes an automatic method to obtain the fibers involved in the pyramidal tract of any subject, in order to compare robustly fiber bundles af...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.12.032
更新日期：2010-03-01 00:00:00
